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Recent progress on nanoparticle-based drug delivery systems for cancer therapy

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Cancer Biology & Medicine 2017年第3期14卷 228-241页

作者： Yanru Xin Mingming Yin liyuan zhao Fanling Meng Liang Luo College of Life Science and Technology National Engineering Research Center for NanomedicineHuazhong University ofScience and TechnologyWuhan 430074China

The development of cancer nanotherapeutics has attracted great interest in the recent decade. Cancer nanotherapeutics have overcome several limitations of conventional therapies, such as nonspecific biodistribution, poor water solubility, and limited bioavailability. Nanoparticles with tuned size and surface characteristics are the key components of nanotherapeutics, and are designed to passively or actively deliver anti-cancer drugs to tumor cells. We provide an overview of nanoparticle-based drug delivery methods and cancer therapies based on tumor-targeting delivery strategies that have been developed in recent years.

关键词： Nanoparticles nanomedicine drug delivery tumor targeting cancer therapy

Defective arginine metabolism impairs mitochondrial homeostasis in Caenorhabditis elegans

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Journal of Genetics and Genomics 2020年第3期47卷 145-156页

作者： Ruofeng Tang Xin Wang Junxiang Zhou Fengxia Zhang Shan zhao Qiwen Gan liyuan zhao Fengyang Wang Qian Zhang Jie Zhang Guodong Wang Chonglin Yang State Key Laboratory of Natural Resource Conservation and Utilization in Yunnan Center for Life ScienceSchool of Life SciencesYunnan UniversityKunming650021China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing100101China Graduate University of Chinese Academy of Sciences Beijing100049China State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing100101China

Arginine catabolism involves enzyme-dependent reactions in both mitochondria and the cytosol,defects in which may lead to hyperargininemia,a devastating developmental *** is largely unknown if defective arginine catabolism has any effects on *** we report that normal arginine catabolism is essential for mitochondrial homeostasis in Caenorhabditis *** of the arginase gene argn-1 lead to abnormal mitochondrial enlargement and reduced adenosine triphosphate(ATP)production in C elegans hypodermal ***-1 localizes to mitochondria and its loss causes arginine accumulation,which disrupts mitochondrial *** expression of human ARGl or ARG2 rescued the mitochondrial defects of argn-1 ***,genetic inactivation of the mitochondrial basic amino acid transporter SLC-25A29 or the mitochondrial glutamate transporter SLC-25A18.1 fully suppressed the mitochondrial defects caused by argn-1 *** findings suggest that mitochondrial damage probably contributes to the pathogenesis of hyperargininemia and provide clues for developing therapeutic treatments for hyperargininemia.

关键词： Arginine Arginase Hyperargininemia Mitochondrial homeostasis C.elegans

An overview of cetacean strandings, bycatches and rescues along the western coast of the Taiwan Strait, China: 2010–2015

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Acta Oceanologica Sinica 2017年第12期36卷 31-36页

作者： zhao liyuan ZHU Qian MIAO Xing XU Min WU Fuxing DAI Yufei TAO Cuihua MOU Jianfeng WANG Xianyan Laboratory of Marine Biology and Ecology Third Institute of OceanographyState Oceanic Administration Ocean College Shandong University (Weihai)

The analysis of cetacean strandings can provide fundamental information about species diversity and composition in a particular region. The present study collected and analyzed cetacean strandings, bycatches and rescues along the western coast of the Taiwan Strait, China, from 2010 to 2015. In total, 48 records, including 37 strandings, 8 bycatches and 3 rescues, involving 13 known species were collected. Among them, Indo-Pacific humpback dolphins（Sousa chinensis） and finless porpoises（Neophocaena phocaenoides） were the most common species, consisting of 31.3% and 25%, respectively. Notably, 10 out of the 48（20.8%） records were collected from the Pingtan Island and included 3 species of Mysticeti and 4 species of Odontoceti. Finally, we compared the cetacean species composition between the western and eastern coasts of the Taiwan Strait; 31 cetacean species occurred in the Taiwan Strait, indicating a relatively high cetacean diversity in this region. Systematic field surveys are urgently needed to explore the cetacean species composition, population stock and the related habitat status in the Taiwan Strait, which may improve conservation management in the future.

关键词： cetacean stranding bycatch rescue species diversity Taiwan Strait

Recombinant adeno-associated virus 8 vector in gene therapy:Opportunities and challenges

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Genes & Diseases 2024年第1期11卷 283-293页

作者： liyuan zhao Zixuan Yang Minhui Zheng Lei Shi Mengyun Gu Gang Liu Feng Miao Yan Chang Fanghua Huang Naping Tang Anhui University of Traditional Chinese Medicine HefeiAnhui 230000China Yangtze Delta Drug Advanced Research Institute Yangtze Delta Pharmaceutical CollegeNantongJiangsu226133China Shanghai Innostar Bio-Technology Co. LtdChina State Institute of Pharmaceutical IndustryShanghai 201203China Innostar Bio-tech Nantong Co. Ltd.NantongJiangsu 226133China Center for Drug Evaluation National Medical Products AdministrationBeijing 100022China

In recent years,significant breakthroughs have been made in the field of gene ***-associated virus(AAV)is one of the most promising gene therapy vectors and a powerful tool for delivering the gene of *** the AAV vectors,AAV serotype 8(AAv8)has attracted much attention for its efficient and stable gene transfection into specific ***,recombinant AAv8 has been widely used in gene therapy research on a va-riety of diseases,including genetic diseases,cancers,autoimmune diseases,and viral diseases.

关键词： AAV8 Adeno-associated virus Gene therapy Primates

Surface Modification and Suspension Stability of Ultrafine Al(OH)_3 Particles

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沈阳建筑大学学报（自然科学版） 2011年第1期27卷 84-90页

作者： zhao Su,QIU liyuan,TIAN Jing,zhao Yingyu(School of Material Science and Engineering,Shenyang Jianzhu University,Shenyang,China,110168) School of Material Science and Engineering Shenyang Jianzhu UniversityShenyangChina110168

The influence of single and compound dispersant on the sedimentation performance of modifiedultrafine Al(OH)3powder aqueous suspension was studied by the determination of the settlement rate and the Zeta *** results showed that the type and dosage of the dispersant have remarkable impacts on the dispersion *** the mixture of DP-270and Sodium C16alkylbenzenesulfonate(mass ratio=1∶1)in the Al(OH)3aqueous suspension,the dispersion stability was improved *** for spherical partic...

关键词： Modification Ultrafine Al(OH)3Powder Suspension Stability

Early divergence and differential population histories of the Indo-Pacific humpback dolphin in the Pacific and Indian Oceans

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Integrative Zoology 2021年第4期16卷 612-625页

作者： liyuan zhao Watchara SAKORNWIMON Wenzhi LIN Peijun ZHANG Rachawadee CHANTRA Yufei DAI Reyilamu AIERKEN Fuxing WU Songhai LI Kongkiat KITTIWATTANAWONG Xianyan WANG Laboratory of Marine Biology and Ecology Third Institute of OceanographyMinistry of Natural ResourcesXiamenChina Marine and Coastal Resources Research Center The Middle Gulf of ThailandChumphonThailand Institute of Deep-sea Science and Engineering Chinese Academy of SciencesSanyaChina Marine and Coastal Resources Research Center The Upper Gulf of ThailandSamut SakhonThailand Fujian Provincial Key Laboratory of Marine Ecological Conservation and Restoration XiamenChina Phuket Marine Biological Research Center PhuketThailand

The currently recognized Indo-Pacific humpback dolphin occurs in estuaries and surrounding shallow waters from the South China Sea to the Asian coast of the Indian ***,a recent study suggested that the humpback dolphin from the Bay of Bengal may represent a distinct phylogenetic *** this study,we sequenced 915-bp mtDNA segments from five geographic populations in both Chinese and Thai waters;together with previously published sequences,these data revealed that the ancestral Indo-Pacific humpback dolphin might have split during the transition from the Oligocene to Miocene(23.45 Mya,95%HPD:16.65–26.55 Mya),and then dispersed along the Pacific and Indian Ocean coasts of *** differentiation was detected between most of the examined populations,except for only a few pairwise populations in the northern South China *** differentiation/distance between the humpback dolphins from the northern and southern South China Sea met the sub-species threshold value proposed for marine mammals,whereas that between the humpback dolphins in the Pacific and the Indian Ocean was above the species *** inference of historic gene flow indicated low but constant northward gene flow along the Indian Ocean coast;however,there was a recent abrupt increase in gene flow in the Pacific region,likely due to the shortening coastline at the low stand of sea *** results revealed that the current taxonomic classification of Indo-Pacific humpback dolphins may not reflect their phylogeography.

关键词： historic gene flow Indo-Pacific region phylogenetic species concept phylogeography Sousa chinensis

Novel insights into the spatial genetic patterns of the finless porpoise from East to Southeast Asia

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Water Biology and Security 2023年第1期2卷 86-95页

作者： Wenzhi Lin liyuan zhao Shenglan Chen Watchara Sakornwimon Reyilamu Aierken Kongkiat Kittiwattanawong Xianyan Wang Songhai Li Marine Mammal and Marine Bioacoustics Laboratory Institute of Deep-sea Science and EngineeringChinese Academy of SciencesSanyaChina Laboratory of Marine Biodiversity Third Institute of OceanographyMinistry of Natural ResourcesXiamenChina Key Laboratory of Marine Ecological Conservation and Restoration Ministry of Natural ResourcesXiamen361005China University of Chinese Academy of Sciences BeijingChina Marine and Coastal Resources Research Center The Middle Gulf of ThailandChumphonThailand Phuket Marine Biological Research Center PhuketThailand

Several cetacean species are endemically distributed throughout the *** to disproportionate sampling and research efforts across the Indo-Pacific region,the spatial genetic structure of these species remains poorly *** has led to poor phylogeographic knowledge and ambiguous taxonomic classification of many Indo-Pacific cetacean *** these,the finless porpoise(genus Neophocaena)is a small cetacean obligatory to the inshore waters from East Asia to the Persian Gulf of the Indian *** date,two species are generally recognized:the narrow-ridged finless porpoise inhabiting temperate and subtropical waters,and wideridged finless porpoises inhabiting subtropical and tropical *** research efforts focused on the temperate waters off the northern ***,recent studies have proposed that the primary divergence within the genus may lie between the Indian Ocean and Pacific region,which remains to be tested with more samples from tropical and subtropical ***,we examined the genetic relationship among the finless porpoises from the Gulf of Thailand to the Taiwan Strait using both mitochondrial and autosomal *** assignment analysis suggested a minimum of four genetic populations within the study areas,corresponding to the narrowridged finless porpoise from the Taiwan Strait(TWSn),and the three wide-ridged finless porpoise populations from the Taiwan Strait(TWSw),Pearl River Delta region(PRDw),and the Gulf of Thailand(Thaiw),*** minimum spanning network of the mtDNA control region found shared haplotypes among finless porpoises in Chinese waters,but those from the Gulf of Thailand formed a unique matriline ***,the genetic differentiation or divergence within the South China Sea(Thaiw ***)appears to be higher than that of most finless porpoise populations examined to date,and meets the threshold values of species or sub-species level proposed for the cetacean *** Mantel

关键词： Neophocaena spp Indo-Pacific region Control region Microsatellite Individual assignment

A pair of transporters controls mitochondrial Zn^(2+) levels to maintain mitochondrial homeostasis

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Protein & Cell 2022年第3期13卷 180-202页

作者： Tengfei Ma liyuan zhao Jie Zhang Ruofeng Tang Xin Wang Nan Liu Qian Zhang Fengyang Wang Meijiao Li Qian Shan Yang Yang Qiuyuan Yin Limei Yang Qiwen Gan Chonglin Yang State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan and Center for Life Sciences School of Life SciencesYunnan UniversityKunming 650091China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

Zn^(2+)is required for the activity of many mitochondrial proteins,which regulate mitochondrial dynamics,apoptosis and ***,it is not understood how the proper mitochondrial Zn^(2+)level is achieved to maintain mitochondrial *** Caenorhabditis elegans,we reveal here that a pair of mitochondrion-localized transporters controls the mitochondrial level of Zn^(2+).We demonstrate that SLC-30A9/ZnT9 is a mitochondrial Zn^(2+)*** of SLC-30A9 leads to mitochondrial Zn^(2+)accumulation,which damages mitochondria,impairs animal development and shortens the life *** further identify SLC-25A25/SCaMC-2 as an important regulator of mitochondrial Zn^(2+)*** of SLC-25A25 suppresses the abnormal mitochondrial Zn^(2+)accumulation and defective mitochondrial structure and functions caused by loss of ***,we reveal that the endoplasmic reticulum contains the Zn^(2+)pool from which mitochondrial Zn^(2+)is *** findings establish the molecular basis for controlling the correct mitochondrial levels for normal mitochondrial structure and functions.

关键词： mitochondria Zn^(2+)transporter C.elegans ER-mitochondrial contact development

青海甘沟话由“给”标记的增宾结构及其扩展结构

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民族语文 2024年第3期 67-84页

作者：赵绿原中国社会科学院语言研究所北京100732

青海民和甘沟话处在汉语与阿尔泰语系语言深度接触的环境中,动词形态较普通话更为复杂。甘沟话可以通过在动词后添加形态标记“给”进行增价派生,派生后的结构增引一个语义上的外围论元作宾语,属于双系结构(applicative construction)... 详细信息

青海民和甘沟话处在汉语与阿尔泰语系语言深度接触的环境中,动词形态较普通话更为复杂。甘沟话可以通过在动词后添加形态标记“给”进行增价派生,派生后的结构增引一个语义上的外围论元作宾语,属于双系结构(applicative construction)的次类,即增宾结构。甘沟话的增宾结构可以增引接受者、受益者、目标三类语义上的外围论元。受三类典型增宾结构影响,标记“给”类推扩展进入其他一些语义相关、表层形式相近的结构中,增宾结构及其扩展结构的语义限制为[+给予]。甘沟话增宾结构的形成是接触导致的SOV语序与汉语语法系统内部协调的结果。与甘沟话有明确接触关系的土族语民和方言受甘沟话增宾结构影响,致使后缀-gha发生了功能扩展,这显示了接触对语法系统影响的双向性。

关键词：增宾结构 “给” 双及物结构西北汉语方言语言接触