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Blow up for Initial-Boundary Value Problem of Wave Equation with a Nonlinear Memory in 1-D

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Chinese Annals of Mathematics,Series B 2017年第3期38卷 827-838页

作者： Ning-An LAI jianli liu Jinglei ZHAO Department of Mathematics Lishui UniversityLishui 323000ZhejiangChina Department of Mathematics Shanghai UniversityShanghai 200444China College of Education Lishui UniversityLishui 323000ZhejiangChina

The present paper is devoted to studying the initial-boundary value problem of a 1-D wave equation with a nonlinear memory: u_(tt) - u_(xx) = 1/ Γ(1 - γ) ∫_0~t (t - s)^(-γ)|u(s)|~pds. The blow up result will be established when p > 1 and 0 < γ < 1, no matter how small the initial data are, by introducing two test functions and a new functional.

关键词： Blow up Wave equation Nonlinear memory Initial-boundary value problem

GLOBAL SIMPLE WAVE SOLUTIONS TO A KIND OF TWO DIMENSIONAL HYPERBOLIC SYSTEM OF CONSERVATION LAWS

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Acta Mathematica Scientia 2020年第1期40卷 261-271页

作者： jianli liu Jie XUE Department of Mathematics Shanghai UniversityShanghai 200444China

This paper is concerned with the simple waves of a kind of two dimensional hyperbolic system of conservation laws,which can be obtained from the two dimensional relativistic membrane equation in Minkowski *** wave decomposition method,we get that a flow adjacent to a nonconstant state can be a global simple ***,the flow is covered by three families of characteristics,in which the first family of characteristics is straight and the others are curved,which is different to the almost related results.

关键词： global simple wave solutions conservation laws relativistic membrane equation

Technological Breakthrough and Domestic Substitution of Key Products Based on Asymmetric Competition:Taking the Integrated Circuit Industry as an Example

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Frontiers of Business Research in China 2023年第3期17卷 379-406页

作者： liu jianli LI Xianjun Institute of Industrial Economics Chinese Academy of Social SciencesBeijing 100006China

Integrated circuit is a typical key product in the digital economy *** external containment,breakthroughs in core technologies of integrated circuit are confronted with barriers of first movers in underlying technological ecology and with their threats of decoupling from the supply ***,China has various bottlenecks in the proprietary industrial ecosystem,and domestic substitution lacks effective overall ***,it is essential to apply the underlying logic of asymmetric competition and to leverage a relatively complete industrial system,abundant application scenarios,solid talent base,and the institutional advantages of the new system for mobilizing resources nationwide to break through in integrated circuit manufacturing technologyand in domestic *** such,it is necessary to further strengthen the top-level design,leverage the advantages of the new system for mobilizing resources nationwide to enhance the institutiona1lguarantee for domestic substitution of bottlenecks,and enhance basic research to consolidate the technological foundation for domestic ***,we should implement talent strategy to enhanceethe driving force of human resource for domestic substitution *** should also further opening-up and cooperation policy to create an open domestic substitution *** addition,we should increase counter-cyclical investment to nurture leaderssin asymmetric competition,and seize the demand window to drive domestic substitution with"epoch-making products."

关键词： key products technological catch-up domestic substitution asymmetric competition integrated circuit

Copper(Ⅱ) and 1,1 ＇-Trimethylene-2,2＇-biimidazole-promoted Arylation of Acetylacetone with Aryl Iodides

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Chinese Journal of Chemistry 2011年第2期29卷 309-313页

作者： liu jianli Zeng Runsheng Zhou Chunmei Zou Jianping Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Materials Science Suzhou University Suzhou Jiangsu 215123 China

A new and efficient way was developed to carry out the reaction of acetylacetone with aryl iodides under the assistance of Cu（II） and 1, 1＇-trimethylene-2,2＇-biimidazole at 100℃. 3-Aryl-2,4-pentanediones were obt... 详细信息

关键词： Cu(II)-promoted arylation reaction 1 1'-trimethylene-2,2'-biimidazole 3-aryl-2,4-pentanedione

Efficient C-S Cross-Coupling of Thiols with Aryl Iodides Catalyzed by Cu(OAc)_(2)·H_(2)O and 2,2'-Biimidazole

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Chinese Journal of Chemistry 2014年第3期32卷 212-218页

作者： Chenglong Zong jianli liu Shengyan Chen Runsheng Zeng Jianping Zou Key Laboratory of Organic Synthesis of Jiangsu Province College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhouJiangsu 215123China

The classical Ullmann C-S cross coupling reaction of aryl iodides with aromatic/alkyl thiols under catalysis of 15 mol%Cu(OAc)_(2)·H_(2)O and 15 mol%2,2'-biimidazole works at 80℃in DMSO for 3 h to provide a variety ... 详细信息

关键词： C-S cross coupling reaction Cu(OAc)_(2)·H_(2)O,2,2'-biimidazole aryl sulfides

Single-molecule force spectroscopy study of the effect of cigarette carcinogens on thrombomodulin–thrombin interaction

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Science Bulletin 2016年第15期61卷 1187-1194页

作者： jianli liu Xuejie Zhang Xiaofeng Wang Li Xu Jingyuan Li Xiaohong Fang Key Laboratory of Molecular Nanostructure and Nanotechnology Institute of Chemistry Chinese Academy ofSciences Beijing 100190 China Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics Chinese Academyof Sciences Beijing 100049 China

Exposure to cigarette smoke is a major risk factor for cancer and cardiovascular disease. Thrombosis is regarded as the main reason for smoking-related car- diovascular disease. However, the detail mechanism of how smoking promotes thrombosis is not fully under- stood. In this work, we investigated the impacts of one major cigarette carcinogens 4-（methylnitrosamino）-l-（3- pyridyl）-l-butanone （NNK） as well as its metabolite 4-（methylnitrosamino）- 1-（3-pyridyl）- 1-butanol （NNAL） on a key process in thrombosis regulation： thrombin- thrombomodulin （TM） binding. Atomic force microscopy based single-molecule force spectroscopy was applied to measure both in vitro and in vivo binding force of thrombin to TM in the absence and presence of NNK and NNAL respectively. The results revealed that NNK and NNAL can reduce the binding probability of TM and thrombin. The inhibition effect and underlying mechanism was further studied by molecular simulation. As indicated by our results, the cigarette carcinogens could cause a higher risk of thrombosis through the disruption of TM- thrombin interaction.

关键词： Cigarette carcinogens Thrombin Thrombomodulin AFM Single-molecule forcespectroscopy Molecular simulation

Effects of soil metal(loid)s pollution on microbial activities and environmental risks in an abandoned chemical smelting site

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Journal of Environmental Sciences 2024年第9期143卷 60-70页

作者： Hao Li Jun Yao jianli liu Ning Min Geoffrey Sunahara Dongyang Men Robert Duran School of Water Resources and Environment Research Center of Environmental Science and EngineeringChina University of Geosciences(Beijing)Beijing 100083China Department of Natural Resource Sciences McGill University21111Lakeshore DriveSte-Anne-de-BellevueQuebecH9X 3V9Canada Equipe Environnement et Microbiologie MELODY groupUniversitéde Pau et des Pays de l’AdourE2S-UPPAIPREM UMR CNRS 5254BP 115564013 Pau CedexFrance

Abandoned chemical smelting sites containing toxic substances can seriously threaten and pose a risk to the surrounding ecological *** samples were collected from different depths(0 to 13 m)and analyzed for metal(loid)s content and fractionation,as well as microbial *** potential ecological risk indices for the different soil depths(ordered from high to low)were:1 m(D-1)>surface(S-0)>5 m(D-5)>13 m(D-13)>9 m(D-9),ranging between 1840.65-13,089.62,and representing extremely high environmental risks,of which Cd(and probably not arsenic)contributed to the highest environmental risk.A modified combined pollution risk index(MCR)combining total content and mobile proportion of metal(loid)s,and relative toxicities,was used to evaluate the degree of contamination and potential environmental *** the near-surface samples(S-0 and D-1 layers),the MCR considered that As,Cd,Pb,Sb,and Zn achieved high and alarming degrees of contamination,whereas Fe,Mn,and Ti were negligible or low to moderate pollution *** microcalorimetry and enzymatic activity measurements of contaminated soil samples were used to assess the microbial metabolic activity *** analysis elucidated the relationship between metal(loid)s exchangeable fraction or content and microbial activity characteristics(p<0.05).The microbial metabolic activity in the D-1 layer was low presumably due to heavy metal *** activity indicators and microcalorimetric growth rate(k)measurements were considered sensitive indicators to reflect the soil microbial activities in abandoned chemical smelting sites.

关键词： Abandoned chemical smelting sites Microbial activities Modified combined pollution risk Microcalorimetry Enzymatic activities

Gga3 gene-deleted C57BL/6J mice have elevated fasting blood glucose levels

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Genes & Diseases 2023年第6期10卷 2206-2209页

作者： Xiaohong Zhang Song Yue Dongjun Jiang Guoan Zhang jianli liu Xuezhi Li Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong 272013China Shandong Key Laboratory of Behavioral Medicine School of Mental HealthJining Medical UniversityJiningShandong 272013China Department of Pathology Weifang Medical UniversityWeifangShandong 261053China Institute of Forensic Medicine and Laboratory Medicine Jining Medical UniversityForensic Science Center of Jining Medical UniversityJiningShandong 272067China Department of Pathology Affiliated Hospital of Jining Medical UniversityJiningShandong 272000China

Diabetes mellitus(DM)is one of the most common diseases in the elderly,and among DM patients,more than 90%have type 2 DM(T2DM).The etiology of T2DM is complex and associated with risk factors such as age,genetic disposition,and *** genetic factors underlying T2DM are currently the focus of intense research,and it has been established that the susceptibility genes associated with T2DM vary among different populations.A recent longitudinal exome-wide association study in the Japanese population has identified GGA3 as a susceptible locus for T2DM.1 GGA3 is one of the Golgi-localized-ear-containing ARF binding proteins(GGAs)that function widely in the transport of Golgi-derived vesicles and in endocytic trafficking ***,although it is widely acknowledged that the control of glucose homeostasis via endocytosis and glucose metabolism plays a vital role in T2DM,the associations between intracellular trafficking and diabetes pathogenesis have not been sufficiently *** this study,we used a Gga3 gene knockout mouse strain to investigate the potential involvement of GGA3 in controlling blood *** study was approved by the ethics committee of Jining Medical University(No.2019-JS-005).Our results indicate that the GGA3 gene might play a protective role against diabetes.

关键词： metabolism elevated protective

Nanoscale imaging with an integrated system combining stimulated emission depletion microscope and atomic force microscope

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Chinese Science Bulletin 2013年第33期58卷 4045-4050页

作者： YU JianQiang YUAN JingHe ZHANG XueJie liu jianli FANG XiaoHong Beijing National Laboratory for Molecular Sciences Key Laboratory of Molecular Nanostructure and NanotechnologyInstitute of ChemistryChinese Academy of Sciences

We have built an integrated imaging system by combining stimulated emission depletion(STED)microscope and atomic force microscope(AFM).The STED microscope was constructed based on the supercontinuum fiber laser and a super lateral resolution of42 nm was *** this integrated imaging system,morphological features,mechanical parameters and fluorescence super resolution imaging were obtained simultaneously for both nanobeads and fixed cell *** new integrated imaging system is expected to obtain comprehensive information at the nanoscale for studies in nanobiology and nanomedicine.

关键词：原子力显微镜成像系统集成系统受激发射纳米级损耗光纤激光器横向分辨率