Orexin excites subthalamic nucleus neurons via OX1 and OX2 receptors
作者单位:南京大学 State Key Laboratory of Pharmaceutical Biotechnology and Department of Biological Science and TechnologySchool of Life SciencesNanjing University
会议名称:《中国生理学会张锡钧基金会第十三届全国青年优秀生理学学术论文交流及评奖会议、中国生理学会第十一届全国青年生理学工作者学术会议》
会议日期:2015年
学科分类:0710[理学-生物学] 07[理学] 071006[理学-神经生物学]
基 金:Supported by grants 31171050,31330033,91332124,31471112,31500848,and 31461163001 from the NSFC SRFDP/RGC ERG grant 20130091140003 from the State Educational Ministry of China grant BK2011014 and BK20140599 from JSNSF
关 键 词:STN Orexin excites subthalamic nucleus neurons via OX1 and OX2 receptors
摘 要:The subthalamic nucleus(STN),one of the key structures in the basal ganglia circuit,is a critical target for Parkinson s disease(PD)treatment with deep brain *** the other hand,it has been well known thatorexin,a hypothalamic neuropeptide,markedly decreased in patients with severe PD and there are direct orexinergic projections from the hypothalamus to the ***,little is known