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A comparative analysis of alternative approaches to fitting species-abundance models

Journal of Plant Ecology 2012年第1期5卷 32-45页

作者： Sean R.connolly loïc m.thibaut School of marine and Tropical Biology and ARc centre of Excellence for coral Reef Studies James Cook UniversityTownsvilleQueensland 4811Australia

Aims Fits of species-abundance distributions to empirical data are increasingly used to evaluate models of diversity maintenance and community structure and to infer properties of communities,such as species *** distributions predicted by several models are the Poisson lognormal(PLN)and the negative binomial(NB)distribution;however,at least three different ways to parameterize the PLN have been proposed,which differ in whether unobserved species contribute to the likelihood and in whether the likelihood is conditional upon the total number of individuals in the *** of these has an analogue for the ***,we propose a new formulation of the PLN and NB that includes the number of unobserved species as one of the estimated *** investigate the performance of parameter estimates obtained from this reformulation,as well as the existing alternatives,for drawing inferences about the shape of species abundance distributions and estimation of species *** We simulate the random sampling of a fixed number of individuals from lognormal and gamma community relative abundance distributions,using a previously developed‘individual-based’bootstrap *** use a range of sample sizes,community species richness levels and shape parameters for the species abundance distributions that span much of the realistic range for empirical data,generating 1000 simulated data sets for each parameter *** then fit each of the alternative likelihoods to each of the simulated data sets,and we assess the bias,sampling variance and estimation error for each *** Findings Parameter estimates behave reasonably well for most parameter values,exhibiting modest levels of median ***,for the NB,median error becomes extremely large as the NB approaches either of two limiting *** both the NB and PLN,>90%of the variation in the error in model parameters across parameter sets is explained by three quantities that corresponded to t

关键词： Poisson lognormal negative binomial Poisson gamma species-abundance distributions species richness

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Epidemiological and Prognostic Aspects of Anemia during Heart Failure in Brazzaville (The Republic of the congo)

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World Journal of cardiovascular Diseases 2023年第7期13卷 396-403页

作者： Stéphane méo Ikama Joffode mobet memougame thibaut Oko Jospin Jospin makani Lydie Ocini Ngolet Bijou moualengue Eric Gibrel Kimbally Kaky thibaut Gankama Suzy Gisèle Kimbally Kaky Department of cardiology University Hospital Center of Brazzaville Brazzaville The Republic of the Congo Department of Hematology Laboratory University Hospital Center of Brazzaville Brazzaville The Republic of the Congo Department of clinical Hematology University Hospital Center of Brazzaville Brazzaville The Republic of the Congo

To improve the management of patients with heart failure and anemia at the University Hospital of Brazzaville, a cross-sectional study of patients diagnosed with heart failure condition (left or global heart failure) was conducted over a period of nine months from January 1 to September 30, 2017. A total of 171 patients were included during the study period. Study participants were divided into two groups: Group A included patients with an additional anemic condition (n = 57) and Group NA patients without anemia (n = 114). Anemia was defined as a hemoglobin rate of men and men. All eligible patients admitted to the Department of cardiology were included in the study. The frequency of anemia was 33.3%, with a mean hemoglobin level of 9.4 ± 1.5 g/dL. men accounted for 46.9% of cases (n = 79) and women 53.8% (n = 92). The mean age of eligible patients was 57.5 ± 16.5 years. Of these, 46.2% (n = 75) had a secondary educational level and 53.8% (n = 92) had a low socioeconomic status. Heart failure was global in 153 cases (89.5%). Patients were on NYHA III-IV functional class in 112 cases (65.5%), with a statistically significant difference between anemic and non-anemic patients (p = 0.0001). The main underlying heart diseases were dilated cardiomyopathy (75.1%), hypertensive heart disease (10.5%), ischemic heart disease (6.5%), and valvular disease (4.7%). The comparison between the two groups (A and NA) showed a longer hospital length of stay (18.4 ± 8.9 versus 12.9 ± 7.6 days;p = 0.00001) and a higher mortality rate (4 versus 2 deaths). The re-hospitalization rate was more important in group A (n = 4) than in group NA (n = 1). Anemia is a common condition in patients with heart failure. It worsens the clinical features and prognosis.

关键词： Anemia Heart Failure Frequency Prognosis The Republic of the congo

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Aetiologic Factors of Anemia During Heart Failure in Brazzaville (The Republic of the congo)

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World Journal of cardiovascular Diseases 2023年第9期13卷 605-612页

作者： Stéphane méo Ikama Joffode mobet memougame Jospin makani thibaut Oko Eric Gibrel Kimbally Kaky Lydie Ocini Ngolet Bijou moualengue thibaut Gankama Suzy Gisèle Kimbally Kaky Department of cardiology University Hospital Center of Brazzaville Brazzaville The Republic of the Congo Department of Hematology Laboratory University Hospital Center of Brazzaville Brazzaville The Republic of the Congo Department of clinical Hematology University Hospital Center of Brazzaville Brazzaville The Republic of the Congo

To contribute to improving the management of patients with heart failure and anemia in Brazzaville, a prospective and descriptive study was conducted in the University Hospital of Brazzaville for nine months (January 1st to September 30, 2017). Included 57 patients hospitalized for left or global heart failure and presenting anemia. Anemia was defined by an haemoglobin level men and men. Proportionings of the reticulocytes rate, serum iron, ferritin, erythrocyte sedimentation rate (ESR) and/or c-reactive protein (cRP), electrophoresis of proteins, and evaluation of renal function by glomerular filtration rate (GFR), as well as the treatments of heart failure, and the auxiliary therapeutic ones, in particular the antithrombotic drugs, allowed aetiologic research. They were 20 men (35%) and 37 women (65%), old on average of 59 ± 17 years. The average rate of haemoglobin was 11.4 ± 1.4 g/dL. Heart failure was de novo in 24 cases (42.1%), old in 33 cases (57.9%);it was global in 54 cases (94.7%).The maintenance treatment associated diuretics in 32 cases (97%), angiotensin-converting enzyme inhibitor (AcEI) or angiotensin II receptor blocker (ARB) in 31 cases (94%), beta-blockers in two cases (6.1%), digoxin in four cases (12.1%), aspirin in five cases (15.1%) and anti-vitamin K in four cases (12.1%). Anemia was microcytic hypochromic in 30 cases (52.6%), normocytic normochromic in 20 cases (35.1%), and macrocytic normochromic in one case (1.7%). The main aetiologic factors were hemodilution in 46 cases (80.7%), renal insufficiency in 30 cases (52.3%), inflammation in 29 cases (50.8%), and iron deficiency in one case (1.7%). The HIV serology, carried out in 11 cases, was negative. Anemia is a frequent comorbidity among heart failure patients. Aetiologic research remains difficult in our context, and its often multifactorial origin.

关键词： Anemia Heart Failure Aetiologies congo

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characterization of meso-scale mechanical properties of longmaxi shale using grid microindentation experiments

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Journal of Rock mechanics and Geotechnical Engineering 2021年第3期13卷 555-567页

作者： Jianting Du Andrew J.Whittle Liming Hu thibaut Divoux Jay N.meegoda State Key Laboratory of Hydro-Science and Engineering Tsinghua UniversityBeijing100084China Department of civil and Environmental Engineering Massachusetts Institute of TechnologyCambridgeMA02139USA multiScale material Science for Energy and Environment UMI 3466CNRS-MITCambridgeMA02139USA Univ Lyon Ens de LyonUniv Claude BernardCNRSLaboratoire de PhysiqueLyonF-69342France Department of civil and Environmental Engineering New Jersey Institute of TechnologyNewarkNJ07102USA

mechanical properties,such as the hardness H,Young’s modulus E,creep modulus c,and fracture toughness Kc,are essential parameters in the design of hydraulic fracturing systems for prospective shale gas *** this study,a practical methodology is presented for obtaining these properties through microindentation experiments combined with quantitative observations of the mineralogical phases using X-ray diffraction(XRD),scanning electron microscopy(SEm)with backscattered electron(BSE)imaging,and energy-dispersive X-ray spectroscopy(EDS)*** apply this method in the case of three types of longmaxi shales with different mineralogies(***-,clay-,and quartz-rich,respectively),which allows us to determine the characteristic indentation depth,hc?8e10 mm,beyond which the mechanical response of the carbonate-rich shale is homogeneous and independent of its complex heterogeneous ***,exploiting the results of a large number of indentation tests,we demonstrate that the indentation modulus m of the shale increases as a power-law of hardness H,and its creep modulus c increases linearly with *** also compute the fracture toughness Kc from the indentation data by assuming a perfectly plastic behavior of the *** results are in good agreement with independent measurements of Kc determined by microscratch ***,further tests on quartz-and clay-rich samples of the longmaxi shale suggest further variations in the samples’mechanical properties depending on their burial conditions and the mechanical properties of their dominant mineral phases.

关键词： Grid microindentation mineral identification Hardness modulus creep Fracture toughness

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Outcome of Patients with lower Limbs Deep Vein Thrombosis at the University Hospital of Brazzaville (The Republic of the congo)

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World Journal of cardiovascular Diseases 2023年第12期13卷 845-853页

作者： Stéphane méo Ikama Eric Gibrel Kimbally Kaky Jospin makani Fresnel Ngoma mabondzo thibaut Naïbe Gankama Bijou moualengue Suzy Gisèle Kimbally Kaky Department of cardiologye University Hospital Center of Brazzaville Brazzaville Congo Faculty of Health Sciences Marien NGOUABI University of Brazzaville Brazzaville Congo Department of Radiology University Hospital Center of Brazzaville Brazzaville Congo

The aim of this study was to describe the characteristics of patients with deep vein thrombosis (DVT) of the pelvic limbs at the time of diagnosis, and their course after hospitalization, in order to improve the management of DVT in our context. This was a descriptive longitudinal study, based on cases of deep vein thrombosis recorded between 1 January 2015 and 30 September 2018, in the cardiology and internal medicine department of the Brazzaville University Hospital centre. During the study period, 4678 patients were hospitalized, including 52 with DVT. Thirty-three were reassessed. The frequency of DVT was 1.1% and the average hospitalization rate was 13.9 cases/year. The 33 patients were divided into 20 women and 13 men (sex ratio: 0.65). The mean age of the patients was 51.4 ± 17.8 years (extremes: 16 and 85 years). The main aetiological factors were cancer (19.1%), sickle cell disease (3%) and HIV immunosuppression (3%). The predominant risk factors were: prolonged immobilization (42.9%), pregnancy, long travel and obesity in the same number of cases (n = 3, i.e. 14.2%). The DVT involved the left pelvic limb in 75.8% of cases. Anticoagulants were administered in all patients, and compression stockings were worn in 97% of cases. The mean time to re-evaluation was 10.9 ± 9.4 months (extremes: three and 35 months). The mean measurements of the limb where the thrombosis had occurred at diagnosis and reassessment showed a significant difference. Venous Doppler showed compressible veins (60.6%), varicosities (36.3%), incompressible veins (30.3%) and thrombus (21.2%). complications were: post-phlebitic disease (42.4%), death (21.2%), pulmonary embolism (18.2%), recurrence (18.2%). The DVT remains relatively rare, and its conventional therapeutic management is satisfactory. Systematic venous Doppler ultrasound reassessment should enable patients at risk of recurrence to be identified.

关键词： Deep Vein Thrombosis Reassessment complications congo

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Epidemiological, clinical and Etiological Profile of Rhythmic Emergencies at the University Hospital of Brazzaville, Republic of congo

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World Journal of cardiovascular Diseases 2022年第6期12卷 342-352页

作者： Suzy Gisèle Kimbally-Kaky thibaut Naïbe Gankama Eric Gibrel Kimbally-Kaky Jospin Karel makani Bijou moualengue Stéphane méo Ikama Soodougoua Baragou Thierry Raoul Alexis Gombet Department of cardiology and Internal medicine University Hospital of Brazzaville Brazzaville Republic of Congo Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of Congo Sylvanus Olympio University Hospital Lomé Togo Faculty of Health Sciences Lomé Togo Department of Emergency University Hospital of Brazzaville Brazzaville Republic of Congo

Objectives: To describe the epidemiological, clinical and etiological aspects of rhythmic emergencies at the University Hospital of Brazzaville. Patients and methods: This was a retrospective descriptive study conducted in the cardiology and internal medicine department of the University Hospital of Brazzaville from January 1, 2014 to June 30, 2016. Were included, all patients admitted for a severe rhythm disorder diagnosed on the surface electrocardiogram. Rhythmic emergency was defined as a severe rhythm disorder of abrupt onset and required rapid management. Data entry and analysis were performed with Epi Info software version 3.5.1. Results: During the study period, 2269 patients were hospitalized, including 138 for a rhythmic emergency. The frequency of rhythmic emergencies was 6.1%. The patients were divided into 76 women and 62 men (sex ratio = 0.81). The mean age of the patients was 63.1 ± 16.9 years (extremes: 17 and 91 years). The socio-economic level was low for 103 patients (74.6%), medium for 26 (17.7%), and high for nine (6.6%). The average time to consultation was 13.7 ± 12.3 days. On admission, the signs were: heart failure (103 cases;74.6%) including 22 acute cases;dyspnea (94 cases;68%);palpitations (38 cases;27.5%);functional impotence (13 cases;9.4%);collapse (nine cases;6.5%);chest pain (two cases;1.4%). The type of rhythmic emergency was: rapid atrial fibrillation (103 cases;74.6%), ventricular tachycardia (14 cases;10.1%), junctional tachycardia (10 cases;7.2%), rapid atrial flutter (10 cases;7.2%), tachysystole (one case;0.7%). The context of occurrence was: hypokalemia (8 cases;5.8%), drunkenness (two cases;1.4%), acute gastroenteritis (one case;0.7%). cardiovascular risk factors were: hypertension (62 cases;45.2%), smoking (17 cases;12.1%), dyslipidemia (12 cases;8.7%), diabetes (11 cases;8%), obesity (10 cases;7.2%). Underlying heart disease was: dilated cardiomyopathy (40 cases;29%), hypertensive cardiomyopathy (26 cases;18.8%), valvulopa

关键词： cardiac Rhythm Disorders Atrial Fibrillation Dilated cardiomyopathy Brazzaville

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Determinants of maternal mortality at the community University Hospital of Bangui: central African Republic

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Open Journal of Obstetrics and Gynecology 2023年第9期13卷 1478-1486页

作者： Gertrude Rose De Lima Kogboma Wongo thibaut Boris clavaire Songo-Kette Gbekere Rodrigue Herman Doyama-Woza Siméon matoulou-m’bala Wa-Ngogbe Alida Koirokpi Sabrina Ouapou Georges Trésor Gamache Norbert Richard Ngbale Abdoulaye Sepou Department of Gynaecology and Obstetrics Centre Hospitalier Universitaire Communautaire Bangui Central African Republic Department of Gynaecology and Obstetrics Centre Hospitalier Universitaire de l’Amitié Sino Centrafricaine Bangui Central African Republic Department of Public Health Faculty of Health Sciences University of Bangui Bangui Central African Republic

Introduction: Pregnancy is a physiological condition that can sometimes end in death. The death of a woman is a constant concern for the obstetrician and is considered a major public health problem in our developing countries. Objective: To identify the determinants that contribute to maternal morbidity and mortality in the Gynaecology and Obstetrics Department of the University community Hospital. methodology: We conducted a retrospective study from 1 January 2015 to 31 December 2019 (5 years) in the obstetrics and gynaecology department of the centre Hospitalier Universitaire communautaire (cHUc). It focused on the determinants of maternal mortality. Our study population consisted of all women who died during the period and met the World Health Organization (WHO) definition of maternal mortality (mOmA). We used non-probability sampling with the exhaustive choice technique. Results: The study revealed that the number of deaths recorded was 98, while 17,172 live births were registered during the same period. The maternal mortality ratio was 570 per 100,000 live births. The most common age group was 20 to 24, with an average age of 26. The frequency of death among primiparous women was 37.74%, pauciparous women 28.30% and multiparous women 26.42%. Direct causes were dominated by abortion complications (22.41%), followed by infections (9.30%) and haemorrhage (8.19%). Indirect causes were dominated by anaemia with a proportion of 45.16%. The majority of maternal deaths occurred in the post-partum period (34.71%). most maternal deaths occurred after vaginal delivery, 19 cases (63.33%), while 11 deaths (36.66%) occurred after caesarean section. The occurrence of direct causes was associated with age less than or equal to 25 years, abortion complications and primiparity, with a statistically significant difference. conclusion: At the end of this study, complications of unsafe abortion and poverty are all factors contributing to the rise in the maternal mortality rate. Emp

关键词： maternal mortality Determinants community Hospital

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Head and neck cancer and immunotherapy: current knowledge and perspective

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Journal of cancer metastasis and Treatment 2019年第10期4卷 33-41页

作者： Thibault Gauduchon thibaut Reverdy max Gau Andy Karabajakian Laetitia collet Eve-marie Neidhardt Jérôme Fayette Universitéclaude Bernard LYON 1 Centre de lutte contre le cancer Léon-BérardDépartement d’oncologie médicaleLyon 69008France

As with many types of cancer,immunotherapy is changing the management of squamous cell carcinoma of the head and neck(HNScc).In a locally advanced or metastatic setting,treatment options have long been curtailed,but this paradigm is currently *** inhibitors were the first to be validated in second-line treatment with PD-1 and PD-L1 inhibitors and these treatments are available in USA for first-line *** addition,many studies are underway to use its molecules earlier in the care or try to increase their effectiveness with *** issues of patient selection that would benefit the most from immunotherapy and the evaluation of the response to these treatments are not completely *** goal is here to update the possibilities of current treatment by immunotherapy in HNScc as well as on various development pathways in progress.

关键词： Head and neck squamous cell carcinoma checkpoint inhibitors immunotherapy clinical trial

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Factors Associated with mother-to-child Transmission of HIV at the maternity Unit of the castors Urban Health center in Bangui

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Open Journal of Obstetrics and Gynecology 2023年第5期13卷 950-959页

作者： thibaut Boris clavaire Songo-Kette Gbekere Gilles Davy Kossa-Ko-Ouakoua Gertrude Rose De Lima Kogboma Wongo Guerengbo Rodrigue Herman Doyama-Woza Siméon matoulou-m’bala Wa-Ngogbe Alida Koirokpi Sabrina Ouapou Kelly mbano-Dede matike-Ayamboka Josué Eezchiel Sandjima Norbert Richard Ngbale The maternity Unit of the centre de Santé Urbain des castors Bangui Central African Republic Department of Gynecology and Obstetrics Centre Hospitalier Universitaire Communautaire Bangui Central African Republic Department of Public Health Faculty of Health Sciences University of Bangui Bangui Central African Republic Department of Gynecology and Obstetrics Centre Hospitalier Universitaire Maman Elisabeth Domitien Bimbo Central African Republic

Introduction: In spite of significant progress towards eliminating mother-to-child transmission (mcT) of HIV by 2025, trends in vertical mother-to-child transmission are still worrying in sub-Saharan African countries. This study aims to take stock of the factors associated with HIV mcT at the level of peripheral health training. Patients and methods: This was a descriptive and analytical retrospective study, over a five-year period from January 1st, 2017 to December 31st, 2021. The study population was represented by HIV-positive women and their cared infants in the Parent-child Transmission Prevention Unit (PcTP) of the castors Urban Health center (cUHc). Results: 288 medical records were selected out of a total of 347 HIV-positive mothers followed. HIV seroprevalence in the population of women who received PreNatal consultation (PNc) during the study period was 8.2%. The HIV mcT rate was 3.7%. HIV+ mothers followed were mostly young (average age of 28), not living in a couple (96.9%), poorly educated (58.7%) and not engaged in income-generating activity (58.4%). They had all received triple therapy and the period of initiation of antiretroviral (ARV) therapy was in the majority of cases during the first trimester. Factors associated with mcT were: primiparity (OR = 18.4 [5.55 - 61.05];Khi2 = 32.61;p covery of infection during large or after childbirth (OR = 0.03 [0.007 - 0.10];Khi2 = 55.22;p clinical Stage 2 and 3 (OR = 0.007 [0.001 - 0.03];Khi2 = 108.73;p cD4 count 200/mm3 (OR = 14.12 [4.03 - 57.20];Khi2 = 21.68;p load > 1000 copies/mm3 (OR = 8.85 [2.33 - 43.20];Khi2 = 10.46;p = 0.001), prolonged labor (OR = 12.33 [3.45 - 57.25];Khi2 = 18.47;p mature rupture of membranes (OR = 24.03 [6.97 - 96.01];Khi2 = 40.60;p 2 = 5.96;p = 0.014), and artificial or mixed breast

关键词： Factors Transmission mother-child HIV Bangui

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Effect of Iron Nanoparticles Synthesized by a Sol-Gel Process on Rhodococcus erythropolis T902.1 for Biphenyl Degradation

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Journal of Water Resource and Protection 2015年第3期7卷 264-277页

作者： Wissal Wannoussa thibaut masy Stephanie D. Lambert Benoit Heinrichs Ludivine Tasseroul Alaaeddin Al-Ahmad Frederic Weekers Philippe Thonar Serge Hiligsmann Walloon center of Industrial Biology Department of Chemistry and Bio-industriesUniversity of LiegeGemblouxBelgium Laboratory of Nanomaterials Catalysis and ElectrochemistryUniversity of LiegeLiegeBelgium Artechno S.A. Gembloux-Les IsnesBelgium

Nanoparticles (NPS) are considered as a new generation of compounds to improve environmental remediation and biological processes. The aim of this study is to investigate the effect of iron NPS encapsulated in porous silica (SiO2) on the biphenyl biodegradation by Rhodococcus erythropolis T902.1 (RT902.1). The iron NPS (major iron oxide FexOy form) were dispersed in the porosity of a SiO2 support synthesized by sol-gel process. These Fe/SiO2 NPS offer a stimulating effect on the biodegradation rate of biphenyl, an organic pollutant that is very stable and water-insoluble. This positive impact of NPS on the microbial biodegradation was found to be dependent on the NPS concentration ranging from 10-6 m to 10-4 m. After 18 days of incubation the cultures containing NPS at a concentration of 10-4 m of iron improved RT902.1 growth and degraded 35% more biphenyl than those without NPS (positive control) or with the sole SiO2 particles. Though the microorganism could not interact directly with the insoluble iron NPS, the results show that about 10% and 35% of the initial 10-4 m iron NPS encapsulated in the SiO2 matrix would be incorporated inside or adsorbed on the cell surface respectively and 35% would be released in the supernatant. These results suggest that RT902.1 would produce siderophore-like molecules to attract iron from the porous silica matrix.

关键词： Biodegradation Biphenyl Rhodococcus erythropolis Encapsulated Nanoparticles Sol-Gel Iron

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