检索结果-南通市图书馆

How cognitive neuroscience can enhance education and population mental health

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science Bulletin 2022年第15期67卷 1542-1543页

作者： Tianye Jia gunter Schumann Center for Population Neuroscience and Precision Medicine(PONS) Institute for Science and Technology of Brain-inspired IntelligenceFudan UniversityShanghai 200433China PONS-Center Department of Psychiatry and PsychotherapyCharitéCampus MitteCharitéUniversitätsmedizin BerlinBerlin 10117Germany

Adolescence is one of the most critical periods for human brain development,as evidenced by neuronal maturation processes of synaptic pruning and synapse stabilization[1-3],which together improve the efficiency of information transfer in the *** development is coincidental with maturing in multiple cognitive and behavioral capabilities,such as better motor skills,abstract thinking,and complex semantic *** the other hand,many psychiatric disorders,such as attention-deficit/hyperactivity disorder(ADHD),conduct disorder,anxiety,and depression,also have their peak onset in adolescence[4].Therefore,it is vital to understand how the maturing process of the brain during adolescence could affect cognitive growth and psychopathology.

关键词：认知神经科学群体心理 pathology

维普期刊数据库

在线全文

学校读者我要写书评

暂无评论

社会资本与农村社区建设的可持续性

浙江社会科学 2008年第11期 68-74页

作者：郎友兴周文浙江大学公共管理学院政治学系杭州310028 浙江大学地方政府与社会治理研究中心

农村社区建设必须树立可持续发展的理念,只有以可持续性的战略对待之,农村才能成为农村居民安居乐业之地。文章从社会资本的概念与理论出发,认为中国农村社区建设的可持续性之关键在于必须有良好的内在发展机制,而这个机制就是农村社区... 详细信息

农村社区建设必须树立可持续发展的理念,只有以可持续性的战略对待之,农村才能成为农村居民安居乐业之地。文章从社会资本的概念与理论出发,认为中国农村社区建设的可持续性之关键在于必须有良好的内在发展机制,而这个机制就是农村社区中社会资本的重构与开拓。文章首先指出了社会资本对于农村社区建设的意义,然后分析了目前农村社会资本的缺失,提出从四个方面重构社会资本,以推进农村社区建设走向可持续发展之路。

关键词：社会资本社区建设农村可持续发展

维普期刊数据库

Predisposing factors for atrial fibrillation in the elderly

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2017年第3期14卷 179-184页

作者： Kristina Wasmer Lars Eckardt gunter Breithardt Division of Electrophysiology Department of Cardiovascular Medicine University Hospital Miinster Germany

Atrial fibrillation （AF） in the elderly occurs as a consequence of cardiovascular aging and an age related increase of comorbidity. Several predisposing factors for AF have been identified for the overall AF population. Most of them, cardiovascular disease in particular, play a role in younger and older patients. The longer time period during which these risk factors can cause structural changes that ultimately lead to AF may, at least in part, explain the association between age and AF. In addition, less well defined age-related changes in cellular electrophysi- ologic properties and structure predispose to AF in the elderly.

关键词： Atrial fibrillation Atrial fibrosis Mechanisms Risk factors Stroke The elderly

GFAP promoter directs lacZ expression specifically in a rat hepatic stellate cell line

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第5期12卷 723-730页

作者： gunter Maubach Michelle Chin Chia Lim Institute of Bioengineering and Nanotechnology 31 Biopolis WayThe Nanos#04-01138669Singapore.

AIM： The GFAP was traditionally considered to be a biomarker for neural gila （mainly astrocytes and nonmyelinating Schwann cells）. Genetically, a 2.2-kb human GFAP promoter has been successfully used to target astrocytes in vitro and in vivo. More recently, GFAP was also established as one of the several makers for identifying hepatic stellate cells （HSC）. In this project, possible application of the same 2.2-kb human GFAP promoter for targeting HSC was investigated. METHODS： The GFAP-lacZ transgene was transfected into various cell lines （HSC, hepatocyte, and other nonHSC cell types）. The transgene expression specificity was determined by X-gal staining of the β-galactosidase activity. And the responsiveness of the transgene was tested with a typical pro-fibrotic cytokine TGF-β1. The expression of endogenous GFAP gene was assessed by real-time RT-PCR, providing a reference for the transgene expression. RESULTS： The results demonstrated for the first time that the 2.2 kb hGFAP promoter was not only capable of directing HSC-specific expression, but also responding to a known pro-fibrogenic cytokine TGF-β1 by upregulation in a doseand time-dependent manner, similar to the endogenous GFAP. CONCLUSION： In conclusion, these findings suggested novel utilities for using the GFAP promoter to specifically manipulate HSC for therapeutic purpose.

关键词： Promoter Regions (Genetics) Animals Base Sequence Cell Line DNA, Recombinant Gene Expression Glial Fibrillary Acidic Protein Hepatocytes Humans Lac Operon RNA, Messenger Rats Transfection Transforming Growth Factor beta Transforming Growth Factor beta1

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

环境战略与中国城市发展(英文)

城市发展研究 2001年第2期8卷 19-22页

作者： Prof.Dipl.-lng.Albert Speer ##德国

可持续发展理论已越来越受到社会广泛关注 ,但如何将可持续发展理论从书斋引向实践一直是大家渴望看到而未如愿的事情。作者结合上海张江高科技园区规划实践论述了城市发展进程中应如何保护生态环境 ,为城市可持续发展创造条件。他指出 ... 详细信息

可持续发展理论已越来越受到社会广泛关注 ,但如何将可持续发展理论从书斋引向实践一直是大家渴望看到而未如愿的事情。作者结合上海张江高科技园区规划实践论述了城市发展进程中应如何保护生态环境 ,为城市可持续发展创造条件。他指出 ,一、降低城市积聚区密度是改善城市发展环境的基本方法 ;二、超大城市中心区内的开敞空间和一定面积的绿化对补偿建成区土地利用带来的负面影响是一个关键要素 ;三、协调通畅的交通组织必须贯彻公交优先原则 ;四、基础设施网络化是城市可持续发展不可或缺的条件 ;五、与开发商的密切合作才能实现城市管理和金融资源合理有效地利用。

关键词：城市可持续发展英文稿件

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

委内瑞拉的甘蔗滴灌

节水灌溉 1988年第3期 52-54页

作者： lng.G.Godoy lng.A.Palacios lng.A.Barrante 郭智明武汉水利电力学院

在委内瑞拉滴灌是个迟到者,石油冲击的十年间,国民经济收入飞快增长,并利用大量外汇十分容易地进口廉价粮食,所有这些都有损于本国农业生产的发展,因此,使糖的年产量由1971年的460,000吨下降到

关键词：委内瑞拉石油收入南美洲矿物燃料财政管理加拉加斯甘蔗产量双壁管滴灌系统

miRNA studies in in vitro and in vivo activated hepatic stellate cells

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第22期17卷 2748-2773页

作者： gunter Maubach Michelle Chin Chia Lim Henry Yang Institute of Bioengineering and Nanotechnology 31 Biopolis Way The Nanos #04-01 Singapore 138669 Singapore Institute of Experimental Internal Medicine Leipziger Strasse 44 Magdeburg 39120 Germany Institute of Bioengineering and Nanotechnology 31 Biopolis Way The Nanos #04-01 Singapore 138669 Singapore Bioinformatics Lab Singapore Immunology Network 8A Biomedical Grove Singapore 138648 Singapore

AIM: To understand which and how different miRNAs are implicated in the process of hepatic stellate cell (HSC) activation. METHODS: We used microarrays to examine the differential expression of miRNAs during in vitro activation of primary HSCs (pHSCs). The transcriptome changes upon stable transfection of rno-miR-146a into an HSC cell line were studied using cDNA microarrays. Selected differentially regulated miRNAs were investigated by quantitative real-time polymerase chain reaction during in vivo HSC activation. The effect of miRNA mimics and inhibitor on the in vitro activation of pHSCs was also ***: We found that 16 miRNAs were upregulated and 26 were downregulated significantly in 10-d in vitro activated pHSCs in comparison to quiescent pHSCs. Overexpression of rno-miR-146a was characterized by marked upregulation of tissue inhibitor of metalloproteinase-3, which is implicated in the regulation of tumor necrosis factor-α activity. Differences in the regulation of selected miRNAs were observed comparing in vitro and in vivo HSC activation. Treatment with miR-26a and 29a mimics, and miR-214 inhibitor during in vitro activation of pHSCs induced significant downregulation of collagen type Ⅰ transcription. CONCLUSION: Our results emphasize the different regulation of miRNAs in in vitro and in vivo activated pHSCs. We also showed that miR-26a, 29a and 214 are involved in the regulation of collagen type I mRNA.

关键词： Hepatic stellate cells miRNA miR-146a Nuclear factor-κB

1 ,5-萘二异氰酸酯与 1,4-丁二醇基为基质的多嵌段聚氨酯弹性体的合成与性能(英文)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高分子通报 2004年第6期 42-62页

作者： gunter Festel Festel Capital-Innovations in Chemicals

利用 1 ,5_萘二异氰酸酯 (NDI)和 1 ,4_丁二醇 (BDO)为均匀硬质分子单体 ,与不同软质分子单体 (聚醚、聚酯、聚硅氧烷 )缩合制备多嵌段聚氨酯弹性体 ,详细研究了硬嵌段相 (NDI)弹性体的结构与性能间的关系 ,发现随着硬嵌段相长度的增加 ... 详细信息

利用 1 ,5_萘二异氰酸酯 (NDI)和 1 ,4_丁二醇 (BDO)为均匀硬质分子单体 ,与不同软质分子单体 (聚醚、聚酯、聚硅氧烷 )缩合制备多嵌段聚氨酯弹性体 ,详细研究了硬嵌段相 (NDI)弹性体的结构与性能间的关系 ,发现随着硬嵌段相长度的增加 ,或者氨基甲酸酯中胺基与聚醚、聚酯、聚硅氧烷中软段氧原子间氢键的减弱 ,都导致微相分离程度的增加 ,造成聚合物熔点和熔化热的升高。硬嵌段相熔化的多峰行为是由于形成了NDI/BDO半微晶区 ,在退火时转变为更加有序的结晶微区 ,当温度高于 1 80℃时 ,由于氢键的断裂 ,NDI/BDO硬嵌段发生分解反应 ,该过程源于不很有序的硬嵌段半结晶微区。当温度高于 2 5 0℃时 ,发生快速的分解。在动态力学行为方面 ,NDI基聚醚弹性体比其它硅氧烷基的弹性体展示了更高的硬嵌段区的稳定性 ,同时 ,在使用温度范围内 ,也显示出最高的储能模量值 ,表明刚性对温度的依赖性。

关键词：二异氰酸酯聚氨酯弹性体聚醚 BDO 单体聚硅氧烷聚酯氢键软段氧原子

维普期刊数据库

Take-over:multiple mechanisms of inter-adipocyte communication

在线全文

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2011年第2期3卷 81-90页

作者： gunter Muller Department Biology I Genetics MartinsriedBiocenterLudwig-Maximilians-University MunichMunichGermany

Adipose tissue mass in mammals is thought to expand with an increase in both volume and total number of the *** findings suggest that in normal-weight as well as obese individuals,the adipocyte number is set during adolescence prior to adulthood,whereas the subsequent increase in size predominantly drives *** simultaneous existence of large and small adipocytes and their unsynchronized growth,even within the same adipose tissue depot,argues against simple filling-up of emerging adipocytes with lipids and lipid droplets(LDs).Consequently,it is tempting to speculate about signals sent by large adipocytes to order small adipocytes the take-over of the burden of lipid *** there is experimental evidence for three distinct types of inter-adipocyte signals,***-to-cell contacts,adipokines,and other soluble factors and *** recently,microvesicles have been shown(i)to harbour the glycosylphosphatidylinositol-anchored(c)AMP-degrading phosphodiesterase Gce1 and 5′-nucleotidase CD73,(ii)to be released from large adipocytes,(iii)to interact with small adipocytes,and(iv)to transfer Gce1 and CD73 to plasma membranes and LDs of small adipocytes where they degrade(c)*** sequence of events leads to the up-regulation of lipid storage in small adipocytes in response to the microvesicle-encoded‘take-over’signal from large adipocytes.A model is proposed for the maturation of small adipocytes driven by large ones along a gradient of those inter-adipocyte *** modulation of inter-adipocyte communication and thereby adipocyte maturation may be useful for the therapy of metabolic diseases.

关键词： adipokines fat cells glycosylphosphatidylinositol lipid droplets lipid metabolism microvesicles obesity type 2 diabetes