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Hepatitis C virus genotypes in Serbia and Montenegro: The prevalence and clinical signifi cance

World Journal of Gastroenterology 2007年第3期13卷 355-360页

作者： Neda Svirtlih Dragan Delic Jasmina Simonovic Djordje Jevtovic ljubisa dokic Eleonora Gvozdenovic Ivan Boricic Dragica Terzic Sladjana Pavic Gorana Neskovic Sonja Zerjav Vladimir Urban Institute for Infectious Diseases Clinical Centre of Serbia Belgrade Serbia Institute for Pathology Medical Faculty University of Belgrade Serbia Clinical Centre of Podgorica Montenegro General Hospital Uzice Serbia Institute for Nuclear Sciences Vinca Serbia Medical Faculty University of Belgrade Serbia

AIM： To investigate the prevalence of hepatitis C virus （HCV） genotypes in Serbia and Montenegro and their influence on some clinical characteristics in patients with chronic HCV infection. METHODS： A total of 164 patients was investigated. Complete history, route of infection, assessment of alcohol consumption, an abdominal ultrasound, standard biochemical tests and liver biopsy were done. Gene sequencing of 5＇ NTR type-specific PCR or commercial kits was performed for HCV genotyping and subtyping. The SPSS for Windows （version 10.0） was used for univariate regression analysis with further multivariate analysis. RESULTS： The genotypes 1, 2, 3, 4, 1b3a and 1b4 were present in 57.9%, 3.7%, 23.2%, 6.7%, 6.7% and 1.8% of the patients, respectively. The genotype 1 （mainly the subtype 1b） was found to be independent of age in subjects older than 40 years, high viral load, more severe necro-inflammatory activity, advanced stage of fibrosis, and absence of intravenous drug abuse. The genotype 3a was associated with intravenous drug abuse and the age below 40. Multivariate analysis demonstrated age over 40 and intravenous drug abuse as the positive predictive factors for the genotypes lb and 3a, respectively.CONCLUSION： In Serbia and Montenegro, the genotypes 1b and 3a predominate in patients with chronic HCV infection. The subtype lb is characteristic of older patients, while the genotype 3a is common in drug abusers. Association of the subtype lb with advanced liver disease, higher viral load and histological activity suggests earlier infection with this genotype and eventually its increased pathogenicity.

关键词： Hepatitis C virus Genotypes Prevalence Serbia Montenegro

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Ternary Au-Ga-Sb system：calculation of thermodynamic properties using general solution model

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Rare Metals 2016年第3期35卷 262-268页

作者： Lidija Gomidzelovic Dragana Zivkovic ljubisa Balanovic Dragan Manasijevic Mining and Metallurgy Institute 19210 Bor Serbia Technical Faculty University of Belgrade 19210 Bor Serbia

The calculated results of thermodynamic properties in ternary Au-Ga-Sb system by general solution model were presented in this *** calculations were carried out in nine cross sections from all three corners in the temperature range of 973–1,573 K,and integral molar excess Gibbs energies,partial molar Gibbs energies,activity coefficients and activities for all components are *** activity of gold and gallium shows negative deviation from Rault＇s law for all investigated sections,while antimony activity is close to the line of ideal conditions and even coincides with the line for high content of antimony in the *** obtained by calculation were compared with those found in *** is concluded that compared values show reasonable good agreement.

关键词： Alloy thermodynamics Calculation Au-Ga-Sb system General solution model

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Statistical Safety Analysis of Maintenance Management Process of Excavator Units

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International Journal of Automation and computing 2010年第2期7卷 146-152页

作者： ljubisa Papic Milorad Pantelic Joseph Aronov Ajit Kumar Verma Research Center of Dependability and Quality Management Kolubara Metal Company Federal Scientific Research Institute of Standardization Indian Institute of Technology Bombay

Within this paper, the process of statistical safety analysis has been presented, which involves the following steps： formulation of basic principles of statistical safety analysis, initial events analysis, accident sceneries progress analysis, risk calculation, and risk calculation results analysis. On this basis, it has been concluded that the bucket wheel excavator SRs 1200×24/4×0（400 kW）＋VR safety criteria is the mechanism for the hoist of rotor＇s arrow failure modes, because in that case whole bucket wheel excavator failure would necessarily happen （excavator falling down on counterweight）. Therefore, excavator units statistical safety analysis is accomplished preventively to obtain its effective maintenance management.

关键词： Safety maintenance management statistical analysis event tree accident scenarios risk analysis excavator units.

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Applications of k-covers

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Acta Mathematica Sinica,English Series 2006年第4期22卷 1151-1160页

作者： G.DI MAIO ljubisa D.R.KOCINAC Enrico MECCARIELLO Dipartimentodi Matematica Seconda Università di NapoliVia Vivaldi 4381100 CasertaItalia Faculty of Sciences and Mathematics University of NisVisegradska 3318000 NisSerbia Facoltàdi Ingegneria Università del SannioPalazzo B.LucarelliPiazza Roma82100 BeneventoItalia

We investigate a role of k-covers in selection principles theory. Some results about relationships between Ramsey theory and game theory and selection principles that involve k-covers are also given.

关键词： selection principles,ω-cover γ-cover k-cover Hurewicz property k-groupability k-weak groupability game theory

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Fatal Overdoses Involving Carfentanil:A Case Series

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Journal of Forensic Science and Medicine 2019年第3期5卷 147-150页

作者： Nicholas J.Corsi ljubisa J.Dragovic Wayne State University School of Medicine 540 E Canfield StDetroitMichiganUSA Department of Public Services Oakland County Medical Examiners’OfficeOakland CountyPontiacMichiganUSA

Carfentanil,an ultrapotent analog of fentanyl,has invaded the street drug market,unbeknownst to many heroin *** 10,000 times more potent than morphine,it was initially suspected that 20μg of the substance was *** this case series,we present 17 confirmed carfentanil overdoses in Michigan,with a primary focus on the concentration *** a retrospective review,each public death reported in Oakland County,Michigan,with a subsequent toxicology report was investigated for suspected carfentanil *** characterize each fatality,the autopsy results were collected,including the postmortem findings at scene and the decedent’s medical and social *** levels were measured through liquid chromatography and tandem mass spectrometry(LC-MS-MS)by National Medical Services(NMS)*** case series found postmortem carfentanil concentrations as low as 10 ng/mL,with a mean concentration of 0.387 ng/***,there are implications on law enforcement,first responders,and health care providers when dealing with this emerging illicit substance,and there is an alarmingly high mortality rate associated with the abuse of carfentanil.

关键词： Autopsy carfentanil death epidemic fentanyl heroin investigation Michigan opioid overdose polysubstance

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U-47700-Incidence of a Novel Psychoactive Substance in a Series of Medical Examiner Cases in Oakland County,MI

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Journal of Forensic Science and Medicine 2020年第3期6卷 105-109页

作者： Lauren Aiello Emily Skwarek Daniel Isenschmidt ljubisa J.Dragovic Oakland County Medical Examiner's Office PontiacMIUSA

U-47700 is one of many drugs that have been part of a group of compounds called novel psychoactive substances(NPS).U-47700 is a synthetic opioid agonist developed by Upjohn pharmaceuticals but never *** Oakland County Medical Examiner's Office in Pontiac,Michigan,began observing this compound in the fall of 2016,primarily in cases with other drugs of abuse and *** communication described 18 drug-related deaths in which U-47700 was *** U-47700 concentrations ranged from 0.37 to 370 ng/mL(mean 35 and median 4.9 ng/mL).Other opioids were detected in 83% of the *** drugs present in these cases are described as well as the scene *** only one death was likely due directly to U-47700,the cases described here demonstrate how NPS have become an important consideration in evaluating drug-related deaths today.

关键词： Autopsy death investigation Michigan opioid overdose U-47700

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Resurgence of Fentanyl as a Drug of Abuse

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Journal of Forensic Science and Medicine 2016年第2期2卷 111-114页

作者： Lauren P Tamburro Jenan H Al‑Hadidi ljubisa Jovan Dragovic Department of Public Services Oakland County Medical Examiners’OfficeOakland CountyPontiacMichigan 48341USA

Fentanyl,a powerful opioid analgesic introduced over 50 years ago,has a major role in modern anesthesia and chronic pain relief but has also gained a major role in illicit *** a spike in fentanyl abuse between 2005 and 2007,fentanyl deaths decreased until 2010,with the introduction of“abuse‑deterrent”*** data indicate a recent rise in fentanyl‑related deaths beginning in 2013,which follows national *** the re‑emergence of the synthetic narcotic analgesic of high potency as a popular drug of abuse and the alarmingly increasing mortality associated with its abuse,there are profound implications for public health,health care providers,law enforcement,and the society in general.

关键词： Abuse fentanyl OxyContin synthetic opioids

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催化:古老却富有挑战性的石墨烯基材料(英文)

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催化学报 2014年第6期35卷 792-797页

作者： ljubisa R.Radovic Camila Mora-Vilches Adolfo J.A.Salgado-Casanova Department of Chemical Engineering University of Concepción Concepción Chile Department of Energy & Mineral Engineering Penn State University University Park PA USA

An assessment is offered regarding the progress made, and the remaining challenges, in the field of carbocatalysis. The fundamental principles that govern the preparation and performance of sp2-hybridized carbon materials in heterogeneous catalysis have been known for decades, and the level of understanding of key issues – especially the importance of textural and ion-exchange properties (i.e., surface area, pore size distribution, and proton transfer) – remains quite satisfactory. The opportunities for novel catalytic materials – especially graphene nanosheets and carbon nanotubes– are tremendous, especially when it comes to taking advantage of their structural order, such that electron transfer can be both better understood and controlled to enhance catalytic activity and selectivity.

关键词：碳材料石墨催化剂个旧基础碳纳米管多相催化离子交换

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Modeling and Simulation of Hydraulic Long Transmission Line by Bond Graph

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Journal of Mechanics Engineering and Automation 2013年第4期3卷 257-262页

作者： Dragan Prsie Novak Nedie ljubisa Dubonjie Faculty of Mechanical Engineering Kraljevo University of Kragujevac Kraljevo 36 000 Serbia

This paper addresses the issue of modeling of the hydraulic long transmission line. In its base, such model is nonlinear with distributed parameters. Since general solution in closed-form for such model in time-domain is not available, certain simplifications have to be introduced. The pipeline in the paper has been divided to a cascaded network of n segments so that a model with lumped parameters could be reached. For segment modeling, a standard library of bond graphs element has been used. On the basis of models with lumped parameters, the effect of the number of segments, pipeline length and effective bulk modulus on the dynamics of long transmission line have been analyzed.

关键词： Long transmission line lumped parameters n segments bond graph

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Thermodynamics and characterization of shape memory Cu-Al-Zn alloys

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Transactions of Nonferrous Metals Society of China 2015年第8期25卷 2630-2636页

作者： Lidija GOMIDZELOVIC Emina POZEGA Ana KOSTOV Nikola VUKOVIC Vesna KRSTIC Dragana ZIVKOVIC ljubisa BALANOVIC Mining and Metallurgy Institute Faculty of Mining and Geology University of Belgrade Technical Faculty in Bor University of Belgrade

The thermodynamic properties and the microstructure, hardness and electrical conductivity of shape memory alloys （SMAs） belonging to ternary Cu？Al？Zn system were studied by Muggianu model and experiment, respectively. The isothermal section of phase diagram at 293 K was calculated using Thermo-Calc software. Experiments were conducted by X-ray diffraction, light optic microscopy, scanning electron microscopy with energy dispersive X-ray spectrometry, hardness and electrical conductivity measurements. The calculated values of thermodynamic properties indicate that Cu shows good miscibility with Al and Zn in all investigated alloys. The microstructural analysis of samples reveals that the structure consists of large and polygonal grains.

关键词： thermodynamics shape memory alloy Cu-Al-Zn alloys hardness electrical conductivity

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