Brain Banks Spur New Frontiers in Neuropsychiatric Research and Strategies for Analysis and Validation

作     者：Le Wang Yan Xia Yu Chen Rujia Dai Wenying Qiu Qingtuan Meng Liz Kuney Chao Chen 

作者机构：Center for Medical Genetics&Hunan Key Laboratory of Medical GeneticsSchool of Life SciencesCentral South UniversityChangsha 410078China Child Health Institute of New JerseyDepartment of NeuroscienceRutgers Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901USA Psychiatry DepartmentSUNY Upstate Medical UniversitySyracuseNY 13210USA Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100101China Affiliated Hospital of Guilin Medical UniversityGuilin 541000China National Clinical Research Centre for Geriatric DisordersXiangya HospitalCentral South UniversityChangsha 410000China 

出 版 物：《Genomics, Proteomics & Bioinformatics》 (基因组蛋白质组与生物信息学报（英文版）)

年 卷 期：2019年第17卷第4期

页      面：402-414页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.31571312,31970572,and81401114) the National Key R&D Project of China(Grant No.2016YFC1306000) Innovation-driven Project of Central South University(Grant Nos.2015CXS034 and 2018CX033)to CC 

主　　题：Neuropsychiatric disorders Brain bank Postmortem brain Expression quantitative trait loci GWAS interpretation 

摘      要：Neuropsychiatric disorders affect hundreds of millions of patients and families *** decode the molecular framework of these diseases,many studies use human postmortem brain *** studies reveal brain-specific genetic and epigenetic patterns via highthroughput sequencing *** best practices for the collection of postmortem brain samples,analyzing such large amounts of sequencing data,and interpreting these results are critical to advance *** provide an overview of human brain banks worldwide,including progress in China,highlighting some well-known projects using human postmortem brain samples to understand molecular regulation in both normal brains and those with neuropsychiatric ***,we discuss future research strategies,as well as state-of-the-art statistical and experimental methods that are drawn upon brain bank resources to improve our understanding of the agents of neuropsychiatric disorders.