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Efficacy and safety of micafungin for invasive candida infections：a meta-analysis of randomized controlled trials

Chinese Medical Journal 2012年第2期125卷 345-351页

作者： Chen Qian Lin Mao-hu Chen Meng-li liu zhe-yuan Chai Dong Wang Rui Chinese Peoples Liberat Army Gen Hosp Dept Clin Pharmacol Beijing 100853 Peoples R China Chinese Peoples Liberat Army Gen Hosp Affiliated Hosp 1 Dept Urol Beijing 100853 Peoples R China

Background Invasive fungal infections such as candidiasis and mold infections cause significant morbidity and mortality in seriously ill *** is an echinocandin antifungal agent with potent activity against most species of Candida and *** did this meta-analysis to clarify whether micafungin offers superior efficacy and safety compared with other antifungal agent for treating infections associated with invasive *** We did a meta-analysis of randomized controlled trials to examine whether micafungin has superior efficacy and safety compared with other antifungal agents recommended by the treatment guidelines for fungal *** trials involving 2913 patients were included in this *** ratios （OR） and 95% confidence intervals （CI） were *** Micafungin was associated with significantly better treatment success compared with the comparator antifungal agents （modified intention to treat,2851 patients; random-effects model,OR 1.20,95% CI 1.00-1.45,P=0.0487）.In addition,micafungin was more effective than the comparators for antifungal prophylaxis of neutropenic patients undergoing hematopoietic stem cell transplantation （OR 1.47,95% CI 1.08-2.00,P=0.01）.Although there was no significant difference between the compared regimens in terms of the incidence of adverse drug effects （OR 0.94,95% CI 0.77-1.11）,fewer patients treated with micafungin withdrew from the studies because of adverse events （OR 0.64,95% CI 0.44-0.94）.Conclusions Micafungin has a good safety and tolerability profile,with an efficacy at least comparable to the other antifungal *** offers advantages over other agents for antifungal *** offers an appropriate alternative for antifungal prophylaxis rather than the treatment of invasive candida infections.

关键词： micafungin meta-analysis invasive candida infections antifungal agent

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High cerium content(Nd-Pr-Ce)_(2)Fe_(14)B melt-spun ribbons with high coercivity

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Journal of Rare Earths 2024年第4期42卷 690-695页

作者： Yujiang Zhong Junming Wang Zikai yuan Ruijin liu Minggang Zhu zhe liu Xin Chen Wei Li Zhaohui Guo Division of Functional Materials Central Iron and Steel Research InstituteBeijing100081China Ningbo Jinji Strong Magnetic Material Co. Ltd.Ningbo315172China Jiangxi Jiangwu Rare Metal New Material Co. Ltd.Nanchang330013China

The effects of wheel speeds on the magnetic properties and microstructures of[(Nd,Pr)_(1-x)Ce_(x)]-Fe-B meltspun ribbons were *** to melt-spun ribbons with low cerium(Ce)content(x=0.2),amorphous formation can be suppressed at high wheel speed in the ribbons with a relatively high Ce content(x=0.8),and with the increase of the wheel speed,the magnetic properties of the ribbons with high Ce content raise *** high wheel speed,the coercivity mechanism of melt-spun ribbons is mainly pinning field,and the high wheel speed introduces a large number of defects into the matrix as pinning ***,ribbons with high Ce content form a fine and uniform grain structure,so the grain boundary area enlarges,which further hinders the movement of domain *** combined effects of the above factors enable ribbons with high Ce content to have excellent magnetic properties(Hcj=0.977 T,Mr=64 m^(2) A/kg)at the wheel speed of 35 m/s.

关键词： Wheel speed Cecontent Microstructure Magnetic properties Rare earths

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Morphology effect on catalytic performance of ebullated-bed residue hydrotreating over Ni-Mo/Al_(2)O_(3)catalyst:a kinetic modeling study

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Green Chemical Engineering 2024年第1期5卷 60-67页

作者： zhe liu Juncong yuan Zongzhuang Sun Xiang Feng Yibin liu Huihong Zhu Chong Peng Chaohe Yang State Key Laboratory of Heavy Oil Processing China University of PetroleumQingdao266580China Dalian Research Institute of Petroleum and Petrochemicals SINOPECDalian116045China State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian116024China

Upgrading of vacuum residue is of prime industrial significance due to the increasing demand for light *** the effect of catalyst morphology on vacuum residue hydrotreating performance by kinetic modeling is therefore of great ***,kinetic analysis of hydrodemetallization(HDM)and hydrodeconradsoncarbon-residue(HDCCR)performances on industrial Ni-Mo/Al_(2)O_(3)catalysts with spherical and cylindrical morphologies in ebullated-bed were evaluated for more than 1600 *** was found that the percentage of light impurities easier to be removed on spherical catalysts were 78.20%and 39.43%in HDM and HDCCR reactions,respectively,higher than 65.20%and 17.50%on cylindrical *** suggests that catalyst morphology affects the impurity removal ability and the impurity properties,resulting in better hydrotreating performance of spherical *** work not only combines catalyst morphology with impurity removal capability through kinetic modeling,but also provides new insights into the design of efficient hydrotreating catalysts.

关键词： Morphology effect Kinetic analysis Vacuum residue Hydrotreating

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Index-free triangle-based graph local clustering

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Frontiers of Computer Science 2024年第3期18卷 143-153页

作者： zhe yuan zhewei WEI Fangrui LV Ji-Rong WEN The Country and Area Studies Academy Beijing Foreign Studies UniversityBeijing 100089China Gaoling School of Artificial Intelligence Renmin University of ChinaBeijing 100872China

Motif-based graph local clustering(MGLC)is a popular method for graph mining tasks due to its various ***,the traditional two-phase approach of precomputing motif weights before performing local clustering loses locality and is impractical for large *** some attempts have been made to address the efficiency bottleneck,there is still no applicable algorithm for large scale graphs with billions of *** this paper,we propose a purely local and index-free method called Index-free Triangle-based Graph Local Clustering(TGLC^(*))to solve the MGLC problem w.r.t.a ***^(*)directly estimates the Personalized PageRank(PPR)vector using random walks with the desired triangleweighted distribution and proposes the clustering result using a standard sweep *** demonstrate TGLC^(*)’s scalability through theoretical analysis and its practical benefits through a novel visualization ***^(*)is the first algorithm to solve the MGLC problem without precomputing the motif *** experiments on seven real-world large-scale datasets show that TGLC^(*)is applicable and scalable for large graphs.

关键词： graph local clustering triangle motif index-free sampling method visualization

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Boosting oxygen reduction activity and CO_(2) resistance on bismuth ferrite-based perovskite cathode for low-temperature solid oxide fuel cells below 600℃

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Journal of Energy Chemistry 2024年第3期90卷 600-609,I0013页

作者： Juntao Gao Zhiyun Wei Mengke yuan zhe Wang zhe Lü Qiang Li Lingling Xu Bo Wei School of Physics Harbin Institute of TechnologyHarbin 150001HeilongjiangChina Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080HeilongjiangChina School of Physics and Electronic Engineering Harbin Normal UniversityHarbin 150025HeilongjiangChina

Developing efficient and stable cathodes for low-temperature solid oxide fuel cells(LT-SOFCs) is of great importance for the practical ***,we propose a series of Sm-modified Bi_(0.7-x)Sm_xSr_(0.3)FeO_(3-δ) perovskites as highly-active catalysts for *** doping can significantly enhance the electrocata lytic activity and chemical stability of *** 600℃,Bi_(0.675)Sm_(0.025)Sr_(0.3)FeO_(3-δ)(BSSF25) cathode has been found to be the optimum composition with a polarization resistance of 0.098 Ω cm^2,which is only around 22.8% of Bi_(0.7)Sr_(0.3)FeO_(3-δ)(BSF).A full cell utilizing BSSF25 displays an exceptional output density of 790 mW cm^(-2),which can operate continuously over100 h without obvious *** remarkable electrochemical performance observed can be attributed to the improved O_(2) transport kinetics,superior surface oxygen adsorption capacity,as well as O_(2)p band centers in close proximity to the Fermi ***,larger average bonding energy(ABE) and the presence of highly acidic Bi,Sm,and Fe ions restrict the adsorption of CO_(2) on the cathode surface,resulting in excellent CO_(2) *** work provides valuable guidance for systematic design of efficient and durable catalysts for LT-SOFCs.

关键词： Low-temperature solid oxide fuel cell Perovskite cathode DFT calculations CO_(2) tolerance

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Nanoindentation behavior and creep-induced cracking of long-term crept austenitic steel at 650℃

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Journal of Iron and Steel Research International 2024年第2期31卷 464-474页

作者： zhen Zhang Yu-hang Duan Shuai Wang Jin-shan Chen An-zhe Wang Xiang-yang Mao yuan-ji Shi Jie Zhang Ming liu zheng-fei Hu School of Materials Science and Engineering Nanjing Institute of TechnologyNanjing211167JiangsuChina Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology Nanjing211167JiangsuChina Jiangsu Wind Power Engineering Technology Center Nanjing210023JiangsuChina Nanjing Vocational University of Industry Technology Nanjing210023JiangsuChina Baoshan Iron&Steel Co. Ltd.Shanghai201900China Fujian Provincial Key Laboratory of Terahertz Functional Devices and Intelligent Sensing School of Mechanical Engineering and AutomationFuzhou UniversityFuzhou350116FujianChina School of Materials Science and Engineering Tongji UniversityShanghai201804China

The grain boundary(GB)damage of long-term crept HR3C(25Cr–20Ni–Nb–N)austenitic steel with solid solution state was investigated by nanoindentation test accompanied with in-situ electron back-scattered *** corresponding microstructure was characterized by scanning electron microscopy and transmission electron *** show that the increase in nanoindentation hardness at the GBs and triple grain junctions may be related to the dislocation accumulation and carbide growth during the *** M23C6 and dislocations piling-up at the GB accelerate the nucleation and coalescence of creep cavity along the *** nanoindentation hardness in grains varies with orientation of the stress *** orientation difference of neighbor grains may induce local high geometrically necessary dislocation densities and strain gradients near the GB,consequently causing stress concentration and subsequent crack growth at specific GBs.

关键词： Austenitic steel Creep Nanoindentation Grain orientation Creep-induced cracking

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Development and performance evaluation of high temperature resistant strong adsorption rigid blocking agent

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Petroleum Science 2024年第4期21卷 2650-2662页

作者： zhe Xu Jin-Sheng Sun Jing-Ping liu Kai-He Lv Xiao-Dong Dong Zong-Lun Wang Tai-Feng Zhang yuan-Wei Sun Zhi-Wen Dai School of Petroleum Engineering China University of Petroleum (East China) CNPC Engineering Technology R&D Company Limited

As drilling wells continue to move into deep ultra-deep layers, the requirements for temperature resistance of drilling fluid treatments are getting higher and higher. Among them, blocking agent, as one of the key treatment agents, has also become a hot spot of research. In this study, a high temperature resistant strong adsorption rigid blocking agent(QW-1) was prepared using KH570 modified silica,acrylamide(AM) and allyltrimethylammonium chloride(TMAAC). QW-1 has good thermal stability,average particle size of 1.46 μm, water contact angle of 10.5., has a strong hydrophilicity, can be well dispersed in water. The experimental results showed that when 2 wt% QW-1 was added to recipe A(4 wt% bentonite slurry+0.5 wt% DSP-1(filtration loss depressant)), the API filtration loss decreased from 7.8to 6.4 m L. After aging at 240.C, the API loss of filtration was reduced from 21 to 14 m L, which has certain performance of high temperature loss of filtration. At the same time, it is effective in sealing 80-100mesh and 100-120 mesh sand beds as well as 3 and 5 μm ceramic sand discs. Under the same conditions,the blocking performance was superior to silica(5 μm) and calcium carbonate(2.6 μm). In addition, the mechanism of action of QW-1 was further investigated. The results show that QW-1 with amide and quaternary ammonium groups on the molecular chain can be adsorbed onto the surface of clay particles through hydrogen bonding and electrostatic interaction to form a dense blocking layer, thus preventing further intrusion of drilling fluid into the formation.

关键词： High adsorption Rigid microsphere High temperature resistance Blocking performance

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Photocatalytic dicarboxylation of strained C-C bonds with CO_(2) via consecutive visible-light-induced electron transfer

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Chinese Chemical Letters 2024年第6期35卷 268-273页

作者： Yi liu zhe-Hao Wang Guan-Hua Xue Lin Chen Li-Hua yuan Yi-Wen Li Da-Gang Yu Jian-Heng Ye Key Laboratory of Green Chemistry&Technology of Ministry of Education College of ChemistrySichuan UniversityChengdu 610064China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China

Dicarboxylic acids have a wide range of applications in the polymer industry to construct valuable *** has recently emerged as an efficient and sustainable strategy to generate dicarboxylic ***,photocatalytic dicarboxylation with CO_(2) is mainly limited to unsaturated bonds,and the dicarboxylation of C-C single bonds still remains a ***,we report a photocatalytic dicarboxylation of C-C single bonds in strained rings with CO_(2) units via consecutive photo-induced electron transfer(ConPET).It is also the first photocatalytic reductive ring-opening reaction of ***,this transition-metal-free protocol exhibits good functional group tolerance,broad substrate scope,facile scalability,and easy product ***,diacids can easily be derivatized to mainchain liquid crystalline polyesters.

关键词： Consecutive photo-induced electron transfer Visible-light catalysis Dicarboxylation Carbon dioxide Cyclopropanes

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A Real-time Prediction System for Molecular-level Information of Heavy Oil Based on Machine Learning

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China Petroleum Processing & Petrochemical Technology 2024年第2期26卷 121-134页

作者： yuan Zhuang Wang yuan Zhang Zhibo yuan Yibo Yang zhe Xu Wei Lin Yang Yan Hao Zhou Xin Zhao Hui Yang Chaohe State Key Laboratory of Chemical Safety SINOPEC Research Institute of Safety Engineering Co.LtdQingdaoShandong 266000People’s Republic of China State Key Laboratory of Heavy Oil Processing China University of PetroleumQingdaoShandong 266580People’s Republic of China College of Chemistry and Chemical Engineering Ocean University of ChinaQingdaoShandong 266100People’s Republic of China

Acquiring accurate molecular-level information about petroleum is crucial for refining and chemical enterprises to implement the“selection of the optimal processing route”*** the development of data prediction systems represented by machine learning,it has become possible for real-time prediction systems of petroleum fraction molecular information to replace analyses such as gas chromatography and mass ***,the biggest difficulty lies in acquiring the data required for training the neural *** address these issues,this work proposes an innovative method that utilizes the Aspen HYSYS and full two-dimensional gas chromatography-time-of-flight mass spectrometry to establish a comprehensive training ***,a deep neural network prediction model is developed for heavy distillate oil to predict its composition in terms of molecular *** training,the model accurately predicts the molecular composition of catalytically cracked raw oil in a *** validation and test sets exhibit R2 values of 0.99769 and 0.99807,respectively,and the average relative error of molecular composition prediction for raw materials of the catalytic cracking unit is less than 7%.Finally,the SHAP(SHapley Additive ExPlanation)interpretation method is used to disclose the relationship among different variables by performing global and local weight comparisons and correlation analyses.

关键词： heavy distillate oil molecular composition deep learning SHAP interpretation method

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A lethal mice model of recombinant vesicular stomatitis viruses for EBOV-targeting prophylactic vaccines evaluation

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Virologica Sinica 2024年第3期39卷 516-519页

作者： Hong-Qing Zhang zhe-Rui Zhang Cheng-Lin Deng Zhi-Ming yuan Bo Zhang Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China Hubei Jiangxia Laboratory Wuhan430200China

Dear editor,Ebola virus(EBOV)is a member of the genus Orthoebolavirus within the family of ***'s the causative agent of Ebola virus disease(EVD),characterized by general malaise,severe gastrointestinal illness,febrile,coagulopathy,multi-organs dysfunction,and high mortality(up to 90%)in humans and nonhuman primates(NHPs)(Jacob et al.,2020).Since its discovery in 1976,EBOV has grabbed the global concerns,especially after the West African epidemic from 2014 to 2016,which resulted in 30,000 cases and over 11,000 deaths(Feldmann et al.,2020;Jacob et al.,2020).From 2018 to 2022,there have been thousands of infections primarily in the Democratic Republic of the Congo(DRC),resulting in over 2000 *** highlights the importance of continued attention and ongoing surveillance(***/emergenci es/disease-outbreak-news).

关键词： organs mortality editor

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