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Design and realization of lung organoid cultures for COVID-19 applications

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Bio-Design and Manufacturing 2023年第6期6卷 646-660页

作者： Bing Ren Tryanni R.Chiaravalloti Nadine L.Belony Diana I.Romero Wenxuan Chai Christopher Leon lizi wu Nazarius S.Lamango Ite A.Offringa Yong Huang Department of Mechanical and Aerospace Engineering University of FloridaGainesvilleFL 32611USA Department of Biomedical Engineering University of FloridaGainesvilleFL 32611USA College of Pharmacy University of FloridaGainesvilleFL 32611USA Norris Comprehensive Cancer Center Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90089USA Department of Molecular Genetics and Microbiology University of FloridaGainesvilleFL 32611USA College of Pharmacy and Pharmaceutical Sciences Florida A&M UniversityTallahasseeFL 32307USA

Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2,has spread globally and threatens public *** in vitro models that recapitulate the architecture and functioning of specific tissues and organs are in high demand for COVID-19-related pathology studies and drug *** three-dimensional in vitro cultures,such as self-assembled and engineered organoid cultures,surpass conventional two-dimensional cultures and animal models with respect to increased cellular complexity,an environment more relevant to humans,and reduced cost,they are promising platforms for understanding viral pathogenesis and developing new *** review highlights the recent advances in self-assembled and engineered organoid technologies that are used for COVID-19 *** challenges and future perspectives are also discussed.

关键词： Lung organoid COVID-19 Self-assembled organoid Engineered organoid

Targeting Notch and EGFR signaling in human mucoepidermoid carcinoma

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Signal Transduction and Targeted Therapy 2021年第2期6卷 531-541页

作者： Wei Ni Zirong Chen Xin Zhou Rongqiang Yang Mu Yu Jianrong Lu Frederic JKaye lizi wu Department of Molecular Genetics and Microbiology University of FloridaGinsille FL 32610USA UF Health Cancer Center University of FloridaGinesilleFL 32610USA UF Genetics Institute University of FloridaGainesilleFL 32610USA Department of Biochemistry and Molecular Biology University of FloridaGainesillFL 32610USA Department of Medicine University of FloridaGainesilleFL 32610.USA

Mucoepidermoid carcinoma(MEC)is the most common type of salivary gland cancers and patients with advanced,metastatic,and recurrent MECS have limited therapeutic options and poor treatment *** is commonly associated with a chromosomal translocation t(11;19)(q14-21:p12-13)that encodes the CRTC1-MAML2 oncogenic *** CRTC1-MAML2 fusion is required for MEC growth in part through inducing autocrine AREG-EGFR *** evidence suggests that MEC malignancy is maintained by cancer stem-like *** this study,we aimed to determine critical signaling for maintaining MEC stem-like cells and the effect of combined targeting of stem cell signaling and CRTC1-MAML2 induced EGFR signaling on blocking MEC ***,we evaluated the significance of Notch signaling in regulating MEC stem-like *** activated Notch signaling was detected in human fusion-positive MEC *** inhibition of Notch signaling with genetic or pharmacological inhibitors reduced oncosphere formation and ALDH-bright population in vitro and blocked the growth of MEC xenografts in ***,we investigated the effect of co-targeting Notch signaling and EGFR signaling,and observed enhanced inhibition on MEC growth in ***,this study identified a critical role of Notch signaling in maintaining MEC stem-like cells and tumor growth,and revealed a novel approach of co-targeting Notch and EGFR signaling as a potential effective anti-MEC treatment.

关键词： Notch salivary maintained

论社会转型时期的乡村管理困境与出路——定县(定州市)再调查的普遍性结论

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江海学刊 2007年第6期 91-97页

作者：吴力子北京工业大学社会学研究所

中国农业社会在历史上形成了一套有效的乡村管理制度,在近代以前的大多数历史阶段,乡村的管理都不是显性的社会问题。工业化改变了社会结构,传统社会的经济基础逐渐丧失,在乡村还没有进入工业化的社会结构以前,乡村社会的管理问题就凸... 详细信息

中国农业社会在历史上形成了一套有效的乡村管理制度,在近代以前的大多数历史阶段,乡村的管理都不是显性的社会问题。工业化改变了社会结构,传统社会的经济基础逐渐丧失,在乡村还没有进入工业化的社会结构以前,乡村社会的管理问题就凸显了出来。首先,农业财政地位大幅度下降使传统社会的"体国经野"行政模式失去了赖以存在的基础,乡村行政陷入困境;其次,乡村组织程度滞后造成了乡村法制困境,乡村人口流动造成了乡村法治困境;第三,社会结构转型导致资源"城市化",使乡村精英趋于流失,乡村财政趋于枯竭,乡村自治也陷入困境。这说明在社会转型时期市场机制正在"必然地"显性化乡村管理问题,我们必须探索非市场手段使乡村管理走出困境。

关键词：农村管理社会结构

基于OBE教育理念的高校师范生创新型人才培养路径研究

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沈阳师范大学学报（教育科学版） 2023年第1期2卷 75-80页

作者：张攀峰仵丽姿河北师范大学教育学院河北石家庄050024

创新型人才培养是高校教育教学的终极目标,高校既是创新型人才培养的实验场所,也是主阵地。目前,针对高校创新型人才培养并没有一套可参照的统一标准。在教育部推行高等教育“四新”建设的背景下,高校可以将新工科人才培养的OBE学习成... 详细信息

创新型人才培养是高校教育教学的终极目标,高校既是创新型人才培养的实验场所,也是主阵地。目前,针对高校创新型人才培养并没有一套可参照的统一标准。在教育部推行高等教育“四新”建设的背景下,高校可以将新工科人才培养的OBE学习成果导向教育理念迁移到新文科人才培养上,并根据新时代对创新型人才的需求,有效调整师范生培养目标及路径。基于OBE教育理念,探索师范生创新型人才培养的价值、师范生创新型人才培养现存的问题,以及师范生创新型人才培养路径与课程建设,有助于高校师范生创新型人才培养质量的提升。

关键词：创新型人才 OBE教育理念师范生培养新文科

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Reproductive toxicity of enrofloxacin in Caenorhabditis elegans involves oxidative stress-induced cell apoptosis

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Journal of Environmental Sciences 2023年第5期127卷 726-737页

作者： Jiahao Huang lizi Liao Guowei Wang Zhongkun Du Zhengxing wu Key Laboratory of Molecular Biophysics Ministry of EducationCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China School of Environmental Ecology and Biological Engineering Wuhan Institute of TechnologyWuhan 430205China Key Laboratory of Green Chemical Engineering Process of Ministry of Education Wuhan 430205China College of Resources and Environment Shandong Agricultural UniversityTaian 271018China

Fluoroquinolone antibiotics(FQs)that persist and bioaccumulate in the environment have aroused people’s great ***,we studied the adverse effects of FQs in soil animals of Caenorhabditis elegans via food-chronically *** result shows *** exposed to FQs exhibited reproductive toxicity with small-brood size and low-egg *** study the underlying mechanism,we conduct a deep investigation of enrofloxacin(ENR),one of the most frequently detected FQs,on nematodes which is one of commonly used animal indicator of soil *** concentration-effect curves simulated by the Hill model showed that the half effect concentrations(EC50)of ENR were(494.3±272.9)μmol/kg and(107.4±30.9)μmol/kg for the brood size and the hatchability,*** gene expression between the control and the ENR-exposure group enriched with the oxidative stress and cell apoptosis *** results together with the enzyme activity in oxidative stress and the cell corpses suggested that ENR-induced reproductive toxicity was related to germ cell apoptosis under oxidative *** risk quotients of some soil and livestock samples were calculated based on the threshold value of EC10 for the egg hatchability(2.65μmol/kg).The results indicated that there was possible reproductive toxicity on the nematodes in certain agricultural soils for the *** study suggested that chronic exposure to FQs at certain levels in environment would induce reproductive toxicity to the nematodes and might reduce the soil sustainability,alarming the environment risks of antibiotics abuse.

关键词： Environmental toxicity Nematodes Chronic exposure Oxidative stress response Germ cell apoptosis

新型电力系统环境下煤电与新能源等多元资源协调优化运行及其挑战

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电网技术 2024年第8期48卷 3105-3113,I0004,I0005页

作者：孙大雁耿建杨胜春张粒子杨军峰乌晓江牟树君史磊夏秋国家电网有限公司国家电力调度控制中心北京市西城区100031 中国电力科学研究院有限公司江苏省南京市210003 华北电力大学电气与电子工程学院北京市昌平区102206 上海交通大学机械与动力工程学院上海市闵行区200000 北京低碳清洁能源研究院北京市昌平区102211 国网宁夏电力有限公司宁夏回族自治区银川市750000

我国新能源装机规模最大、且持续高速发展,电网运行面临新能源消纳与电力保障供应的双重挑战,需多方位提升系统灵活性,构建新型供给消纳体系,促进资源优化配置。立足我国电源结构和新能源快速发展态势,提出和分析了五大关键技术:煤电与... 详细信息

我国新能源装机规模最大、且持续高速发展,电网运行面临新能源消纳与电力保障供应的双重挑战,需多方位提升系统灵活性,构建新型供给消纳体系,促进资源优化配置。立足我国电源结构和新能源快速发展态势,提出和分析了五大关键技术:煤电与新能源灵活性运行能力提升技术、柔性电-氢-化系统集成设计与运行控制优化技术、多资源互补优化调度运行技术、容量和新型辅助服务市场机制及出清技术、煤电与新能源综合调节和优化运行系统应用技术,促进煤电与新能源的协调发展,推动构建适应我国国情的新能源供给消纳体系建设,推动电力系统的转型升级。

关键词：新型电力系统多元灵活资源优化调度灵活调节能力

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我国不同城市在生物医学工程领域的国际合作参与度定量测度

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中国医疗设备 2024年第8期39卷 93-99,105页

作者：潘黎姿陈娟欧阳昭连吴旭生中国医学科学院/北京协和医学院医学信息研究所北京100020 深圳市卫生健康发展研究和数据管理中心广东深圳518028

目的识别我国在生物医学工程领域国际合作参与度较高的城市和机构,并发现我国在该领域的国际合作特点。方法在Web of Science数据库中检索生物医学工程主题的论文,使用Excel和Pajek软件对我国城市和机构的国际合作论文发文情况进行描述... 详细信息

目的识别我国在生物医学工程领域国际合作参与度较高的城市和机构,并发现我国在该领域的国际合作特点。方法在Web of Science数据库中检索生物医学工程主题的论文,使用Excel和Pajek软件对我国城市和机构的国际合作论文发文情况进行描述性统计分析和合作网络的变化趋势分析,并采用逼近理想解排序法(Technique for Order Preference by Similarity to an Ideal Solution,TOPSIS)综合评价城市和机构在合作网络中的重要性。结果共检索获得生物医学工程相关论文45944篇,经描述性统计发现,北京、上海、广州和深圳的国际合作发文量处于全国前列,香港地区、西安和温州的国际合作发文比例较高;通过量化国际合作水平发现,以上城市在国际合作中的积极性、合作网络中的重要性及TOPSIS得分均处于较高水平。从机构层面来看,北京、上海和广东的一些高校国际合作较为积极。结论本研究通过量化生物医学工程领域研究论文的国际合作网络,识别了国内国际合作方面最为积极和重要的城市与机构,了解了目前该学科国际合作下较为热门的研究方向,并为提升我国生物医学工程领域的国际合作程度提出建议。

关键词：生物医学工程社会网络分析国际合作科学研究

Significant effects of transport on nanoparticles during new particle formation events in the atmosphere of Beijing

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Particuology 2023年第9期80卷 1-10页

作者： Dongjie Shang Min Hu lizi Tang Xin Fang Ying Liu Yusheng wu Zhuofei Du Xuhui Cai Zhijun wu Shengrong Lou Mattias Hallquist Song Guo Yuanhang Zhang State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and EngineeringInternational JointLaboratory for Regional Pollution ControlMinistry of Education(IJRC)Peking UniversityBeijing100871China Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Nanjing University of Information Science&TechnologyNanjing210044China Department of Chemistry and Molecular Biology University of GothenburgGothenburg41296Sweden Shanghai Academy of Environmental Sciences Shanghai200233China

The mechanisms of new particle formation(NPF)events that occurred under high aerosol loadings(“polluted”NPF)in the atmosphere have been unclear,which has inhibited the precision of particlepollution *** deepen the understanding of how the“polluted”NPF events occur,a one-monthcomprehensive measurement was conducted in the atmosphere of Beijing during the summer ***“clean”NPF events(frequency=22%)(condensation sink,CS0.015 s^(-1))were influenced by both local nucleation-growth and regional transport,and the contributions from thetwo factors to 6e25 nm particle number concentration were 60%and 40%,*** studyemphasized the importance of the transport for nanoparticles in relatively polluted atmospheres,and forthat the regional joint particle pollution control would be an essential policy.

关键词： New particle formation Transport Nanoparticles Sulfuric acid

市政污水处理中硝化反应的影响因素与硝化负荷参数的设计取值

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天津科技 2024年第6期51卷 83-86页

作者：魏若桢刘成军吴秋萍陈力子北京智宇天成设计咨询有限公司北京101101

市政污水处理厂进水总氮逐步升高,传统的设计计算并未引入进水氨氮或硝化负荷参数,过高的进水总氮可能影响硝化反应。因此,在设计中需校核硝化负荷。通过阐述生物硝化的反应原理、硝化反应的主要影响因素、国内外关于硝化负荷的参数描... 详细信息

市政污水处理厂进水总氮逐步升高,传统的设计计算并未引入进水氨氮或硝化负荷参数,过高的进水总氮可能影响硝化反应。因此,在设计中需校核硝化负荷。通过阐述生物硝化的反应原理、硝化反应的主要影响因素、国内外关于硝化负荷的参数描述、国内部分已建污水厂的硝化负荷参数值,推测硝化负荷参数范围。

关键词：市政污水处理厂硝化负荷亚硝酸盐硝酸盐