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经前侧入路应用肱骨近端锁定钢板结合微创技术治疗肱骨近中段粉碎骨折的疗效

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骨科临床与研究杂志 2019年第5期4卷 291-294页

作者：宗双乐苏立新梁卫东李立东王爱军王振旺郑秋涛胡启峰河北省唐山市第二医院创伤骨科

目的探讨经肱骨前侧入路应用肱骨近端锁定钢板结合微创技术治疗肱骨近中段粉碎骨折的疗效。方法回顾分析2014年6月至2017年9月唐山市第二医院创伤骨科收治的29例肱骨近中段粉碎骨折患者的病历资料。其中,男19例,女10例;平均年龄39.5(25~... 详细信息

目的探讨经肱骨前侧入路应用肱骨近端锁定钢板结合微创技术治疗肱骨近中段粉碎骨折的疗效。方法回顾分析2014年6月至2017年9月唐山市第二医院创伤骨科收治的29例肱骨近中段粉碎骨折患者的病历资料。其中,男19例,女10例;平均年龄39.5(25~64)岁。采用上肢功能评分系统(DASH)评估患肢功能情况,采用Mayo肘关节功能评分系统(MEP)评估预后。结果29例患者术后均获得随访,平均随访时间15.4(12~24)个月。所有患者均获得骨性愈合,肱骨骨折愈合时间平均3.6(3~5)个月。随访至术后12个月,未发现感染、医源性神经损伤、骨折不愈合、内固定断裂失效等并发症。DASH评分平均4.6(0~16)分。Mayo评分:优28例,良1例。结论经肱骨前侧入路应用肱骨近端锁定钢板结合微创技术治疗肱骨近中段粉碎骨折的临床疗效显著,骨折愈合率高,且近期随访未见肱骨骨折不愈合及医源性神经损伤等情况。

关键词：肱骨骨折锁定钢板外科手术,微创性

Existence of Solutions for a Non-Autonomous Evolution Equations with Nonlocal Conditions

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Journal of Applied Mathematics and Physics 2023年第12期11卷 4079-4091页

作者： lixin Sheng Weimin Hu Youhui su Yongzhen Yun School of Mathematics and Statistics Yili Normal University Yining China School of Mathematics and Statistics Xuzhou University of Technology Xuzhou China Institute of Applied Mathematics Yili Normal University Yining China

The existence of mild solutions for non-autonomous evolution equations with nonlocal conditions in Banach space is studied in this article. We obtained the existence of at least one mild solution to the evolution equations by using Krasnoselskii’s fixed point theorem as well as the theory of the evolution family. The interest of this paper is that any assumptions are not imposed on the nonlocal terms and Green’s functions and a new alternative method is applied to prove the existence of mild solutions. The results obtained in this paper may improve some related conclusions on this topic. An example is given as an application of the results.

关键词： Non-Autonomous Evolution Equation Nonlocal Conditions Mild Solution Evolution Family

经肘关节后侧扩大入路内固定治疗向后孟氏损伤合并桡骨近端粉碎骨折的临床疗效

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骨科临床与研究杂志 2020年第6期5卷 344-347页

作者：宗双乐苏立新梁卫东李立东胡启峰李勇胡平马珊珊窦秀云河北省唐山市第二医院创伤骨科 063000

目的探讨经肘关节后侧扩大入路内固定治疗成人向后孟氏损伤合并桡骨近端粉碎骨折的临床疗效。方法回顾性分析2013年6月至2017年7月河北省唐山市第二医院创伤骨科收治的合并桡骨近端粉碎骨折成人向后孟氏损伤患者23例,男14例,女9例;平均... 详细信息

目的探讨经肘关节后侧扩大入路内固定治疗成人向后孟氏损伤合并桡骨近端粉碎骨折的临床疗效。方法回顾性分析2013年6月至2017年7月河北省唐山市第二医院创伤骨科收治的合并桡骨近端粉碎骨折成人向后孟氏损伤患者23例,男14例,女9例;平均年龄49.5(35~66)岁。患者均采用尺骨鹰嘴解剖锁定钢板固定尺骨近端骨折及微型锁定钢板固定桡骨近端骨折。结果23例患者术后均获得随访,平均随访时间为15.5(13~22)个月;合并桡骨近端粉碎骨折成人向后孟氏损伤患者均获得骨性愈合,骨折平均愈合时间为3.2(2.5~4.0)个月。术后12个月随访无骨折不愈合、内固定断裂失效、肘关节半脱位、感染、医源性神经损伤等并发症。并采用Mayo肘关节功能评分系统(MEPS)评分进行随访的疗效评定,结果为优13例,良8例,可2例,差0例,平均92(0~100)分,优良率为91.3%。结论应用经肘关节后侧扩大入路内固定治疗成人向后孟氏损伤合并桡骨近端粉碎骨折的临床治疗效果确切,患者尺骨鹰嘴及桡骨头颈骨折愈合率高,无骨折不愈合及内固定断裂发生,肘关节功能良好。

关键词：肘关节尺骨骨折鹰嘴突桡骨头

Progress Toward Measles Elimination--China,January 2013-June 2019

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China CDC weekly 2019年第2期1卷 21-25页

作者： Chao Ma Lance Rodewald lixin Hao Qiru su Yan Zhang Ning Wen Chunxiang Fan Hong Yang Huiming Luo Huaqing Wang James LGoodson Zundong Yin Zijian Feng National Immunization Program Chinese Center for Disease Control and PreventionChina World Health Organization Western Pacific Regional Office.Regional Reference Measles and Rubella Laboratory National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionChina Global Immunization Division Center for Global HealthCDCUnited States of America

What is already known about this topic?China has historically had high measles incidence and many associated deaths.A comprehensive measles elimination plan during 2006-2012 substantially reduced measles incidence;however,a resurgence occurred during *** is added by this report?In China,measles surveillance,outbreak response,research,and program evaluation were used to strengthen routine immunization and target immunization activities for eliminating *** incidence declined from 31 per million in 2015 to 2.8 in 2018;only one measles-associated death has been reported during 2018-June *** are the implications for public health practice?The World Health Organization-recommended strategy to eliminate measles can be effective,including in large,densely populated countries like China.

关键词： Measles routine eliminate

Highly Selective Transformation of Alkynes

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Highly Selective Transformation of Alkynes

本科护生死亡伦理认知及安宁疗护能力调查与对策

中国化学会·第十六届全国有机合成化学学术研讨会

作者： Jianyu Dong Lebin su lixin Liu 周永波 College of Chemistry and Chemical Engineering Hunan University 湖南大学

The selective transformation of alkynes plays very important roles in the fields of synthetic chemistry,and chemical industry,which has always been the hot topic in chemistry and material ***,due to the diversity of reaction types and reaction sites,there still remain many long-standing challenges in selective transformation of *** instance,there are no general methods for selective activation of different terminal alkynes or the two carbon atoms of C-C triple *** the past five years,we have developed two new strategies for selective activation of alkynes.1)Specially structured dual-function transition metal catalysts are prepared and used to selectively activate π-bonds and spC-H bonds of different terminal alkynes,respectively.2) Metal acetylide intermediates are used to activate the carbon-carbon triple bond,which results in different electrophilic and nucleophilic abilities of the two carbon atoms of carbon-carbon triple bond.

关键词： terminal alkynes selective transformation Metal acetylide intermediates C-C triple bond

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卫生职业教育 2024年第1期42卷 145-150页

作者：苏立蕊张朝辉常银桥周荣慧康利馨黄志伟孙亚楠郝玉玲滨州医学院护理学院山东烟台264003

目的了解本科护生死亡伦理认知及安宁疗护能力状况,并分析其影响因素,为制订科学有效的护生安宁疗护能力培养方案提供依据。方法采用分层整群抽样法选取山东省某医学院校333名本科护生进行问卷调查。结果本科护生死亡伦理认知处于较高水... 详细信息

目的了解本科护生死亡伦理认知及安宁疗护能力状况,并分析其影响因素,为制订科学有效的护生安宁疗护能力培养方案提供依据。方法采用分层整群抽样法选取山东省某医学院校333名本科护生进行问卷调查。结果本科护生死亡伦理认知处于较高水平,安宁疗护能力处于中等水平。性别、生源地、母亲文化程度、家庭常住人口数、接受过安宁疗护及死亡教育、愿意成为安宁疗护专科护士是本科生安宁疗护能力的主要影响因素。结论应加强死亡伦理教育,重视安宁疗护专业人才培养,完善专科教育体系,优化培养方案,重视教师队伍建设,强化安宁疗护知识和技能培训,提升护生专业认同感和从业能力,为其将来从事相关临床护理工作打下坚实基础。

关键词：本科护生死亡伦理安宁疗护能力

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清热祛浊胶囊对非酒精性脂肪肝炎小鼠NF-κB/NLRP3信号通路的调控机制研究

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天津中医药 2024年第2期41卷 214-221页

作者：刘爱茹李华君王立新姬云妍王亚男王元松苏秀海吕树泉河北省沧州中西医结合医院内分泌科沧州061000

[目的]研究清热祛浊胶囊(QRQZ)对非酒精性脂肪肝炎(NASH)模型小鼠的治疗效果及对核转录因子-κB(NF-κB)/核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)信号通路的影响。[方法]通过蛋氨酸和胆碱缺乏(MCD)饮食诱导建立NASH小鼠模型,并灌胃... 详细信息

[目的]研究清热祛浊胶囊(QRQZ)对非酒精性脂肪肝炎(NASH)模型小鼠的治疗效果及对核转录因子-κB(NF-κB)/核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)信号通路的影响。[方法]通过蛋氨酸和胆碱缺乏(MCD)饮食诱导建立NASH小鼠模型,并灌胃不同剂量的QRQZ。通过检测各组小鼠体质量、肝指数、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、三酰甘油(TG)、总胆固醇(TC),肝苏木素-伊红(HE)染色及油红O染色评估QRQZ对NASH模型小鼠的治疗作用;通过检测超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)水平评估QRQZ对NASH模型小鼠氧化应激水平;通过酶联免疫吸附测定(ELISA)检测白细胞介素-1β(IL-1β)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平评估QRQZ对NASH模型小鼠炎症的影响;通过检测磷酸化核因子κB抑制蛋白(p-IκB)、磷酸化核转录因子κB P65(p-NF-κB P65)、NLRP3、凋亡相关斑点样蛋白(ASC)、活化的半胱氨酸天冬氨酸蛋白酶1(cleaved Caspase-1)、mature IL-1β的蛋白水平以及NLRP3、ASC、Caspase-1、IL-1β的mRNA表达来评估QRQZ对NASH小鼠NF-κB/NLRP3信号通路的影响。[结果] QRQZ可改善MCD引起的体质量减轻,降低肝指数,降低血清ALT、AST活性及TC、TG水平,同时改善肝组织病理学变化,提示QRQZ对NASH模型小鼠具有治疗作用;此外,QRQZ提升肝组织中SOD、GSH-Px活性,降低了MDA水平,降低了IL-6、IL-1β、iuTNF-α炎症因子水平,提示了QRQZ的抗氧化及抗炎作用;进一步研究发现QRQZ降低了IκB与P65的磷酸化水平,减少NLRP3、ASC、Caspase-1、IL-1β蛋白及基因表达。提示QRQZ干预抑制了NASH小鼠NF-κB/NLRP3信号通路活化。[结论] QRQZ对NASH模型小鼠具有治疗作用,并且可以提升抗氧化能力改善炎症,其作用机制可能与抑制NF-κB/NLRP3信号通路活化有关。

关键词：清热祛浊胶囊非酒精性脂肪肝炎氧化应激炎症 NF-κB/NLRP3通路

Tunable Luminescence and Energy Transfer Properties in YVO4:Bi3+,Ln3+(Ln=Dy,Sm,Eu) Phosphors Prepared by Microwave Sintering Method

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Tunable Luminescence and Energy Transfer Properties in YVO4:...

A cynomolgus monkey with naturally occurring Parkinson's disease

中国稀土学会2017学术年会

作者： lixin Yang Xiaoyun Mi Jiangang su Xin Zhang Xing Gao School of Materials Science and Engineering Changchun University of Science and Technology

YVO:Bi,Ln(Ln=Dy,Sm,Eu) phosphors were successful synthesized by microwave sintering method,and characterized by X-ray powder diffraction(XRD),photoluminescence(PL) spectra,lifetime and GSAS structure *** results indicated that the introduced ions occupy the site of *** 275 nm excitation,the luminescent intensity of YVO:Bi samples reach the maximum when Bi concentration is 0.02,the broad emission spectrum of YVO:Bi has a strongest peak at near 540 nm attributed to energy transition of Bi(P→S).The optimum doped concentration of Ln were 0.02,0.03 and 0.06 in YVO:0.02Bi,xLn(Ln=Dy,Sm,Eu) samples corresponding to the 4F9/2→6H13/2 electric dipole transition of the Dy(575 nm),the G→H magnetic dipole transition of the Sm(602 nm) and the D→F electric dipole transition of the Eu(620 nm),*** can effectively improve the emission intensity of YVO:Ln,and also can adjust the emitting *** energy transfer(ET) mechanism of Bi→Ln was dipole-quadrupole mechanism of electric multipole *** critical distance(Rc) between Ln and Bi were calculated by concentration quenching ***-tunable of YVO:Bi,Ln phosphors were *** a word,the material has a good application prospects on light emitting diodes(LEDs).

关键词： YVO4 Bi3+ Ln3+ phosphors microwave sintering method luminescence

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National Science Review 2021年第3期8卷 17-20页

作者： Hao Li Ling-Yan su lixin Yang Min Li Qianjin Liu Zhenhui Li Yan Hu Hongwei Li Shihao Wu Wenchao Wang Yingzhou Hu Zhengbo Wang Joshua D.Rizak Baihui Huang Min Xu Jing Wu Long-Bao Lv Christoph W.Turck Yong Yin Yong-Gang Yao Bing su Xintian Hu Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province Kunming Institute of Zoology Chinese Academy of Sciences State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Shenzhen Key Laboratory for Molecular Biology of Neural Development Guangdong Provincial Key Laboratory of Brain Connectome and Behavior CAS Key Laboratory of Brain Connectome and Manipulation The Brain Cognition and Brain Disease Institute Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences China Kunming College of Life Science University of Chinese Academy of Sciences Institute of Neuroscience CAS Key Laboratory of Primate Neurobiology State Key Laboratory of NeuroscienceChinese Academy of Sciences National Resource Center for Non-Human Primates Kunming Primate Research Center and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) Kunming Institute of Zoology Chinese Academy of Sciences Max Planck Institute of Psychiatry Department of Translational Research in Psychiatry Department of Rehabilitation Medicine the Second People’s Hospital of Yunnan Province Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences KIZ–CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences

Evidence for the existence of monkeys with spontaneous Parkinson’s disease (PD) has been lacking. Here,we screened macaque colonies at the Kunming Primate Research Center(Association for Assessment and Accreditation of Laboratory Animal Care(AAALAC) accredited), Kunming Institute of Zoology, Chinese Academy of Sciences, which has a large population of monkeys (>2400), to identify naturally occurring PD monkeys.

关键词： ALPHA-SYNUCLEIN