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Fate of Right Coronary Artery Occlusion after a Surgically Repaired Aorto- Ventricular Tunnel in a Neonate

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Congenital Heart Disease 2024年第3期19卷 267-273页

作者： Sherif Negm loic Mace Fedoua El Louali Beatrice Desnous Philipe Aldebert Virginie Fouilloux Marien Lenoir Department of Pediatric Cardiac Surgery Hôpital Timone enfantAssistance Public-Hopitaux MarseilleAix-Marseille UniversitéMarseilleFrance Department of Cardiothoracic Surgery Tanta UniversityTantaEgypt Department of Pediatric Cardiology Hôpital Timone enfantAssistance Public-Hopitaux MarseilleAix-Marseille UniversitéMarseilleFrance Department of Neurology Hôpital Timone enfantAssistance Public-Hopitaux MarseilleAix-Marseille UniversitéMarseilleFrance

The aorto-ventricular tunnel is a rare congenital cardiac *** present a case of aorto-ventricular tunnel diagnosed via fetal *** surgery was performed on the 2nd day of life to close the tun-nel,located just in front of the right coronary ostium,due to the patient’s unstable health *** post-operative period revealed complete occlusion of the right coronary *** to the patient’s stability,we opted not to reintervene on the right coronary *** patient fully recovered without the need for further coronary *** cases of patients with an aorto-ventricular tunnel(AVT)and associated coronary lesions,it is crucial to exercise caution when intervening in the coronary arteries.

关键词： Aorto-ventricular tunnel aorta right coronary artery

Predictive Factors for Pre-Eclampsia: A Case-Control Study in Two Hospitals in Yaounde

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Open Journal of Obstetrics and Gynecology 2024年第4期14卷 565-574页

作者： Junie Annick Metogo Ntsama Ines Winnie Gouanfo Claude Hector Mbia Wilfried loic Tatsipie Pascal Mpono Madye Ngo Dingom Felix Essiben Claude Cyrille Noa Ndoua Faculty of Medicine and Biomedical Sciences University of Yaound&#233 I Yaound&#233 Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Dschang Dschang Cameroon

Introduction: Pre-eclampsia is a major cause of maternal and prenatal morbidity and mortality, that complicates 2% to 8% of pregnancies worldwide. The aim of this study was to determine the predictive factors for pre-eclampsia in two hospitals in the city of Yaoundé. Methods: A case-control study was conducted at the Gynaecology & Obstetrics department of the Yaoundé Gynaeco-Obstetric and Paediatric Hospital (YGOPH) and the Main Maternity of the Yaoundé Central Hospital (MM-YCH) from February 1 to July 30, 2022. The cases were all pregnant women presenting with pre-eclampsia. The control group included pregnant women without pre-eclampsia. Descriptive statistics followed by logistic regression analyses were conducted with level of significance set at p-value Results: Included in the study were 33 cases and 132 controls, giving a total of 165 participants. The predictive factors for pre-eclampsia after multivariate analysis were: primiparity (aOR = 51.86, 95% CI: 3.01 - 1230.96, p = 0.045), duration of exposure to partner’s sperm Conclusion: The odds of pre-eclampsia increased with primiparity, duration of exposure to partner’s sperm < 3 months, personal history of pre-eclampsia and maternal history of pre-eclampsia. Recognition of these predictor factors would improve the ability to diagnose and monitor women likely to develop pre-eclampsia before the onset of disease for timely interventions.

关键词： Pre-Eclampsia Predictive Factors Yaoundé

The Hidden Side of the Story between the Placenta and Preeclampsia: Preliminary Results of a Prospective Cohort of Pregnant Women in Cameroon

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Open Journal of Obstetrics and Gynecology 2024年第4期14卷 610-620页

作者： Junie Annick Metogo Ntsama Ambroise Merci Engounou Seme Urielle Julie Tchuente Sutchueng Wilfried loic Tatsipie Christian Vagoda Henry-Leonard Chatelin Mol Madye Ngo Dingom Felix Essiben Cyrille Claude Noa Ndoua Yann chris Eng Odile Fernande Zeh Faculty of Medicine and Biomedical Sciences University of Yaound&#233 I Yaound&#233 Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Dschang Dschang Cameroon

Introduction: Pre-eclampsia is a complication of pregnancy that generally occurs in the third trimester. It is associated with a maternal and foetal mortality rate of around 27%. In view of the grim picture painted by this condition for both mother and newborn, studies have been carried out into the early detection of patients at risk of developing pre-eclampsia. These make it possible to introduce pregnancy-specific monitoring and preventive strategies to reduce the incidence of the condition. Objective: To establish the link between placental ultrasound characteristics and the onset of pre-eclampsia. Methodology: A multicentre prospective cohort study was conducted in two hospitals in Yaoundé, namely the Yaoundé Gynaecological Obstetrics and Paediatrics Hospital and the Nkolndongo Health and Social Animation Centre, in the gynaecology and radiology departments over a period of 11 months, from October 2022 to August 2023. It included pregnant women who had undergone obstetric ultrasound between 12 and 18 weeks’ gestation. In addition to routine obstetric ultrasound, we performed obstetric Doppler measurements in these patients. The resistance index of the left and right uterine arteries, the umbilical artery and the placental volume were the characteristics sought. At the end of this examination, two groups were formed: cases (pathological Doppler group) and controls (normal Doppler group). Blood pressure and urine dipstick were taken at each antenatal visit until delivery, then during the immediate postpartum period and finally at 7 days, 21 days and 42 days after delivery. Results: Sixty-seven (67) patients were included. Of these, 35 (47.8%) had pathological Dopplers. Sixteen patients had arterial hypertension associated with proteinuria and were therefore labelled as pre-eclampsia (PE). This gives a prevalence of 23.9%. Fifteen (42.8%) of these patients belonged to the exposed group and one to the unexposed group. The mean IR of the pre-eclampsia patients was s

关键词： Pre-Eclampsia Doppler Ultrasound Placenta

Formal verification of synchronous data-flow program transformations toward certified compilers

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Frontiers of Computer Science 2013年第5期7卷 598-616页

作者： Van Chan NGO Jean-Pierre TALPIN Thierry GAUTIER Paul Le GUERNIC loic BESNARD INRIA Rennes-Bretagne Atlantique Rennes 35042 France IRISA/CNRS Rennes 35042 France

Translation validation was invented in the 90＇s by Pnueli et al. as a technique to formally verify the correctness of code generators. Rather than certifying the code generator or exhaustively qualifying it, translation validators attempt to verify that program transformations preserve semantics. In this work, we adopt this approach to formally verify that the clock semantics and data dependence are preserved during the compilation of the Signal compiler. Translation valida- tion is implemented for every compilation phase from the initial phase until the latest phase where the executable code is generated, by proving the transformation in each phase of the compiler preserves the semantics. We represent the clock semantics, the data dependence of a program and its trans- formed counterpart as first-order formulas which are called clock models and synchronous dependence graphs （SDGs）, respectively. We then introduce clock refinement and depen- dence refinement relations which express the preservations of clock semantics and dependence, as a relation on clock mod- els and SDGs, respectively. Our validator does not require any instrumentation or modification of the compiler, nor any rewriting of the source program.

关键词： formal verification translation validation certi-fied compiler multi-clocked synchronous programs embed-ded systems.

Polychronous automata and their use for formal validation of AADL models

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Frontiers of Computer Science 2019年第4期13卷 677-697页

作者： Thierry GAUTIER Clement GUY Alexandre HONORAT Paul LE GUERNIC Jean-Pierre TALPIN loic BESNARD Univ. Rennes Inria Rennes-Bretagne-Atlantique Research Centre F-35000 Rennes France Univ. Rennes CNRS IRISA F-35000 Rennes France

This paper investigates how state diagrams can be best represented in the polychronous model of computation (MoC) and proposes to use this model for code validation of behavior specifications in architecture analysis & design language (AADL). In this relational MoC, the basic objects are signals, which are related through dataflow equations. Signals are associated with logical clocks, which provide the capability to describe systems in which components obey multiple clock rates. We propose a model of finite-state automata, called polychronous automata, which is based on clock relationships. A specificity of this model is that an automaton is submitted to clock constraints, which allows one to specify a wide range of control-related configurations, being either reactive or restrictive with respect to their control environment. A semantic model is defined for these polychronous automata, which relies on boolean algebra of clocks. Based on a previously defined modeling method for AADL software architectures using the polychronous MoC, the proposed model is used as a formal model for the AADL behavior annex. This is illustrated with a case study involving an adaptive cruise control system.

关键词： architecture modeling formal semantics finitestate automaton polychronous model synchronous concurrency code generation AADL

Tayloring cell populations for neurodegenerative diseases

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Neural Regeneration Research 2016年第10期11卷 1582-1583页

作者： jeff m.fortin loic p.deleyrolle brent a.reynolds Lillian S.Wells Department of Neurosurgery University of FloridaGainesvilleFLUSA PrestonA.Wells Jr.for Brain Tumor TherapyUniversity of FloridaGainesvilleFLUSA

Neurological disorders are increasing in prevalence world- wide, and interest in stem cell therapies for these amictions has increased over the past two decades. While many neu- rological injuries are too devastating for the repair capabil- ities of endogenous neural stem cells （NSCs） an alternative is to harvest stem cells from a donor and grow them in vitro, to be used later as a donor source for transplantation. Many research groups have already done this, first using animal models and now using clinical trial participants. Despite the regular flow of publications about cell replace- ment therapies for central nervous system （CNS） disorders, there is still a scarcity of clinically-relevant reports of effi- cacy. The capability of donor cells to undergo ample site-di- rected differentiation and functional integration seems to be lacking （Andressen, 2013）. So, while stem cells do have properties that are suited for repair of the injured CNS, a primary remaining question is how these cells can best be grafted to produce long-term functional benefit to the host environment. Moreover, among the challenges in neural cell transplantation is controlling the ultimate characteris- tics of grafted cells, pertaining to their survival, phenotypes and performance.

关键词： cell Tayloring cell populations for neurodegenerative diseases

Extracts of the seaweed Bifurcaria bifurcata display antifungal activity against human dermatophyte fungi

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Journal of Oceanology and Limnology 2019年第3期37卷 848-854页

作者： CARVALHO G.loic SILVA Raquel GONCALVES J.Maria BATISTA T.Maria PEREIRA Leonel Environmental and Biochemical Sciences Group the James Hutton InstituteDundee DD2 5DAScotlandUK Institute of Mechanical Process and Energy EngineeringSchool of Engineering and Physical SciencesHeriot Watt UniversityEdinburgh EH14 4ASScotlandUK MARE (Marine and Environmental Sciences Centre) Department of Life SciencesFaculty of Sciences and TechnologyUniversity of CoimbraCoimbra 3030-790Portugal CIEPQPF Department of Chemical EngineeringFaculty of Science and TechnologyUniversity of CoimbraCoimbra 3030-790Portugal

Bifurcaria bifurcata is a seaweed of the Order Fucales(Ochrophyta,Phaeophyceae)that can be found all year round along the Portuguese Atlantic *** it is considered edible in some countries,its biotechnological potential has not yet been assessed in detail and here we report its antimicrobial potential against human dermatophyte *** samples were harvested from Baleal Island(Peniche,Portugal)harvested in winter(BbPe);from Aguda Beach(Arcozelo,Vila Nova de Gaia,Portugal),harvested in autumn(BbAg)and a sample obtained by culturing the Aguda sample under laboratory conditions(BbLC).A broth macrodilution assay was applied to determine the MIC(minimum inhibitory concentration)and MLC(minimum lethal concentration)of the *** *** show that the BbPe MeOH extracts were the most effective and had higher antifungal activity against all the tested dermatophyte strains than the BbLC and BaAg extracts[Epidermophyton floccosum FF9(100–200μg/mL MIC;200μg/mL MLC),Microsporum canis FF1(400μg/mL MIC;≥400μg/mL MLC),Trichophyton mentagrophytes FF7(100μg/mL MIC;>800μg/mL MLC),*** CECT 2908(800μg/mL MIC;≥800μg/mL MLC),*** *** CECT 2958(800μg/mL MIC;≥800μg/mL MLC),*** CECT 2794(200μg/mL MIC;≥400μg/mL MLC)].In fact,only *** FF9 was sensitive to BbAg and BbLC MeOH *** our knowledge,this is the first report of antifungal activity of *** against human dermatophyte fungi.

关键词： seaweed Bifurcaria bifurcata bioactivity antifungal dermatophytes minimum inhibitory concentration minimum lethal concentration

What lessons can be learned from y T cell-based cancer immunotherapy trials？

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Cellular & Molecular Immunology 2013年第1期10卷 35-41页

作者： Jean-Jacques Fournie Helene Sicard Mary Poupot Christine Bezombes Amandine Blanc Franqois-Romagne loic Ysebaert Guy Laurent INSERM UMR1037-Cancer ResearchCenter of Toulouse Toulouse France University of Toulouse Toulouse France ERL 5294 CNRS BP3028 Hospital Purpan ToulouseFrAnce lnnate Pharma Marseilles France and Department of Hematology Hospital Purpan Toulouse France

During the last several years, research has produced a significant amount of knowledge concerning the characteristics of human 76 T lymphocytes. Findings regarding the immune functions of these cells, particularly their natural killer cell-like lyric activity against tumor cells, have raised expectations for the therapeutic applications of these cells for cancer. Pharmaceutical companies have produced selective agonists for these lymphocytes, and several teams have launched clinical trials of y8 T cell-based cancer therapies. The findings from these studies include hematological malignancies （follicular lymphoma, multiple myeloma, acute and chronic myeloid leukemia）, as well as solid tumors （renal cell, breast and prostate carcinomas）, consisting of samples from more than 250 patients from Europe, Japan and the United States. The results of these pioneering studies are now available, and this short review summarizes the lessons learned and the role of y6 T cell-based strategies in the current landscape of cancer immunotherapies.

关键词： cancer cell therapy gamma-delta lymphocytes immunotherapy lymphoma trials

The Effect of the Process on Mechanical Properties of Polylactic Acid-Date Palm Leaf Fibers Composite Films Produced By Extrusion Blowing

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Journal of Renewable Materials 2019年第9期7卷 891-901页

作者： Fatma Kharrat Rania Chaari Mohamed Khlif loic Hilliou José A.Covas Mohamed Haboussi Hedi Nouriand Chedly Bradai National School of Engineers of Sfax(ENIS) Laboratory of Electromechanical Systems(LASEM)B.P.W.3038SfaxTunisia Institute for Polymers and Composites University of MinhoGuimarãesPortugal Laboratoire des Sciences des Procédés et des Matériaux(LSPM) CNRS UPR 3407UniversitéParis 13Sorbonne-Paris-Cité93430VilletaneuseFrance

Biocomposite films prepared with melt compounding and film blowing have become a new trend in plastic research to deliver more eco-friendly *** acid(PLA)was melt compounded with minimally processed date palm leaf fiber(DPLF)and converted into films by blown film *** compounding was done in order to enhance the film mechanical properties in one hand,and to decrease the film production cost in the other *** this present study,a reference PLA film and films with 1%,2%,and 5%of DPLF(weight%)were produced with different process *** spatial variations in films thickness and lay flat width indicate that the addition of DPLF up to 2%enhances the bubble stability for the tested process ***,the composite with 5%DPLF shows nearly the same processability window as the neat *** structural and mechanical characterizations of films suggest a reinforcing effect of the PLA matrix up to 2%of fiber(with an optimum at 1%).Larger DPLF loading leads to depressed and more anisotropic mechanical properties,related to an increased density of defects at the fiber-PLA fragile interface and to a DPLF-induced enhanced PLA thermal degradation and amorphous phase orientation.

关键词： PLA palm leaf fibers biocomposites film blowing