A lethal mice model of recombinant vesicular stomatitis viruses for EBOV-targeting prophylactic vaccines evaluation

作     者：Hong-Qing Zhang Zhe-Rui Zhang Cheng-Lin Deng Zhi-Ming Yuan Bo Zhang 

作者机构：Key Laboratory of Special Pathogens and BiosafetyWuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan430071China University of Chinese Academy of SciencesBeijing100049China Hubei Jiangxia LaboratoryWuhan430200China 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2024年第39卷第3期

页      面：516-519页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：国家自然科学基金 the Strategic Priority Research Program of the Chinese Academy of Sciences 

主　　题：organs mortality editor 

摘      要：Dear editor,Ebola virus(EBOV)is a member of the genus Orthoebolavirus within the family of *** s the causative agent of Ebola virus disease(EVD),characterized by general malaise,severe gastrointestinal illness,febrile,coagulopathy,multi-organs dysfunction,and high mortality(up to 90%)in humans and nonhuman primates(NHPs)(Jacob et al.,2020).Since its discovery in 1976,EBOV has grabbed the global concerns,especially after the West African epidemic from 2014 to 2016,which resulted in 30,000 cases and over 11,000 deaths(Feldmann et al.,2020;Jacob et al.,2020).From 2018 to 2022,there have been thousands of infections primarily in the Democratic Republic of the Congo(DRC),resulting in over 2000 *** highlights the importance of continued attention and ongoing surveillance(***/emergenci es/disease-outbreak-news).