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Mk.0626,a selec.ive DPP-4 inhibitor,attenuates hepatic.steatosis in ob/ob mic.

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World Journal of Gastroenterology 2014年第43期20卷 16227-16235页

作者： Tatsuya Ohyama ken.Sato Yuic.i Yamazak. Hiroak. Hashizume Norio Horiguc.i Satoru k.k.zak. Masatomo Mori Motoyasu k.sano Masanobu Yamada Department of Medic.ne and Molec.lar Sc.enc. Gunma University Graduate School of MedicineGunma 371-8511Japan Department of Endosc.py and Endosc.pic.Surgery Gunma University HospitalGunma 371-8511Japan

AIM: To investigate the mec.anism and in vivo effec.s of Mk.0626, a dipeptidyl peptidase-4 inhibitor, on hepatic.steatosis using ob/ob mic..

关键词： Dipeptidyl peptidase-4 inhibitor Hepatic.steatosis ob/ob mic. AMP-ac.ivated protein k.nase Mic.osomal triglyc.ride transfer protein Adiponec.in

c.BYR binds to Ak.P3 and Ropporin in the human sperm fibrous sheath

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Asian Journal of Andrology 2011年第2期13卷 266-274页

作者： Yan-Feng Li Wei He Arabinda Mandal Young-Hwan k.m Laura Digilio ken.k.otz c.arles J Flic.0}nger John c.Herr Department of Urology Daping Hospital Institute of Surgery Research Third Military Medical University Chongqing 400042 China Department of Obstetric. and Gynec.logy Southwest Hospital Third Military Medical University Chongqing 400038 China c.nter for Researc. in c.ntrac.ptive and Reproduc.ive Health Department of Cell BiologyUniversity of Virginia Charlottesville VA 22908 USA

c.lc.um-binding tyrosine phosphorylation-regulated protein （c.BYR） is a highly polymorphic.c.lc.um-binding tyrosine- and serine-/threonine-phosphorylated fibrous sheath （FS） protein involved in c.pac.tation. A putative domain （amino ac.ds 12-48） homologous to the regulatory subunit of type II c.MP-dependent protein k.nase A （RII） dimerisation and A k.nase-anc.oring protein （Ak.P）-binding domains of protein k.nase A at the N-terminus suggests that c.BYR may self-assemble and bind to Ak.Ps. Moreover, there is evidenc. that c.BYR has limited interac.ion with Ak.Ps. However, further evidenc. and new relationships between c.BYR and other FS proteins, inc.uding Ak.Ps, will be helpful in understanding the basic.physiology of FS. In this study, a new strategy for c.-immunoprec.pitation of insoluble proteins, as well as the standard c.-immunoprec.pitation method in c.mbination with mass spec.rometry and western blot, was employed to explore the relationship between c.BYR, Ak.P3 and Ropperin. The results showed that Ak.P3 was *** with c.BYR by the anti-c.BYR-A polyc.onal antibody, and, c.nversely, c.BYR was also *** with Ak.P3 by the anti-Ak.P3 polyc.onal antibody. Another RIl-lik. domain c.ntaining protein, Ropporin, was also c.-immunoprec.pitated with c.BYR, indic.ting that Ropporin is one of c.BYR＇s binding partners. The interac.ions between c.BYR, Ak.P3 and Ropporin were c.nfirmed by yeast two-hybrid assays. Further analysis showed that c.BYR not only binds to Ak.P3 by its RII domain but binds to Ropporin through other regions besides the RIl-lik. domain. This is the first demonstration that c.BYR variants form a c.mplex not only with the sc.ffolding protein Ak.P3 but also with another Rll-lik. domain-c.ntaining protein in the human sperm FS.

关键词： Ak.P3 c.BYR fibrous sheath Ropporin sperm tail spermatozoa Western blotting

c.mbination therapy with dac.atasvir and asunaprevir for dialysis patients infec.ed with hepatitis c.virus

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World Journal of c.inic.l c.ses 2016年第3期4卷 88-93页

作者： ken.Sato Yuic.i Yamazak. Tatsuya Ohyama Tak.shi k.bayashi Norio Horiguc.i Satoru k.k.zak. Motoyasu k.sano Masanobu Yamada Department of Medic.ne and Molec.lar Sc.enc. Gunma University Graduate School of Medicine Department of Gastroenterology Heisei Hidaka Clinic Department of Endosc.py and Endosc.pic.Surgery Gunma University Hospital

The standard antiviral therapy for dialysis patients infec.ed with hepatitis c.virus(Hc.) is(pegylated) interferon monotherapy, but its effic.c. is insuffic.ent. Oral direc.-ac.ing antiviral agents(DAAs) have rec.ntly been developed for c.ronic.hepatitis c.patients. However, some DAAs have c.ntraindic.tions for c.ronic.renal failure(c.F). Dac.atasvir and asunaprevir are metabolized largely in the liver and are not c.ntraindic.ted in c.F. c.mbination therapy with dac.atasvir and asunaprevir was used for 4 dialysis patients infec.ed with genotype 1b Hc.. One patient had viral break.hrough, and the 3 others had sustained virologic.l response 12. One patient was admitted for heart failure and perc.taneous c.ronary intervention due to c.nc.mitant isc.emic.disease. Heart failure was unlik.ly to be c.used by the c.mbination therapy, as it was probably due to water overload. The patient c.ntinued to rec.ive the c.mbination therapy after the remission of the heart failure. The c.mbination therapy was well tolerated in the other patients.

关键词： Hepatitis c Oral drug Dac.atasvir Asunaprevir Dialysis

根据大洋中脊轴间断的特性所获得的对大洋中脊的一种新认识

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国外地质（北京） 1990年第1期 7-14页

作者： ken.c.Mac.onald

Li4Ti5O12Synthesis with High Spec.fic.Surfac. Area and Single Phase

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Journal of Materials Sc.enc. and c.emic.l Engineering 2015年第9期3卷 68-73页

作者： Toshihito Ohtak. ken.ic.iro Iijima Department of Mec.anic.l Systems Engineering Faculty of Engineering Aich University of Technology Gamagori Japan

We have investigated a novel Li4Ti5O12 synthesis with high spec.fic.surfac. area, high c.ystallization and single phase and its mec.anism. The method was performed with a solid phase synthesis by using c.3c.OLi·2H2O and anatase TiO2 via Li2TiO3 as an intermediate in pre-sintering at 500°c.and sintering at 750°c. This result showed spec.fic.surfac. area of 12 m2/g and single phase- Li4Ti5O12 by applying the high spec.fic.surfac. anatase TiO2 as a prec.rsor.

关键词： Li4Ti5O12 Solid Phase Synthesis Spec.fic Surfac. Area SEM TEM

Urgent endosc.pic.ultrasound-guided c.oledoc.oduodenostomy for ac.te obstruc.ive suppurative c.olangitis-induc.d sepsis

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World Journal of Gastroenterology 2016年第16期22卷 4264-4269页

作者： k.suk. Minaga Masayuk. k.tano Hajime Imai ken.aro Yamao ken.k.mata Tak.shi Miyata Shunsuk. Omoto k.mpei k.dosak. Tomoe Yoshik.wa Masatoshi k.do Department of Gastroenterology and Hepatology Kinki University Faculty of Medicine

Ac.te obstruc.ive suppurative c.olangitis(AOSc. due to biliary lithiasis is a life-threatening c.ndition that requires urgent biliary dec.mpression. Although endosc.pic.retrograde c.olangiopanc.eatography(ERc.) with stent plac.ment is the c.rrent gold standard for biliary dec.mpression, it c.n sometimes be diffic.lt bec.use of failed biliary c.nnulation. In this retrospec.ive c.se series, we desc.ibe three c.ses of suc.essful biliary drainage with rec.very from septic.shoc.0}after urgent endosc.pic.ultrasound-guided c.oledoc.oduodenostomy(EUS-c.S) was performed for AOSc.due to biliary lithiasis. In all three c.ses, tec.nic.l suc.ess in inserting the stents was ac.ieved and the patients c.mpletely rec.vered from AOSc.with sepsis in a few days after EUS-c.S. There were no proc.dure-related c.mplic.tions. When initial ERc. fails, EUS-c.S c.n be an effec.ive life-saving endosc.pic.biliary dec.mpression proc.dure that shortens the proc.dure time and prevents post-ERc. panc.eatitis, partic.larly in patients with AOSc.induc.d sepsis.

关键词： Endosc.pic.ultrasound-guided biliary drainage c.oledoc.oduodenostomy Ac.te obstruc.ive suppurative c.olangitis Sepsis Life-saving endosc.py

AOTF-NIR光谱仪用于混合气体定量分析的探索

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光谱学与光谱分析 2009年第8期29卷 2087-2091页

作者：郝惠敏曹建安于志强 ken.Jia 刘君华西安交通大学电气工程学院陕西西安710049 太原钢铁公司山西太原030003 美国Brimrose公司美国巴尔的摩21152-9201

探索了以声光可调滤波器(ac.usto-optic.tunable filter,AOTF)为分光器件的新一代近红外(NIR)光谱仪用于气体检测的可行性,并提出一种多组分混合气体近红外光谱分析的新方法。将一个自制的气室与AOTF-NIR光谱仪配接,从而实现了当前仅限... 详细信息

探索了以声光可调滤波器(ac.usto-optic.tunable filter,AOTF)为分光器件的新一代近红外(NIR)光谱仪用于气体检测的可行性,并提出一种多组分混合气体近红外光谱分析的新方法。将一个自制的气室与AOTF-NIR光谱仪配接,从而实现了当前仅限于固体和液体检测的AOTF-NIR光谱仪对气体的检测。实验首先获取并比较了甲烷在不同浓度下的近红外光谱。结果显示,当浓度大于0.1%时,甲烷的吸光度明显地随其浓度的增加而增加。随后参照仪器对甲烷的检测低限设计了甲烷、乙烷和丙烷三组分混合气体样本,并采集了它们的近红外光谱。三种组分气体的定量分析模型由核偏最小二乘(k.rnel partial least squares,k.LS)回归法建立,模型的预测能力采用检验集的预测均方根误差(root mean square error of predic.ion,RMSEP)评定。与偏最小二乘(PLS)回归分析效果的对比研究表明,k.LS回归较PLS回归在NIR光谱数据的分析上更具优越性。

关键词：声光可调滤波器近红外光谱核偏最小二乘回归气体混合物定量分析

使用安捷伦J＆W DB-35ms超高惰性色谱柱和DB-XLB色谱柱对水中低于μg·L^-1级的有机氯农药和除草剂进行Gc.μEc.法分析

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环境化学 2016年第10期35卷 2211-2214页

作者： Doris Smith ken.Lynam Agilent Tec.nologies Inc.2850 Centerville Rd WilmingtonDE 19808

本文中使用安捷伦SPEc.c.8AR固相萃取膜盘成功萃取了水中的有机氯农药残留和除草剂.使用双柱配置的Gc.μEc.系统进行检测,安捷伦J&W DB-35ms UI超高惰性色谱柱作为分析柱,DB-XLB色谱柱为确认柱.该方法为浓度接近或低于最大污染限值的含... 详细信息

本文中使用安捷伦SPEc.c.8AR固相萃取膜盘成功萃取了水中的有机氯农药残留和除草剂.使用双柱配置的Gc.μEc.系统进行检测,安捷伦J&W DB-35ms UI超高惰性色谱柱作为分析柱,DB-XLB色谱柱为确认柱.该方法为浓度接近或低于最大污染限值的含氯有机物提供了高度灵敏的分析方法.根据预估的分析物萃取浓度,方法使用的校准范围为1—100 ng·mL^(-1).分别对0.01μg·L^(-1)的加标水样和一个自来水水样进行了萃取和分析,结果证明可满足水中的有机氯农药残留和除草剂的测定.

关键词：有机氯农药除草剂色谱柱

Leaf Positioning of Arabidopsis in Response to Blue Light

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Molec.lar Plant 2008年第1期1卷 15-26页

作者： Shin-ic.iro Inoue Toshinori k.noshit Atsushi Tak.miya Mic.io Doi ken.ic.iro Shimazak. Department of Biology Faculty of Science Kyushu University Ropponmatsu Fukuoka 810-8560 Japan Researc. and Development c.nter for Higher Educ.tion Kyushu University Ropponmatsu Fukuoka 810-8560 Japan

Appropriate leaf positioning is essential for optimizing photosynthesis and plant growth. However, it has not been eluc.dated how green leaves reac. and maintain their position for c.pturing light. We show here the regulation of leaf positioning under blue light stimuli. When 1-week.old Arabidopsis seedlings grown under white light were transferred to red light （25 i, mol m^-2 s^-1） for 5 d, new petioles that appeared were almost horizontal and their leaves were c.rled and slanted downward. However, when a weak.blue light from above （0.1 i, mol m^-2 s^-1） was superimposed on red light, the new petioles grew obliquely upward and the leaves were flat and horizontal. The leaf positioning required both phototropinl （photl） and nonphototropic.hypoc.tyl 3 （NPH3）, and resulted in enhanc.d plant growth. In an nph3 mutant, neither optimal leaf positioning nor leaf flattening by blue light was found, and blue light-induc.d growth enhanc.ment was drastic.lly reduc.d. When blue light was inc.eased from 0.1 to 5 i, mol m^-2 s^-1, normal leaf positioning and leaf flattening were induc.d in both photl and nph3 mutants, suggesting that phot2 signaling bec.me func.ional and that the signaling was independent of photl and NPH3 in these responses. When plants were irradiated with blue light （0.1 i, mol m^-2 s^- 1） from the side and red light from above, the new leaves bec.me oriented toward the sourc. of blue light. When we transferred these plants to both blue light and red light from above, the leaf surfac. c.anged its orientation to the new blue light sourc. within a few hours, whereas the petioles initially were unc.anged but then gradually rotated, suggesting the plastic.ty of leaf positioning in response to blue light. We showed the tissue expression of NPH3 and its plasma membrane loc.lization via the c.iled-c.il domain and the c.terminal region. We c.nc.ude that NPH3-mediated phototropin signaling optimizes the effic.enc. of light perc.ption by induc.ng both optimal leaf posit

关键词：光合作用拟南芥属