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Orexin excites subthalamic nucleus neurons via OX1 and OX2 receptors

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Orexin excites subthalamic nucleus neurons via OX1 and OX2 r...

中国生理学会张锡钧基金会第十三届全国青年优秀生理学学术论文交流及评奖会议、中国生理学会第十一届全国青年生理学工作者学术会议

作者：李光英 Qian-Xing Zhuang Shu-Liang Cao Jing-Ning Zhu Jian-junwang 南京大学 State Key Laboratory of Pharmaceutical Biotechnology and Department of Biological Science and Technology School of Life SciencesNanjing University

The subthalamic nucleus(STN),one of the key structures in the basal ganglia circuit,is a critical target for Parkinson's disease(PD)treatment with deep brain *** the other hand,it has been well known thatorexin,a hypothalamic neuropeptide,markedly decreased in patients with severe PD and there are direct orexinergic projections from the hypothalamus to the ***,little is known

关键词： STN Orexin excites subthalamic nucleus neurons via OX1 and OX2 receptors

Direct Involvement of Orexin in the Vestibular Motor Control and Motion Sickness

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Direct Involvement of Orexin in the Vestibular Motor Control...

中国生理学会张锡钧基金会第十三届全国青年优秀生理学学术论文交流及评奖会议、中国生理学会第十一届全国青年生理学工作者学术会议

作者：张潇洋 Bin LI Shu-Liang Cao Qian-Xing Zhuang Jing-Ning Zhu Jian-junwang 南京大学生命科学学院 State Key Laboratory of Pharmaceutical Biotechnology and Department of Biological Science and Technology School of Life SciencesNanjing University

The deficiency of orexin,a neuropeptide restrictedly synthetized in the hypothalamic,may result in *** the function of the central orexinergicsystem in sleep regulation has been well studied,the role of orexin in motor control is largely *** vestibular nucleus(MVN)is the most important subnucleus in the vestibularnuclear complex in brainstem,which

关键词： Direct Involvement of Orexin in the Vestibular Motor Control and Motion Sickness orexin

Roles of RyRs activated calcium disorder in lead induced cognitive impairment in rats

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Roles of RyRs activated calcium disorder in lead induced cog...

2016中国毒理学会神经毒理专业委员会学术年会

作者： Fankun Zhou Guihua Du junwang Gu Shuyun Zhang Wei Zhang Jie Xie Haizhen liu Yanyan Gao Guangming Yin Dandan Bo Yuanyuan Zhang Chang Feng Guangqin Fan Department of Occupational Health and Toxicology School of Public HealthNanchang University

＜正＞Objective:The calcium ion,as a second messenger,plays a fundamental role in orchestrating dynamic changes in the function and structure of nerve cell circuits in the *** previous and other studies found that lea... 详细信息

关键词： lead calcium disorder RyRs cognitive impairment

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硫精矿磁选浮选联合降砷试验研究

有色金属（选矿部分） 2018年第6期 67-71页

作者：李俊旺曹飞北京矿冶科技集团有限公司矿物加工科学与技术国家重点实验室北京102628 九江学院化学与环境工程学院江西九江332005

内蒙古某铜矿选矿厂生产的硫精矿中砷含量较高,严重影响了硫精矿的品质。经过试验研究,确定采用磁浮联合选矿工艺,通过一次磁选,磁选尾矿一次粗选两次扫选一次精选浮选工艺流程,最终获得了硫品位35. 06%、含砷0. 13%,硫回收率90. 53%的... 详细信息

内蒙古某铜矿选矿厂生产的硫精矿中砷含量较高,严重影响了硫精矿的品质。经过试验研究,确定采用磁浮联合选矿工艺,通过一次磁选,磁选尾矿一次粗选两次扫选一次精选浮选工艺流程,最终获得了硫品位35. 06%、含砷0. 13%,硫回收率90. 53%的硫精矿,对同类矿山解决砷硫分离问题具有一定的参考价值。

关键词：硫精矿砷硫分离磁选浮选联合

The Solar Upper Transition Region Imager(SUTRI)Onboard the SATech-01 Satellite

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Research in Astronomy and Astrophysics 2023年第6期23卷 153-171页

作者： Xianyong Bai Hui Tian Yuanyong Deng Zhanshan Wang Jianfeng Yang Xiaofeng Zhang Yonghe Zhang Runze Qi Nange Wang Yang Gao Jun Yu Chunling He Zhengxiang Shen Lun Shen Song Guo Zhenyong Hou Kaifan Ji Xingzi Bi Wei Duan Xiao Yang Jiaben Lin Ziyao Hu Qian Song Zihao Yang Yajie Chen Weidong Qiao Wei Ge Fu Li Lei Jin Jiawei He Xiaobo Chen Xiaocheng Zhu junwang He Qi Shi liu liu Jinsong Li Dongxiao Xu Rui liu Taijie Li Zhenggong Feng Yamin Wang Chengcheng Fan Shuo liu Sifan Guo Zheng Sun Yuchuan Wu Haiyu Li Qi Yang Yuyang Ye Weichen Gu Jiali Wu Zhe Zhang Yue Yu Zeyi Ye Pengfeng Sheng Yifan Wang Wenbin Li Qiushi Huang Zhong Zhang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 101408China School of Earth and Space Sciences Peking UniversityBeijing 100871China Key Laboratory of Solar Activity and Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China Tongji University Institute of Precision Optical EngineeringSchool of Physics Science and EngineeringKey Laboratory of Advanced Micro-Structured Materials MOEShanghaiChina Xi'an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi'an 710119China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201304China Yunnan Observatories Chinese Academy of SciencesKunming650011China

The Solar Upper Transition Region Imager(SUTRI)onboard the Space Advanced Technology demonstration satellite(SATech-01),which was launched to a Sun-synchronous orbit at a height of~500 km in 2022 July,aims to test the on-orbit performance of our newly developed Sc/Si multi-layer reflecting mirror and the 2k×2k EUV CMOS imaging camera and to take full-disk solar images at the Ne VII 46.5 nm spectral line with a filter width of~3 *** employs a Ritchey-Chrétien optical system with an aperture of 18 *** on-orbit observations show that SUTRI images have a field of view of~416×416 and a moderate spatial resolution of~8″without an image stabilization *** normal cadence of SUTRI images is 30 s and the solar observation time is about16 hr each day because the earth eclipse time accounts for about 1/3 of SATech-01's orbit ***15 GB data is acquired each day and made available online after *** images are valuable as the Ne VII 46.5 nm line is formed at a temperature regime of~0.5 MK in the solar atmosphere,which has rarely been sampled by existing solar *** observations will establish connections between structures in the lower solar atmosphere and corona,and advance our understanding of various types of solar activity such as flares,filament eruptions,coronal jets and coronal mass ejections.

关键词： Sun:transition region Sun:UV radiation Sun:activity space vehicles:instruments

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益胃健脾汤治疗慢性萎缩性胃炎20例

中国中医药现代远程教育 2015年第1期13卷 50-52页

作者：陈俊旺江西省抚州市职工医疗保险门诊部胃镜室抚州344000

目的观察慢性萎缩性胃炎(CAG)患者采取益胃健脾汤治疗的临床效果。方法将我院2012年1月至2014年8月接诊的慢性萎缩性胃炎患者40例作为研究对象,随机均分为研究组与对照组,各20例。对照组采取吗丁啉、乳酶生治疗,而研究组在对照组基础上... 详细信息

目的观察慢性萎缩性胃炎(CAG)患者采取益胃健脾汤治疗的临床效果。方法将我院2012年1月至2014年8月接诊的慢性萎缩性胃炎患者40例作为研究对象,随机均分为研究组与对照组,各20例。对照组采取吗丁啉、乳酶生治疗,而研究组在对照组基础上加用益胃健脾汤治疗。观察记录两组患者临床疗效与不良反应情况,并对比分析。结果两组患者治疗后,研究组总有效率为90.00%(18/20),对照组则为75.00%(15/20),研究组明显优于对照组(P<0.05);研究组发生不良反应2例,发生率为10.00%,而对照组则发生6例,发生率为30.00%,研究组不良反应发生率明显低于对照组(P<0.05)。结论慢性萎缩性胃炎患者采取益胃健脾汤治疗可以取得比较良好的效果,疗效确切,而且不良反应少,安全性高,值得借鉴。

关键词：慢性萎缩性胃炎益胃健脾汤中医药疗法

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基于突变特征的边坡工程失稳判据研究

防灾减灾工程学报 2020年第6期40卷 852-859页

作者：李帅苏永华杜俊旺河南省交通规划设计研究院股份有限公司河南郑州450099 湖南大学土木工程学院湖南长沙410082

边坡系统时刻与外界环境进行着物质、能量和信息的交换,导致其失稳演化过程具有典型的非线性、非连续性特征,这是边坡工程稳定性难以准确评估的重要原因之一。结合非线性突变理论,以势函数为响应变量,破裂区长度为控制变量,构建边坡突... 详细信息

边坡系统时刻与外界环境进行着物质、能量和信息的交换,导致其失稳演化过程具有典型的非线性、非连续性特征,这是边坡工程稳定性难以准确评估的重要原因之一。结合非线性突变理论,以势函数为响应变量,破裂区长度为控制变量,构建边坡突变失稳分析模型,对边坡力学机制及突变模型特征进行分析,获得边坡发生突变失稳时的破裂区临界长度,量化边坡稳定状态判定依据,为边坡的稳定性评估提供一种新的可选路径。实例分析结果表明,基于所述方法得到的结果与实际情况间误差在工程上是可以接受的,验证了方法的可行性。

关键词：边坡稳定性失稳判据结构面突变理论

Conformational changing properties of hLSECtin-CRD after interaction with CD44 by EPRSDSL technology

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Conformational changing properties of hLSECtin-CRD after int...

第五届中国结构生物学学术讨论会

作者： Ke Wu Guofu Dong Changzhen Wang Jianbo Cong junwang Guo Lei Ma Jierui Zou Chenggang Zhang Beijing Institute of Radiation Medicine Beijing Key Laboratory of Radiation Biology No.BZ0325

Electron paramagnetic resonance-site directed spin labeling（EPR-SDSL） technology is nowadays an interested technique for its specific usage in the analysis of conformational changing properties relating to molecular interaction. LSECtin can negatively regulate activated T cell in the immune tolerance in liver. The interaction between LSECtin and CD44 is the molecular basis of the binding between LSECtin and activated T cell. In this work, to explore the molecular mechanism of the interaction between LSECtin and CD44, EPR-SDSL technology was used to detect conformational mobility characteristics of different sites on CRD which is the main functional domains of h LSECtin. As a result, the h LSECtin-CRD domain of single/double Cys mutation protein models were successfully constructed and expressed at the high-yield and soluble expression level by p ET28b-Tat prokaryotic expression vector;Based on EPR spectroscopic detection and analysis, the conformational mobility characteristics of different sites and distance between different sites on h LSECtin-CRD were obtained before and after interactions between CRD and Ca2+, monosaccharide and CD44 respectively. Besides the remarkable rotational movement changing on some site points on CRD, distances changing between site points of fast movement were also present. To confirm the result, stable distance calibration rulers were established within the range of 0.8-1.4nm via synthesizing distance calibration rulers which by the experimental method was set up for distance correction and calibration. The results partially explain some molecular mechanisms of the interaction between LSECtin and *** work also provide a novel method and research basis for studying relationship between structure and functions of C-type lectin molecule.

关键词： EPR-SDSL Molecular interaction LSECtin CD44

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信息系统状态综合监控下的主动式运维研究

福建电脑 2020年第3期36卷 10-14页

作者：张峻旺中石化森美(福建)石油有限公司福州350003

信息技术在企业的应用越来越广,从核心的生产经营业务到日常的管理事务,从办公自动化到事务流程的办理,都可以通过信息系统来开展。离开信息系统,企业的业务开展必然受到制约,甚至无法开展。而保证信息系统的正常运行则成了系统运维部... 详细信息

信息技术在企业的应用越来越广,从核心的生产经营业务到日常的管理事务,从办公自动化到事务流程的办理,都可以通过信息系统来开展。离开信息系统,企业的业务开展必然受到制约,甚至无法开展。而保证信息系统的正常运行则成了系统运维部门的首要任务,快速有效地解决系统问题成为系统运维部门的基本要求。信息系统状态综合监控系统能够保证系统运维部门更好地完成工作,从应急处理的"被动"式运维转为可预见性的"主动"式运维,做到提早发现问题、及时解决问题,保证信息系统正常可靠地运行,为业务的顺利开展提供有力的技术支持。

关键词：信息系统操作系统数据库监控预警