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Effect of infarct location and volume on cognitive dysfunction in elderly patients with acute insular cerebral infarction

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World Journal of Psychiatry 2024年第8期14卷 1190-1198页

作者： Fei-Fei Liang xiao-xia liu Jiang-Hong liu Yang Gao Jian-Guo Dai Zi-Hui Sun Department of Geriatrics Zhangjiakou First Hospital in Hebei ProvinceZhangjiakou 075000Hebei ProvinceChina The Fourth Ward Zhangjiakou Infectious Disease HospitalZhangjiakou 075000Hebei ProvinceChina Department of Hepatobiliary and Pancreatic Surgery Zhangjiakou First Hospital in Hebei ProvinceZhangjiakou 075000Hebei ProvinceChina Department of General Medicine Zhangjiakou First Hospital in Hebei ProvinceZhangjiakou 075000Hebei ProvinceChina

BACKGROUND The aging of the population has become increasingly obvious in recent years,and the incidence of cerebral infarction has shown an increasing trend annually,with high death and disability *** To analyze the effects of infarct location and volume on cognitive dysfunction in elderly patients with acute insular cerebral *** Between January 2020 and December 2023,we treated 98 cases of elderly acute insula,patients with cerebral infarction in the cerebral infarction acute phase(3-4 weeks)and for the course of 6 months in Montreal Cognitive Assessment Scale(MoCA)for screening of ***,58 and 40 patients were placed in the cognitive impairment group and without-cognitive impairment group,*** patients with cerebral infarction,magnetic resonance imaging was used to screen and clearly analyze the MoCA scores of two groups of patients with different infarctions,the relationship between the parts of the infarction volume,and analysis of acute insula cognitive disorder in elderly patients with cerebral RESULTS The number of patients with cognitive impairment in the basal ganglia and thalamus was significantly higher than that without cognitive impairment(P<0.05).The total infarct volume in the cognitive impairment group was higher than that in the non-cognitive impairment group,and the difference was statistically significant(P<0.05).The infarct volumes at different sites in the cognitive impairment group was higher than in the non-cognitive impairment group(P<0.05).In the cognitive impairment group,the infarct volumes in the basal ganglia,thalamus,and mixed lesions were negatively correlated with the total MoCA score,with correlation coefficients of-0.67,-0.73,and-0.77,*** In elderly patients with acute insular infarction,infarction in the basal ganglia,thalamus,and mixed lesions were more likely to lead to cognitive dysfunction than in other areas,and patients with large infarct volumes were more like

关键词： Elderly Acute insular infarction Infarction site Cognitive impairment Infarction volume

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Synthesis and oxidative desulfurization activity of vanadium-substituted Keggin-type polyoxometalate hybrid compounds

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Tungsten 2024年第3期6卷 529-535页

作者： Min Xing xiao-Ying Ji Shu-xia liu Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Department of Chemistry Northeast Normal University

SOxfrom fuel oil has caused much air pollution. Therefore, the desulfurization of fuel oil is necessary. Oxidative desulfurization（ODS）, as one of the most efficient nonhydrodesulfurization technologies, has become a major solution of desulfurization for fuel oil owing to its high reactivity for the removal of refractory organic sulfur compounds including dibenzothiophene（DBT） and its derivatives under mild reaction conditions [1]. Among them,

关键词： FRAMEWORK CHAIN

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Highly Thermally Conductive Polydimethylsiloxane Composites with Controllable 3D GO@f-CNTs Networks via Self-sacrificing Template Method

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Chinese Journal of Polymer Science 2024年第7期42卷 897-906,I0005页

作者： Shuang-Shuang Wang Dian-Ying Feng Zhi-Ming Zhang xia liu Kun-Peng Ruan Yong-Qiang Guo Jun-Wei Gu Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an710072China Shandong Institute of Nonmetallic Materials Jinan250031China Queen Mary University of London Engineering School Northwestern Polytechnical UniversityXi’an710072China

Constructing controllable thermal conduction networks is the key to efficiently improve thermal conductivities of polymer *** this work,graphite oxide(GO)and functionalized carbon nanotubes(f-CNTs)are combined to prepare“Line-Plane”-like hetero-structured thermally conductive GO@f-CNTs fillers,which are then performed to construct controllable 3D GO@f-CNTs thermal conduction networks via selfsacrificing template method based on oxalic ***,thermally conductive GO@f-CNTs/polydimethylsiloxane(PDMS)composites are fabricated via casting *** the size of oxalic acid is 0.24 mm and the volume fraction of GO@f-CNTs is 60 vol%,GO@f-CNTs/PDMS composites present the optimal thermal conductivity coefficient(λ,4.00 W·m^(-1)·K^(-1)),about 20 times that of theλof neat PDMS(0.20 W·m^(-1)·K^(-1)),also much higher than theλ(2.44 W·m^(-1)·K^(-1))of GO/f-CNTs/PDMS composites with the same amount of randomly dispersed ***,the obtained GO@f-CNTs/PDMS composites have excellent thermal stability,whoseλdeviation is only about 3%after 500 thermal cycles(20-200℃).

关键词： Polydimethylsiloxane Hetero-structured thermally conductive fillers Self-sacrificing template Thermal conduction networks

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Lower extremity peripherally inserted central catheter placement ectopic to the ascending lumbar vein:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1430-1436页

作者： xiao-Ju Zhu Ling Zhao Na Peng Jia-Min Luo Shui-xia liu Cancer Center Daping HospitalArmy Medical UniversityChongqing 400042China

BACKGROUND Peripherally inserted central catheters(PICCs)are an essential infusion route for oncology patients receiving intravenous treatments,but lower extremity veni-puncture is the preferred technique for patients with superior vena cava syndrome(SVCS).We report the case of a patient with a lower extremity PICC ectopic to the ascending lumbar vein,to indicate and verify PICC catheterisation in the lower extremity is safe and *** hope to provide different per-spectives for clinical PICC venipuncture to get the attention of *** SUMMARY On 24 August 2022,a 58-year-old male was admitted to our department due to an intermittent cough persisting for over a month,which worsened 10 d *** and laboratory investigations suggested the patient with pulmonary malignancy and *** was not an absolute contraindication in this *** extremity venipuncture is the preferred technique because administering upper extremity venous transfusion to patients with SVCS can exacerbate oedema in the head,neck,and upper *** patient and his family were informed about the procedure,and informed consent was *** successful puncture and prompt treatment,the patient was discharged,experiencing some relief from *** Inferior vena cava catheterisation is rare and important for cancer patients with SVCS,particularly in complex situations involving ectopic placement.

关键词： Superior vena cava syndrome Peripherally inserted central catheter Ascending lumbar vein Complications Case report

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Herb pair of Huangqi-Danggui exerts anti-tumor immunity to breast cancer by upregulating PIK3R1

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Animal Models and Experimental Medicine 2024年第3期7卷 234-258页

作者： Hai-Xin liu Li Lian Li-Li Hou Cai-xia liu Jin-Hong Ren Yuan-Biao Qiao Shi-Yuan Wen Qing-Shan Li College of Traditional Chinese Medicine and Food Engineering Shanxi University of Chinese MedicineTaiyuanChina Shanxi Key Laboratory of Innovative Drug for the Treatment of Serious Diseases Basing on the Chronic Inflammation College of Traditional Chinese Medicine and Food EngineeringShanxi University of Chinese MedicineTaiyuanChina College of Basic Medical Sciences Shanxi Medical UniversityTaiyuanChina

Background:According to traditional Chinese medicine(TCM),drugs supplementing the vital energy,Qi,can eliminate tumors by restoring host *** objective of this study is to investigate the underlying immune mechanisms of anti-tumor activity associated with Qi-supplementing herbs,specifically the paired use of Huangqi and ***:Analysis of compatibility regularity was conducted to screen the combination of Qi-supplementing *** the MTT assay and a transplanted tumor mice model,the anti-tumor effects of combination TCMs were investigated in vitro and in *** content analysis and flow cytometry were then used to evaluate cellular immunity,followed by network pharmacology and molecular docking to dissect the significant active compounds and potential ***,the anti-tumor activity and the mechanism of the active ingredients were verified by molecular ***:There is an optimal combination of Huangqi and Danggui that,administered as an aqueous extract,can activate immunity to suppress tumor and is more effective than each drug on its own in vitro and in *** on network pharmacology analysis,PIK3R1 is the core target for the anti-tumor immunity activity of combined Huangqi and *** docking analysis shows 6 components of the combined Danggui and Huangqi extract(quercetin,jaranol,isorhamnetin,kaempferol,calycosin,and suchilactone)that bind to *** is the most important component against breast *** suchilactone/jaranol combination and,especially,the suchilactone/kaempferol combination are key for immunity enhancement and the anti-tumor effects of the ***:The combination of Huangqi and Danggui can activate immunity to suppress breast cancer and is more effective than the individual drugs alone.

关键词： anti-tumor Danggui Huangqi immunity

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Combining thermal scanning probe lithography and dry etching for grayscale nanopattern amplification

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Microsystems & Nanoengineering 2024年第1期10卷 335-344页

作者： Berke Erbas Ana Conde-Rubio xia liu Joffrey Pernollet Zhenyu Wang Arnaud Bertsch Marcos Penedo Georg Fantner Mitali Banerjee Andras Kis Giovanni Boero Juergen Brugger Microsystems Laboratory École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Center of MicroNanoTechnology(CMi) EPFLLausanne 1015Switzerland Laboratory of Nanoscale Electronics and Structures École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Laboratory for Bio-and Nano-Instrumentation École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Laboratory of Quantum Physics Topology and CorrelationsÉcole Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Present address:Institute of Materials Science of Barcelona ICMAB-CSIC Campus UABBellaterra 08193Spain Present address:School of Integrated Circuits and Electronics MIIT Key Laboratory for Low-Dimensional Quantum Structure and DevicesBeijing Institute of TechnologyBeijing 100081China

Grayscale structured surfaces with nanometer-scale features are used in a growing number of applications in optics and *** scanning probe lithography achieves a lateral resolution below 10 nm and a vertical resolution below 1 nm,but its maximum depth in polymers is ***,we present an innovative combination of nanowriting in thermal resist and plasma dry etching with substrate cooling,which achieves up to 10-fold amplification of polymer nanopatterns into SiO_(2) without proportionally increasing surface *** nanopatterns in SiO_(2) with 400 nm pitch and 150 nm depth are fabricated free of shape distortion after dry *** exemplify the possible applications of the proposed method,grayscale dielectric nanostructures are used for scalable manufacturing through nanoimprint lithography and for strain nanoengineering of 2D *** a method for aspect ratio amplification and smooth grayscale nanopatterning has the potential to find application in the fabrication of photonic and nanoelectronic devices.

关键词： lithography thermal pattern

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Effectiveness of the“online+offline+practice”trinity teaching model on the learning of junior nursing students:an exploratory study

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Nursing Communications 2024年第12期8卷 1-6页

作者： Cai-xia liu Ling Wang Center of Clinical Nursing Research China Three Gorges UniversityYichang 443100China The First College of Clinical Medical Science China Three Gorges UniversityYichang 443100China Department of Cardiothoracic Surgery Yi chang Central People’s HospitalYichang 443100China

Background:Surgical Nursing is a main course of nursing specialty and a large course lasting 96 credit *** response to the teaching pain points such as the complicated and boring content of the surgical nursing course and the disconnection between classroom theory and clinical practice,surgical nursing is undergoing a teaching ***:The Surgical Nursing course builds trinity teaching model of“online+offline+practice”and implements teaching reforms by combining the Bridge,Objective,Pre-assessment,Participatory learning,Post-assessment,and Summary(BOPPPS)teaching *** constructed a trinity teaching model,and these teaching reform measures included building an online learning platform,offline case teaching and scenario simulation and hospital and community *** 50 students in the junior year of the undergraduate nursing program in the class of 2020 were used as the study subjects,and the students’comprehensive scores were *** questionnaire was also used to assess students’independent learning ability and to evaluate students’satisfaction with the ***:The students’course pass(≥60 points)rate was 100%,and the excellence(≥80 points)rate was 24.00%.Students’independent learning ability improved,and the scores and total scores of cognitive self-management ability,information ability and learning co-operation ability were significantly better than those of the national norm(P<0.01).The satisfaction of students in the BOPPPS group with classroom teaching was also significantly higher than that of the control ***:The“online+offline+practice”trinity teaching mode can effectively integrate the“Rain Classroom”online platform with the BOPPPS teaching *** guides students to actively participate in classroom thinking and discussion,improves students’independent learning ability,and effectively enhances the effect of classroom teaching.

关键词： BOPPPS Rain Classroom Surgical Nursing teaching

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Advancements in nutritional diagnosis and support strategies during the perioperative period for patients with liver cancer

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2409-2425页

作者： xiao-Qin Li Yun Liang Chen-Feng Huang Sui-Ning Li Lei Cheng Chuan You Yao-xia liu Tao Wang Department of Hepatobiliary Surgery The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Paediatric Surgery The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Cardiovascular Surgery The First Affiliated HospitalJinan UniversityGuangzhou 510632Guangdong ProvinceChina Department of Geriatric Endocrinology Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina Department of Pediatric Cardiology West China Second University HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Pediatrics Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University)Ministry of EducationChengdu 610041Sichuan ProvinceChina

Liver cancer represents a grave hepatic condition and constitutes a significant global health *** resection remains the principal therapeutic modality for liver ***,perioperative malnutrition exerts a notable impact on patients with liver cancer,emerging as an independent risk factor for disease mortality and adverse ***,precise nutritional diagnosis and timely nutritional support hold the potential to enhance therapeutic efficacy and quality of life for liver cancer *** study represents a meticulous foray into the literature,extracting data from PubMed,Web of Science,and EMBASE databases,with a focus on the past 5 *** scrutinizes the impact of malnutrition on patients undergoing liver cancer surgery,the etiological underpinnings of malnutrition within this patient cohort,the critical assessment of perioperative nutritional status,and the strategic approaches to nutritional *** rigorous inclusion and exclusion criteria,the amassed scholarly works are meticulously synthesized,methodically organized,and categorically elaborated ***,the authors propose the incorporation of a multidisciplinary nutrition management team during the perioperative period,comprising nutritionists,pharmacists,physicians,nurses,psychologists,and rehabilitation therapists,among other specialized ***,they collaborate to devise and implement personalized nutritional support plans,monitor patients’nutritional status,and make necessary adjustments as *** comprehensive management and intervention,improvements in the nutritional status of liver cancer patients can be achieved,thereby enhancing surgical success rates and facilitating postoperative *** is believed that this manuscript will offer valuable insights to advance the nutritional management during the perioperative phase of liver cancer,aiding in ameliorating patients'nutritional status and treatment outcomes.

关键词： Liver cancer Nutritional diagnosis Nutritional support Perioperative period Genetic testing Immunonutrition Probiotics and gut microbiota

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Leech Poecilobdella manillensis protein extract ameliorated hyperuricemia by restoring gut microbiota dysregulation and affecting serum metabolites

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World Journal of Gastroenterology 2024年第29期30卷 3488-3510页

作者： xia liu Xing-Qiu Liang Tian-Cai Lu Zhe Feng Min Zhang Nan-Qing Liao Feng-Lian Zhang Bo Wang Li-Sheng Wang Medical College Guangxi UniversityNanning 530004Guangxi Zhuang Autonomous RegionChina Department of Traditional Chinese Medicine HIV/AIDS Clinical Treatment Center of Guangxi(Nanning)The Fourth People’s Hospital of NanningNanning 530023Guangxi Zhuang Autonomous RegionChina Department of Science and Technology Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina General Manager’s Office Guangxi Fuxinyi Biological Technology Co.Ltd.Pingnan 537300Guangxi Zhuang Autonomous RegionChina Department of Joint and Sports Medicine Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina Department of Gerontology Nanning Social Welfare HospitalNanning 530004Guangxi Zhuang Autonomous RegionChina

BACKGROUND Hyperuricemia(HUA)is a public health concern that needs to be solved *** lyophilized powder of Poecilobdella manillensis has been shown to significantly alleviate HUA;however,its underlying metabolic regulation remains *** To explore the underlying mechanisms of Poecilobdella manillensis in HUA based on modulation of the gut microbiota and host *** A mouse model of rapid HUA was established using a high-purine diet and potassium oxonate *** mice received oral drugs or ***,16S rRNA sequencing and ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry-based untargeted metabolomics were performed to identify changes in the microbiome and host metabolome,*** levels of uric acid transporters and epithelial tight junction proteins in the renal and intestinal tissues were analyzed using an enzyme-linked immunosorbent *** The protein extract of Poecilobdella manillensis lyophilized powder(49 mg/kg)showed an enhanced anti-trioxypurine ability than that of allopurinol(5 mg/kg)(P<0.05).A total of nine bacterial genera were identified to be closely related to the anti-trioxypurine activity of Poecilobdella manillensis powder,which included the genera of Prevotella,Delftia,Dialister,Akkermansia,Lactococcus,Escherichia_Shigella,Enterococcus,and ***,22 metabolites in the serum were found to be closely related to the anti-trioxypurine activity of Poecilobdella manillensis powder,which correlated to the Kyoto Encyclopedia of Genes and Genomes pathways of cysteine and methionine metabolism,sphingolipid metabolism,galactose metabolism,and phenylalanine,tyrosine,and tryptophan *** analysis found that changes in the gut microbiota were significantly related to these *** The proteins in Poecilobdella manillensis powder were effective for ***,they are associated with improvements in g

关键词： Gut microbiota Metabolism Multi-omics Poecilobdella manillensis Sphingolipid metabolism pathway Galactose metabolism pathway Hyperuricemia

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Analysis of the Effect of GINS4 Regarding the Proliferation and Invasion of Breast Cancer Cells

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Journal of Clinical and Nursing Research 2024年第4期8卷 61-68页

作者： Yaxuan liu Fen Yun Yongfeng Jia Lin Shi xia liu Basic Medical College Inner Mongolia Medical UniversityHohhot 010030Inner MongoliaChina Department of Pathology The Affiliated Hospital of Inner Mongolia Medical UniversityHohhot 010030Inner MongoliaChina

Objective: To analyze the role and influence of the GINS4 gene in breast cancer progression and to explore its expression in triple-negative and non-triple-negative breast cancer cell lines. Methods: Single-gene analysis of GINS4 was performed by breast cancer RNA transcriptome data from The Cancer Genome Atlas (TCGA). Real-time quantitative polymerase chain reaction (PCR) was used to detect the expression of GINS4 in triple-negative and non-triple-negative breast cancer cell lines. The knockdown effects of GINS4 in MDA-MB-231 and MCF-7 cell lines on the proliferation and invasion of breast cancer cells were examined by cell counting kit 8 (CCK8) and Transwell assays. Results: Bioinformatics analysis showed that the expression of GINS4 in breast cancer was significantly higher than that in normal breast tissues (P > 0.05). At the same time, cell experiments confirmed that GINS4 was highly expressed in human breast cancer cell lines with normal breast cells as reference and in MDA-MB-231 and MCF-7 cell lines as reference, where the ability of proliferation and invasion of MDA-MB-231 and MCF-7 cells decreased after GINS4 knockdown. Conclusion: GINS4 is a gene associated with breast cancer malignancy, which can act as a novel tumor marker and has the potential as a new therapeutic target for breast cancer.

关键词： Breast Cancer GINS4 Proliferation Tumor marker Invasion

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