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Toxic Effects of Seed Methanolic Extracts of Endemic Albizia Species （Fabaceae） from Madagascar on Animals

Journal of Life Sciences 2014年第8期8卷 676-689页

作者： Hanitra Ranjana Randrianarivo Anjarasoa Ravo Razafindrakoto Holy Christiane Ratsimanohatra Lovarintsoa Judicael Randriamampianina Clara Fredeline Rajemiarimoelisoa lolona ramamonjisoa David Ramanitrahasimbola Danielle Aurore Doll Rakoto Victor Louis Jeannoda Laboratory of Applied Biochemistry to Medical Sciences Fundamental and Applied Biochemistry Department Faculty of SciencesUniversity of Antananarivo PO Bo 906 Antananarivo 101 Madagascar Department of Pharmacy Faculty of Medicine PO Box 375 Antananarivo 101 Madagascar National Tree Seed Centre (SNGF) PO Box 5091 Antananarivo 101 Madagascar

In order to find natural compounds of interest such as pesticides and therapeutic molecules, toxicological properties of seed methanolic extracts (SME) of nine Malagasy Albizia species were investigated. Toxicity was assessed on living animals by intraperitoneal and oral route, and pharmacological effects on isolated organs. All SME induced various disorders in mice but the signs of the nervous system disturbs were the earliest and the most often observed. The main organ lesions, examined on histological sections, induced vasodilatation, inflammatory infiltrate of neutrophil polymorphonuclears and hemorrhagic areas. At low concentrations (until 20 μg/mL), A. masikororum and A. viridis provoked on isolated auricular a positive inotrope effect followed by a progressive inhibition of the contraction and a complete atrial arrhythmia. Besides, A. viridis and A. bernieri induced some hepatic functional impairment after a chronic treatment during one month. Albizia greveana with a LD50 of 1.13-2 mg/kg was the most toxic and Albizia bernieri the least one with a LD50 of 52 mg/kg. Alkaloids and/or saponins, the major chemical groups found by phytochemical screening on these extracts, could be responsible of their toxicity.

关键词：马达加斯加甲醇提取物毒性效应活体动物合欢种子物种中性粒细胞

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