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Comprehensive bibliometric analysis of pharmacotherapy for bipolar disorders:Present trends and future directions

World Journal of Psychiatry 2025年第1期15卷 153-167页

作者： Bo-Fan Chen Li liu Fang-Zhen Lin Hai-Min Zeng Hai-Qiang Huang Chun-Fang Zhang Cong-Cong liu Xiang Chen Jie Peng yun-Fa Wang Zhi-Lin Wang Bin Chen De-Le liu yun liu Zheng-Zheng Li Xin-Xing Zeng The Second Affiliated Hospital Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina The Second Clinical Medical College Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Rehabilitation Medicine The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Jiangxi Provincial People’s Hospital The First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006Jiangxi ProvinceChina Department of Psychiatry Jiangxi Mental HospitalHospital of Nanchang UniversityNanchang UniversityNanchang 330029Jiangxi ProvinceChina

BACKGROUND Bipolar disorder(BD)is a severe mental illness characterized by significant mood *** drug treatment modalities are crucial for managing *** To analyze the current status and future trends of global research on BD drug treatment over the last *** The Web of Science Core Collection database spanning from 2015 to 2024 was utilized to retrieve literature related to BD drug treatment.A total of 2624 articles were *** visualization and analysis were conducted using CiteSpace,VOSviewer,Pajek,Scimago Graphica,and R-studio bibliometrix to identify RESULTS The United States,China,and the United Kingdom have made the most significant contributions to research on BD drug treatment and formed notable research collaboration *** University of Pittsburgh,Massachusetts General Hospital,and the University of Michigan have been identified as the major research institutions in this *** Journal of Affective Disorders is the most influential journal.A keyword analysis revealed research hotspots related to clinical symptoms,drug efficacy,and genetic mechanisms.A citation analysis identified the management guidelines published by Yatham et al in 2018 as the most cited *** This study provides a detailed overview of the field of BD drug treatment,highlighting key contributors,research hotspots,and future *** study findings can be employed as a reference for future research and policymaking,which may enable further development and optimization of BD pharmacotherapy.

关键词： Bipolar disorder Drug treatment Bibliometric analysis Visualization Mental disorder

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Intelligent Assessment of Active and ReactivePower Flow with Satisfying Accuracy forN-k_(1)-k_(2) Cascading Outages

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Journal of Modern Power Systems and Clean Energy 2021年第5期9卷 986-999页

作者： Yusheng Xue yun liu NARI Group Corporation(State Grid Electric Power Research Institute) NanjingChina School of Electrical Engineering Shandong UniversityJinanChina

Addressed to the N-k_(1)-k_(2) cascading outages,it is computationally burdensome for the reliable calculation of active and reactive power *** paper builds a comprehensive framework with three algorithms,including the distribution factor(DF),the Newton-Raphson(NR),and the first iteration of NR algorithm(termed as 1J).Classifiers are designed to determine whether the NR algorithm should be employed for *** features are extracted upon the analytical error of *** reactive power is partially considered in the 1J but neglected in the DF algorithm,the deviation between the solutions is taken as one crucial *** support vector machine(SVM)is then utilized for classifier *** the deep integration of the causal inference and the statistical paradigm,this framework calculates active and reactive power flows rapidly,reliably,and *** effectiveness and robustness are fully validated in three typical IEEE systems.

关键词： Active power flow algorithm coordination causal algorithm integration of research paradigms N-k_(1)-k_(2)cascading outage reactive power flow

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Genetic analysis of the reproductive axis in fish using genome-editing nucleases

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Science Bulletin 2017年第4期62卷 302-308页

作者： yun liu Haoran Lin State Key Laboratory of Biocontrol Institute of Aquatic Economic Animals and the Guangdong Province Key Laboratory for Aquatic Economic Animals. School of Life Sciences Sun Yat-sen University Cuangzhou 510275 China

Reproduction in fish is controlled by the brain-pituitary-gonad reproductive axis. Although genes of the reproductive axis are conserved from fish to humans, their in vivo functions are less clear in fish. Mutant lines of the reproductive axis have been systematically investigated in zebrafish and medaka using recently developed genome-editing nucleases. Here, we review recent progress in the genetic analysis of the reproductive axis in fish as well as the opportunities and challenges of applying genome-editing nucleases in fisheries.

关键词： Zebrafish reproduction Gene knockout Gonadotropin Aquaculture

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The Mexican hat effect on the delamination buckling of a compressed thin film

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Acta Mechanica Sinica 2014年第6期30卷 927-932页

作者： Yin Zhang yun liu State Key Laboratory of Nonlinear Mechanics (LNM) Institute of Mechanics Chinese Academy of Sciences Faculty of Information and Automation Kunming University of Science and Technology

Because of the interaction between film and substrate,the film buckling stress can vary significantly,depending on the delamination geometry,the film and substrate mechanical *** Mexican hat effect indicates such *** analytical method is presented,and related dimensional analysis shows that a single dimensionless parameter can effectively evaluate the effect.

关键词： Buckling Delamination Elastic foundation Thin film Compliant substrate

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Quantum Chemistry Calculation of Quercetin-silver Complex

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Chinese Journal of Structural Chemistry 2005年第11期24卷 1340-1346页

作者： JIANG liu-yun liu Yu-Ming Analytical and Testing Center of Sichuan University Chengdu 610064 China

Three possible molecular structures of quercetin-silver complexes obtained from the reaction of quercetin and Ag^＋ in equivalent molar ratio were designed and optimized by using Gaussian 98 program at the B3LYP/LanL2DZ basis set. Through theoretical analysis, one of the three designed structures is discovered to have the most stable coordination position. Then its geometry structure, natural bond orbital analyses, vibrational frequency and biological activity were performed. The results show that it has good stability and relatively stronger antioxidative activity because it is favorably attacked by O2^-. Therefore theoretical foundation is provided for the development of new quercetin metal complexes with higher activity antioxidants.

关键词： quercetin,silver-complex quantum chemistry

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Investigate the Wake Flow on Houseflies with Particle-Tracking-Velocimetry and Schlieren Photography

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Journal of Bionic Engineering 2023年第2期20卷 656-667页

作者： yun liu Angel David Lozano Department of Mechanical and Civil Engineering Purdue University NorthwestWestvilleIN46323USA

Utilizing high-speed schlieren photography and particle-tracking-velocimetry,the wake flow of tethered houseflies is *** high-speed schlieren photography is implemented on tethered houseflies inside an air container with a stable vertical temperature gradient to visualize the disturbed wake flow from the *** resulting photography images were then processed with the physics based optical flow method to derive the light-path averaged flow ***,the state of the art:Shake-the-Box system is implemented on a tethered housefly to measure the volumetric flow field in the wake of the insect,revealing interesting flow behavior and structures that can also be observed and correlated to the schlieren photography *** the dimensionless velocity magnitude of the wake flow from the two experiments,a good qualitative agreement is reached,suggesting the viability of high-speed schlieren photography in investigating the wake flow of small ***,the high-speed schlieren photography is successfully applied on a housefly that is taking off from the ground,visualizing the disturbed wake flow on the freely flying insect that is challenging to visualize with other methods.

关键词： Insect flight Schlieren photography Shake-the-Box Wake flow

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^(182)W anomalies in mantle:a brief review

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Acta Geochimica 2022年第4期41卷 704-716页

作者： Yining Zhang yun liu State Key Laboratory of Ore Deposit Geochemistry Chinese Academy of SciencesGuiyang550081China University of Chinese Academy of Sciences Beijing100049China International Research Center for Planetary Science College of Earth SciencesChengdu University of TechnologyChengdu610059China CAS Center for Excellence in Comparative Planetology Hefei230026China

With significant advances in mass spectrometry for isotope analysis in the last decade,e.g.,negative thermal ionization mass spectrometry and multi-collector inductively coupled plasma mass spectrometry,high-precision(ppm-level)measurements of tungsten(W)isotopes have been widely used for early earth differentiation processes,such as metal-silicate segregation,melting and crystallization processes during the magma ocean,and putative core-mantle exchange and ***,we give a brief review of works on ^(182)W anomalies in terrestrial samples,including methods,results,explanations,implications,and *** review will be presented by including the following parts:the introduction of W isotopes and the short-lived radioactive ^(182)Hf-^(182)W system;data notations and W isotope measurement methods;^(182)W anomalies observed in terrestrial samples;a summary of models developed for interpreting origins of positive and negative ^(182)W anomalies;future prospects.

关键词： ^(182)W anomalies Mantle samples MC-ICPMS N-TIMS Normalization

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Rebuilding the theory of isotope fractionation for evaporation of silicate melts under vacuum condition

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Acta Geochimica 2024年第4期43卷 661-676页

作者： Jie Wang yun liu Research Center for Planetary Science College of Earth and Planetary SciencesChengdu University of TechnologyChengdu 610059China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China CAS Center for Excellence in Comparative Planetology Hefei 230026China

Isotope eff ects are pivotal in understanding silicate melt evaporation and planetary accretion *** on the Hertz-Knudsen equation,the current theory often fails to predict observed isotope fractionations of laboratory experiments due to its oversimplified ***,we point out that the Hertz-Knudsen-equation-based theory is incomplete for silicate melt evaporation cases and can only be used for situations where the vaporized species is identical to the one in the *** propose a new model designed for silicate melt evaporation under *** model considers multiple steps including mass transfer,chemical reaction,and *** derivations reveal a kinetic isotopic fractionation factor(KIFF orα)αour model=[m(^(1)species)/m(^(2)species)]^(0.5),where m(species)is the mass of the reactant of reaction/nucleation-limiting step or species of diffusion-limiting step and superscript 1 and 2 represent light and heavy isotopes,*** model can eff ectively reproduce most reported KIFFs of laboratory experiments for various elements,i.e.,Mg,Si,K,Rb,Fe,Ca,and ***,the KIFF-mixing model referring that an overall rate of evaporation can be determined by two steps jointly can account for the eff ects of low P_(H2)pressure,composition,and *** addition,we find that chemical reactions,diffusion,and nucleation can control the overall rate of evaporation of silicate melts by using the fitting slope in ln(−ln f)versus ln(t).Notably,our model allows for the theoretical calculations of parameters like activation energy(E_(a)),providing a novel approach to studying compositional and environmental eff ects on evaporation processes,and shedding light on the formation and evolution of the proto-solar and Earth-Moon systems.

关键词： Evaporation Kinetic isotopic fractionation Chemical kinetics Hertz-Knudsen equation CAIS

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Equilibrium mercury and lead isotope fractionation caused by nuclear volume effects in crystals

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Acta Geochimica 2021年第2期40卷 150-162页

作者： Sha Yang yun liu Department of Geological Engineering Qinghai University.Xining 810016China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China International Center for Planetary Science College of Earth SciencesChengdu University of TechnologyChengdu 610059China CAS Center for Excellence in Comparative Planetology Hefei 230026China

To investigate equilibrium mercury(Hg)and lead(Pb)isotope fractionation caused by the nuclear volume effect(NVE)in crystals,the electron densities at nuclei(i.e.,|Ψ(0)|2)for Hg-or Pb-bearing crystalline compounds were investigated by using the relativistic spin orbit zeroth-order regular approximation(ZORA)method with a three-dimensional periodic boundary condition based on the density functional theory(DFT).Many isotope fractionation factors of crystalline compounds are provided for the first *** results show,even at1000℃,NVE-driven Hg and Pb isotope fractionation are meaningfully large,i.e.,range from 0.12‰to 0.49‰(202Hg/^(198)Hg),from-0.20‰to 0.17‰(208Pb/^(206)Pb)and from-0.08‰to 0.06‰(207Pb/^(206) Pb)relative to Hg0 vapor and Pb0 vapor,***,the fractionations range from-0.06‰to-0.20‰(208Pb/^(206)Pb)and from-0.02‰to-0.08‰(207Pb/^(206)Pb)for Pb2+-bearing species,from 0.10‰to 0.17‰(208Pb/^(206)Pb)and from 0.04‰to 0.06‰(207Pb/^(206)Pb)for Pb4+-bearing species in *** calculated Hg-bearing species in crystals will enrich heavier isotope(202Hg)relative to Hg0 ***,Pb4+-bearing species enrich heavier Pb isotopes(208Pb and 207Pb)than Pb^(2+)-bearing species in crystals,which the enrichment can be up to 0.37‰(208-Pb/^(206)Pb)and 0.14‰(207Pb/^(206)Pb)at 1000℃,due to their NVEs are in opposite *** NVE-driven MIFs of Hg isotopes,which are compared to the Hg202-Hg198baseline,are up to-0.158‰(ΔNV199Hg),-0.024‰(ΔNV200Hg)and-0.094‰(ΔNV201Hg)relative to Hg0 vapor at5000 *** all studied Hg-bearing species in crystals,the MIFs of two odd-mass isotopes(i.e.,ΔNV199Hg andΔNV201Hg)will be changed proportionally and their ratio(i.e.,ΔNV199Hg/ΔNV201Hg)will be a constant *** NVE can also cause mass-independent fractionations for 207Pb and 204 Pb compared to the baseline of 208Pb and *** largest NVEdriven MIFs are 0.043‰(ΔNV207Pb)and-0.040‰(ΔNV204Pb)among all the studied species relative to Pb0 vapor at 5000 *** magnit

关键词： Mercury and lead isotopes Crystals Nuclear volume effect DFT relativistic effect calculations

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Isotopic analysis based on terahertz spectrum

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Acta Geochimica 2023年第5期42卷 859-869页

作者： Qijun Chen yun liu Research Center for Planetary Science College of Earth SciencesChengdu University of TechnologyChengdu 610059China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China

As a new promising detection technology in the terahertz research field,the terahertz time-domain spec-troscopy(THz-TDS)has very broad application potential in many fields because its advantage on the characteristic spectrum,wide spectrum and non-destructive analysis of interested *** this paper,the terahertz absorption spectra of gases mixed with 12 CO and 13 CO in the spec-trum range of 0.5–2.5 THz are measured by terahertz time-domain spectroscopy for the first *** isotopo-logues can be clearly distinguished based on the difference in their rotational energies and the consequent terahertz *** experimental results show that 12 CO and 13 CO have obvious characteristic absorption peaks in the spectrum range of 0.5–2.5 THz due to the difference in rotational energy,and the rotational constant B can be calculated according to the experimental values to distin-guish the two gaseous *** frequency posi-tions of the characteristic absorption peak measured by this experiment and the rotation constant B calculated accord-ing to the experimental values are compared with those previous theoretical calculations and experimental results,and they are in good *** result lays a foun-dation for developing more sophisticated terahertz instru-ments to the detection of different isotopologues.

关键词： Isotope analysis CO isotopologue Terahertz time-domain spectroscopy(THz-TDS) Rotational spectrum

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