检索结果-南通市图书馆

Approximation of the Mean Escape Time for a Tilted Periodic Potential

在线全文

学校读者我要写书评

暂无评论

Communications in Computational Physics 2019年第1期25卷 1-40页

作者： Tamra Heberling lisa Davis Tomas Gedeon Los Alamos National Laboratory XTD-SSLos AlamosNM87545USA Department of Mathematical Sciences Montana State UniversityBozemanMT59717-2400USA

We present a formula approximating the mean escape time(MST)of a particle from a tilted multi-periodic potential *** potential function consists of a weighted sum of a finite number of component functions,each of which is *** this particular case,the least period of the potential function is a common period amongst all of its component *** approximation of the MST for the potential function is derived,and this approximation takes the form of a product of the MSTs for each of the individual periodic component *** first example illustrates the computational advantages of using the approximation for model validation and parameter tuning in the context of the biological application of DNA *** also use this formula to approximate the MST for an arbitrary tilted periodic potential by the product of MSTs of a finite number of its Fourier *** examples using truncated Fourier series are presented and analyzed.

关键词： Brownian Ratchet multi-periodic potential tilted periodic potential Fokker-Plank equation

Disease monitoring in inflammatory bowel disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第40期21卷 11246-11259页

作者： Shannon Chang lisa Malter David Hudesman Division of Gastroenterology New York University

The optimal method for monitoring quiescent disease in patients with Crohn's disease(CD) and ulcerative colitis is yet to be determined. Endoscopic evaluation with ileocolonoscopy is the gold standard but is invasive,costly,and time-consuming. There are many commercially available biomarkers that may be used in clinical practice to evaluate disease status in patients with inflammatory bowel disease(IBD),but the most widely adopted biomarkers are C-reactive protein(CRP) and fecal calprotectin(FC). This review summarizes the evidence for utilizing CRP and FC for monitoring IBD during clinical remission and after surgical resection. Endoscopic correlation with CRP and FC is evaluated in each disease state. Advantages and drawbacks of each biomarker are discussed with special consideration of isolated ileal CD. Fecal immunochemical testing,traditionally used for colorectal cancer screening,is mentioned as a potential new alternative assay in the evaluation of IBD. Based on a mixture of information gleaned from biomarkers,clinical status,and endoscopic evaluation,the best treatment decisions can be made for the patient with IBD.

关键词： Inflammatory bowel disease Crohn’s disease Ulcerat

Hunting down the dominating subclone of cancer stem cells as a potential new therapeutic target in multiple myeloma: An artificial intelligence perspective

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2020年第8期12卷 706-720页

作者： lisa X Lee Shengwen Calvin Li Division of Hematology/Oncology Department of MedicineChao Family Comprehensive Cancer CenterUCI HealthOrangeCA 92868United States Neuro-oncology and Stem Cell Research Laboratory CHOC Children's Research InstituteChildren's Hospital of Orange CountyOrangeCA 92868United States Department of Neurology University of California-Irvine School of MedicineOrangeCA 92868United States

The development of single-cell subclones,which can rapidly switch from dormant to dominant subclones,occur in the natural pathophysiology of multiple myeloma(MM)but is often"pressed"by the standard treatment of *** emerging subclones present a challenge,providing reservoirs for chemoresistant *** advancement is required to track MM subclonal changes,as understanding MM's mechanism of evolution at the cellular level can prompt the development of new targeted ways of treating this *** methods to study the evolution of subclones in MM rely on technologies capable of phenotypically and genotypically characterizing plasma cells,which include immunohistochemistry,flow cytometry,or ***,all of these technologies may be limited by the sensitivity for picking up rare *** contrast,more incisive methods such as RNA sequencing,comparative genomic hybridization,or whole-genome sequencing are not yet commonly used in clinical *** we introduce the epidemiological diagnosis and prognosis of MM and review current methods for evaluating MM subclone evolution,such as minimal residual disease/multiparametric flow cytometry/next-generation sequencing,and their respective advantages and *** addition,we propose our new single-cell method of evaluation to understand MM's mechanism of evolution at the molecular and cellular level and to prompt the development of new targeted ways of treating this disease,which has a broad prospect.

关键词： Multiple myeloma Single cells Single-cell transcriptome Subclonal evolution Cancer stem cells Systemic tracking of single-cell landscape Artificial intelligence medicine

Complex pathologies of angiotensin Ⅱ-induced abdominal aortic aneurysms

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第8期12卷 624-628页

作者： Alan DAUGHERTY lisa A. CASSIS Hong LU Saha Cardiovascular Research Center University of KentuckyLexington KY40536-0509 USA Graduate Center for Nutritional Sciences University of KentuckyLexington KY40536-0200 USA

Angiotensin II （Angll） is the primary bioactive peptide of the renin angiotensin system that plays a critical role in many cardiovascular diseases. Subcutaneous infusion of Angll into mice induces the development of abdominal aortic aneurysms （AAAs）. Like human AAAs, Angll-induced AAA tissues exhibit progressive changes and considerable heterogeneity. This complex pathology provides an impediment to the quantification of aneurysmal tissue composition by biochemical and immunostaining techniques. Therefore, while the mouse model of Angll-induced AAAs provides a salutary approach to studying the mechanisms of the evolution of AAAs in humans, meaningful interpretation of mechanisms requires consideration of the heterogeneous nature of the diseased tissue.

关键词： Abdominal aortic aneurysms Angiotensin II,Pathologies Mouse

Lisfranc Joint Injuries

在线全文

学校读者我要写书评

暂无评论

中国运动医学杂志 2009年第6期28卷 699-702页

作者： lisa Chinn University of Virginia

The ankle and foot are the most common sites forathletic injuries.[1 Midfoot,or Lisfranc,injuries are the]second most common foot injury and have a high incidence in particular sports.

关键词：脚踝跖跗关节运动损伤临床分析

Perspectives on the clinical development of mmunotherapy in prostate cancer

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2018年第3期20卷 253-259页

作者： lisa M Cordes James L Gulley Ravi A Madan Clinical Center National Institutes of Health Bethesda MD 20892 USA Genitourinary Malignancies Branch Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda MD 20892 USA

Despite impressive survival benefits with immunotherapy in patients with various solid tumors, the full potential of these agents in prostate cancer has yet to be realized. SipuleuceI-T demonstrated a survival benefit in this population, indicating that prostate cancer is an immunoresponsive disease; however, these results have not been matched by other agents. A large trial with ipilimumab in prostate cancer failed to meet its primary objective, and small trials with PD-1/PD-L1 inhibitors did not yield a significant improvement in overall response. However, several late-stage clinical trials are underway with other vaccines in prostate cancer. Reports of clinical benefit with immunotherapies, particularly when used in combination or a select population, have provided the framework to develop sound clinical trials. Understanding immunogenic modulation, antigen spread, biomarkers, and DNA-repair defects will also help mold future strategies. Through rational patient selection and evidence-based combination approaches, patients with prostate cancer may soon derive durable survival benefits with immunotherapies.

关键词： checkpoint inhibitor immunotherapy prostate cancer therapeutic vaccine

Interactions of sex and early life social experiences at two developmental stages shape nonapeptide receptor profiles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrative Zoology 2018年第6期13卷 745-760页

作者： lisa C.HIURA Alexander G.OPHIR Department of Psychology Cornell UniversityIthacaNew YorkUSA

Early life social experiences are critical to behavioral and cognitive development,and can have a tremendous influence on developing social *** work has focused on outcomes of experiences at a single stage of development(*** or post-weaning).Few studies have assessed the impact of social experience at multiple developmental stages and across *** and vasopressin are profoundly important for modulating social behavior and these nonapeptide systems are highly sensitive to developmental social experience,particularly in brain areas important for social *** investigated whether oxytocin receptor(OTR)and vasopressin receptor(V1aR)distributions of prairie voles(Microtus ochrogaster)change as a function of parental composition within the natal nest or social composition after *** raised pups either in the presence or absence of their *** weaning,offspring were housed either individually or with a same-sex *** also examined whether changes in receptor distributions are sexually dimorphic because the impact of the developmental environment on the nonapeptide system could be *** found that differences in nonapeptide receptor expression were region-specific,sex-specific and rearing condition-specific,indicating a high level of complexity in the ways that early life experiences shape the social *** found many more differences in V1aR density compared to OTR density,indicating that nonapeptide receptors demonstrate differential levels of neural plasticity and sensitivity to environmental and biological *** data highlight that critical factors including biological sex and multiple experiences across the developmental continuum interact in complex ways to shape the social brain.

关键词： development of social behavior oxytocin and vasopressin receptors parental and paternal care sex differences social isolation and housing

COMPUTATIONAL ISSUES IN SENSITIVITY ANALYSIS FOR 1-D INTERFACE PROBLEMS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Computational Mathematics 2011年第1期29卷 108-130页

作者： lisa G. Davis John R. Singler Montana State University Department of Mathematical Sciences PO Box 172400 Bozeman MT 59717-2400 USA Missouri University of Science and Technology Department of Mathematics and Statistics 300 W. 12th St. Rolla MO 65409 0020 USA

This paper is concerned with the construction of accurate and efficient computational algorithms for the numerical approximation of sensitivities with respect to a parameter dependent interface location. Motivated by sensitivity analysis with respect to piezoelectric actuator placement on an Euler-Bernonlli beam, this work illustrates the key concepts related to sensitivity equation formulation for interface problems where the parameter of interest determines the location of the interface. A fourth order model problem is considered, and a homogenization procedure for sensitivity computation is constructed using standard finite clement methods. Numerical results show that proper formulation and approximation of the sensitivity interface conditions is critical to obtaining convergent numerical sensitivity approximations. A second order elliptic interface model problem is also mentioned, and the homogenization procedure is outlined briefly for this model.

关键词： Finite element method Interface Problems Sensitivity Equation.

Zebrafish embryo toxicity of 15 chlorinated, brominated, and iodinated disinfection by-products

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2017年第8期29卷 302-310页

作者： David Hanigan lisa Truong Michael Simonich Robert Tanguay Paul Westerhoff Department of Civil and Environmental Engineering University of Nevada School of Sustainable Engineering and the Built Environment Arizona State University Department of Environmental and Molecular Toxicology Oregon State University

Disinfection to protect human health occurs at drinking water and wastewater facilities through application of non-selective oxidants including chlorine. Oxidants also transform organic material and form disinfection by-products（DBPs）, many of which are halogenated and cyto-and genotoxic. Only a handful of assays have been used to compare DBP toxicity,and researchers are unsure which DBP（s） drive the increased cancer risk associated with drinking chlorinated water. The most extensive data set employs an in vitro model cell,Chinese hamster ovary cells. Traditionally, most DBP research focuses on the threat to human health, but the effects on aquatic species exposed to DBPs in wastewater effluents remain ill defined. We present the developmental toxicity for 15 DBPs and a chlorinated wastewater to a model aquatic vertebrate, zebrafish. Mono-halogenated DBPs followed the in vivo toxicity rank order： acetamides 〉 acetic acids 〉 acetonitriles ~ nitrosamines, which agrees well with previously published mammalian in vitro data. Di-and tri-halogenated acetonitriles were more toxic than their mono-halogenated analogues, and bromine-and iodine-substituted DBPs tended to be more toxic than chlorinated analogues. No zebrafish development effects were observed after exposure to undiluted or non-concentrated,chlorinated wastewater. We find zebrafish development to be a viable in vivo alternative or confirmatory assay to mammalian in vitro cell assays.

关键词： Zebrafish Disinfection by-product Developmental Ecological Toxicity