Graphene foam/hydrogel scaffolds for regeneration of peripheral nerve using ADSCs in a diabetic mouse model
作者机构：Department of Vascular SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Guangdong Provincial Key Laboratory of Functional Oxide Materials and DevicesDepartment of Materials Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China Vascular Center of Shanghai Jiao Tong UniversityShanghai 200011China Department of Chemical and Biological Engineeringand William Mong Institute of Nano Science and Technologythe Hong Kong University of Science and TechnologyHong Kong 999077China Bioinspired Engineering and Biomechanics Center(BEBC)the Key Laboratory of Biomedical Information Engineering of Ministry of EducationSchool of Life Science and TechnologyXi'an Jiaotong UniversityXi'an 710049China Shenzhen InstitutePeking UniversityShenzhen 518057China School of Integrative EngineeringChung-Ang UniversitySeoul 06974Republic of Korea School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200030China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2022年第15卷第4期
页 面：3434-3445页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1002[医学-临床医学] 08[工学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 10[医学]
基 金：This study is financially supported by the National Natural Science Foundation of China(Nos.81971758,51890892,81971712,81870346,and 81700432) the Natural Science Foundation of Shanghai Science and Technology Committee(No.20ZR1431600) This research is also supported by the National Natural Science Foundation of China(No.11761161004) Z.L.acknowledge supports by the National Natural Science Foundation of China-Research Grants Council Joint Research Scheme(Nos.11761161004 and N_HKUST607/17) the IER foundation(No.HT-JD-CXY-201907) “International science and technology cooperation projects”of Science and Technological Bureau of Guangzhou Huangpu District(No.2019GH06) Guangdong Science and Technology Department(No.2020A0505090003) Research Fund of Guangdong-Hong Kong-Macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology(No.2020B1212030010) Technical assistance from the Materials Characterization and Preparation Facilities of The Hong Kong University Of Science And Technology is greatly appreciated We also acknowledge the support of Guangdong Provincial Key Laboratory Program(No.2021B1212040001)from the Department of Science and Technology of Guangdong Province
主 题：peripheral nerve injury(PNI) diabetes mellitus(DM) adipose-derived stem cells(ADSCs) graphene hydrogel scaffold
摘 要：The functional recovery of peripheral nerve injury(PNI)is unsatisfactory,whereas diabetes mellitus(DM)and its related complications further attenuate the restoration of diabetic PNI(DPNI).Adipose-derived stem cells(ADSCs)are promising candidates for treatment of DPNI due to their abundant source,excellent differentiation and paracrine *** results showed that ADSCs remarkably enhanced the proliferation and migration of Schwann cells and endothelial cells,and tube ***,ADSCs could regulate Nrf2/HO-1,NF-κB and PI3K/AKT/mTOR signaling pathways,showing multiple functions in reducing oxidative stress and inflammation,and regulating cell metabolism,growth,survival,proliferation,angiogenesis,differentiation of Schwann cell and myelin *** current study,novel graphene foam(GF)/hydrogel-based scaffold was developed to deliver ADSCs for treatment of ***/hydrogel scaffold exhibited excellent mechanical strength,suitable porous network,superior electrical conductivity,and good *** vitro results revealed that GF/hydrogel scaffold could obviously accelerate proliferation of Schwann ***,in vivo experiments demonstrated that ADSCs-loaded GF/hydrogel scaffold significantly promoted the recovery of DPNI and inhibited the atrophy of targeted muscles,thus providing a novel and attractive therapeutic approach for DPNI patients.
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