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Injectable Fiber Electronics for Tumor Treatment

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Advanced Fiber Materials 2022年第2期4卷 246-255页

作者： Yang Zhao Chuanrui Chen Yangyang Qiu Tenglong Mei Lei Ye Huan Feng Ye Zhang liyuan wang Yue Guo Xuemei Sun Jiaxue Wu Huisheng Peng State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science and Laboratory of Advanced MaterialsFudan UniversityShanghai 200438China The State Key Laboratory of Genetic Engineering School of Life ScienceZhongshan HospitalFudan UniversityShanghai 200438China National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artifcial Functional Materialsand College of Engineering and Applied SciencesNanjing UniversityNanjing 210023China

Electrochemical therapy emerged as a low-cost and efective method for tumor ***,it has challenges such as the production of toxic byproducts and the use of rigid electrodes that damage soft ***,we report a new injectable and tissue-compatible fber therapeutic electronics for safe and efcient tumor *** design of aligned carbon nanotube(CNT)fber as electrodes endowed the device with high softness and enabled mini-invasive implantation through *** a mild voltage(1.2 V),the fber device released hydroxyl ions to alter the local chemical environment of the tissues without additional toxic products/gases,leading to immediate death of tumor *** fexible fber device could form stable interface with tissues and showed good biocompatibility after implantation for 30 *** in vitro experimental results showed the fber device could efciently kill 90.9%of QGY-7703 cancer cells after a single treatment in a few *** tumor-bearing animal models proved that the fber therapeutic device could efectively inhibit the growth of tumor tissues,indicating it is a safe,efective,controllable and low-cost method for tumor therapy.

关键词： Flexible Biocompatible Implantable Fiber device Tumor therapy

Abiotic stress treatment reveals expansin like A gene OfEXLA1 improving salt and drought tolerance of Osmanthus fragrans by responding to abscisic acid

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Horticultural Plant Journal 2024年第2期10卷 573-585页

作者： Bin Dong Qianqian wang Dan Zhou Yiguang wang Yunfeng Miao Shiwei Zhong Qiu Fang liyuan Yang Zhen Xiao Hongbo Zhao School of Landscape Architecture Zhejiang Agriculture and Forestry UniversityHangzhouZhejiang 311300China Zhejiang Provincial Key Laboratory of Germplasm Innovation and Utilization for Garden Plants HangzhouZhejiang 311300China Key Laboratory of National Forestry and Grassland Administration on Germplasm Innovation and Utilization for Southern Garden Plants HangzhouZhejiang 311300China

Sweet osmanthus(Osmanthus fragrans) is a having general approval aromatic tree in China that is widely applied to landscaping and gardening. However, the evergreen tree adaptability is limited by many environmental stresses. Currently, limited information is available regarding the genetic analysis and functional identification of expansin genes in response to abiotic stress in sweet osmanthus. In this study, a total of 29 expansin genes were identified and divided into four groups by genome-wide analysis from the sweet osmanthus genome. Transcriptome and quantitative Real-time PCR analysis showed that the cell wall-localized protein expansin-like A(OfEXLA1) gene was significantly induced by salt and drought treatment. Histochemical GUS staining of transgenic Arabidopsis lines in which GUS activity was driven with the OfEXLA1 promoter, GUS activity was significantly induced by salt, drought, and exogenous abscisic acid(ABA). In yeast, we found OfEXLA1overexpression significantly improved the population of cells compared with wild-type strains after NaCl and polyethylene glycol(PEG)treatment. Additionally, OfEXLA1 overexpression not only promoted plant growth, but also improved the salt and drought tolerance in Arabidopsis. To gain insight into the role of ABA signaling in the regulation of OfEXLA1 improving abiotic tolerance in sweet osmanthus, four differentially expressed ABA Insensitive 5(ABI5)-like genes(OfABL4, OfABL5, OfABL7, and OfABL8) were identified from transcriptome, and dualluciferase(dual-LUC) and yeast one hybrid(Y1H) assay showed that OfABL4 and OfABL5 might bind to OfEXLA1 promoter to accumulate the OfEXLA1 expression by responding to ABA signaling to improve abiotic tolerance in sweet osmanthus. These results provide the information for understanding the molecular functions of expansin-like A gene and molecular breeding of sweet osmanthus in future.

关键词： Osmanthus fragrans Abiotic tolerance Expansin Abscisic acid

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硫酸亚锡废液回收利用研究

云南化工 2024年第5期51卷 70-72页

作者：唐菲龙在创张增伦花蓓薛莅凡胡洋王丽媛云南锡业锡化工材料有限责任公司云南个旧661000

研究了硫酸亚锡废液的回收利用工艺。探究了真空度、加热时间、稳定剂种类、稳定剂加入质量等对产品的影响。当下层废液和水的体积比为1∶2(下层废液500 mL,加水稀释至1500 mL)、加入0.8 g稳定剂2、真空度为0.08 MPa、温度为(55±2)℃... 详细信息

研究了硫酸亚锡废液的回收利用工艺。探究了真空度、加热时间、稳定剂种类、稳定剂加入质量等对产品的影响。当下层废液和水的体积比为1∶2(下层废液500 mL,加水稀释至1500 mL)、加入0.8 g稳定剂2、真空度为0.08 MPa、温度为(55±2)℃、加热时间为(90±5)min时,产出的硫酸亚锡浊度较低,产品质量符合相关标准。实现资源高效集约化利用。

关键词：硫酸亚锡废液浊度回收

Surface reconstruction and structural transformation of twodimensional Ni-Fe MOFs for oxygen evolution in seawater media

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Nano Research 2024年第4期17卷 2429-2437页

作者： liyuan Xiao Xue Bai Jingyi Han Tianmi Tang Siyu Chen Hui Qi Changmin Hou Fuquan Bai Zhenlu wang Jingqi Guan Institute of Physical Chemistry College of ChemistryJilin UniversityChangchun 130021China The Second Hospital of Jilin University Changchun 130021China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012China Laboratory of Theoretical and Computational Chemistry Institute of Theoretical ChemistryCollege of ChemistryChangchun 130023China

As a four-electron transfer reaction,oxygen evolution reaction(OER)is limited by large overpotential and slow ***,we in-situ synthesized two-dimensional(2D)Ni-Fe metal-organic framework nanosheets on nickel foam(NixFe-TPA/NF,TPA=terephthalic acid)for oxygen evolution in alkaline and alkaline seawater *** 1 M KOH,Ni3Fe-TPA/NF shows a low overpotential(η10)of 189 mV at 10 mA·cm^(-2) and an ultra-low overpotential of only 260 mV at 500 mA·cm^(-2).In alkaline seawater,Ni3Fe-TPA/NF still provides impressive OER performance,with anη10 of 265 ***-situ Raman characterization results show that the phase transition occurs during the OER,and Ni3FeOOH with more oxygen vacancies is in-situ formed,reducing the OER energy *** functional theory(DFT)reveals that the synergy between Ni and Fe reduces the energy barrier and accelerates the rate-determining *** addition,the ultra-thin 2D sheet structure and the close combination of Ni3FeOOH and highly conductive NF support ensure the high catalytic OER ***,the surface reconstruction and structural modification strategy can be used to design and prepare high-performance OER electrocatalysts for energy-related applications.

关键词： density functional theory(DFT)calculation Ni3FeOOH oxygen evolution reaction seawater electrolysis surface reconstruction

Involvement of DEG5 and DEG8 proteases in the turnover of the photosystem II reaction center D1 protein under heat stress in Arabidopsis thaliana

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Chinese Science Bulletin 2007年第13期52卷 1742-1745页

作者： SUN XuWu wang liyuan ZHANG LiXin Key Laboratory of Arid and Grassland Ecology School of Life Sciences Lanzhou University Lanzhou 730000 China Key Laboratory of Photosynthesis and Environmental Molecular Physiology Photosynthesis Research Center Institute of Botany Chinese Academy of Sciences Beijing 100093 China

Deg5,deg8 and the double mutant,deg5deg8 of Arabidopsis thaliana were used to study the physiological role of the DEG proteases in the repair cycle of photosystem II (PSII) under heat stress. PSII activity in deg mutants showed increased sensitivity to heat stress, and the extent of this effect was greater in the double mutant, deg5deg8, than in the single mutants, deg5 and deg8. Degradation of the D1 protein was slower in the mutants than in the WT plants. Furthermore, the levels of other PSII reaction center proteins tested remained relatively stable in the mutant and WT plants following high-temperature treatment. Thus, our results indicate that DEG5 and DEG8 may have synergistic function in degradation of D1 protein under heat stress.

关键词： D1蛋白蛋白酶阿布属光合作用

Unique genes carried by abundant species enhance CH_(4) emissions during the growing season at the Tibetan Plateau

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Soil Ecology Letters 2024年第2期6卷 83-95页

作者： Yue Liang liyuan He Jieying wang Yanfang Liu Wenying wang Chengjie Ren Jun wang Yaoxin Guo Ninglian wang Fazhu Zhao Shaanxi Key Laboratory of Earth Surface System and Environmental Carrying Capacity Northwest UniversityXi’an710127China College of Urban and Environmental Sciences Northwest UniversityXi’an710127China Department of Biology San Diego State UniversitySan DiegoCA92182USA Key Laboratory of Biodiversity Formation Mechanism and Comprehensive Utilization in Qinghai-Tibet Plateau School of Life SciencesQinghai Normal UniversityXining810008China College of Agronomy Northwest A&F UniversityYangling712100China The College of Life Sciences Northwest UniversityXi’an710072China Carbon Neutrality College (Yulin) Northwest UniversityXi’an710127China

CH_(4) emission rates followed an increased pattern during the growing season at Tibetan Plateau.•Unique genes carried by abundant species were positively correlated with CH_(4) emission rates.•Climate factors influenced CH_(4) emission rates by regulating microbial community and their *** play pivotal roles in soil methane(CH_(4))emissions and their functional genes are origins of a key mechanism for soil ***,understanding of the roles of specific genes(e.g.,unique or shared genes carried by species)underlying CH_(4)-cycling remains ***,we measured CH_(4) emission rates and investigated variations in microbial community and the abundance of genes carried by species during the growing season in alpine meadow on the Tibetan *** discovered that CH_(4) emission rates increased from 394.4,745.9,and 1092.7µg CH4 m−2 h−1,in April,June,and August,respectively,and had a positive correlation with unique genes carried by abundant species during the growing ***,we found that unique genes carried by abundant species involved in methanogenesis processes have a higher abundance than methanotrophic *** analysis indicated that climate factors(i.e.,mean monthly temperature(MMT)and mean monthly precipitation(MMP))influenced microbial community and their functional genes,and therefore affected the CH_(4) emission ***,the present study provides a novel insight into the variation of soil CH4 emissions from a functional gene perspective,highlighting the important roles of unique genes carried by abundant species in CH4 emissions in the Tibetan Plateau under seasonal variation.

关键词： soil CH_(4) emissions unique genes abundant species CH_(4)-cycling growing season

白花蛇舌草多糖对异烟肼致肝损伤的影响及机制

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中国药房 2024年第6期35卷 665-670页

作者：庄秀萍李莉陈超王丽媛曹广尚周朋王信山东中医药大学药学院济南250355 山东中医药大学附属医院儿科济南250011 山东中医药大学附属医院药学部济南250011

目的探讨白花蛇舌草多糖(HDP)对异烟肼致肝损伤的影响及机制。方法以正常发育的具有肝脏特异性荧光的转基因斑马鱼为对象,分为正常组、模型组(4 mmol/L异烟肼)、HDP低浓度组(4 mmol/L异烟肼+50 mg/mL HDP)和HDP高浓度组(4 mmol/L异烟肼+... 详细信息

目的探讨白花蛇舌草多糖(HDP)对异烟肼致肝损伤的影响及机制。方法以正常发育的具有肝脏特异性荧光的转基因斑马鱼为对象,分为正常组、模型组(4 mmol/L异烟肼)、HDP低浓度组(4 mmol/L异烟肼+50 mg/mL HDP)和HDP高浓度组(4 mmol/L异烟肼+100 mg/mLHDP),分组处理后观察斑马鱼肝脏荧光面积、荧光强度以及肝组织病理变化。以人肝L02细胞为对象,分为正常组、模型组(4mmol/L异烟肼)、HDP低浓度组(4mmol/L异烟肼+2mg/mLHDP)和HDP高浓度组(4mmol/L异烟肼+4mg/mLHDP),分组处理后检测细胞存活情况,细胞上清液中丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)水平及细胞裂解液中谷胱甘肽(GSH)含量,沉默信息调节因子1(Sirt1)、核转录因子红系2相关因子2(Nrf2)、血红素加氧酶1(HO-1)、醌氧化还原酶1(NQO1)蛋白的表达水平。结果与模型组比较,HDP低、高浓度组斑马鱼肝脏荧光面积和荧光强度(HDP低浓度组除外)均显著增加(P<0.05或P<0.01),肝损伤坏死特征均有不同程度改善。与模型组比较,HDP低、高浓度组L02细胞存活率,GSH含量(HDP低浓度组除外),Sirt1(HDP低浓度组除外)、Nrf2、NQO1、HO-1(HDP低浓度组除外)蛋白表达水平均显著升高(P<0.05或P<0.01);ALT、AST(HDP低浓度组除外)水平均显著降低(P<0.05);存活细胞数量均明显增加,损伤或死亡细胞数量均明显减少。结论HDP对异烟肼诱导的肝损伤具有一定的改善作用,其机制可能与激活Sirt1/Nrf2信号通路、改善线粒体功能、提高抗氧化能力相关。

关键词：白花蛇舌草多糖异烟肼肝损伤斑马鱼人肝L02细胞 Sirt1/Nrf2信号通路

The Adaptation of Chinese Split-Site Business Students to British Classrooms:A Cross-Cultural Perspective

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Frontiers of Education in China 2018年第3期13卷 401-425页

作者： wang liyuan Hilary NESI Foreign Languages School Jiangxi University of Finance and EconomicsNanchang 330013China School of Humanities Coventry UniversityCoventry CV15FBEngland

Chinese business education differs from British business education in many *** the whole,it focuses on the acquisition of theoretical knowledge,whereas British business education places far more emphasis on soft management skills and *** paper examines a split-site business degree program offered by a Chinese international school and a British business school,and explores the attitudes and expectations of the Chinese participants and their Chinese and British lecturers from an“English for specific purposes”*** study conducted classroom observation,semi-structured interviews,and a questionaire survey,and identifies areas of difficulty for Chinese business students in the UK,in particular regarding their beliefs about teacher and student roles,their learning priorities and learning strategies,and their“goal-oriented”approach to discussion,which is at odds with the more collaborative and exploratory Western discussion *** findings have implications for pre-sessional and in-sessional English course design,the management of split-site business degree programs,the teaching of Chinese students,and the enhancement of learning experiences generally in international business programs.

关键词： Chinese students tertiary business education cultures of learning English for specific purposes

Promoting Metro Operation Safety by Exploring Metro Operation Accident Network

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Journal of Systems Science and Information 2021年第4期9卷 455-468页

作者： Qi SUO liyuan wang Tianzi YAO Zihao wang School of Economics and Management Qingdao University of Science and TechnologyQingdao 266061China

Understanding the causation of accidents is essential to promote metro operation *** terms of 243 reported metro operation accident cases in China, a directed weighted network was constructed based on complex network theory, where nodes and directed edges denotes factors and event chains respectively. To reveal the key causal factors, the topological characteristics of metro operation accident network(MOAN) were analyzed from both global and local views. The results show that facility-type factors are more closely related to the occurrence of the accidents from the perspectives of average path length and cascading effects. Accident types like train delay and train suspension are the great risk recipients. Key causal factors with large out-degree, out-strength, betweenness centrality and cluster coefficient, such as communication and signal failure, vehicle failure and piling into the train should be noticed. The research framework proposed in the paper is not only applicable to China’s metro operation system, but also appropriate for other transportation system safety studies.

关键词： operation accident analysis directed weighted network metro operation accident network(MOAN) complex network