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Nursing perspective of expert consensus for diagnosis and treatment of colorectal cancer with integrated traditional Chinese and Western medicine

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Journal of Integrative Nursing 2022年第2期4卷 49-58页

作者： shuhong liu Ling TANG Yanan ZHAO Jingjing HUO Yan ZHAO Kang YAN Baoya ZHAO Department of Oncology Dongfang Hospital of Beijing University of Chinese MedicineBeijingChina Department of Nursing Dongfang Hospital of Beijing University of Chinese MedicineBeijingChina

As one of the most common malignant tumors in the world,colorectal cancer(CRC)is accompanied by a variety of symptoms in the process of disease development and treatment,which seriously affect the functional state and quality of life of *** China,comprehensive intervention measures of traditional Chinese medicine(TCM)play an indispensable role in the treatment and rehabilitation of *** order to further standardize and improve the treatment and management of CRC by medical staff,the Chinese Association of Integrative Medicine issued the“Expert Consensus for Diagnosis and Treatment of Colorectal Cancer with Integrated Traditional Chinese and Western Medicine”in August *** paper interprets this consensus in detail from the perspective of nursing,focusing on the common understanding of the pathogenesis of CRC,TCM diagnosis and syndrome differentiation,integrated traditional Chinese and Western medicine nursing,TCM characteristic therapies,etc.,with a view to deepening the understanding and practical application of the consensus among clinical doctors and nurses and improving the level of diagnosis,treatment,and nursing of CRC.

关键词： Colorectal cancer consensus integrated traditional Chinese and Western medicine nursing traditional Chinese medicine treatment

Nursing perspective of expert consensus for diagnosis and treatment of gastric cancer with integrated traditional Chinese and Western medicine

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Journal of Integrative Nursing 2023年第1期5卷 8-14页

Gastric cancer is a common and highly malignant tumor of the digestive system,which seriously threatens human *** benefit of surgical treatment is *** effect of radiotherapy and chemotherapy is not significant,and the toxic and side effects are *** the diagnosis and treatment modes of molecular targeting and multidisciplinary cooperation have also been further developed and applied,a relatively unified comprehensive treatment standard scheme has not been *** Chinese medicine(TCM),as complementary and alternative medicine,has unique advantages in the development of diagnosis and treatment of diseases in ***,the Chinese Association of Integrative Medicine formed“Expert Consensus for Diagnosis and Treatment of Gastric Cancer with Integrated Traditional Chinese and Western Medicine”on the basis of clinical practice and *** this article,the consensus is interpreted from the perspective of nursing,focusing on the pathogenesis,high‑risk factors,characteristic therapies of TCM,and nursing of integrated traditional Chinese and Western medicine for gastric cancer,to provide a reference for front‑line medical personnel in the roots in the future nursing care of gastric cancer.

关键词： Consensus interpretation gastric cancer integrated traditional Chinese and western medicine nursing integrative nursing traditional Chinese medicine

Transcription factor ETV4 promotes the development of hepatocellular carcinoma by driving hepatic TNF-αsignaling

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Cancer Communications 2023年第12期43卷 1354-1372页

作者： Dandan Qi Min Lu Pengfei Xu Xinli Yao Yongchen Chen Lipeng Gan Yong Li Yahua Cui Xiaomei Tong shuhong liu Jingmin Zhao Ningning liu Xin Ye Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Beijing P. R. China Savaid Medical School University of Chinese Academy of Sciences Beijing P. R. China The Fifth Medical Center of Chinese People's Liberation Army General Hospital Beijing P. R. China School of Life Sciences University of Science and Technology of China Hefei Anhui P. R. China

Background Hepatic inflammation is the major risk factor of hepatocellular carcinoma(HCC).However,the underlying mechanism by which hepatic inflammation progresses to HCC is poorly *** study was designed to investigate the role of ETS translocation variant 4(ETV4)in linking hepatic inflammation to *** Quantitative real-time PCR and immunoblotting were used to detect the expression of ETV4 in HCC tissues and cell *** sequencing and luciferase reporter assays were performed to identify the target genes of ***-specific ETV4-knockout(ETV4fl/fl,alb-cre)and transgenic(ETV4Hep-TG)mice and diethylnitrosamine-carbon tetrachloride(DEN-CCL4)treatment experiments were applied to investigate the function of ETV4 in *** Cancer Genome Atlas(TCGA)database mining and pathological analysis were carried out to determine the correlation of ETV4 with tumor necrosis factor-alpha(TNF-α)and mitogen-activated protein kinase 11(MAPK11).Results We revealed that ETV4 was highly expressed in *** levels of ETV4 predicted a poor survival rate of HCC *** we identified ETV4 as a transcription activator of TNF-αand ***4 was positively correlated with TNF-αand MAPK11 in HCC *** expected,an increase in hepatic TNF-αsecretion and macrophage accumulation were observed in the livers of ETV4Hep-TG *** protein levels of TNF-α,MAPK11,and CD68 were significantly higher in the livers of ETV4Hep-TG mice compared with wild type mice but lower in ETV4fl/fl,alb-cre mice compared with ETV4fl/fl mice as treated with DEN-CCL4,indicating that ETV4 functioned as a driver of TNF-α/MAPK11 expression and macrophage accumulation during hepatic ***-specific knockout of ETV4 significantly prevented development of DEN-CCL4-induced HCC,while transgenic expression of ETV4 promoted growth of *** ETV4 promoted hepatic inflammation and HCC by activating transcription of TNF-αand *** the ETV4/TNF-αand ETV4/MAPK11 a

关键词： ETV4 TNF-α MAPK11 macrophage hepatocellular carcinoma hepatic inflammation

Neuroprotective effects of Ginkgo biloba extract and GinkgoUde B against oxygen-glucose deprivation/reoxygenation and glucose injury in a new in vitro multicellular network model

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Frontiers of Medicine 2018年第3期12卷 307-318页

作者： Xiaohan Yang Tiezheng Zheng Hao Hong Nan Cai Xiaofeng Zhou Changkai Sun Liying Wu shuhong liu Yongqi Zhao Lingling Zhu Ming Fan Xuezhong Zhou Fengxie Jin Department of Biomedical Engineering Faculty of Electronic Information and Electrical Engineering Dalian University of Technology Dalian 116024 China Research Center for the Control Engineering of Translational Precision Medicine Dalian University of Technology Dalian 116024 China State Key Laboratory of Fine Chemicals Dalian R&D Center for Stem Cell and Tissue Engineering Dalian University of Technology Dalian 116024 China Liaoning Provincial Key Laboratory of Cerebral Diseases Institute for Brain Disorders Dalian Medical University Dalian 116044 China Institute of Basic Medical Sciences Academy of Military Medical Sciences Beijing 100850 China School of Computer and Information Technology and Beijing Key Lab of Traffic Data Analysis and Mining Beijing Jiaotong University Beijing 100044 China College of Biotecknology Dalian Polytechnic University Dalian 116034 China

Acute ischemic stroke （AIS）, as the third leading cause of death worldwide, is characterized by its high incidence, mortality rate, high incurred disability rate, and frequent reoccurrence. The neuroprotective effects of Ginkgo biloba extract （GBE） against several cerebral diseases have been reported in previous studies, but the underlying mechanisms of action are still unclear. Using a novel in vitro rat cortical capillary endothelial cell- astrocyte-neuron network model, we investigated the neuroprotective effects of GBE and one of its important constituents, Ginkgolide B （GB）, against oxygenglucose deprivation/reoxygenation and glucose （OGD/R） injury. In this model, rat cortical capillary endothelial cells, astrocytes, and neurons were cocultured so that they could be synchronously observed in the same system. Pretreatment with GBE or GB increased the neuron cell viability, ameliorated cell injury, and inhibited the cell apoptotic rate through Bax and Bcl-2 expression regulation after OGD/R injury. Furthermore, GBE or GB pretreatment enhanced the transendothelial electrical resistance of capillary endothelial monolayers, reduced the endothelial permeability coefficients for sodium fluorescein （Na-F）, and increased the expression levels of tight junction proteins, namely, ZO-1 and occludin, in endothelial cells. Results demonstrated the preventive effects of GBE on neuronal cell death and enhancement of the function of brain capillary endothelial monolayers after OGD/R injury in vitro; thus, GBE could be used as an effective neuroprotective agent for AIS/reperfusion, with GB as one of its significant constituents.

关键词： acute ischemic stroke Ginkgo biloba extract Ginkgolide B network model neuroprotection

Neurotensin Receptor 1 (NTSR1) Overexpression in Breast Carcinomas Is Common and Independent of ER/PR/Her2 Expression

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Journal of Cancer Therapy 2013年第7期4卷 12-17页

作者： Xianyong Gui shuhong liu Ziran Meng Zu-Hua Gao Calgary Laboratory Services Department of Pathology and Laboratory Medicine University of Calgary Calgary Canada Calgary Laboratory Services Department of Pathology and Laboratory Medicine University of Calgary Calgary Canada Department of Pathology McGill University Montreal Canada

Neurotensin (NT) is a 13-amino acid peptide with trophic effects on some neoplasms. Its bioactivities are mainly mediated by neurotensin receptor 1 (NTSR1). Both NT and NTSR1 were found to be upregulated in breast cancer. NT/NTSR1 thus becomes a potential therapeutic target. We studied whether any correlation exists between the expression of NTSR1 in breast carcinomas and the expression of ER, PR, and Her2. A total 85 cases of invasive ductal (62) and lobular (23) breast carcinomas were studied. Based on their ER/PR profiles, the ductal carcinomas (DCs) were subcategorized into ER+/PR+ (21), ER+/PR﹣ (20), and ER﹣/PR﹣ (21). All of the lobular carcinomas (LCs) were ER+/PR+. 21.57% of all DCs and 5.56% of LCs were Her2 positive. 77.78% of ER﹣/PR﹣ DCs were also Her2 negative (triple negative). The expression of NTSR1 was detected by immunohistochemistry and was semiquantitated (as negative, 1+, 2+, 3+). Both 2+ and 3+ were collectively defined as overexpression. The expression of NTSR1 was weak and focal in non-neoplastic mammary epithelial cells. It is increased in 74.19% of DCs (80.95% in ER+/PR+, 75% in ER+/PR﹣, and 66.67% in ER﹣/PR﹣ group), and in 95.65% of LCs. The overexpression of NTSR1 is similar between ER+ DCs and ER﹣ DCs (75% vs 66.67%, p > 0.05) as well as between PR+ DCs and PR﹣ DCs (80.95% in ER+/PR+ DCs vs 75% in ER+/PR﹣ DCs, p > 0.05). And it was seen in 77.78% of Her2+ DCs, 78.38% of Her2﹣ DCs, 94.12% of Her2﹣ LCs, and 78.57% of triple negative DCs. Overall, NTSR1 is commonly overexpressed in both ductal and lobular breast carcinomas and is independent of the ER/PR/Her2 profiles of the tumors. The present data supports the potential benefit of developing NTSR1 blockers in the adjuvant therapy of breast carcinomas, particularly for those “triple negative” tumors.

关键词： Neurotensin Neurotensin Receptor NTSR1 Breast Carcinoma Estrogen Receptor Progesterone Receptor Her2

以夏变夷和因俗而治:明代民族文教政策的一体两面

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广西民族研究 2012年第3期 132-138页

作者：刘淑红西北师范大学兰州城市学院教育学院

明代民族文教政策表现为以夏变夷的民族儒化政策和因俗而治的民族文化政策两个方面,它们是明廷治理少数民族以巩固王朝统治的教育措施。二者在主要内涵、价值取向和实施效果方面呈现出不同的特点且互相补充,缺一不可。探析明代以夏变夷... 详细信息

明代民族文教政策表现为以夏变夷的民族儒化政策和因俗而治的民族文化政策两个方面,它们是明廷治理少数民族以巩固王朝统治的教育措施。二者在主要内涵、价值取向和实施效果方面呈现出不同的特点且互相补充,缺一不可。探析明代以夏变夷和因俗而治的民族文教政策有助于我国民族教育事业的进一步发展和完善。

关键词：明代民族文教政策以夏变夷因俗而治

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关于研究生党员先进性教育的思考与实践

学位与研究生教育 2006年第5期 36-40页

作者：刘树宏中国人民大学马克思主义学院

阐述了研究生党员先进性教育的内涵及其与研究生党员教育的关系,客观分析了研究生党员教育中的薄弱环节。对研究生党员进行先进性教育,建议做好以下三方面的工作:①找准先进性教育的切入点、着力点和落脚点,虚功实做;②建立健全教育主... 详细信息

阐述了研究生党员先进性教育的内涵及其与研究生党员教育的关系,客观分析了研究生党员教育中的薄弱环节。对研究生党员进行先进性教育,建议做好以下三方面的工作:①找准先进性教育的切入点、着力点和落脚点,虚功实做;②建立健全教育主体系统,真抓实干;③纳入研究生教育管理全过程,实施动态监控。

关键词：研究生党员先进性教育

钢筋混凝土水池壁板弯曲裂缝的开展、自愈及渗漏试验研究

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土木工程学报 2016年第3期49卷 98-104页

作者：高霖郭恩栋赵颖刘智刘述虹中国地震局工程力学研究所中国地震局地震工程与工程振动重点实验室黑龙江哈尔滨150080 重庆文理学院重庆402160 东北林业大学黑龙江哈尔滨150040

储液结构混凝土的开裂是液体渗漏的主要原因。水池设计规范、规程以控制裂缝宽度来保证结构的耐久性和功能,水池的地震破坏等级划分标准也主要以构件开裂和液体渗漏程度为依据。该文进行了足尺钢筋混凝土水池壁板承受弯拉荷载作用试验,... 详细信息

储液结构混凝土的开裂是液体渗漏的主要原因。水池设计规范、规程以控制裂缝宽度来保证结构的耐久性和功能,水池的地震破坏等级划分标准也主要以构件开裂和液体渗漏程度为依据。该文进行了足尺钢筋混凝土水池壁板承受弯拉荷载作用试验,验证了混凝土裂缝具有较好的自愈性能,建议水池基本完好、轻微破坏等级的裂缝宽度限值可增加0.1mm,该值可供实际应用参考;弯曲裂缝的受压区能有效地阻止液体渗漏,建议储液结构不同种类裂缝限值规定应区别对待,弯曲裂缝需规定裂缝宽度和受压区高度;水池地震破坏等级划分应综合考虑渗漏程度,裂缝长度、宽度、分布密度及震后维修加固可行性等指标。

关键词：水池壁板弯曲裂缝自愈性能液体渗漏

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超小型泵中前盖板对传统叶轮水力性能的影响

清华大学学报（自然科学版） 2006年第8期46卷 1422-1425页

作者：刘树红邵杰罗先武清华大学热能工程系北京100084

为提高超小型泵性能和实用性，研究了其中前盖板对叶轮水力性能的影响。基于传统方法设计了两种超小型泵叶轮，其中一个为闭式，另一个为半开式。在转速3000～10000r·min^-1的范围内进行实验，测定了超小型泵的水力性能。对半开式叶轮... 详细信息

为提高超小型泵性能和实用性，研究了其中前盖板对叶轮水力性能的影响。基于传统方法设计了两种超小型泵叶轮，其中一个为闭式，另一个为半开式。在转速3000～10000r·min^-1的范围内进行实验，测定了超小型泵的水力性能。对半开式叶轮，在0．2～0．8mm间调整叶尖和前泵盖之间的轴向间隙，以考察其对泵水力性能的影响。试验结果表明：两种超小型泵的效率（闭式叶轮：51％，半开式叶轮：47％）均高于以往统计的泵效率值；由于机械密封等外部损失所占比重大，泵效率随雷诺数减小而降低，而内部效率则接近一个定值；随轴向间隙扩大，超小型泵的扬程系数、功率系数和效率都逐渐降低。

关键词：超小型泵机械损失轴向间隙水力性能