Head and neck cancer and immunotherapy: current knowledge and perspective

作     者：Thibault Gauduchon Thibaut Reverdy Max Gau Andy Karabajakian Laetitia Collet Eve-Marie Neidhardt Jérôme Fayette 

作者机构：UniversitéClaude Bernard LYON 1Centre de lutte contre le cancer Léon-BérardDépartement d’oncologie médicaleLyon 69008France 

出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)

年 卷 期：2019年第4卷第10期

页      面：33-41页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Head and neck squamous cell carcinoma checkpoint inhibitors immunotherapy clinical trial 

摘      要：As with many types of cancer,immunotherapy is changing the management of squamous cell carcinoma of the head and neck(HNSCC).In a locally advanced or metastatic setting,treatment options have long been curtailed,but this paradigm is currently *** inhibitors were the first to be validated in second-line treatment with PD-1 and PD-L1 inhibitors and these treatments are available in USA for first-line *** addition,many studies are underway to use its molecules earlier in the care or try to increase their effectiveness with *** issues of patient selection that would benefit the most from immunotherapy and the evaluation of the response to these treatments are not completely *** goal is here to update the possibilities of current treatment by immunotherapy in HNSCC as well as on various development pathways in progress.