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Storylines of family medicine Ⅴ:ways of thinking—honing the therapeutic self

Family Medicine and Community Health 2024年第S3期12卷 43-51页

作者： William B Ventres Leslie A Stone Johanna F Shapiro Cynthia Haq Jéssica R B Leao Donald E Nease Jr liz grant Stewart W Mercer John C M Gillies Pablo González Blasco Maria Auxiliadora C De Benedetto Graziela Moreto Marcelo R Levites Jennifer E DeVoe William R Phillips Jane M Uygur Thomas R Egnew Colette S Stanley Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family Medicine University of California Irvine School of MedicineIrvineCaliforniaUSA Faculty of Medicine University of Sao PauloSao PauloBrazil Family Medicine University of Colorado Anschutz Medical Campus School of MedicineAuroraColoradoUSA Usher Institute Edinburgh Medical SchoolUniversity of EdinburghEdinburghUK SOBRAMFA-Medical Education and Humanism Sao PauloBrazil Family Medicine Oregon Health&Science University School of MedicinePortlandOregonUSA Family Medicine University of Washington School of MedicineSeattleWashingtonUSA General Practice Royal College of Surgeons in IrelandDublinIreland General Internal Medicine Geriatrics&Palliative MedicineTulane University School of MedicineNew OrleansLouisianaUSA

Storylines of Family Medicine is a 12-part series of thematically linked essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅴ:ways of thinking—honing the therapeutic self’,authors present the following sections:‘Reflective practice in action’,‘The doctor as drug—Balint groups’,‘Cultivating compassion’,‘Towards a humanistic approach to doctoring’,‘Intimacy in family medicine’,‘The many faces of suffering’,‘Transcending suffering’and‘The power of listening to stories.’May readers feel a deeper sense of their own therapeutic agency by reflecting on these essays.

关键词： illustration dimensions suffering

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通过多视角定性访谈了解病人及看护人员的观点、体验以及需求

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英国医学杂志中文版 2010年第2期13卷 104-107页

作者： Marilyn Kendall Scott A Murray Emma Carduff Allison Worth Fiona Harris Anna Lloyd Debbie Cavers liz grant Kirsty Boyd Aziz Sheikh 武弢(译) 武阳丰(校) Centre for Population Health Sciences :General Practice Section University of EdindurghEdinburgh EH8 9DX 澳大利亚悉尼大学医学科学学院北京大学医学部中国乔治中心

在定性研究中，与最常见的单一视角研究相比，通过对病人及专业和非专业看护人员进行关联访谈能够更多、更好地了解他们的需求和经验。二视角或三视角访谈，即把2个或3个（不同角色的）被访者作为一组或一个案例进行访谈，可以探讨复杂... 详细信息

在定性研究中，与最常见的单一视角研究相比，通过对病人及专业和非专业看护人员进行关联访谈能够更多、更好地了解他们的需求和经验。二视角或三视角访谈，即把2个或3个（不同角色的）被访者作为一组或一个案例进行访谈，可以探讨复杂的互补视角和矛盾视角。这种方法在很多长期病患研究中有着很大的应用价值。

关键词：病人看护人员定性研究护理学

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Towards a global One Health index: a potential assessment tool for One Health performance

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Infectious Diseases of Poverty 2022年第3期11卷 12-26页

作者： Xiao-Xi Zhang Jing-Shu Liu Le-Fei Han Shang Xia Shi-Zhu Li Odel YLi Kokouvi Kassegne Min Li Kun Yin Qin-Qin Hu Le-Shan Xiu Yong-Zhang Zhu Liang-Yu Huang Xiang-Cheng Wang Yi Zhang Han-Qing Zhao Jing-Xian Yin Tian-Ge Jiang Qin Li Si-Wei Fei Si-Yu Gu Fu-Min Chen Nan Zhou Zi-Le Cheng Yi Xie Hui-Min Li Jin Chen Zhao-Yu Guo Jia-Xin Feng Lin Ai Jing-Bo Xue Qian Ye liz grant Jun-Xia Song Geoff Simm Jürg Utzinger Xiao-Kui Guo Xiao-Nong Zhou School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiPeople’s Republic of China One Health Center Shanghai Jiao Tong University-The University of EdinburghShanghaiPeople’s Republic of China National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesShanghaiPeople’s Republic of China Shanghai Legislative Research Institute ShanghaiPeople’s Republic of China Zhuhai Branch ESPREBeijing Normal University Zhuhai CampusZhuhaiGuangdongPeople’s Republic of China Global Health Academy The University of EdinburghEdinburghUK Food and Agriculture Organization of the United Nations RomeItaly Global Academy of Agriculture and Food Systems The University of EdinburghEdinburghUK Swiss Tropical and Public Health Institute AllschwilSwitzerland University of Basel BaselSwitzerland

Background:A One Health approach has been increasingly mainstreamed by the international community, as it provides for holistic thinking in recognizing the close links and inter-dependence of the health of humans, animals and the environment. However, the dearth of real-world evidence has hampered application of a One Health approach in shaping policies and practice. This study proposes the development of a potential evaluation tool for One Health performance, in order to contribute to the scientific measurement of One Health approach and the identification of gaps where One Health capacity building is most urgently ***:We describe five steps towards a global One Health index (GOHI), including (i) framework formulation;(ii) indicator selection;(iii) database building;(iv) weight determination;and (v) GOHI scores calculation. A cell-like framework for GOHI is proposed, which comprises an external drivers index (EDI), an intrinsic drivers index (IDI) and a core drivers index (CDI). We construct the indicator scheme for GOHI based on this framework after multiple rounds of panel discussions with our expert advisory committee. A fuzzy analytical hierarchy process is adopted to determine the weights for each of the ***:The weighted indicator scheme of GOHI comprises three first-level indicators, 13 second-level indicators, and 57 third-level indicators. According to the pilot analysis based on the data from more than 200 countries/territories the GOHI scores overall are far from ideal (the highest score of 65.0 out of a maximum score of 100), and we found considerable variations among different countries/territories (31.8–65.0). The results from the pilot analysis are consistent with the results from a literature review, which suggests that a GOHI as a potential tool for the assessment of One Health performance might be ***:GOHI—subject to rigorous validation—would represent the world’s first evaluation tool that constructs the

关键词： Antimicrobial resistance Cell-like framework Climate change Food security Global One Health index(GOHI) Global performance assessment Governance Zoonotic diseases

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Brain Banks Spur New Frontiers in Neuropsychiatric Research and Strategies for Analysis and Validation

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Genomics, Proteomics & Bioinformatics 2019年第4期17卷 402-414页

作者： Le Wang Yan Xia Yu Chen Rujia Dai Wenying Qiu Qingtuan Meng liz Kuney Chao Chen Center for Medical Genetics&Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangsha 410078China Child Health Institute of New Jersey Department of NeuroscienceRutgers Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901USA Psychiatry Department SUNY Upstate Medical UniversitySyracuseNY 13210USA Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100101China Affiliated Hospital of Guilin Medical University Guilin 541000China National Clinical Research Centre for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410000China

Neuropsychiatric disorders affect hundreds of millions of patients and families *** decode the molecular framework of these diseases,many studies use human postmortem brain *** studies reveal brain-specific genetic and epigenetic patterns via highthroughput sequencing *** best practices for the collection of postmortem brain samples,analyzing such large amounts of sequencing data,and interpreting these results are critical to advance *** provide an overview of human brain banks worldwide,including progress in China,highlighting some well-known projects using human postmortem brain samples to understand molecular regulation in both normal brains and those with neuropsychiatric ***,we discuss future research strategies,as well as state-of-the-art statistical and experimental methods that are drawn upon brain bank resources to improve our understanding of the agents of neuropsychiatric disorders.

关键词： Neuropsychiatric disorders Brain bank Postmortem brain Expression quantitative trait loci GWAS interpretation

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Plasmonic metal‐organic frameworks

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SmartMat 2021年第4期2卷 446-465页

作者： Guangchao Zheng Isabel Pastoriza‐Santos Jorge Pérez‐Juste Luis M.liz‐Marzán School of Physics and Microelectronics Key Laboratory of Material PhysicsMinistry of EducationZhengzhou UniversityZhengzhouChina CINBIO Universidade de VigoDepartamento de Química FísicaVigoSpain Galicia Sur Health Research Institute(IIS Galicia Sur) SERGAS‐UVIGOVigoSpain CIC biomaGUNE Basque Research and Technology Alliance(BRTA)Donostia‐San SebastianSpain Ikerbasque Basque Foundation for ScienceBilbaoSpain Centro de Investigación Biomédica en Red BioingenieríaBiomateriales y NanomedicinaCIBER‐BBNDonostia‐San SebastiánSpain

Plasmonic metal‐organic frameworks are composite nanoparticles comprising plasmonic metal nanoparticles(NPs)embedded within a metalorganic framework(MOF)*** a result,not only the functionalities of the individual components are retained,but synergistic effects additionally provide improved chemical and physical *** progress in plasmonic MOFs has demonstrated the potential for nanofabrication and various nanotechnology *** challenges toward plasmonic MOFs have been recently addressed,resulting in new opportunities toward practical applications,such as surface‐enhanced Raman scattering,therapy,and *** impact of key parameters(thermodynamic ***)on the synthetic pathways of plasmonic MOFs is reviewed,while providing insight into related progress toward structure‐derived applications.

关键词： catalysis drug delivery metal‐organic frameworks nanocomposites plasmonic metal nanoparticles plasmonic MOFs surface‐enhanced Raman scattering

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Templated Colloidal Self-Assembly for Lattice Plasmon Engineering

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Accounts of Materials Research 2021年第9期2卷 816-827页

作者： Leonardo Scarabelli David Vila-Liarte Agustín Mihi Luis M.liz-Marzán Institute of Materials Science of Barcelona ICMAB-CSIC08193 BellaterraSpain CIC biomaGUNE Basque Research and Technology Alliance(BRTA)20014 Donostia-San SebastiánSpain Centro de Investigación Biomédica en Red BioingenieríaBiomateriales y Nanomedicina(CIBER-BBN)20014 Donostia-San SebastiánSpain Ikerbasque Basque Foundation for Science48013 BilbaoSpain

CONSPECTUS:Over the past 30 years,the engineering of plasmonic resonances at the nanoscale has progressed dramatically,with important contributions in a variety of different fields,including chemistry,physics,biology,engineering,and ***,heavy optical losses related to the use of noble metals for the fabrication of plasmonic structures hindered their application in various ***,an answer to these long-lasting issues emerged in the use of lattice plasmon resonances(LPRs,also called surface lattice resonances),bringing new excitement in the field of ***,the organization of plasmonic nanoparticles into ordered arrays enables far-field coupling of the scattered light exploiting the diffraction modes of the array,generating plasmonic resonances with bandwidths as narrow as a few nanometers,corresponding to an increase of over 10-fold in the quality factors compared to localized plasmon *** such,LPRs offer new opportunities to harness light−matter interactions at the nanoscale,while generating renewed interest in the self-assembly of colloidal metal nanoparticles,as a scalable approach to the preparation of such plasmonic *** self-assembly emerged as one of the most versatile approaches,being compatible with soft-lithographic techniques such as nanoimprint lithography and amenable to a variety of materials,colloids,and *** self-assembly additionally allows the preparation of arrays where the repeating units are composed of multiple self-assembled nanoparticles(i.e.,plasmonic clusters).In this system,near-field coupling can be finely tuned,thereby showing promising results in biosensing,catalysis,or plasmonic *** this Account,we review the preparation of ordered arrays of clusters of plasmonic *** present various aspects involved in the templated self-assembly of colloidal nanoparticles,with the aim of achieving at the same time close-packed structures within each cavity

关键词： coupling enable versatile

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Induction of IgA and sustained deficiency of cell proliferative response in chronic hepatitis C

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World Journal of Gastroenterology 2008年第44期14卷 6844-6852页

作者： Yalena Amador-Caizares liz Alvarez-Lajonchere Ivis Guerra Ingrid Rodríguez-Alonso Gillian Martínez-Donato Julián Triana Eddy E González-Horta Angel Pérez Santiago Dueas-Carrera Centro de Ingeniería Genética y Biotecnología Ave 31e/ 158 and 190PlayaP.O. Box 6162HavanaCuba

AIM： In the present study, antibody and peripheral blood mononuclear cells （PBMC） proliferative responses against hepatitis C virus （HCV） antigens were evaluated in HCV chronically infected patients. METHODS： Paired serum and PBMC samples were taken six months apart from 34 individuals, either treated or not, and tested by enzyme-linked immunosorbent assay （ELISA） and carboxyfluorescein succinimidyl ester staining. RSULTS： Over 70% of the patients showed specific IgG and IgM against capsid, E1 and NS3, while HVR-1 was recognized by half of the patients. An increase in the levels of the anti-capsid IgM （P = 0.027） and IgG （P = 0.0006） was observed in six-month samples, compared to baseline. Similarly, a significantly higher percent of patients had detectable IgA reactivity to capsid （P = 0.017） and NS3 （P = 0.005） after six months, compared to baseline. Particularly, IgA against structural antigens positively correlated with hepatic damage （P = 0.036）. IgG subclasses evaluation against capsid and NS3 revealed a positive recognition mediated by IgG1 in more than 80% of the individuals. On the contrary, less than 30% of the patients showed a positive proliferative response either of CD4＋ or CD8＋ T cells, being the capsid poorly recognized. CONCLUSION： These results confirm that while the cellular immune response is narrow and weak, a broad and vigorous humoral response occurs in HCV chronic infection. The observed correlation between IgA and hepatic damage may have diagnostic significance, although it warrants further confirmation.

关键词： Hepatitis C Antibody response Lymphoproliferation Core Envelope

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