RNA binding protein TIAR modulates HBV replication by tipping the balance of pgRNA translation

作     者：Ting Zhang Huiling Zheng Danjuan Lu Guiwen Guan Deyao Li Jing Zhang Shuhong Liu Jingmin Zhao Ju-Tao Guo Fengmin Lu Xiangmei Chen Ting Zhang;Huiling Zheng;Danjuan Lu;Guiwen Guan;Deyao Li;Jing Zhang;Shuhong Liu;Jingmin Zhao;Ju-Tao Guo;Fengmin Lu;Xiangmei Chen

作者机构：Department of Microbiology and Infectious Disease CenterSchool of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Department of Pathology and HepatologyThe Ffth Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Experimental TherapeuticsBaruch S.Blumberg InstituteDoylestownPA 18902USA Bejing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseasesPeking University Hepatology InstitutePeking University People's HospitalBeijing 100044China 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2023年第8卷第10期

页      面：4889-4902页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：This work is supported by grants from the National Natural Science Foundation of China(82272315) the Natural Science Foundation of Beijing Municipality(7222108) National Key R&D Program of China(2022YFA1303600) 

主　　题：translate template translation 

摘      要：The pregenomic RNA(pgRNA)of hepatitis B virus(HBV)serves not only as a bicistronic message RNA to translate core protein(Cp)and DNA polymerase(Pol),but also as the template for reverse transcriptional replication of viral DNA upon packaging into *** it is well known that pgRNA translates much more Cp than Pol,the molecular mechanism underlying the regulation of Cp and Pol translation efficiency from pgRNA remains elusive.