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红丝线多糖对大鼠急性肝损伤的保护作用

华西药学杂志 2010年第5期25卷 559-560页

作者：秦树森刘笑甫张可锋桂林市妇女儿童医院广西桂林541001 桂林医学院广西桂林541004

目的研究红丝线多糖对大鼠急性肝损伤的保护作用。方法采用CCl4诱导大鼠急性肝损伤模型,观察红丝线多糖对大鼠血清中丙氨酸氨基转换酶(ALT)、天门冬氨酸氨基转换酶(AST)、丙二醛(MDA)、超氧化物歧化酶(SOD)水平的影响。结果红丝线多糖... 详细信息

目的研究红丝线多糖对大鼠急性肝损伤的保护作用。方法采用CCl4诱导大鼠急性肝损伤模型,观察红丝线多糖对大鼠血清中丙氨酸氨基转换酶(ALT)、天门冬氨酸氨基转换酶(AST)、丙二醛(MDA)、超氧化物歧化酶(SOD)水平的影响。结果红丝线多糖各剂量组可抑制急性肝损伤大鼠血清中ALT、AST的活性,降低MDA的水平,升高SOD的活性。结论红丝线多糖对CCl4致大鼠急性肝损伤具有较好的保护作用。

关键词：红丝线多糖保肝作用急性肝损伤

Effects of recombinant human brain natriuretic peptide on the heart rate variability in patients with heart failure

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Effects of recombinant human brain natriuretic peptide on th...

不同浓度钙离子对人腹膜间皮细胞E－钙黏蛋白、成纤维细胞特异蛋白、波形蛋白表达的影响

第13届中国南方国际心血管病学术会议

作者： LUO Yuan-yuan SUN Shao-xi LI Heng LI Yan liu fu-qiang MENG Su-rong XU Ding-li PENG Jian (Department of Cardiology Nanfang Hospital Guangzhou 501515 China)

＜正＞Objectives To explore effects of recombinant human brain natriuretic peptide（rhBNP） on circadian heart rate variability（HRV） in patients with acute decompensated heart failure（ADHF）.Methods 60 ADHF patients were randomly divided into rhBNP group and the control group.30 patients in control group received standard heart failure therapy, while the 30 patients in rhBNP group were treated with standard heart failure therapy and intravenous injection of *** intravenous injection of rhBNP was performed as intravenous bolus with 1.5μg per kilogram of body weight initially,followed by an infusion at 0.0075μg per kilogram of body weight per minute for 24 *** heart rate power spectral density and time-domain were analyzed with 24 hour DCG for all the patients before and after the treatment in both *** After treatment,standard of all means of 5-minutes R-R intervals all over 24 hours（SDANN）,root mean square of successive R-R differences（rMSSD）,percentage of adjacent differences more than apart（PNN50）, low frequence（LF）,and high frequency（HF） of the patients in rhBNP group were significantly higher than those in control *** RhBNP combined with routine treatment of heart failure can improve cardiac function and HRV in heart failure patients significantly so as to improve the balance of autonomic nervous system and the prognosis.

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肾脏病与透析肾移植杂志 2011年第1期20卷 29-33页

作者：彭翔刘伏友孙林李瑛肖力李军清远市人民医院肾内科清远511515 中南大学湘雅二院肾内科中南大学肾病研究所

目的:观察钙浓度变化对人腹膜间皮细胞上皮细胞-间充质细胞转分化的影响,探讨腹膜透析中腹膜纤维化的可能机制。方法:以人腹膜间皮细胞永生化细胞株(HMrSV5)为研究对象,予不同浓度钙(0.25、0.75、1.25、1.75、2.25mmol/L)处理细胞48h,... 详细信息

目的:观察钙浓度变化对人腹膜间皮细胞上皮细胞-间充质细胞转分化的影响,探讨腹膜透析中腹膜纤维化的可能机制。方法:以人腹膜间皮细胞永生化细胞株(HMrSV5)为研究对象,予不同浓度钙(0.25、0.75、1.25、1.75、2.25mmol/L)处理细胞48h,以不含钙处理组为对照。采用蛋白免疫印迹和间接免疫荧光染色方法检测E-钙黏蛋白(E-cadherin)、成纤维细胞特异蛋白(fibroblast specific protein,FSP1)和波形蛋白(Vimentin)的表达。结果:不含钙组HMrSV5细胞基本不表达E-cadherin,极低水平表达Vimentin和FSP1;而予含不同浓度钙离子处理48h后,HMrSV5中E-cadherin先呈剂量依赖性上调,1.25mmol/L组至顶峰,再呈剂量依赖性下降;而Vimentin和FSP1均在1.75mmol/L组HMrSV5中明显升高(P<0.05)并呈剂量依赖性上调。间接免疫荧光染色结果也显示,高钙组Vimentin和FSP1荧光强度比低钙组显著增强。结论:钙离子浓度的变化能诱导人腹膜间皮细胞E-cadherin、FSP1、Vimentin蛋白表达发生变化,提示钙离子可能是参与调控间皮细胞间充质转分化的一个重要因素。

关键词：人腹膜间皮细胞上皮细胞-间充质转分化钙腹膜透析

Construction of Nucleic Acid Vaccine: Canine Infectious Hepatitis Adenovirus Type 1

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Construction of Nucleic Acid Vaccine: Canine Infectious Hepa...

2005全国第二届核酸疫苗研讨会

作者： WANG Jun-Xia SONG Shu-Xia Song liu fu-Ying ZHENG Long SUN Shu-Han (Department of geneticse Medical,Second Military Medical University, Xiang-yin Road 800,Shanghai, China)

Canine Infectious Hepatitis (CIH) is an acute viral infection with high mortality rate in puppy. CIH is a member of adenovirus family and transmits by suffering canine. CM virus contains a single strand DNA. By now, there is a kind of inactivated virus vaccine that is costly and lack of long-term immunity protection, and requirement of multiple dose. In recent years, plasmid DNA vaccines have attracted much attention for their ability to induce both humoral and cellar immune responses. There are likely to be inexpensive and easy to produce and provide an alternative to inactivated or virus vector subunit vaccine. Directed injection of the plasmid DNA in vivo results in the synthesis of viral proteins in host cells and may thus mimic the action of attenuated *** the present study, a plasmid vector expressing CIH Loop1 and Loop2 protein was constructed. Canine adenovirus DNA was isolated and purified from the cultured BHK cells. The loop1 and loop2 fragments were amplified by polymerase chain reaction (PCR) method. Then the PCR product was digested with restriction enzyme Smal I for 10h. After digestion, the loopl and loop2 linked with T4 ligase. The gene fragment of DNA (loop1-loop2) was obtained by second PCR. It was cloned into pVAX1 plasmid that the CpG have been inserted. Finally, canine hepatitic DNA vaccine was constructed successfully.

关键词： canine hepatitis adenovirus type 1 nucleic acid vaccine

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喷射成形高铝锌合金热处理工艺的研究

热加工工艺 2007年第4期36卷 49-51页

作者：吴德枫刘敬福李荣德辽宁工程技术大学材料科学与工程系辽宁阜新123000 沈阳工业大学材料科学与工程学院辽宁沈阳110023

利用喷射成形与挤压工艺相结合的办法制备高铝锌合金,设计了正交试验方案,研究了固溶温度、固溶时间、时效温度、时效时间等工艺参数对高铝锌合金的抗拉强度、硬度、伸长率的影响,确定出最佳的热处理制度。结果表明,在此种工艺下制备的... 详细信息

利用喷射成形与挤压工艺相结合的办法制备高铝锌合金,设计了正交试验方案,研究了固溶温度、固溶时间、时效温度、时效时间等工艺参数对高铝锌合金的抗拉强度、硬度、伸长率的影响,确定出最佳的热处理制度。结果表明,在此种工艺下制备的合金较传统铸造的合金具有更优异的性能。

关键词：喷射成形挤压热处理工艺

Oxidation behavior of 4774DD1 Ni-based single-crystal superalloy at 980℃ in air

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China Foundry 2024年第2期21卷 116-124页

作者： Yu Fang Ya-zhou Li Qiang Yang Qun-gong He Xiu-fang Gong Qian Duan Hai-yang Song fu Wang Qiong-yuan Zhang Hong Zeng State Key Laboratory of Long-Life High Temperature Materials Dongfang Turbine Co.Ltd.Deyang 618000SichuanChina State Key Laboratory for Manufacturing System Engineering School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710049China

The oxidation behavior of a novel Ni-based single-crystal 4774DD1 superalloy for industrial gas turbine applications was investigated by the isothermal oxidation at 980℃ and discontinuous oxidation weight gain *** phase constitution and morphology of surface oxides and the characteristics of the crosssection oxide film were analyzed by XRD,SEM and *** show that the oxidation kinetics of the 4774DD1 superalloy follows the cubic law,indicating its weak oxidation resistance at this *** the oxidation time increases,the composition of the oxide film evolves as following:One layer consisting of a bottom Al_(2)O_(3)sublayer and an upper(Al_(2)O_(3)+NiO)mixture sublayer after oxidized for 25 ***,two layers composed of an outermost small NiO discontinuous grain layer and an internal layer for 75 *** internal layer is consisted of the bottom Al_(2)O_(3)sublayer,an intermediate narrow CrTaO_(4)sublayer,and an upper(Al_(2)O_(3)+NiO)mixture *** two layers comprising an outermost relative continuous NiO layer with large grain size and an internal layer as the oxidation time increases to 125 *** internal layer is composed of the upper(Al_(2)O_(3)+NiO)mixture sublayer,an intermediate continuous(CrTaO_(4)+NiWO_(4))mixture sublayer,and a bottom Al_(2)O_(3)***,three layers consisting of an outermost(NiAl2O_(4)+NiCr2O_(4))mixture layer,an intermediate(CrTaO_(4)+NiWO_(4))mixture layer,and a bottom Al_(2)O_(3)layer for 200 h.

关键词： nickel-base single crystal superalloy oxidation kinetics oxide film microstructure mechanism

推割刀经皮微创松解术治疗狭窄性腱鞘炎的临床研究

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北京中医药大学学报 2018年第3期41卷 259-264页

作者：于长禾罗涛刘长信赵宇捷田贵华王锡友刘景王福北京中医药大学东直门医院推拿疼痛科北京100700

目的验证推割刀经皮微创松解术治疗狭窄性腱鞘炎的有效性及安全性。方法选择符合纳入标准的狭窄性腱鞘炎患者,根据随机数字表及随机隐藏将患者1∶1分配到推割刀组和针刀组。推割刀组采用推割刀疗法,针刀组采用传统针刀疗法,各组治疗1次... 详细信息

目的验证推割刀经皮微创松解术治疗狭窄性腱鞘炎的有效性及安全性。方法选择符合纳入标准的狭窄性腱鞘炎患者,根据随机数字表及随机隐藏将患者1∶1分配到推割刀组和针刀组。推割刀组采用推割刀疗法,针刀组采用传统针刀疗法,各组治疗1次。主要结局指标为治疗后第27周的治愈率,次要结局指标包括患指关节疼痛评分、患指关节活动度及扳机指征。安全性指标包括治疗并发症及不良事件。结果纳入120人,针刀组1例患者由于病情较重自行退出,共119例患者完成研究并纳入主要结局指标的统计分析。治疗后第27周推割刀组治愈55例(91.67%),针刀组治愈39例(66.10%),差异有统计学意义(P<0.001)。治疗后,2组扳机指征、疼痛、关节活动度均明显改善,而且随着时间进展,改善程度越大,差异有统计学意义(P<0.05)。在第1、3、6、12、27周时间点的组间比较显示,推割刀组改善扳机指征、疼痛、关节活动度等方面均优于针刀组,差异有统计学意义(P<0.05)。2组均无不良事件或并发症发生。结论推割刀治疗狭窄性腱鞘炎的一次性治愈率较高,且疼痛、关节活动度、扳机指征等体征治疗后即刻缓解,治疗后半年内持续改善,无不良事件发生。

关键词：推割刀针刀经皮微创松解术狭窄性腱鞘炎弹响指扳机指

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ITS中基于视频的交通异常情况检测

计算机工程与应用 2006年第36期42卷 212-215页

作者：方晓莹黄林伟刘富强浙江国际海运职业技术学院浙江省舟山市城乡建设委员会浙江舟山316000 同济大学信息与通信工程系上海200092

交通异常情况检测一直是交通管理中的重要任务,其在智能交通系统中显得尤为重要。传统的检测方法存在许多不足,不能满足视频监控的需要。一种基于视频图像处理的异常情况检测算法,在对视频图像进行非线性校正后,通过基本的图像处理获得... 详细信息

交通异常情况检测一直是交通管理中的重要任务,其在智能交通系统中显得尤为重要。传统的检测方法存在许多不足,不能满足视频监控的需要。一种基于视频图像处理的异常情况检测算法,在对视频图像进行非线性校正后,通过基本的图像处理获得较准确的交通信息,对各时刻的交通状态进行判断并可对下一阶段的状态进行预测。实验结果表明该算法具有较强的有效性和在ITS中有较好的应用。

关键词：交通异常非线性形变最小二乘法指数平滑法

New insights into the deposition of natural gas hydrate on pipeline surfaces:A molecular dynamics simulation study

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Petroleum Science 2024年第1期21卷 694-704页

作者： Jun Zhang Hai-Qiang fu Mu-Zhi Guo Zhao Wang Li-Wen Li Qi Yin You-Guo Yan Wei Wei Wei-Feng Han Jie Zhong School of Materials Science and Engineering China University of Petroleum(East China)Qingdao 266580ShandongChina School of Petroleum Engineering China University of Petroleum(East China)Qingdao 266580ShandongChina Department of Alternative Energy PetroChina Research Institute of Petroleum Exploration&DevelopmentLangfang 065007HebeiChina

Natural gas hydrate(NGH)can cause pipeline blockages during the transportation of oil and gas under high pressures and low *** hydrate adhesion on pipelines is viewed as an efficient way to prevent NGH *** studies suggested the water film can greatly increase hydrate adhesion in gas-dominant ***,by performing the molecular dynamics simulations,we find in water-dominant system,the water film plays different roles in hydrate deposition on Fe and its corrosion ***,due to the strong affinity of water on Fe surface,the deposited hydrate cannot convert the adsorbed water into hydrate,thus,a water film *** water affinities decrease(Fe>Fe_(2)O_(3)>FeO>Fe_(3)O_(4)),adsorbed water would convert to amorphous hydrate on Fe_(2)O_(3)and form the ordered hydrate on FeO and Fe_(3)O_(4)after hydrate *** absorbed water film converts to amorphous or to hydrate,the adhesion strength of hydrate continuously increases(Fe

关键词： Deposition Natural gas hydrate Pipelines Water affinity Adhesion strength