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Bacteroides-derived isovaleric acid enhances mucosal immunity by facilitating intestinal IgA response in broilers

Journal of Animal Science and Biotechnology 2023年第3期14卷 1252-1273页

作者： Xinkai Wang Yifan Hu Xiaoyan Zhu Liyuan Cai Muhammad Zahid Farooq Xianghua Yan State Key Laboratory of Agricultural Microbiology Hubei Hongshan LaboratoryFrontiers Science Center for Animal Breeding and Sustainable ProductionCollege of Animal Sciences and TechnologyHuazhong Agricultural UniversityWuhan 430070HubeiChina Department of Animal Sciences University of Veterinary and Animal Sciences(Jhang Campus)Lahore 54000Pakistan

Background:The interaction between nutrition and immunity plays a vital role in nutrient digestion,absorption,and metabolism during poultry production.Recent studies showed that the gut microbiota contributes to the development of intestinal mucosal immunity.However,the mechanisms by which gut microbes regulate this process remain unclear.Methods:We compared the intestinal mucosal immunity and gut microbiota of Arbor Acre broilers AA(lower mucosal immunity)and Chinese native Wuliang Mountain Black-bone chickens(WLMB)(higher mucosal immunity)using 16S rDNA sequencing,transcriptomic analysis,and immunoglobulin A(IgA)antibody repertoire sequencing.We then combined 16S rDNA sequencing with transcriptomics to identify the key microbes and found that they were positively correlated with IgA production.Next,we transplanted candidate microbes into 1-day-old broiler to explore their role in intestinal mucosal immunity.Finally,we verified the function of candidate microbial metabolites in regulating the immune function of macrophages and the intestinal-epithelial cells(IECs)using in vitro experiments.Results:WLMB performs stronger mucosal immunity than AA,including higher IgA levels,more diverse IgA antibody repertoire,and higher bacterial affinity.Bacteroides was identified as the key microbes related to the intestinal IgA response.Bacteroides transplantation could increase IgA concentration in the duodenal contents by enhancing the expression of IgA,polymeric immunoglobin receptor(PIgR),B cell-activating factor of the TNF family(BAFF),and activation-induced cytidine deaminase(AID)in the duodenum.Additionally,Bacteroides-derived isovaleric acid promoted M2 macrophage polarization of macrophage via mTOR/PPAR-γ/STAT3 signaling pathways and regulated the immunologic function of IECs to produce cytokines,including interleukin(IL)-10,IL-4,BAFF,and transforming growth factor-beta(TGF-β),thus promoting IgA production in B cells by facilitating AID expression.Conclusion:Our study revealed that Bacteroides modulate the intestinal

关键词： Bacteroides Chicken IgA Intestinal health Isovaleric acid Macrophage

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Emission factors of particulate matter, CO and CO_2 in the pyrolytic processing of typical electronic wastes

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Journal of Environmental Sciences 2019年第7期31卷 93-101页

作者： liyuan Chen Chuanyang cai Shuangyu Yu Yu Liu Shu Tao Wenxin Liu Key Laboratory for Earth Surface Processes College of Urban and Environmental Sciences Peking University

A self-designed experimental device was employed to simulate the pyrolytic dismantling process of selected electronic wastes(E-wastes), including printed wiring boards(PWBs)and plastic casings. The generated particulate matter(PM) of different particle sizes, carbon monoxide(CO) and carbon dioxide(CO_2) were determined, and the corresponding emission factors(EFs) were estimated. Finer particles with particle sizes of 0.4–2.1 μm accounted for78.9% and 89.3% of PM emitted by the pyrolytic processing of PWBs and plastic casings,respectively, and the corresponding EFs were 9.68 ± 4.81 and 18.49 ± 7.2 g/kg, respectively.The EFs of CO and CO_2 from PWBs and plastic casings were 55.9 ± 26.9 and 1182 ± 439 g/kg,and 133.6 ± 34.6 and 2827 ± 276 g/kg, respectively. Compared with other emission sources,such as coal, biomass, and traffic exhaust, the EFs of E-wastes were relatively higher,especially for PM. There were significant positive correlations(p < 0.05) of the initial contents of carbon and nitrogen in PWBs with the related EFs of PM, CO, and CO_2, while the correlations for plastic casings were insignificant. The EFs of CO of PWBs were significantly positively correlated with the corresponding EFs of PM and the parent polycyclic aromatic hydrocarbons(PAHs); however, the same result was not observed for plastic casings.

关键词： Pyrolytic processing of electronic-wastes Particulate matter CO CO2 Emission factor

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Anisotropic corrosion behavior of hot-rolled Mg-8 wt.%Li alloy

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Journal of Materials Science & Technology 2020年第18期52卷 102-111页

作者： Baojie Wang Kai Xu Daokui Xu Xiang cai Yanxin Qiao liyuan Sheng School of Environmental and Chemical Engineering Shenyang Ligong University.Shenyang.110159China Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang212003China Peking University Shenzhen InstituteShenzhen Key Lab Human Tissue Regenerate RepairShenzhen518057China

By performing the immersion,hydrogen evolution and electrochemical corrosion testing in a 0.1 mol/L NaCl solution,the corrosion performance of differently oriented samples cut from an as-rolled Mg-8wt.%Li alloy plate has been investigated and compared.It demonstrated that obvious anisotropy in corrosion resistance existed between the sample surfaces with different orientations.Among them,the corrosion rate of"ND"(the normal direction)samples with their surfaces perpendicular to the normal direction of the plate was the highest.The corrosion rate of"TD"(the transverse direction)samples with their surfaces perpendicular to the transverse direction of the plate took the second place.For the"RD"(the rolling direction)samples with their surfaces perpendicular to the rolling direction of the plate,they had the lowest corrosion rate.For all the samples,their corrosion performance and the pitting severity were mainly ascribed to the crystallographic texture ofα-Mg matrix phases because the formed surface films onβ-Li phases could provide good protection to the substrate.For the"ND"and"TD"samples,the exposed surfaces were composed of{0002},{1010}and{1120}planes ofα-Mg phases and subsequently resulted in their severe corrosion attack due to the corrosion couples between basal and prism planes.Since the crystallographic planes of exposedα-Mg phases on the surfaces of"RD"samples were mainly{1010}and{1120}prism planes,the pitting severity was the weakest.

关键词： Mg-Li alloys Texture Anisotropic corrosion Pitting Crystallographic plane

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Exploration of high-speed 3.0 THz imaging with a 65 nm CMOS process

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半导体学报:英文版 2023年第10期44卷 78-85页

作者： Min Liu Ziteng cai Jian Liu Nanjian Wu liyuan Liu State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Faculty of Information Technology Beijing University of TechnologyBeijing 100124China

This paper describes a promising route for the exploration and development of 3.0 THz sensing and imaging with FET-based power detectors in a standard 65 nm CMOS process.Based on the plasma-wave theory proposed by Dyakonov and Shur,we designed high-responsivity and low-noise multiple detectors for monitoring a pulse-mode 3.0 THz quantum cascade laser(QCL).Furthermore,we present a fully integrated high-speed 32×32-pixel 3.0 THz CMOS image sensor(CIS).The full CIS measures 2.81×5.39 mm^(2) and achieves a 423 V/W responsivity(Rv)and a 5.3 nW integral noise equivalent power(NEP)at room temperature.In experiments,we demonstrate a testing speed reaching 319 fps under continuous-wave(CW)illumina-tion of a 3.0 THz QCL.The results indicate that our terahertz CIS has excellent potential in cost-effective and commercial THz imaging and material detection.

关键词： power detectors quantum cascade laser(QCL) CMOS image sensor(CIS) terahertz

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Enabling high-efficiency ethanol oxidation on NiFe-LDH via deprotonation promotion and absorption inhibition

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Journal of Energy Chemistry 2023年第10期85卷 76-82,I0004页

作者： Jiawei Shi Huawei He Yinghua Guo Feng Ji Jing Li Yi Zhang Chengwei Deng liyuan Fan Weiwei cai Hydrogen Energy Technology Innovation Center of Hubei Province Faculty of Materials Science and ChemistryChina University of GeosciencesWuhan 430074HubeiChina State Key Laboratory of Space Power-Sources Technology Shanghai Institute of Space Power SourcesShanghai 200245China College of Science and Engineering James Cook University1 James Cook DriveTownsvilleQLD 4811Australia

Nucleophile oxidation reaction(NOR), represented by ethanol oxidation reaction(EOR), is a promising pathway to replace oxygen evolution reaction(OER). EOR can effectively reduce the driving voltage of hydrogen production in direct water splitting. In this work, large current and high efficiency of EOR on a Ni, Fe layered double hydroxide(NiFe-LDH) catalyst were simultaneously achieved by a facile fluorination strategy. F in NiFe-LDH can reduce the activation energy of the dehydrogenation reaction, thus promoting the deprotonation process of NiFe-LDH to achieve a lower EOR onset potential. It also weakens the absorption of OH-and nucleophile electrooxidation products on the surface of NiFe-LDH at a higher potential, achieving a high current density and EOR selectivity, according to density functional theory calculations. Based on our experiment results, the optimized fluorinated NiFe-LDH catalyst achieves a low potential of 1.386 V to deliver a 10 mA cm^(-2)EOR. Moreover, the Faraday efficiency is greater than 95%, with a current density ranging from 10 to 250 mA cm^(-2). This work provides a promising pathway for an efficient and cost-effective NOR catalyst design for economic hydrogen production.

关键词： Ethanol oxidation reaction High efficiency Ni Fe layered double hydroxide Fluorination strategy Deprotonation

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Organic interlayer engineering of TiS_(2) for enhanced aqueous Zn ions storage

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Journal of Materials Science & Technology 2023年第9期140卷 135-141页

作者： Chengcheng Huang Yiwen Liu Jing Li Zhonghao Miao Xinhao cai Zhouxiang Wu Haoxiang Yu Lei Yan liyuan Zhang Jie Shu School of Materials Science and Chemical Engineering Ningbo UniversityNingbo 315211China

Aqueous rechargeable zinc-ion batteries(ARZIBs)have a bright future for energy storage due to their high energy density and safety.However,for traditional ARZIBs,cathode materials always suffer from the limited space for large-sized zinc ions storage and transport,leading to low Coulombic efficiency and inferior cycling performance.To build a reliable host with large tunnel,1-butyl-1-methylpyrrolidinium ion(PY14^(+))pre-intercalated TiS_(2)(PY14^(+)-TiS_(2))is designed as an alternative intercalation-type electrode.As the insertion organic guest widens the interlayer space of TiS_(2)and buffers the lattice stress generated during the electrochemical cycles,the structural reversibility,cycling stability and kinetics properties of PY14^(+)-TiS_(2) are enhanced greatly.A specific capacity of 130.9 mAh g^(−1) with 84.3%capacity retention over 500 cycles can be achieved at 0.1 A g^(−1).Therefore,this study paves the way for enhancing the aqueous Zn ions storage capability by organic interlayer engineering.

关键词： Pre-intercalation Organic interlayer engineering TiS_(2) Intercalation-type electrode Aqueous zinc-ion batteries

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Interlayer gap widened TiS_(2) for highly efficient sodium-ion storage

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Journal of Materials Science & Technology 2022年第12期107卷 64-69页

作者： Chengcheng Huang Yiwen Liu Runtian Zheng Zhengwei Yang Zhonghao Miao Junwei Zhang Xinhao cai Haoxiang Yu liyuan Zhang Jie Shu School of Materials Science and Chemical Engineering Ningbo UniversityNingbo 315211China

As an alternative for lithium-ion batteries(LIBs),sodium-ion batteries(SIBs)have lately received tremendous interest due to their abundant reserves as well as low cost.Nevertheless,the lack of suitable anode materials severely hinders the application of sodium-ion batteries.TiS_(2)is elected as a representative material owing to its unique layered structure.But it always suffers from capacity fade due to poor electrochemical kinetics and structural stability.In this work,we fabricate a pre-potassiated TiS_(2)as a host material for sodium storage by an electrochemical pre-potassiation strategy.The intercalation/extraction mechanism,structural changes and reaction kinetics are completely investigated to reveal the outstanding electrochemical property of pre-potassiated TiS_(2)electrode.It turns out that the large interlayer space of pre-potassiated TiS_(2)is conducive to the diffusion of sodium ions,inducing the reduction of entropic barrier for the electrochemical reactions.In addition,the pre-potassiated host structure is still firmly maintained upon repeated cycles.Therefore,the pre-potassiated TiS_(2)presents superior rate capability(165.9 mA h g^(−1) at 1 C and 132.1 mA h g^(−1) at 20 C)and long-term cycling stability(85.3%capacity retention at 5 C after 500 cycles)for SIBs.This research provides an avenue to construct long-life sodium energy storage systems based on pre-potassiated TiS_(2).

关键词： Pre-potassiation TiS_(2) Expanded interlayer gap Anode material Sodium-ion batteries

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九宫山道教御制派的兴衰与现状

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中国道教 2020年第5期 40-45页

作者：蔡历源中国道教学院

九宫山位于湖北省通山县南端边陲,与江西省武宁县、修水县北面交界,属幕阜山脉中段,这里曾诞生过在道教史上留下惊鸿一笔的道教派别——御制派。据北京《白云观志》“诸真宗派总簿”记载,道教派别有八十六派之多,这些道派拥有各自的经... 详细信息

九宫山位于湖北省通山县南端边陲,与江西省武宁县、修水县北面交界,属幕阜山脉中段,这里曾诞生过在道教史上留下惊鸿一笔的道教派别——御制派。据北京《白云观志》“诸真宗派总簿”记载,道教派别有八十六派之多,这些道派拥有各自的经典、祖师、道场、传承,九宫山御制派就是其中比较具有代表性和影响力的派别之一。

关键词：道教史九宫山白云观道教御制派幕阜山脉武宁县湖北省通山县宗派

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中国广告学研究进展的知识图谱分析——基于Citespace的CSSCI数据库分析

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全球传媒学刊 2020年第3期7卷 139-154页

作者：蔡立媛李晓江西师范大学新闻与传播学院

本论文基于文献计量学中的共词分析方法,利用Citespace提供的科学知识图谱的可视化技术,以1998—2018年间发表于新闻传播与出版类CSSCI(含CSSCI扩展版)的1305篇广告学术论文为研究对象,梳理了20年间在新闻传播学领域内广告研究的重要文... 详细信息

本论文基于文献计量学中的共词分析方法,利用Citespace提供的科学知识图谱的可视化技术,以1998—2018年间发表于新闻传播与出版类CSSCI(含CSSCI扩展版)的1305篇广告学术论文为研究对象,梳理了20年间在新闻传播学领域内广告研究的重要文献,以及中国知网的期刊论文中呈现出的热点议题变迁、核心作者机构及其合作关系等。

关键词：广告学知识图谱共现分析 CSSCI

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Graphene foam/hydrogel scaffolds for regeneration of peripheral nerve using ADSCs in a diabetic mouse model

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Nano Research 2022年第4期15卷 3434-3445页

作者： Qun Huang Yuting cai Xinrui Yang Weimin Li Hongji Pu Zhenjing Liu Hongwei Liu Mohsen Tamtaji Feng Xu liyuan Sheng Tae-Hyung Kim Shiqing Zhao Dazhi Sun Jinbao Qin Zhengtang Luo Xinwu Lu Department of Vascular Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Guangdong Provincial Key Laboratory of Functional Oxide Materials and Devices Department of Materials Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China Vascular Center of Shanghai Jiao Tong University Shanghai 200011China Department of Chemical and Biological Engineering and William Mong Institute of Nano Science and Technologythe Hong Kong University of Science and TechnologyHong Kong 999077China Bioinspired Engineering and Biomechanics Center(BEBC) the Key Laboratory of Biomedical Information Engineering of Ministry of EducationSchool of Life Science and TechnologyXi'an Jiaotong UniversityXi'an 710049China Shenzhen Institute Peking UniversityShenzhen 518057China School of Integrative Engineering Chung-Ang UniversitySeoul 06974Republic of Korea School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200030China

The functional recovery of peripheral nerve injury(PNI)is unsatisfactory,whereas diabetes mellitus(DM)and its related complications further attenuate the restoration of diabetic PNI(DPNI).Adipose-derived stem cells(ADSCs)are promising candidates for treatment of DPNI due to their abundant source,excellent differentiation and paracrine ability.Our results showed that ADSCs remarkably enhanced the proliferation and migration of Schwann cells and endothelial cells,and tube formation.Mechanistically,ADSCs could regulate Nrf2/HO-1,NF-κB and PI3K/AKT/mTOR signaling pathways,showing multiple functions in reducing oxidative stress and inflammation,and regulating cell metabolism,growth,survival,proliferation,angiogenesis,differentiation of Schwann cell and myelin formation.In current study,novel graphene foam(GF)/hydrogel-based scaffold was developed to deliver ADSCs for treatment of DPNI.GF/hydrogel scaffold exhibited excellent mechanical strength,suitable porous network,superior electrical conductivity,and good biocompatibility.In vitro results revealed that GF/hydrogel scaffold could obviously accelerate proliferation of Schwann cells.Moreover,in vivo experiments demonstrated that ADSCs-loaded GF/hydrogel scaffold significantly promoted the recovery of DPNI and inhibited the atrophy of targeted muscles,thus providing a novel and attractive therapeutic approach for DPNI patients.

关键词： peripheral nerve injury(PNI) diabetes mellitus(DM) adipose-derived stem cells(ADSCs) graphene hydrogel scaffold

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