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基于经验模态分解和固有模态函数重构的局部放电去噪方法

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电工技术学报 2008年第1期23卷 13-18页

作者：贾嵘徐其惠田录林李辉刘伟西安理工大学电力工程系西安710048

为了提取局部放电信号的特征,提出一种基于经验模态分解(EMD)和固有模态函数(IMF)重构算法的局部放电噪声抑制方法。首先对含有噪声的局部放电信号进行经验模态分解,得到含特征频率的固有模态函数,然后对所得的固有模态函数分量进行自... 详细信息

为了提取局部放电信号的特征,提出一种基于经验模态分解(EMD)和固有模态函数(IMF)重构算法的局部放电噪声抑制方法。首先对含有噪声的局部放电信号进行经验模态分解,得到含特征频率的固有模态函数,然后对所得的固有模态函数分量进行自适应阈值处理后重构,从而抑制噪声干扰。相比于常规的小波去噪算法,该方法具有自适应性强,不受小波函数和最佳小波分解层数选取的限制等优点,而且实现了阈值和固有模态函数阈值处理层数的自动选取。分别以仿真信号和实际信号为例,证明了该方法的有效性。

关键词：局部放电经验模态分解固有模态函数重构自适应阈值算法

香港世界地质公园东平洲平洲组新发现火山岩的锆石U-Pb测年、地球化学及地质意义

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地学前缘 2023年第2期30卷 239-258页

作者：王璐琳刘晓鸿张志光中国地质大学(北京)自然文化研究院北京100083 中国地质科学院北京100037

香港世界地质公园东平洲平洲组由于缺乏地质年代学数据,其时代归属一直存在较大争议。在该组中段下部新发现火山岩夹层,经薄片鉴定为流纹质玻屑凝灰岩,进行锆石U-Pb年代学和岩石地球化学研究,并在此基础上探讨其岩石成因和构造意义。锆... 详细信息

香港世界地质公园东平洲平洲组由于缺乏地质年代学数据,其时代归属一直存在较大争议。在该组中段下部新发现火山岩夹层,经薄片鉴定为流纹质玻屑凝灰岩,进行锆石U-Pb年代学和岩石地球化学研究,并在此基础上探讨其岩石成因和构造意义。锆石LA-ICP-MS U-Pb定年结果表明平洲组火山岩形成于早白垩世。地球化学数据显示,流纹质玻屑凝灰岩全碱含量较高(w(Na_(2)O+K_(2)O)=5.58%~9.45%),轻稀土元素分馏明显,轻稀土富集,重稀土亏损,Eu的负异常明显;微量元素呈现Rb、Ba等大离子亲石元素相对富集,高场强元素Th、U、Pb、Zr等相对富集,Sr强烈亏损,Ta、Nb相对亏损的特征。表明研究区平洲组火山岩是由大陆地壳的深熔作用形成,形成于太平洋板块俯冲引起的弧后伸展环境,是香港早白垩世火山活动最后阶段的产物,与我国东南沿海早白垩世大规模岩石圈伸展减薄和岩浆作用有关。本文的岩石地球化学和同位素年代学数据为东平洲平洲组的最新资料,为我国东南部早白垩世火山活动和构造演化提供了新的年代数据。

关键词：平洲组火山岩锆石U-Pb年龄地球化学早白垩世香港世界地质公园

Dynamic blood single-cell immune responses in patients with COVID-19

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1280-1291页

作者： lulin Huang Yi Shi Bo Gong Li Jiang Zhixin Zhang Xiaoqi liu Jialiang Yang Yongquan He Zhilin Jiang Ling Zhong Juan Tang Chunfang You Qi Jiang Bo Long Tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Shuqiang Wang Xingxiang Yang Zhenglin Yang The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanChina Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical SciencesChengduSichuanChina Natural Products Research Center Institute of Chengdu BiologySichuan Translational Medicine HospitalChinese Academy of SciencesChengduSichuanChina Institute of Health Management Health Management CenterSichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduChina Department of Infection Disease Zigong First Peopled HospitalZigongSichuanChina Department of Infection Disease Mianyang No.404 HospitalMianyangSichuanChina Infectious diseases laboratory Public Health and Clinical Center of ChengduChengduSichuanChina Sichuan Dazhou Central Hosptical DazhouSichuanChina Department of Infection Disease Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanChina

The 2019 coronavirus disease(COVID-19)outbreak caused by the SARS-CoV-2 virus is an ongoing global health ***,the virus'pathogenesis remains unclear,and there is no cure for the *** investigated the dynamic changes of blood immune response in patients with COVID-19 at different stages by using 5'gene expression,T cell receptor(TCR),and B cell receptors(BCR)V(D)J transcriptome analysis at a single-cell *** obtained single-cell mRNA sequencing(scRNA-seq)data of 341,420 peripheral blood mononuclear cells(PBMCs)and 185,430 donotypic T cells and 28,802 donotypic B cells from 25 samples of 16 patients with COVID-19 for dynamic *** addition,we used three control *** found expansion of dendritic cells(DCs),CD14+monocytes,and megakaryocytes progenitor cells(MP)/platelets and a reduction of naive CD4+T lymphocytes in patients with COVID-19,along with a significant decrease of CD8+T lymphocytes,and natural killer cells(NKs)in patients in critical *** type I interferon(IFN-I),mitogen-activated protein kinase(MAPK),and ferroptosis pathways were activated while the disease was active,and recovered gradually after patient conditions *** with this finding,the mRNA level of IFN-I signal-induced gene IFI27 was significantly increased in patients with COVID-19 compared with that of the controls in a validation cohort that included 38 patients and 35 *** concentration of interferon-a(IFN-a)in the serum of patients with COVID-19 increased significantly compared with that of the controls in an additional cohort of 215 patients with COVID-19 and 106 controls,further suggesting the important role of the IFN-I pathway in the immune response of *** and BCR sequences analyses indicated that patients with COVID-19 developed specific immune responses against SARS-CoV-2 *** study reveals a dynamic landscape of human blood immune responses to SARS-CoV-2 infection,providing clues for therapeutic poten

关键词： patients interferon lymphocytes

自主研发的柔性套阴茎保护装置对包皮环切术后阴茎具有保护作用:一项前瞻性随机对照试验

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现代泌尿外科杂志 2024年第4期29卷 363-367页

作者：拓鹏飞陈克伟刘鑫辰朱国栋贺会兴蔡涛李宇轩赵勋葛力源张树栋马潞林郭巍刘茁北京大学第三医院泌尿外科北京100191 北京大学第三医院延安分院泌尿外科陕西延安716099

目的探讨一种柔性套阴茎保护装置对包皮环切患者术后疼痛和伤口水肿的缓解作用。方法纳入2023年2月1日—2023年5月31日北京大学第三医院延安分院行包皮环切术的54例患者作为研究对象。采用随机数表法将患者分为试验组27例、对照组27例,... 详细信息

目的探讨一种柔性套阴茎保护装置对包皮环切患者术后疼痛和伤口水肿的缓解作用。方法纳入2023年2月1日—2023年5月31日北京大学第三医院延安分院行包皮环切术的54例患者作为研究对象。采用随机数表法将患者分为试验组27例、对照组27例,试验组患者术后使用柔性套阴茎保护装置,对照组患者术后使用传统纱布包扎的方法,比较两组患者术后疼痛、伤口水肿和并发症发生情况。结果在疼痛方面,试验组术后6 h[(1.7±0.9)分vs.(3.3±1.9)分,P0.05)。在水肿方面,试验组在术后第2天[(2.0±1.0)分vs.(4.0±0.8)分,P0.05)。结论在接受包皮环切术的患者中使用柔性套阴茎保护装置有减少术后早期疼痛和减轻水肿的显著效果,在临床上有一定的应用价值,值得推广。

关键词：包皮过长包茎包皮环切术随机对照试验阴茎保护装置

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肾癌并肝段和肝以上下腔静脉癌栓的诊治体会

中华泌尿外科杂志 2017年第7期38卷 481-484页

作者：马潞林刘茁北京大学第三医院泌尿外科北京100083

外科手术是可能治愈肾癌并肝段和肝以上下腔静脉癌栓患者的唯一治疗方式。术前对肝段和肝以上下腔静脉癌栓的准确诊断至关重要。术前影像学检查中，腹部CT增强扫描和下腔静脉MRI扫描是诊断和评价肝段和肝以上下腔静脉癌栓的最佳方法。... 详细信息

外科手术是可能治愈肾癌并肝段和肝以上下腔静脉癌栓患者的唯一治疗方式。术前对肝段和肝以上下腔静脉癌栓的准确诊断至关重要。术前影像学检查中，腹部CT增强扫描和下腔静脉MRI扫描是诊断和评价肝段和肝以上下腔静脉癌栓的最佳方法。与肝以下癌栓相比，肝内和肝以上下腔静脉癌栓延伸范围广，手术难度增大。对于简单的肝段下腔静脉癌栓（癌栓顶端刚达到肝静脉水平者）可尝试采用后腹腔镜联合经腹途径腹腔镜手术方式。对于其他的肝段和肝以上癌栓患者，开放手术成为标准手术方式。术中除游离肝下的下腔静脉外，还需要充分游离、暴露肝脏及第一肝门，显露肝后下腔静脉及肝静脉。对于进入心房的癌栓，首选纵行切开膈肌，用＂Milking＂技术挤压癌栓至下腔静脉，用＂导尿管法＂取出癌栓。对于其他较高难度的心房内癌栓，需建立体外循环，取肋缘下切口和胸部正中切口开胸并打开心包，取出癌栓。肝段和肝以上下腔静脉癌栓患者应尽早诊断，积极采取手术治疗。

关键词：肾癌癌栓下腔静脉肝段

Extracorporeal Shock Wave Lithotripsy for Upper Urinary Tract Stones in Obese Patients

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Extracorporeal Shock Wave Lithotripsy for Upper Urinary Trac...

第十五届全国泌尿外科学术会议

作者： liu Yuqing, Zhuang shenrong, Ma lulin Department of Urology, 3rd Hospital of Peking University, Beijing 100083

Objective To study the efficiency and safety of extracorporeal shock wave lithotripsy (ESWL) for upper urinary tract stones of obese patients. Methods In a retrospective manner, 10 male and 7 female obese (body mass index, BWI≥28kg/m2) patients who underwent ESWL as the initial treatment for their single upper urinary tract stones were included in the study. The calculi were visualized and measured by radiological and/or ultrasound examinations before ESWL. A 3-month follow-up from the initial procedure was required, including kidney-ureter-bladder radiographs to document stone-free status. The indications for retreatment were usually calculi that did not pass spontaneously after 3 weeks. Results The mean stone size was 11.88±2.67mm (8─18mm). At the end of follow-up, 76.47% (13/17) patients were stone free, and no one received further invasive therapy. Among them, the mean times of ESWL were 2.82±1.17, and the efficiency quotient (EQ)* was 0.351. 4 patients suffered from mild subcutaneous ecchymosis. Fever only occurred in 2 cases but was completely reversible. Conclusion ESWL in site is available to treat upper urinary tract stones in obese cases with low risk of side effects with a relatively low efficiency yet.

关键词： urinary tract stones obesity lithotripsy Efficiency Quotient (EQ) Formula Percentage of Stone free/(100 + Percentage of Retreatment + Percentage of Auxiliary Procedures)

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液体活检技术在肾细胞癌中的应用及研究进展

中华泌尿外科杂志 2020年第11期41卷 873-876页

作者：肖若陶刘承马潞林北京大学第三医院泌尿外科 100191

液体活检是指对人体体液样本中的肿瘤相关物质进行无创性分析,克服了传统组织学活检的局限性,有助于肿瘤的早期诊断与鉴别诊断,并可预测对治疗的反应、纵向监测疾病进展和预测预后等。肾癌目前缺乏成熟的血清肿瘤标志物,疾病诊断及监测... 详细信息

液体活检是指对人体体液样本中的肿瘤相关物质进行无创性分析,克服了传统组织学活检的局限性,有助于肿瘤的早期诊断与鉴别诊断,并可预测对治疗的反应、纵向监测疾病进展和预测预后等。肾癌目前缺乏成熟的血清肿瘤标志物,疾病诊断及监测仍然依靠影像学检查。近些年液体活检在肾癌领域中的应用成为研究热点,本文将对循环肿瘤细胞(CTCs)、循环肿瘤DNA(ctDNA)、循环肿瘤RNA(ctRNA)、外泌体、肿瘤"教育"的血小板(TEPs)等液体活检技术在肾癌中的应用及研究进展进行总结与探讨。

关键词：癌,肾细胞液体活检应用

A genetic variant in IL-6 lowering its expression is protective for critical patients with COVID-19

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1627-1633页

作者： Bo Gong lulin Huang Yongquan He Wen Xie Yi Yin Yi Shi Jialing Xiao Ling Zhong Yi Zhang Zhilin Jiang Fang Hao Yu Zhou Huan Li Li Jiang Xingxiang Yang Xiangrong Song Yan Kang Lin Tuo Yi Huang Ping Shuai Yuping liu Fang Zheng Zhenglin Yang Department of Health Management Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanChina Sichuan Provincial Key Laboratory for Human Disease Gene Study Center for Medical GeneticsDepartment of laboratory medicineSichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanChina Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanChina Institute of Chengdu Biology Sichuan Translational Medicine HospitalChinese Academy of SciencesChengduSichuanChina Center for Gene Diagnosis&Department of Laboratory Medicine Zhongnan Hospital of Wuhan UniversityWuhanChina Department of Laboratory Medicine Wuhan Leishenshan HospitalWuhanHubeiChina Infectious Disease Department Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610041China Department of Critical Care Medicine Frontiers Science Center for Disease-related Molecular NetworkState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduChina

Critical coronavirus disease 2019(COVID-19)is associated with high mortality and potential genetic factors have been reported to be involved in the development of critical *** performed a genome-wide association study to identify the genetic factors responsible for developing critical COVID-19.632 critical patients with COVID-19 and 3021 healthy controls from the Chinese population were ***,we identified a genome-wide significant difference of IL-6 rs2069837(p=9.73×10^(−15),OR=0.41)between 437 critical patients with COVID-19 and 2551 normal controls in the discovery cohort.

关键词： protective patients mortality

Shock Wave LithotriPsy Versus Semirigid UreteroscoPy for Proximal Ureteral Calculi(＜20 mm):A ComParative Matched-Pair Study

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Shock Wave LithotriPsy Versus Semirigid UreteroscoPy for Pro...