检索结果-南通市图书馆

Numerical simulation and optimization of Al alloy cylinder body by low pressure die casting

在线全文

学校读者我要写书评

暂无评论

China Foundry 2008年第2期5卷 99-103页

作者： Mi Guofa liu yanlei Zhao Hengtao Fu Hengzhi School of Materials Science and Engineering Henan Polytechnic University Jiaozuo 454000 China

Shrinkage defects can be formed easily at critical location during low pressure die casting (LPDC) of aluminum alloy cylinder body. It has harmful effect on the products. Mold filling and solidification process of a cylinder body was simulated by using of Z-CAST software. The casting method was improved based on the simulation results. In order to create effective feeding passage, the structure of casting was modified by changing the location of strengthening ribs at the bottom, without causing any adverse effect on the part's performance. Inserting copper billet at suitable location of the die is a valid way to create suitable solidification sequence that is beneficial to the feeding. Using these methods, the shrinkage defect was completely eliminated at the critical location.

关键词： aluminum alloy cylinder body numerical simulation optimization

Crossover patterns under meiotic chromosome program

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2021年第6期23卷 562-571页

作者： Shunxin Wang Yongliang Shang yanlei liu Binyuan Zhai Xiao Yang Liangran Zhang Center for Reproductive Medicine Cheeloo College of MedicineShandong UniversityJinan 250012China Key Laboratory of Reproductive Endocrinology of Ministry of Education Shandong UniversityJinan 250012China Shandong Key Laboratory of Reproductive Medicine Jinan 250012China Shandong Provincial Clinical Research Center for Reproductive Health Jinan 250012China National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong UniversityJinan 250012China Advanced Medical Research Institute Shandong UniversityJinan 250014China State Key Laboratory of Microbial Technology Shandong UniversityQingdao 266237China

Repairing DNA double-strand breaks(DSBs)with homologous chromosomes as templates is the hallmark of *** critical outcome of meiotic homologous recombination is crossovers,which ensure faithful chromosome segregation and promote genetic diversity of *** patterns are tightly controlled and exhibit three characteristics:obligatory crossover,crossover interference,and crossover *** crossover patterns are the leading cause of infertility,miscarriage,and congenital *** recombination occurs in the context of meiotic chromosomes,and it is tightly integrated with and regulated by meiotic chromosome structure both locally and *** chromosomes are organized in a loop-axis *** evidence shows that chromosome axis length determines crossover ***,short chromosomes show different crossover patterns compared to long chromosomes.A high frequency of human embryos are aneuploid,primarily derived from female meiosis *** increased aneuploidy in older women is the well-known“maternal age effect.”However,a high frequency of aneuploidy also occurs in young women,derived from crossover maturation inefficiency in human *** addition,frequency of human aneuploidy also shows other age-dependent ***,current advances in the understanding of these issues are reviewed,regulation of crossover patterns by meiotic chromosomes are discussed,and issues that remain to be investigated are suggested.

关键词： aneuploidy chromosome crossover crossover interference crossover pattern meiosis recombination

Human iPS Cells Loaded with MnO2-Based Nanoprobes for Photodynamic and Simultaneous Enhanced Immunotherapy Against Cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2020年第10期12卷 36-52页

作者： yanlei liu Jingxing Yang Bin liu Wen Cao Jingpu Zhang Yuming Yang Lijun Ma Jesus Martinez de la Fuente Jie Song Jian Ni Chunfu Zhang Daxiang Cui Institute of Nano Biomedicine and Engineering Key Laboratory for Thin Film and Microfabrication of Ministration of EducationShanghai Engineering Research Centre for Intelligent Diagnosis and Treatment InstrumentDepartment of Instrument Science and EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong University800 Dongchuan RoadShanghai 200240People’s Republic of China National Engineering Center for Nanotechnology Shanghai 200240People’s Republic of China Department of Nuclear Medicine Rui Jin HospitalSchool of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Scientific Research Center Shanghai Public Health Clinical CenterFudan UniversityShanghai 201508People’s Republic of China Tongren Hospital Shanghai Jiao Tong University School of Medicine1111 XianXia RoadShanghai 200336People’s Republic of China

How to trigger strong anti-tumor immune responses has become a focus for tumor ***,we report the human-induced pluripotent stem cells(iPSs)to deliver MnO2@Ce6 nanoprobes into tumors for simultaneous photodynamic therapy(PDT)and enhanced ***6 photosensitizer was attached on manganese dioxide(MnO2)nanoparticles,and resultant MnO2@Ce6 nanoprobes were delivered into mitomycin-treated iPSs to form iPS-MnO2@Ce6 *** iPS-MnO2@Ce6 actively targeted in vivo tumors,the acidic microenvironment triggered interaction between MnO2 and H2O2,released large quantities of oxygen,alleviated hypoxia in *** PDT,singlet oxygen formed,broken iPSs released tumor-shared antigens,which evoked an intensive innate and adaptive immune response against the tumor,improving dendritic cells matured,effector T cells,and natural killer cells were ***,regulatory T cells were reduced,and then the immune response induced by iPS-MnO2@Ce6 was markedly stronger than the immune reaction induced by MnO2@Ce6(P<0.05).The iPS-MnO2@Ce6 markedly inhibited tumor growth and metastasis and reduced mortality in mice models with *** iPS s loaded with MnO2-based nanoprobes are a promising strategy for simultaneous PDT and enhanced immunotherapy against tumor and own clinical translational prospect.

关键词： Human iPS MnO2@Ce6 nanoprobes Photodynamic therapy Immunotherapy Cancer

Dual-targeted lung cancer therapy via inhalation delivery of UCNP-siRNA-AS1411 nanocages

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2022年第7期19卷 1047-1060页

作者： Yu Han Yuming Yang Qiuyang Sun Bin Li Caixia Yue yanlei liu Jesús M.de la Fuente Daxiang Cui Institute of Nano Biomedicine and Engineering Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of EducationShanghai Engineering Research Center for Intelligent Diagnosis and Treatment InstrumentDepartment of Instrument Science&EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China National Engineering Center for Nanotechnology Collaborative Innovational Center for System BiologyShanghai 200241China Department of Neurosurgery Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 200092China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Instituto de Nanociencia de Aragon(INA) Universidad de ZaragozaZaragoza 50018Spain

Objective:Although great progress has been made in the field of siRNA gene therapy,safe,efficient,and targeted delivery of siRNA are still major challenges in siRNA ***:We developed an up-conversion nanoparticle-based nanocage *** system protected the siRNA from being degraded by nucleases in organisms and selectively delivered the siRNAs to the tumor sites,due to modifications of targeted molecules on the surfaces of nanocages and local ***:The siRNAs delivered by the up-conversion nanoparticle nanocages were protected from degradation in transit to the tumor sites,where they *** with the passive target and control groups,the up-conversion nanoparticles based on the nanocage system showed a tumor suppressive effect after approximately 3 weeks of ***:The up-conversion nanoparticle nanocages efficiently delivered vascular endothelial growth factor siRNAs to tumor *** with lung tumors treated with tumors targeting up-conversion nanoparticle nanocages showed steady body weight changes,high tumor inhibition ratios,and longer survival times.

关键词： Nanomaterials VEGF siRNA lung cancer gene therapy siRNA delivery

Ionic liquid-trimetallic electrocatalytic system for C–O bond cleavage in lignin model compounds and lignin under ambient conditions

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第4期17卷 2420-2428页

作者： Guangyong liu Yumiao Lu JunFeng Lu yanlei Wang Shijing Liang Hongyan He Lilong Jiang National Engineering Research Center of Chemical Fertilizer Catalyst Fuzhou UniversityFuzhou 350002China CAS Key Laboratory of Green Process and Engineering State Key Laboratory of Multiphase Complex SystemsBeijing Key Laboratory of Ionic Liquids Clean ProcessInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Longzihu New Energy Laboratory Zhengzhou Institute of Emerging Industrial TechnologyZhengzhou 450000China

Electrocatalytic depolymerization of lignin into value-added chemicals offers a promising technique to make biorefining ***,we report a robust trimetallic PdNiBi electrocatalyst for reductive C–O bond cleavage of different lignin model dimers and oxidized lignin under mild *** reduction reaction proceeds with complete substrate conversion and excellent yields toward monomers of phenols(80%–99%)and acetophenones(75%–96%)in the presence of an ionic liquid electrolyte with operational *** experimental investigations together with density functional theory(DFT)calculations reveal that the outstanding performance of the catalyst results from the synergistic effect of the metal elements,which facilitates the easier formation of a key Cαradical intermediate and the facile desorption of the as-formed products at the *** results open up new opportunities for lignin valorization through the green electrocatalytic approach.

关键词： electrocatalytic depolymerization lignin Ionic liquids density functional theory(DFT)calculation

Ionic liquids inhibit the dynamic transition fromα-helices toβ-sheets in peptides

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fundamental Research 2024年第4期4卷 777-784页

作者： Ju liu yanlei Wang Feng Huo Hongyan He Beijing Key Laboratory of Ionic Liquids Clean Process State Key Laboratory of Mesoscience and EngineeringCAS Key Laboratory of Green Process and EngineeringInstituteof Process EngineeringChineseAcademyof SciencesBeijing100190China Longzihu New Energy Laboratory Zhengzhou Institute of Emerging Industrial TechnologyHenan UniversityZhengzhou 450000China University of Chinese Academyof Sciences Beijing100049China

Abnormalities in the transition betweenα-helices andβ-sheets(α-βtransition)may lead to devastating neurodegenerative diseases,such as Parkinson's syndrome and Alzheimer's *** liquids(ILs)are potential drugs for targeted therapies against these diseases because of their excellent bioactivity and designability of ***,the mechanism through which ILs regulate the aα-βtransition remains ***,a combination of GPU-accelerated microsecond molecular dynamics simulations,correlation analysis,and machine learning was used to probe the dynamicalα-βtransition process induced by ILs of 1-alkyl-3-methylimidazolium chloride([C_(n)mim]cl)and its molecular ***,the cation of [C_(n)mim]+in ILs can spontaneously insert into the peptides as free ions(n≤10)and clusters(n≥11).Such insertion can significantly inhibit theα-β,transition and the inhibiting ability for the clusters is more significant than that of free ions,where[Ciomim]+and[C_(12)mim]+can reduce the maximumβ-sheet content of the peptide by 18.5% and 44.9%,***,the correlation analysis and machine learning method were used to develop a predictive model accounting for the influencing factors on theα-βtransition,which could accurately predict the effect of ILs on theα-β***,these quantitative results may not only deepen the understanding of the role of ILs in theα-βtransition but also guide the development of the IL-based treatments for related diseases.

关键词： α-βtransition Moleculardynamics simulation lonic liquids Machine learning Membrane channel protein

Realization of Oriented and Nanoporous Bismuth Chalcogenide Layers via Topochemical Heteroepitaxy for Flexible Gas Sensors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research 2022年第4期2022卷 211-221页

作者： Zhiwei Wang Jie Dai Jian Wang Xinzhe Li Chengjie Pei yanlei liu Jiaxu Yan Lin Wang Shaozhou Li Hai Li Xiaoshan Wang Xiao Huang Wei Huang Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)30 South Puzhu RoadNanjing 211816China Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics(IFE)and Xi'an Institute of Biomedical Materials EngineeringNorthwestern Polytechnical University127 West Youyi RoadXi'an 710072China Key Laboratory for Organic Electronic e Information Displays(KLOEID)and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts and Telecommunications9 Wenyuan RoadNanjing 210023China

Most van der Waals two-dimensional(2D)materials without surface dangling bonds show limited surface activities except for their edge *** Bi_(2)Se_(3),a topological insulator that behaves metal-like under ambient conditions,has been overlooked on its surface ***,through a topochemical conversion process,ultrathin nanoporous Bi_(2)Se_(3) layers were epitaxially deposited on BiOCl nanosheets with strong electronic coupling,leading to hybrid electronic states with further bandgap *** oriented nanoporous Bi_(2)Se_(3) layers possessed largely exposed active edge sites,along with improved surface roughness and film forming ability even on inkjet-printed flexible *** room-temperature NO_(2) sensing performance was achieved compared to other 2D materials under bent *** work demonstrates that creating nanoscale features in 2D materials through topochemical heteroepitaxy is promising to achieve both favorable electronic properties and surface activity toward practical applications.

关键词： chemical bonds roughness

Human natural killer cells for targeting delivery of gold nanostars and bimodal imaging directed photothermal/photodynamic therapy and immunotherapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2019年第4期16卷 756-770页

作者： Bin liu Wen Cao Jin Cheng Sisi Fan Shaojun Pan Lirui Wang Jiaqi Niu Yunxiang Pan yanlei liu Xiyang Sun Lijun Ma Jie Song Jian Ni Daxiang Cui Institute of Nano Biomedicine and Engineering Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment InstrumentDepartment of Instrument Science and EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China National Center for Translational Medicine Collaborative Innovational Center for System BiologyShanghai Jiao Tong UniversityShanghai 200240China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200030China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Oncology Tongren HospitalShanghai Jiao Tong University School of MedicineShanghai 200336China

Objective:To construct a novel nanoplatform GNS@CaCO3/Ce6-NK by loading the CaCO3-coated gold nanostars(GNSs)with Chlorin e6 molecules(Ce6)into human peripheral blood mononuclear cells(PBMCs)-derived NK cells for tumor targeted ***:GNS@CaCO3/Ce6 nanoparticles were prepared and characterized by TEM and *** cell surface markers and cytokines secretion of NK cells before and after loading the GNS@CaCO3/Ce6 nanoparticles were detected by Flow Cytometry(FCM)and *** of the GNS@CaCO3/Ce6-NK cells on A549 cancer cells was determined by FCM and *** fluorescent signals of GNS@CaCO3/Ce6-NK cells were detected via Confocal laser scanning microscopic(CLSM)and FCM at different time *** ROS generation of GNS@CaCO3/Ce6-NK cells under laser irradiation were examined by *** distribution of GNS@CaCO3/Ce6-NK in A549 tumor-bearing mice were observed by fluorescence imaging and PA *** combination therapy of GNS@CaCO3/Ce6-NK under laser irradiation were investigated on tumor-bearing ***:The coated CaC03 shell on the surface of GNSs exhibited prominent delivery and protection effect of Ce6 during the cellular uptake *** as-prepared multifunctional GNS@CaCO3/Ce6-NK cells possessed bimodal functions of fluorescence imaging and photoacoustic *** as-prepared multifunctional GNS@CaCO3/Ce6-NK cells could actively target tumor tissues with the enhanced photothermal/photodynamic therapy and ***:The GNS@CaCO3/Ce6-NK shows effective tumor-targeting ability and prominent therapeutic efficacy toward lung cancer A549 tumor-bearing *** fully utilizing the features of GNSs and NK cells,this new nanoplatform provides a new synergistic strategy for enhanced photothermal/photodynamic therapy and immunotherapy in the field of anticancer development in the near future.

关键词： Gold nanostars natural killer cells photothermal therapy photodynamic therapy immunotherapy

在线全文

学校读者我要写书评

暂无评论

锅炉水冷壁管鳍片对漏磁检测影响的分析

无损检测 2024年第1期46卷 1-5页

作者：陈涛钮建良廖晓玲任强杨志军刘延雷杭州市特种设备检测研究院杭州310051 东北石油大学机械科学与工程学院大庆163318

漏磁检测技术可应用于锅炉水冷壁管内腐蚀缺陷的检测中,而锅炉水冷壁管的鳍片会对漏磁检测产生影响,因此,对有无鳍片的水冷壁管建立三维模型,分别分析缺陷处漏磁场的空间分布状况,并进行对比,最后开展了试验验证。试验结果表明:有无鳍... 详细信息

漏磁检测技术可应用于锅炉水冷壁管内腐蚀缺陷的检测中,而锅炉水冷壁管的鳍片会对漏磁检测产生影响,因此,对有无鳍片的水冷壁管建立三维模型,分别分析缺陷处漏磁场的空间分布状况,并进行对比,最后开展了试验验证。试验结果表明:有无鳍片水冷壁管的漏磁场强度均随腐蚀缺陷尺寸的增大而增大,两者趋势相同;鳍片的存在会分走一部分磁场,使缺陷处的漏磁场强度减弱,漏磁信号变小,漏磁特征信号强度下降40%左右。试验能够为漏磁检测技术在锅炉水冷壁管中的应用提供理论支撑。

关键词：锅炉水冷壁管鳍片漏磁检测有限元仿真