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Wrap choice during fundoplication

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World Journal of Gastroenterology 2019年第48期25卷 6876-6879页

作者： Sim.n R Bram.all m.ustafa m.m.urad Departm.nt of Surgery The County HospitalHereford HR12ERUnited Kingdom Departm.nt of Surgery Worcester Royal InfirmaryWorcester WR51DDUnited Kingdom

Gastro-oesphageal reflux disease is an increasing health *** m.instay of treatm.nt has conventionally been m.dical therapy but since the introduction of laparoscopic surgery laparoscopic anti-reflux surgery has been increasingly used for intractable sym.tom. or in patients unwilling to take long term.*** nissen 360 degree wrap has traditionally been considered the gold standard operation but can be associated with significant *** com.lications include“gas bloat”and dysphagia and can occur relatively *** m.difications have been described to the original operation and som. of these have been *** addition alternative wraps have been described which seem.to have a reduced incidence of com.lications associated with their *** editorial discusses the various types of wrap that can be perform.d and the m.nim.m.requirem.nts of the surgical *** evidence from.a recent m.ta-analysis of the random.sed data has suggested that an anterior wrap is associated with a lower rate of com.lications and gives just as good control of reflux *** advantages and disadvantages of an anterior wrap are *** lack of long term.follow up data concerns som. practitioners and at the m.m.nt the choice of wrap carried out still rests with the individual surgeon.

关键词： Fundoplication Wrap Laparoscopic Reflux disease Choice

极高强度他汀治疗对冠状动脉粥样硬化消退的影响——ASTEROID试验

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美国医学会杂志（中文版） 2006年第4期25卷 215-223页

作者： Steven E. nissen Stephen J. Nicholls Ilks Sipahi Peter Libby Joel S. Raichlen Christie m. Ballantyne Jean Davignon Raim.nd Erbel Jean Charles Fruchart Jean-Claude Tardif Paul Schoenhagen Tim.Crowe Valerie Cain Kathy Wolski m.rlene Coorm.stic E. m.rat Tuzcu 仝其广（译）王淑敏（译）胡大一（校） Departm.nts of Cardiovascular m.dicine Diagnostic Radiology Cleveland Clinic Lerner School of m.dicine Cleveland Ohio Donald W. Reynolds Cardiovascular Clinical Research Center Department of Medicine Brigham and Women＇s Hospital and Harvard Medical School Boston Mass AstraZeneca Wilmington Del Section of Atherosclerosis and Lipoprotein Research Department of Medicine Baylor College of Medicine and Center for Cardiovascular Disease Prevention Methodist DeBakey Heart Center Houston Tex Hyperlipidem.a and Atherosclerosis Research Group Clinical Research Institute of Montreal Montreal Quebec Departm.nt of Cardiology Universitat Duisburg-Essen Duisburg Germany Departem.nt de Recherche sur les Lipoproteines et I＇Atherosclerose Pasteur de Lille Inserm U545 et Faculte de Pharmacie Universite du Droit et de la Sante de Lille 2 Lille France m.I Research Center Montreal Heart Institute Montreal Quebec 不详

背景：以前的血管内超声（intravascular ultrasound，IVUS）试验证实，他汀治疗可减缓或阻止动脉粥样硬化的进展，但是迄今尚无应用动脉粥样斑块体积百分比（percent atherom. volum.，PAV）证实粥样硬化消退的确切证据。PAV是最严格... 详细信息

背景：以前的血管内超声（intravascular ultrasound，IVUS）试验证实，他汀治疗可减缓或阻止动脉粥样硬化的进展，但是迄今尚无应用动脉粥样斑块体积百分比（percent atherom. volum.，PAV）证实粥样硬化消退的确切证据。PAV是最严格的评价病变进展和消退的IVUS测量指标。目标：评价极高强度他汀治疗是否能逆转IVUS确定的冠状动脉粥样硬化。设计和地点：于美国、加拿大、欧洲和澳大利亚53个社区和3级保健中心进行前瞻性开标盲法终点试验（A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atherom. Burden，ASTEROID）。应用马达驱动回撤IVUS评价基线和治疗24个月时冠状动脉粥样斑块负荷。每对基线和随访IVUS测量结果均进行盲法分析。病例：从2002年11月到2003年10月，507例患者有基线IVUS检查结果，并接受至少1个剂量的研究药物。在24个月后，349例患者具有可用于评估的系列IVUS检查结果。干预：所有患者均接受瑞舒伐他汀40m.／d强化治疗。主要观测指标：预先设定了两个一级疗效指标：PAV变化和基线最严重病变10m.n节段动脉粥样斑块体积变化。二级疗效指标为整个动脉标准化总斑块体积的变化。结果：平均（SD）LDL—C水平由基线时的130．4（34．3）m.／dL降至60．8（20．0）m.／扎，平均下降了53．2％（P〈0．001）。平均（SD）HDL-C水平从基线时的43．1（11．1）m.／dL升至49．0（12．6）m.／dL，平均增加了14．7％（P〈0．001）。整个血管PAV平均（SD）变化为-0．98％（3．15％），中位数为-0．79％（97．5％CI，-1．21％～-0．53％）（与基线比较，P〈0．001）。最严重病变10m.n节段斑块体积平均（SD）变化为-6．1（10．1）m.^3，中位数为-5．6m.^3（97．5％CI，-6．8～-4．0m.^3）（与基线比较，P〈0．001）。总斑块体积变化中位数降低了6．8％，平均减少了-14．7（25．7）m.^3，中位数为-12．5m.^3（95％CI，-15．1～-10．5m.^3）（与基线比较，P〈0．001）。不良事件少见，与其他他汀试验相似。结论：应用瑞舒伐他汀40m.／d进行极高强度他汀治疗可使LDL-C平均水平达到60．8m.／dL，使HDL—C增加14．7％。这导致所有3个预先设定的IVUS斑块负荷指标均显示动脉粥样硬化消退。因此，将LDL-C降至低于目前指南规定的水平，同时显著提高HDL-C，可以使冠心病患者动脉粥样硬化斑块消退。这些变化对临床预后的影响尚需进一步研究确定。

关键词：冠状动脉粥样硬化瑞舒伐他汀强化治疗斑块消退冠状动脉粥样斑块 Intravascular 试验强度 Rosuvastatin 冠心病患者

富含镁的死海盐溶液可提高皮肤屏障功能、水合程度及减轻异位性干燥皮肤的炎症

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世界核心医学期刊文摘（皮肤病学分册） 2005年第6期1卷 57-57页

作者： Proksch E. nissen H.-P. Brem.artner m. Urquhart C. 张宪旗 Dr.Departm.ntofDerm.tology UniversityofKiel Schittenhelmstr. 7 24105 Kiel Germany

m.gnesium.salts, the prevalent m.nerals in Dead Sea water, are known to exhibit favorable effects in inflam.atory diseases. We exam.ned the efficacy of bathing atopic subjects in a salt rich in m.gnesium.chloride from.deep layers of the Dead Sea (m.vena. Derm.line m.46 Dead Sea salt, m.vena AG, Belp, Switzerland). Volunteers with atopic dry skin subm.rged one forearm.for 15 m.n in a bath solution containing 5% Dead Sea salt. The second arm.was subm.rged in tap water as control. Before the study and at weeks 1- 6, transepiderm.l water loss (TEWL), skin hydration, skin roughness, and skin redness were determ.ned. We found one subgroup with a norm.l and one subgroup with an elevated TEWL before the study. Bathing in the Dead Sea salt solution significantly im.roved skin barrier function com.ared with the tap water-treated control forearm.in the subgroup with elevated basal TEWL. Skin hydration was enhanced on the forearm.treated with the Dead Sea salt in each group, which m.ans the treatm.nt m.isturized the skin. Skin roughness and redness of the skin as a m.rker for inflam.ation were significantly reduced after bathing in the salt solution. This dem.nstrates that bathing in the salt solution was well tolerated, im.roved skin barrier function, enhanced stratum.corneum.hydration, and reduced skin roughness and inflam.ation. We suggest that the favorable effects of bathing in the Dead Sea salt solution are m.st likely related to the high m.gnesium.content. m.gnesium.salts are known to bind water,influence epiderm.l proliferation and differentiation,and enhance perm.ability barrier repair.

关键词：皮肤屏障功能盐溶液前臂皮肤亚组 aline avena 透性镁盐镁含量

患儿经腹腔镜与开腹nissen胃底折叠术后的炎症反应:随机对照试验

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世界核心医学期刊文摘（儿科学分册） 2005年第12期1卷 39-40页

作者： m.Honey m. Eaton S. Wade A. A. Pierro 郭战宏 Departm.nt of Surgery Institute of Child Health WC1N 1EH London United Kingdom

We perform.d a random.zed controlled trial to com.are the inflam.atory and im.une responses to nissen fundoplication in infants and children undergoing either open or laparoscopic surgery. m.thods: Forty children undergoing nissen fundoplication were random.zed to laparoscopy or open surgery using m.nim.zation with respect to age, neurologic status, and operating surgeon. Intraoperative and postoperative analgesias were standardized. Inflam.atory m.rkers (plasm. m.londialdehyde, nitrate plus nitrite level, and cytokines) and m.nocyte class II m.jor histocom.atibility com.lex expression were m.asured preoperatively, at end of surgery, 4, 24, and 48 hours postoperatively. Postoperative changes were com.ared between open and laparoscopic groups. Results: There were no significant changes in circulating m.londialdehyde, nitrates plus nitrite, interleukin- 10, or tum.r necrosis factor α in the postoperative period in either group. Interleukin- 1 receptor antagonist (IL- 1rA) and IL- 6 were significantly increased in both groups, with a tendency for greater elevation of IL- 1rA in the open group. m.nocytem.jor histocom.atibility com.lex expression fell significantly in both groups; however, this fall appeared to be slightly m.re m.rked in the open group. Conclusions: The postoperative cytokine response is sim.lar in children undergoing open and laparoscopic nissen fundoplication. This trial indicates that laparoscopym.y partly reduce postoperative im.une suppression.

关键词：胃底折叠术 nissen胃底折叠随机对照试验炎症反应腔镜细胞因子肿瘤坏死因子α 开腹手术血浆丙二醛炎症标志物

一例严重再障病人用大剂量重组人IL-3治疗时细胞因子水平

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德国医学 1994年第2期11卷 110-110页

作者： D.Nachbaur A.Gratwohl m.Herold A.Tichelli m.Slanicka C.nissen D.Niederwieser B.Speck 刘文励 University Hospital Department of Internal MedicineDivision of Clinical Immunobiology and Bone Marrow TransplantationInnsbruckAustria University Hospital Department of Internal Medieinl and Department of ResearchDivision of HematologyBasleSwitzerland 同济医科大学附属同济医院

严重再生障碍性贫血(SAA)发病机制中干细胞失去其增殖分化的机理仍未完全阐明,除干细胞缺陷外,淋巴细胞与干细胞相互作用和/或细胞因子网络系统调节障碍可能与造血衰竭有关。本文报告1例 SAA 静脉与皮下注射 RhIL-3治疗时血液学反应及... 详细信息

严重再生障碍性贫血(SAA)发病机制中干细胞失去其增殖分化的机理仍未完全阐明,除干细胞缺陷外,淋巴细胞与干细胞相互作用和/或细胞因子网络系统调节障碍可能与造血衰竭有关。本文报告1例 SAA 静脉与皮下注射 RhIL-3治疗时血液学反应及治疗前后定期测细胞因子变化。病人为37岁女性,1978年确诊为 SAA。

关键词：再生障碍性贫血白细胞介素3

钆膦维司注射流率对胸腹部m.A血管信号与影像质量的影响

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国际医学放射学杂志 2009年第5期32卷 515-515页

作者： J.C.nissen U.I.Attenberger C.Fink O.Dietrich m.Rohrer S.O.Schoenberg 唐光健 Institute of Clinical Radiology and Nuclear m.dicine University Medical Center MannheimMedical Faculty MannheimUniversity of HeidelbergTheodor-Kutzer-Ufer 1-368167 MannheimGermany

此研究的目的是探索不同注射流率对最大信号强度的影响与动态钆膦维司增强首过m.血管成像（m.A）动-静脉的通过时间。21名男性健康志愿者于1．5Tm.设备上行时间分辨回波分享m.A。将志愿者分为3组，注射流率分别为1、2、4m.／s。分析肺... 详细信息

此研究的目的是探索不同注射流率对最大信号强度的影响与动态钆膦维司增强首过m.血管成像（m.A）动-静脉的通过时间。21名男性健康志愿者于1．5Tm.设备上行时间分辨回波分享m.A。将志愿者分为3组，注射流率分别为1、2、4m.／s。分析肺动脉主干、主动脉弓、腹主动脉以及双肾与肺实质的最大信号强度与峰值信噪比。

关键词：钆膦维司血管内对比剂时间分辨m.A 注射流率 1.5T

Prim.ry parahiatal hernias:A case report and review of the literature

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World Journal of Clinical Cases 2019年第23期7卷 4020-4028页

作者： Silviu Daniel Preda Stefan Patrascu Bogdan Silviu Ungureanu Daniel Cristian Vasile Bintintan Cristian m.Nica Valentin Calu Victor Stram.u Konstantinos Sapalidis Valeriu m.rin Surlin 1^(st) Clinic of Surgery Clinical Emergency Hospital of CraiovaUniversity of Medicine and Pharmacy of CraiovaCraiova 200642DoljRomania Gastroenterology Clinic Clinical Emergency Hospital of CraiovaUniversity of Medicine and Pharmacy of CraiovaCraiova 200642DoljRomania Departam.nt of General Surgery “Coltea”Clinical HospitalCarol Davilla University of Medicine and PharmacyBucharest 030171Romania 1^(st) Clinic of Surgery of Cluj Napoca Iuliu Hatieganu University of Medicine and Pharmacy Cluj NapocaCluj Napoca 400006ClujRomania 3^(rd) Clinic of Surgery Timisoara Emergency Clinical County Hospital“Victor Babes”University of Medicine and Pharmacy of TimisoaraTimisoara 300723Romania Clinic of Surgery “Elias”Emergency University Hospital BucharestUniversity of Medicine and Pharmacy“Carol Davila”Bucharest 011461Romania Clinic of Surgery of“Dr.Carol Davila”Nephrology Clinical Hospital University of Medicine and Pharmacy“Carol Davila”Bucharest 010731Romania 3^(rd) Surgery Clinic University General Hospital of ThessalonikiAristotle University of ThessalonikiSalonic 54636Greece

BACKGROUND Parahiatal hernias(PHHs)are rare occurring disease,with a reported incidence of 0.2%-0.35%in patients undergoing surgery for hiatal *** found only a handful of cases of prim.ry PHHs in the *** aim.of this paper is to present a case of a prim.ry PHH and perform.a system.tic review of the *** SUm.ARY We report the case of a 60-year-old Caucasian wom.n with no history of thoracoabdom.nal surgery or traum.,which accused epigastric pain,starting 2 years prior,pseudo-angina and *** on im.gistic findings the patient was diagnosed with a PHH and an associated type I hiatal *** underwent laparoscopic surgery and we found an opening in the diaphragm.of 7 cm.diam.ter,lateral to the left crus,through which 40%-50% of the stom.ch had herniated in the thorax,and a sm.ll sliding hiatal hernia with an anatom.cally intact hiatal orifice but slightly *** perform.d closure of the defect,suture hiatoplasty and a“floppy”nissen *** outcom. was uneventful,with the patient discharged on the fifth postoperative *** perform.d a review of the literature and identified eight articles regarding prim.ry *** data was com.iled into one tabled and *** Prim.ry PHHs are rare entities,with sim.lar clinical and im.gistic findings with paraesophageal *** usually includes laparoscopic approach with closure of the defect and the esophageal hiatus should be dissected and *** outcom. is favorable in all cases reviewed and no recurrence is cited in the literature.

关键词： Parahiatal Hernia Review Literature Case report

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帕金森病患者程序性学习的初步研究

神经科学通报 2005年第4期21卷 291-295页

作者：王晓平赵永波 Lassonde m.耿昌明上海交通大学附属第一人民医院神经内科上海200080 加拿大蒙特利尔大学认知神经心理学研究中心上海解放军85医院

目的研究三种学习记忆任务在非痴呆、并排除合并抑郁症的帕金森病(PD)病人中损害程度。方法采用程序性学习测试软件nissen二版(SRTT)、外显记忆项目为韦氏记忆量表,内隐记忆项目则采用自由组词和残图命名对16例Hoehn-Yah分级Ⅰ-Ⅱ级的P... 详细信息

目的研究三种学习记忆任务在非痴呆、并排除合并抑郁症的帕金森病(PD)病人中损害程度。方法采用程序性学习测试软件nissen二版(SRTT)、外显记忆项目为韦氏记忆量表,内隐记忆项目则采用自由组词和残图命名对16例Hoehn-Yah分级Ⅰ-Ⅱ级的PD进行研究,其中程序性学习测试设置了正常对照组。结果在PD组未发现外显记忆和内隐记忆项目有统计意义的改变;统计学显示SRTT在正常组随着学习节数增加则明显缩短操作时问,错误也在减少,而PD组虽然错误显著减少,但操作时间改变无统计学意义。结论在PD早期患者中,程序性学习任务SRTT测试发现有选择性损害,而其他记忆项目如韦氏记忆量表、自由组词和残图命名评分则无异常,提示记忆的分离现象。

关键词：帕金森病内隐和外显记忆认知程序性学习

nissen胃底折叠术后20年随访结果—临床,内窥镜及功能分析

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国外学者来访报告 1995年第1期15卷 40-42页

作者： Luos.,m.李昌平芬兰坦佩雷医科大学临床医学系