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Impact of the source and serial passaging of goat mesenchymal stem cells on osteogenic differentiation potential:implications for bone tissue engineering

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Journal of Animal Science and Biotechnology 2016年第4期7卷 482-494页

作者： Hoda Elkhenany lisa Amelse Marc Caldwell Ramadan Abdelwahed Madhu Dhar Department of Large Animal Clinical Sciences University of Tennessee Department of Surgery Faculty of Veterinary MedicineAlexandria University

Background： Adult mesenchymal stem cells （MSCs） can be conveniently sampled from bone marrow, peripheral blood, muscle, adipose and connective tissue, harvested from various species, including, rodents, dogs, cats, horses, sheep, goats and human beings. The MSCs isolated from adult tissues vary in their morphological and functional properties. These variations are further complicated when cells are expanded by passaging in culture. These differences and changes in MSCs must be considered prior to their application in the clinic or in a basic research study. Goats are commonly used as animal models for bone tissue engineering to test the potential of stem cells for bone regeneration. As a result, goat MSCs isolated from bone marrow or adipose tissue should be evaluated using in vitro assays, prior to their application in a tissue engineering project. Results： In this study, we compared the stem cell properties of MSCs isolated from goat bone marrow and adipose tissue. We used quantitative and qualitative assays with a focus on osteogenesis, including, colony forming unit, rate of cell proliferation, tri-lineage differentiation and expression profiling of key signal transduction proteins to compare MSCs from low and high passages. Primary cultures generated from each source displayed the stem cell characteristics, with variations in their osteogenic potentials. Most importantly, low passaged bone marrow MSCs displayed a significantly higher and superior osteogenic potential, and hence, will be the preferred choice for bone tissue engineering in future in vivo experiments. In the bone marrow MSCs, this process is potentially mediated by the p38 MAPK pathway. On the other hand, osteogenic differentiation in the adipose tissue MSCs may involve the p44/42 MAPK pathway. Conclusions： Based on these data, we can conclude that bone marrow and fat-derived MSCs undergo osteogenesis via two distinct signaling pathways. Even though the bone marrow MSCs are the preferred source fo

关键词： Caprine mesenchymal Osteogenesis stem cells

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微粉碎设备-高速锤片式粉碎机(续)

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饲料研究 2010年第4期33卷 62-63页

作者： Mark heimann 程宗佳美国大豆协会国际项目北京办事处

6锤片各类锤片用于不同锤片式粉碎机的粉碎。锤片最长使用寿命和最有效操作首选锤片末端。锤片可1孔（2角）工作或2孔（4角）用于粉碎。锤片1孔通常优先保持转子平衡,使锤片损坏的可能性降到最低。

关键词：锤片式粉碎机微粉碎设备使用寿命转子平衡

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Semistructured interviewing in primary care research:a balance of relationship and rigour

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Family Medicine and Community Health 2019年第2期7卷 30-37页

作者： Melissa DeJonckheere lisa M Vaughn Department of Family Medicine University of MichiganAnn ArborMichiganUSA Department of Pediatrics University of Cincinnati College of MedicineCincinnatiOhioUSA Division of Emergency Medicine Cincinnati Children's Hospital Medical CenterCincinnatiOhioUSA

Semistructured in-depth interviews are commonly used in qualitative research and are the most frequent qualitative data source in health services *** method typically consists of a dialogue between researcher and participant,guided by a flexible interview protocol and supplemented by follow-up questions,probes and *** method allows the researcher to collect open-ended data,to explore participant thoughts,feelings and beliefs about a particular topic and to delve deeply into personal and sometimes sensitive *** purpose of this article was to identify and describe the essential skills to designing and conducting semistructured interviews in family medicine and primary care research *** reviewed the literature on semistructured interviewing to identify key skills and components for using this method in family medicine and primary care research ***,semistructured interviewing requires both a relational focus and practice in the skills of *** include:(1)determining the purpose and scope of the study;(2)identifying participants;(3)considering ethical issues;(4)planning logistical aspects;(5)developing the interview guide;(6)establishing trust and rapport;(7)conducting the interview;(8)memoing and reflection;(9)analysing the data;(10)demonstrating the trustworthiness of the research;and(11)presenting findings in a paper or *** interviews provide an effective and feasible research method for family physicians to conduct in primary care research *** using semistructured interviews for data collection should take on a relational focus and consider the skills of interviewing to ensure *** interviewing can be a powerful tool for family physicians,primary care providers and other health services researchers to use to understand the thoughts,beliefs and experiences of *** the utility,semistructured interviews can be intimidating and challenging for

关键词： interview qualitative thoughts

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Physical activity as a treatment of non-alcoholic fatty liver disease:A systematic review

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World Journal of Hepatology 2015年第16期7卷 2041-2052页

作者： Maureen Whitsett lisa B VanWagner Department of Medicine Division of Gastroenterology and Hepatology Northwestern University Feinberg School of Medicine Chicago

AIM: To review the effectiveness of exercise as a therapy for nonalcoholic fatty liver disease(NAFLD) and potential benefits in treating insulin resistance and ***: Medline(EBSCOhost) and Pub Med were searched for English-language randomized controlled trials and prospective cohort studies in human adults aged ≥ 18 which investigated the various effects of exercise alone, a combination of exercise and diet, or exercise and diet coupled with behavioral modification on NAFLD from 2010 to Feburary ***: Eighteen of 2298 available studies were chosen for critical review, which included 6925 patients. Nine(50%) studies were randomized controlled trials. Five(27.8%) studies utilized biopsy to examine the effects of physical activity on hepatic histology. The most commonly employed imaging modality to determine change in hepatic steatosis was hydrogen-magnetic resonance spectroscopy. Only two studies examined the effects of low impact physical activity for patients with significant mobility limitations and one compared the efficacy of aerobic and resistance exercise. No studies examined the exact duration of exercise required for hepatic and metabolic improvement in ***: While exercise improved hepatic steatosis and underlying metabolic abnormalities in NAFLD, more studies are needed to define the most beneficial form and duration of exercise treatment.

关键词： Nonalcoholic fatty liver disease Nonalcoholicsteatohepatitis Fatty liver Exercise Obesity

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Incidence and determinants of sudden infant death syndrome:a population-based study on 37 million births

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World Journal of Pediatrics 2015年第1期11卷 41-47页

作者： Ghaidaa F Hakeem lisa Oddy Christina A Holcroft Haim A Abenhaim Department of Obstetrics and Gynecology Jewish General HospitalMcGill University Center for Clinical Epidemiology and Community Studies Jewish General HospitalMontréalQuébecCanada

Background:The objective of our study is to measure the incidence of sudden infant death syndrome(SIDS),estimate the birth to death interval,and identify associated maternal and infant risk ***:We carried out a population-based cohort study on 37418280 births using data from the Centers for Disease Control and Prevention's"Linked Birth-Infant Death"and"Fetal Death"data files from 1995 to *** statistics and cox-proportional hazard models were used to estimate the adjusted effect of maternal and newborn characteristics on the risk of ***:There were 24101 cases of SIDS identified for an overall 10-year incidence of 6.4 cases per 10000 *** the study period,the incidence decreased from 8.1 to 5.6 per 10000 and appeared to be most common among infants aged 2-4 *** factors inchuded maternal age<20 years,black,non-Hispanic race,smoking,increasing parity,inadequate prenatal care,prematurity and growth ***:While the incidence of SIDS in the US has declined,it currently remains the leading cause of post-neonatal mortality,highlighting an important public health *** campaigns should be targeted towards mothers at increased risk in order to raise their awareness of modifiable risk factors for SIDS such as maternal smoking and inadequate prenatal care.

关键词： incidence risk factors sudden infant death syndrome

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Alternative methods for measurement of the global polarization of Λhyperons

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Chinese Physics C 2019年第1期43卷 103-108页

作者： Irfan Siddique Zuo-tang Liang Michael Annan lisa Qun Wang Zhang-bu Xu Department of Modern Physics University of Science and Technology of China School of Physics & Key Laboratory of Particle Physics and Particle Irradiation (MOE) Physics Department The Ohio State University Physics Department Brookhaven National Laboratory

We propose alternative methods for measurement of the global polarization of Λ hyperons. These methods involve event averages of proton and Λ momenta in the laboratory frame. We carry out simulations using these met... 详细信息

关键词： heavy ion collisions global polarization collective flow

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Another look at social innovation:From community-For community

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International Journal of Innovation Studies 2022年第2期6卷 92-101页

作者： lisa J.Daniel Peter Jenner School of Business and Creative Industries University of the Sunshine CoastFraser CoastQueensland4655Australia

Social innovation(SI)continues to raise interest among scholars and policymakers,as a potential panacea for social disenfranchisement and civic *** is troubling is diverse perspectives of SI abound,creating inconsistencies in methodological approaches which confound theory *** paper clarifies that discussion by considering the locus of initiation and locus of benefit as informing characteristics that differentiate grounded social innovation from other types of well-recognized socially beneficent *** notion of‘from community e for community’is presented to aid understanding of the unique nature of authentically grounded social *** paper is significant as it presents a practical approach to help researchers and practitioners consider where opportunities for targeted policy support,institutional involvement,and agency action can aid community development and wellbeing.

关键词： Social innovation Community markets Social change Community development

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Heating demand and economic feasibility analysis for year-round vegetable production in Canadian Prairies greenhouses

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Information Processing in Agriculture 2019年第1期6卷 81-90页

作者： Md Shamim Ahamed Huiqing Guo lisa Taylor Karen Tanino Department of Farm Power and Machinery Bangladesh Agricultural UniversityBangladesh Department of Mechanical Engineering University of SaskatchewanCanada Department of Plant Sciences University of SaskatchewanCanada

Greenhouse vegetable production in Canadian Prairies is important for creating a sustainable regional food economy,especially in northern *** study included the estimation of heating demand for year-round production and evaluation of the economic feasibility of greenhouse vegetable production(tomato,cucumber,and pepper)in a conceptually designed greenhouse(0.6 ha)located in remote northern communities in Saskatchewan,*** heating simulation was based on a greenhouse heating simulation model(GREENHEAT)developed by the authors *** simulation results showed that the annual heating requirement for the production of tomato,cucumber,and pepper are 1486 MJ m^2,1657 MJ m^2,and 1754 MJ m^2,*** economic analysis indicates the net return(NR)from the production of tomato,cucumber,and pepper,are C$69.2/m^2(in Canadian dollar,CAD),C$41.5/m^2,and C$43.8/m^2,respectively,based on the market price C$3.5/kg,C$2.7/kg,and C$8.0/kg,and yields of 55.0 kg m^-2,65.0 kg m^-2,and 23.0 kg m^-*** net present value(NPV)for the tomato,cucumber,and pepper production are C$1.9 M,C$1.2 M,and C$1.1 M,respectively,and the benefit-cost ratio(BCR)are 1.38,1.21,and *** economic feasibility analysis indicates the year-round production of vegetables in a greenhouse at remote northern Saskatchewan would be economically profitable.

关键词： Northern latitudes Heating requirement Economic analysis Sensitivity analysis Year-round production

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Motor inhibition efficiency in healthy aging: the role of γ-aminobutyric acid

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Neural Regeneration Research 2019年第5期14卷 741-744页

作者： lisa Pauwels Celine Maes Lize Hermans Stephan P.Swinnen KU Leuven Movement Control and Neuroplasticity Research Group Department of Movement Sciences Group Biomedical Sciences Leuven Brain Institute (LBI)

The ability to cancel a motor response is critical for optimal functioning in various facets of daily life. Hence, efficient inhibitory motor control is a key function throughout the lifespan. Considering the fact that inhibitory motor function gradually declines with advancing age, it is not surprising that the study of motor inhibition in this age group is gaining considerable interest. In general, we can distinguish between two prominent types of motor inhibition, namely proactive and reactive inhibition. Whereas the anticipation for upcoming stops(proactive inhibition) appears readily preserved at older age, the ability to stop an already planned or initiated action(reactive inhibition) generally declines with advancing age. The differential impact of aging on proactive and reactive inhibition at the behavioral level prompts questions about the neural architecture underlying both types of inhibitory motor control. Here we will not only highlight the underlying structural brain properties of proactive and reactive inhibitory control but we will also discuss recent developments in brain-behavioral approaches, namely the registration of neurochemical compounds using magnetic resonance spectroscopy. This technique allows for the direct detection of the primary inhibitory neurotransmitter in the brain, i.e., γ-aminobutyric acid, across the broader cortical/subcortical territory, thereby opening new perspectives for better understanding the neural mechanisms mediating efficient inhibitory control in the context of healthy aging. Ultimately, these insights may contribute to the development of interventions specifically designed to counteract age-related declines in motor inhibition.

关键词： proactive inhibition reactive inhibition motor inhibition healthy aging gamma-aminobutyric acid magnetic resonance spectroscopy GABA inhibitory neurotransmitter neuroimaging

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Quantifying the effect of improved school and residential building codes for tornadoes in community resilience

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Resilient Cities and Structures 2022年第1期1卷 65-79页

作者： Wanting(lisa)Wang John W.van de Lindt Department of Civil and Environmental Engineering Colorado State UniversityU.S.A

Tornadoes can destroy or severely damage physical infrastructure including buildings in a *** can result in direct losses but also indirect losses such as the closure of key social institutions reverberating further through the community(e.g.,schools).Despite significant losses in past events,building codes and standards have not previously included tornado hazards because of the relatively low probability of a direct *** recent release of the ASCE 7-22 standard considers tornadoes for Risk Category 3 and 4 buildings,*** from schools to critical *** study proposes a series of design combinations of a reinforced masonry school building with different performance targets intended to enable schools to reopen *** fragilities were developed for a school building having improved designs using tornado loads determined based on the new tornado chapter in ASCE 7-22,and then integrated into a community level model with school attendance zones to examine the *** ultimate goal in this study is to investigate the effect of improving school building designs would have on maintaining school continuity(and more rapid return)for school children.

关键词： ASCE 7-22 Community resilience Improved designs School buildings Wind fragilities Tornado

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