Tayloring cell populations for neurodegenerative diseases

作     者：jeff m.fortin loic p.deleyrolle brent a.reynolds 

作者机构：Lillian S.Wells Department of NeurosurgeryUniversity of FloridaGainesvilleFLUSA PrestonA.WellsJr.for Brain Tumor TherapyUniversity of FloridaGainesvilleFLUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2016年第11卷第10期

页      面：1582-1583页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：cell Tayloring cell populations for neurodegenerative diseases 

摘      要：Neurological disorders are increasing in prevalence world- wide, and interest in stem cell therapies for these amictions has increased over the past two decades. While many neu- rological injuries are too devastating for the repair capabil- ities of endogenous neural stem cells （NSCs） an alternative is to harvest stem cells from a donor and grow them in vitro, to be used later as a donor source for transplantation. Many research groups have already done this, first using animal models and now using clinical trial participants. Despite the regular flow of publications about cell replace- ment therapies for central nervous system （CNS） disorders, there is still a scarcity of clinically-relevant reports of effi- cacy. The capability of donor cells to undergo ample site-di- rected differentiation and functional integration seems to be lacking （Andressen, 2013）. So, while stem cells do have properties that are suited for repair of the injured CNS, a primary remaining question is how these cells can best be grafted to produce long-term functional benefit to the host environment. Moreover, among the challenges in neural cell transplantation is controlling the ultimate characteris- tics of grafted cells, pertaining to their survival, phenotypes and performance.