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Prognostic significance of a combined and controlled nutritional status score and EBV-DNA in patients with advanced nasopharyngeal carcinoma:a long-term follow-up study

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Cancer Biology & Medicine 2022年第4期19卷 551-564页

作者： Hui Lu Shanshan Guo liting liu Qiuyan Chen Yujing Liang Sailan liu Xuesong Sun QingnanTang Xiaoyun Li Ling Guo Haoyuan Mo Linquan Tang Haiqiang Mai State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhou 510060China Department of Radiation Oncology Guangzhou Concord Cancer CenterGuangzhou 510045China Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer CenterGuangzhou 510060China

Objective:Several studies have reported that the controlling nutritional status(CONUT)score is a prognostic predictor for survival among patients with different types of *** assessed the prognostic value of changes in the CONUT score during treatment and theΔCONUT-EBV DNA score in patients with advanced nasopharyngeal carcinoma(NPC).Methods:We retrospectively analyzed 433 patients with advanced NPC having no evidence of metastasis from January 2007 to June 2011;the patients underwent radical concurrent chemoradiotherapy(CCRT)at Sun Yat-sen University Cancer Center and were grouped based on theirΔCONUT andΔCONUT-EBV DNA ***-Meier curves were used to compare the patient outcomes according to the cut-offΔCONUT score and theΔCONUT-EBV DNA scoring ***:Among all patients,overall survival(OS)was independently predicted by a highΔCONUT score(P=0.031)and high EBV DNA(P<0.001).TheΔCONUT-EBV DNA score[OS area under the curve(AUC)=0.621;progression free survival(PFS)-AUC=0.612;distant metastasis-free survival(DMFS)-AUC=0.622]was more predictive of OS,PFS,and DMFS in patients with advanced NPC than theΔCONUT score(OS-AUC=0.547;PFS-AUC=0.533;DMFS-AUC=0.522)and pretreatment plasma EBV DNA levels alone(OS-AUC=0.600;PFS-AUC=0.591,DMFS-AUC=0.610).TheΔCONUT-EBV DNA score was significantly correlated with OS,PFS,and DMFS in patients with advanced NPC treated with ***:TheΔCONUT-EBV DNA score may be useful in clinical practice as a convenient biomarker for predicting the outcomes in patients with advanced NPC treated with CCRT.

关键词： Controlling nutritional status score Epstein-Barr virus deoxyribonucleic acid nasopharyngeal carcinoma prognosis predictive factor

Establishment of a prognostic scoring model for regional recurrent nasopharyngeal carcinoma after neck dissection

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Cancer Biology & Medicine 2020年第1期17卷 227-236页

作者： Xiaoyun Li Chao Lin Jinjie Yan Qiuyan Chen Xuesong Sun Sailan liu Shanshan Guo liting liu Haojun Xie Qingnan Tang Yujing Liang Ling Guo Hao Li Xuekui liu Xiang Guo Linquan Tang Haiqiang Mai State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhou 510060China Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer CenterGuangzhou 510060China Department of Head and Neck Surgery Sun Yat-sen University Cancer CenterGuangzhou 510060China

Objective:The main aim of this study was to establish a scoring model to predict risk of progression and survival in patients with regionally recurrent nasopharyngeal carcinoma(NPC).Methods:Three hundred and forty-eight patients subjected to neck dissection from 2003 to 2017 were included for *** information for each patient was *** prognostic factors were selected using the Cox proportional hazards model and incorporated into the scoring *** index(C-index)and calibration curves were used to verify discrimination and calibration,respectively and the results validated using bootstrap ***:Microscopic positive lymph node>2[hazard ratio(HR),2.19;95%confidence interval(CI),1.30–3.68;P=0.003],extranodal extension(HR,2.75;95%CI,1.69–4.47;P<0.001),and lower neck involvement(HR,1.78;95%CI,1.04–3.04;P=0.034)were identified from multivariate analysis as independent factors for overall survival(OS).A qualitative 4-point scale was generated to stratify patients into 4 risk groups for predicting OS and progression-free survival(PFS).The novel scoring model demonstrated enhanced discrimination(C-index=0.69;95%CI,0.62–0.76)relative to the original recurrent tumor-node-metastasis(rTNM)staging system(C-index=0.56;95%CI,0.50–0.62),and was internally validated with a bootstrap-adjusted C-index of *** calibration curve showed good agreement between predicted probabilities and actual ***:The scoring system established in this study based on a large regionally recurrent NPC cohort fills a gap regarding assessment of risk and prediction of survival outcomes after neck dissection in this population and could be further applied to identify high-risk patients who may benefit from more aggressive intervention.

关键词： Nasopharyngeal carcinoma recurrence lymphatic metastasis operation prognosis

NLRP3-dependent pyroptosis is required for HIV-1 gp120- induced neuropathology

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Cellular & Molecular Immunology 2020年第3期17卷 283-299页

作者： Xiaolong He Weijun Yang Zhijie Zeng Yi Wei Jie Gao Bao Zhang Li Li Liqun liu Yu Wan Qing Zeng Zelong Gong liting liu Hanyun Zhang Yubin Li Shaojie Yang Tongtong Hu Lixian Wu Eliezer Masliah Shenghe Huang Hong Cao Department of Microbiology Guangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public HealthSouthern Medical UniversityGuangzhou 510515China Kunming Key Laboratory of Children Infection and Immunity Yunnan Institute of PediatricsKunming Children’s HospitalKunmingYunnan 650228China Department of Pediatrics The Second Xiangya HospitalCentral South UniversityChangsha 410011China Department of Medical Microbiology and Immunology Dali UniversityDali 671000China Division of Neurosciences National Institute on AgingNational Institutes of HealthBethesdaMD 20892USA Departments of Neuroscience and Pathology University of CaliforniaSan DiegoLa JollaCA 92093USA Saban Research Institute Children’s Hospital Los AngelesUniversity of Southern CaliforniaLos AngelesCA 90027USA

The human immunodeficiency virus-1(HIV-1)envelope protein gp120 is the major contributor to the pathogenesis of HIVassociated neurocognitive disorder(HAND).Neuroinflammation plays a pivotal role in gp120-induced neuropathology,but how gp120 triggers neuroinflammatory processes and subsequent neuronal death remains ***,we provide evidence that NLRP3 is required for gp120-induced neuroinflammation and *** results showed that gp120-induced NLRP3-dependent pyroptosis and IL-1βproduction in *** of microglial NLRP3 inflammasome activation alleviated gp120-mediated neuroinflammatory factor release and neuronal ***,we showed that chronic administration of MCC950,a novel selective NLRP3 inhibitor,to gp120 transgenic mice not only attenuated neuroinflammation and neuronal death but also promoted neuronal regeneration and restored the impaired neurocognitive *** conclusion,our data revealed that the NLRP3 inflammasome is important for gp120-induced neuroinflammation and neuropathology and suggest that NLRP3 is a potential novel target for the treatment of HAND.

关键词： NLRP3 inflammasome HIV-1 gp120 HIV-associated neurocognitive disorder Neuroinflammation Neuropathology

A homozygous frameshift mutation in ADAD2 causes male infertility with spermatogenic impairments

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Journal of Genetics and Genomics 2023年第4期50卷 284-288页

作者： Shixiong Tian Ziqi Wang liting liu Yiling Zhou Yue Lv Dongdong Tang Jiaxiong Wang Jing Jiang Huan Wu Shuyan Tang Guanxiong Wang Hao Geng Fangbiao Tao Hongbin liu Xiaojin He Feng Zhang Jinsong Li Li Jin Tao Huang Chunyu liu Yunxia Cao Institute of Metabolism and Integrative Biology State Key Laboratory of Genetic EngineeringHuman Phenome InstituteObstetrics and Gynecology HospitalFudan UniversityShanghai 200011China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Institute of Reproduction and DevelopmentFudan UniversityShanghai 200011China Center for Reproductive Medicine Shandong UniversityJinanShandong 250012China Key Laboratory of Reproductive Endocrinology of Ministry of Education Shandong UniversityJinanShandong 250012China Reproductive Medicine Center Department of Obstetrics and GynecologyThe First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract(Anhui Medical University) HefeiAnhui 230032China Shandong Key Laboratory of Reproductive Medicine Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandong250012China Key Laboratory of Population Health Across Life Cycle(Anhui Medical University) Ministry of Education of the People's Republic of ChinaHefeiAnhui 230032China Center for Reproduction and Genetics State Key Laboratory of Reproductive MedicineThe Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalSuzhouJiangsu 215002China Genome Tagging Project(GTP)Center Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China Reproductive Medicine Center Department of Obstetrics and GynecologyThe First Affliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China

Male infertility is a complex reproductive disorder that impedes a huge number of couples from having children naturally in the world(Agarwal et al.,2021).As an important pathogenic factor of male infertility,spermatogenic impairments are mainly characterized by impaired male gamete production,reduced sperm quality,or function(Tournaye et al.,2017).Spermatogenesis is a delicate and complex biological process that requires the collaboration of a large number of proteins performing different biological functions(liu et al.,2021).

关键词： impaired impairment infertility

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恐惧和愤怒对认知控制的影响

心理学探新 2016年第1期36卷 31-35页

作者：刘丽婷浙江大学心理与行为科学系杭州310028

目的:探讨愤怒和恐惧对认知控制的影响。方法:采用3(情绪条件:平静、愤怒和恐惧)×2(任务类型:任务重复和任务转换)两因素被试内设计,使用自传体回忆的方法诱发目标情绪,然后要求被试依次完成任务转换作业、情绪自评报告和分心任务。结... 详细信息

目的:探讨愤怒和恐惧对认知控制的影响。方法:采用3(情绪条件:平静、愤怒和恐惧)×2(任务类型:任务重复和任务转换)两因素被试内设计,使用自传体回忆的方法诱发目标情绪,然后要求被试依次完成任务转换作业、情绪自评报告和分心任务。结果:(1)在任务转换试次,在恐惧和愤怒情绪条件下的反应时显著慢于平静情绪条件下的;(2)在任务重复试次,三种情绪条件下的反应时没有显著差异;(3)愤怒和恐惧条件下的反应时转换代价显著高于平静情绪条件下的。实验结果支持情绪的动机维度模型。

关键词：消极情绪恐惧愤怒认知控制任务转换

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基于二维半导体的垂直晶体管

科学通报 2023年第22期68卷 2901-2910页

作者：乐志凯刘潇李运鑫刘丽婷刘渊湖南大学物理与微电子科学学院长沙410082

二维半导体具有原子级薄的体厚度和表面无悬挂键的特点,是实现下一代晶体管微缩的重要候选材料之一.超短沟道的二维水平结构晶体管已通过多种方法成功制备,但通常需要复杂的设备和高精度的制造工艺,并且难以微缩至亚10 nm或亚5 nm的沟... 详细信息

二维半导体具有原子级薄的体厚度和表面无悬挂键的特点,是实现下一代晶体管微缩的重要候选材料之一.超短沟道的二维水平结构晶体管已通过多种方法成功制备,但通常需要复杂的设备和高精度的制造工艺,并且难以微缩至亚10 nm或亚5 nm的沟道长度.垂直晶体管是一种电流自上而下输运的新型器件结构,其中器件的栅极长度或者沟道长度取决于半导体的厚度而非光刻精度.因此,二维半导体在垂直晶体管中展现出了独特的应用前景.本文综述了基于二维半导体构建垂直晶体管的进展,包括二维垂直晶体管的基本结构、工作机制与器件性能等.

关键词：二维半导体垂直晶体管器件结构器件性能

中国护士职业倦怠心理社会影响因素的Meta分析

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中国实用护理杂志 2014年第8期30卷 58-61页

作者：刘丽婷浙江大学心理与行为科学系杭州310028

目的深入了解护士职业倦怠的心理社会影响因素.方法在中国期刊全文数据库、维普数据库、万方数据库等在线检索相关文献资料,使用统一的纳入和剔除标准对收集到的有关护士职业倦怠心理社会影响因素的文献进行筛选,使用CMA2.0对纳入的5... 详细信息

目的深入了解护士职业倦怠的心理社会影响因素.方法在中国期刊全文数据库、维普数据库、万方数据库等在线检索相关文献资料,使用统一的纳入和剔除标准对收集到的有关护士职业倦怠心理社会影响因素的文献进行筛选,使用CMA2.0对纳入的50篇文献进行Meta分析.结果（1）对于情绪衰竭和人格解体,消极应对具有中等正向影响;神经质和工作压力分别具有较高和中等的正向影响;积极应对、自我效能感、内外向及社会支持3个因子都具有低的负向影响;精神质、掩饰性对人格解体分别具有中等正向和负向影响.（2）对于个人成就感,自我效能感有较高的正向影响;积极应对、掩饰性和主观支持都具有中等正向影响;神经质、精神质和工作压力都具有低的负向影响;内外向、客观支持和支持利用度具有低的正向影响;消极应对相关不稳定.（3）自尊与职业倦怠3个因子的关系都不密切.结论职业倦怠是心理社会多方面因素共同作用的结果,包括应对方式、自我效能、人格特质、社会支持和工作压力等.

关键词：职业倦怠护士心理社会因素 Meta分析

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自尊和同伴压力对关联性错误记忆的影响

心理学探新 2013年第3期33卷 220-224页

作者：刘丽婷浙江大学心理与行为科学系杭州310028

目的:探索不同自尊水平的初中生在无同伴压力或有同伴压力下完成记忆任务时,产生的关联性错误记忆情况。方法:使用自尊量表(SES)从78名中学生中挑出高自尊和低自尊学生42人,采用错误记忆研究的DRM范式,探讨自尊、同伴压力对关联性错误... 详细信息

目的:探索不同自尊水平的初中生在无同伴压力或有同伴压力下完成记忆任务时,产生的关联性错误记忆情况。方法:使用自尊量表(SES)从78名中学生中挑出高自尊和低自尊学生42人,采用错误记忆研究的DRM范式,探讨自尊、同伴压力对关联性错误记忆的影响。结论:(1)关键诱饵的错误再认率高于有关项目和无关项目,有关项目的错误再认率高于无关项目;(2)自尊和同伴压力对关联性错误记忆会产生影响,高自尊和低自尊被试在有无同伴压力条件下对三种未学习词的错误再认率有所不同;在有同伴压力条件下,三种未学习词的错误再认率在高自尊被试和低自尊被试间都不存在显著差异,产生了记忆一致性效应。

关键词：关联性错误记忆 DRM范式自尊同伴压力

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支气管肺发育不良诊断及治疗中几个关注问题

临床儿科杂志 2022年第6期40卷 413-419页

作者：李芳刘立婷重庆医科大学附属儿童医院新生儿科国家儿童健康与疾病临床医学研究中心儿童发育疾病研究教育部重点实验室儿科学重庆市重点实验室重庆400014

支气管肺发育不良(BPD)是早产儿尤其是极低出生体质量儿和超低出生体质量儿中最常见的慢性肺部疾病,严重影响患儿的生存和生活质量。目前,BPD发病率仍居高不下。随着对BPD认识的深入,BPD的诊断标准不断修正,治疗方法不断改进和完善,但BP... 详细信息

支气管肺发育不良(BPD)是早产儿尤其是极低出生体质量儿和超低出生体质量儿中最常见的慢性肺部疾病,严重影响患儿的生存和生活质量。目前,BPD发病率仍居高不下。随着对BPD认识的深入,BPD的诊断标准不断修正,治疗方法不断改进和完善,但BPD诊断标准的选择、治疗中的呼吸支持模式的选择和糖皮质激素的使用仍是临床医师存在困惑和关注的问题。本文在回顾了不同时期的BPD的诊断标准,比较它们各自的优点和不足,并针对BPD患儿的呼吸支持管理及糖皮质激素防治BPD中的关注问题进行讨论和展望。

关键词：支气管肺发育不良诊断标准呼吸支持糖皮质激素