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Neoantigen cancer vaccines:a new star on the horizon

Cancer Biology & Medicine 2024年第4期21卷 274-311页

作者： Xiaoling Li Jian You liping hong Weijiang Liu Peng Guo Xishan Hao Cell Biotechnology Laboratory Tianjin Cancer Hospital Airport HospitalTianjin 300308China National Clinical Research Center for Cancer Tianjin 300060China Haihe Laboratory of Synthetic Biology Tianjin 300090China Department of Thoracic Oncology Tianjin Cancer Hospital Airport HospitalTianjin 300308China Department of Thoracic Oncology Surgery Tianjin Medical University Cancer Institute&HospitalTianjin 300060China Tianjin Medical University Cancer Institute&Hospital Tianjin 300060China

Immunotherapy represents a promising strategy for cancer treatment that utilizes immune cells or drugs to activate the patient's own immune system and eliminate cancer *** of the most exciting advances within this field is the targeting of neoantigens,which are peptides derived from non-synonymous somatic mutations that are found exclusively within cancer cells and absent in normal *** neoantigen-based therapeutic vaccines have not received approval for standard cancer treatment,early clinical trials have yielded encouraging outcomes as standalone monotherapy or when combined with checkpoint *** made in high-throughput sequencing and bioinformatics have greatly facilitated the precise and efficient identification of ***,personalized neoantigen-based vaccines tailored to each patient have been developed that are capable of eliciting a robust and long-lasting immune response which effectively eliminates tumors and prevents *** review provides a concise overview consolidating the latest clinical advances in neoantigen-based therapeutic vaccines,and also discusses challenges and future perspectives for this innovative approach,particularly emphasizing the potential of neoantigen-based therapeutic vaccines to enhance clinical efficacy against advanced solid tumors.

关键词： Immunotherapy neoantigen cancer vaccine solid tumors high-throughput sequencing bioinformatics PDOs AI HLA TCR

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Fabrication and evaluation of a portable and reproducible quartz crystal microbalance immunochip for label-free detection ofβ-lactoglobulin allergen in milk products

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Food Science and Human Wellness 2022年第5期11卷 1315-1321页

作者： Mingfei Pan liping hong Jingying Yang Xiaoqian Xie Kaixin Liu Shuo Wang Key Laboratory of Food Nutrition and Safety Ministry of Education of ChinaTianjin University of Science and TechnologyTianjin 300457China State Key Laboratory of Food Nutrition and Safety Tianjin University of Science&TechnologyTianjin 300457China

In this study,a label-free,portable and reproducible immunochip based on quartz crystal microbalance(QCM)was developed for the qualitative detection ofβ-lactoglobulin(β-LG),an allergen,in milk *** parameters in the fabrication and regeneration procedure such as pH of the coupling microenvironment,amount of anti-β-LG antibody and regeneration reagent were optimized in *** optimal conditions,the proposed QCM immunochip exhibited good recognition of β-LG,with a calibration curve of ΔF=12.877 C_(β-LG)^(0.4809)(R^(2)=0.9982)and limit of detection of 0.04μg/***,this portable QCM immunochip had good stability,high specificity,and no obvious cross-reaction to three other milk proteins(α-casein,α-lactalbumin,and lactoferrin).It could compete a qualitative measurement within5 min,and could be reused at least ten *** the β-LG analysis of actual milk samples,the developed QCM immunochip yielded reliable and accurate results,which correlated strongly with those from the standard HPLC method(R^(2)=0.9969).Thus,the portable,stable,and reproducible QCM immunochip developed in this study allowed the rapid,cost-effectively and sensitively measure theβ-LG in milk products.

关键词： β-Lactoglobulin allergen Quartz crystal microbalance Immunochip Milk products

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图书馆网络视频运营传播现状研究——以B站为例

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四川图书馆学报 2024年第1期 78-86页

作者：李庆华徐姗姗洪丽平杨荣成新疆医科大学图书馆乌鲁木齐830011

以B站官方认证账号及视频为研究对象,通过对比分析视频发布数据、推广效果数据及内容特征,划分账号活跃度,计算账号的传播指数,揭示图书馆网络视频服务的现状,提出从区域协同发展、爆款视频制作、发展中账号运营三个方面改善图书馆视频... 详细信息

以B站官方认证账号及视频为研究对象,通过对比分析视频发布数据、推广效果数据及内容特征,划分账号活跃度,计算账号的传播指数,揭示图书馆网络视频服务的现状,提出从区域协同发展、爆款视频制作、发展中账号运营三个方面改善图书馆视频运营的策略。

关键词：图书馆 B站网络视频视频运营传播指数

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氯雷他定口溶膜质量标准的建立

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中国医药工业杂志 2024年第3期55卷 361-369页

作者：杨柳榴王兵洪丽萍王稳奇陈芳中国医药工业研究总院医药先进制造国家工程研究中心上海201203 康芝药业股份有限公司海南海口570311

为控制氯雷他定(1)口溶膜的产品质量,同时为同类剂型质量标准的建立提供参考,根据ICH和NMPA发布的指导原则,参考1普通口服固体制剂的药典标准,以及国外上市口溶膜的质量研究资料,结合1口溶膜的实际情况,建立了1口溶膜的质量标准。对3批... 详细信息

为控制氯雷他定(1)口溶膜的产品质量,同时为同类剂型质量标准的建立提供参考,根据ICH和NMPA发布的指导原则,参考1普通口服固体制剂的药典标准,以及国外上市口溶膜的质量研究资料,结合1口溶膜的实际情况,建立了1口溶膜的质量标准。对3批1口溶膜进行了质量检验及稳定性考察。结果显示,自制1口溶膜的性状、鉴别、有关物质、溶出度、溶化时间、含量、含量均匀度和微生物限度均符合标准规定,提示自制产品稳定性良好,所制定的质量标准可有效控制1口溶膜的产品质量。

关键词：氯雷他定口溶膜质量标准含量均匀度溶出度有关物质

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Widely Untargeted Metabolome Profiling Provides Insight into Browning and Nutritional Quality Changes in Short-Term Stored Fresh-Cut Potato(Solanum tuberosum L.)Shreds

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国际实验植物学杂志(英文) 2023年第10期92卷 2785-2805页

作者： liping hong Enming He Wenhui Zhang Mingqiong Zheng Jingwen Wu Wenhua Wang Fujian Key Laboratory of subtropical Plant Physiology and Biochemistry Fujian Institute of Subtropical BotanyXiamen361006China

Potato(Solanum tuberosum L.)is susceptible to enzymatic browning after fresh processing,resulting in color change and potential alteration in the nutritional *** this study,a popular potato cultivar,Feiwuruita,was used to profile the metabolites involved in color and nutritional quality changes in fresh shreds stored at 0 and 4 h at 25°C(designated CK and CK4H,respectively).The shreds turned brown within 4 h of *** all,723 metabolites consisting 12 classes of compounds were detected in the samples,largely lipids,phenolic acids,alkaloids,amino acids and derivatives,flavonoids,organic acids,nucleotides and *** these,163 metabolites accumulated differentially between CK and CK4H *** compounds(phenolic acids and flavonoids)mostly increased in the shreds after 4 h ***,the short-term storage drastically reduced lipid compounds(25 LysoPC and 19 LysoPE),while essential alkaloids and terpenoid compounds that are beneficial to human health increased in *** findings present global metabolome and nutritional composition changes in short-term stored shreds of *** study provides important foundation for future studies on browning prevention/reduction and for better utilization of Feiwuruita.

关键词： Enzymatic browning colorimetric values metabolites phenylpropanoid biosynthesis polyphenol oxidases activity

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Reconfigurable memlogic long wave infrared sensing with superconductors

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Light(Science & Applications) 2024年第5期13卷 908-920页

作者： Bingxin Chen Huanyi Xue hong Pan liping Zhu Xiaomi Yan Jingzhe Wang Yanru Song Zhenghua An State Key Laboratory of Surface Physics and Institute for Nanoelectronic Devices and Quantum Computing Department of PhysicsFudan UniversityShanghai 200438China. ShanghaiTech Quantum Device Lab ShanghaiTech UniversityShanghai 201210China. Shanghai Qi Zhi Institute 41th FloorAI TowerNo.701 Yunjin RoadXuhui DistrictShanghai 200232China. Yiwu Research Institute of Fudan University Chengbei RoadYiwu City 322000 ZhejiangChina. Zhangjiang Fudan International Innovation Center Fudan UniversityShanghai 201210China

Optical sensors with in-cell logic and memory capabilities offer new horizons in realizing machine vision beyond von Neumann architectures and have been attempted with two-dimensional materials,memristive oxides,phasechanging materials *** the unparalleled performance of superconductors with both quantum-limited optical sensitivities and ultra-wide spectrum coverage,here we report a superconducting memlogic long-wave infrared sensor based on the bistability in hysteretic superconductor-normal phase *** cooperatively by electrical and optical pulses,the device offers deterministic in-sensor switching between resistive and superconducting(hence dissipationless)states with persistence>105 *** results in a resilient reconfigurable memlogic system applicable for,e.g.,encrypted ***,a high infrared sensitivity at 12.2μm is achieved through its in-situ metamaterial perfect absorber *** work opens the avenue to realize all-in-one superconducting memlogic sensors,surpassing biological retina capabilities in both sensitivity and wavelength,and presents a groundbreaking opportunity to integrate visional perception capabilities into superconductor-based intelligent quantum machines.

关键词： wave superconductor quantum

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国内老年人健康信息素养研究现状及趋势的可视化分析

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科技资讯 2024年第3期22卷 247-251页

作者：李庆华洪丽平徐姗姗杨荣成杨文军新疆医科大学新疆乌鲁木齐830011

目的利用CiteSpace工具分析老年人健康信息素养领域的文献,揭示该领域的研究现状和发展趋势。方法收集了中国知网数据库中的相关文献,经过筛选和整理后,进行可视化分析,对于领域内的文献、作者、机构和关键词进行了全面梳理和分析。结... 详细信息

目的利用CiteSpace工具分析老年人健康信息素养领域的文献,揭示该领域的研究现状和发展趋势。方法收集了中国知网数据库中的相关文献,经过筛选和整理后,进行可视化分析,对于领域内的文献、作者、机构和关键词进行了全面梳理和分析。结果老年人健康信息素养领域的发文量逐年上升;作者、机构合作网络不够紧密;领域内热点关键词为健康素养、信息素养、影响因素等。结论老年人健康信息素养领域的研究呈现出较高的热度和活跃度,未来的研究应当进一步深入不同学科及机构间合作、加强健康信息教育和推广数字化健康服务等方面的研究。

关键词：老年人健康素养信息素养 Citespace软件

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B and Fe co-doped Co_(2)P hollow nanocubes for nitrate electroreduction to ammonia

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Chinese Chemical Letters 2024年第2期35卷 278-282页

作者： Jing Miao Qingling hong liping Liang Guomin Li Zhihong Liu Shibin Yin Yu Chen School of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China School of Materials Science and Engineering Shaanxi Normal UniversityXi'an 710062China School of Chemistry and Chemical Engineering Shaanxi Normal UniversityXi'an 710062China Guangxi Key Laboratory of Electrochemical Energy Materials School of Chemistry and Chemical EngineeringGuangxi UniversityNanning 530004China

Nitrate(NO_(3)^(−))electroreduction reaction(NO_(3)^(−)RR)provides an attractive and sustainable route for NO_(3)^(−)pollution mitigation or energy-saved ammonia(NH3)*** this work,high-quality B and Fe co-doped Co_(2) P hollow nanocubes(B/Fe-Co_(2) P HNCs)are successfully synthesized though simultaneous boronation-phosphorization treatment,which reveal outstanding selectivity,activity,stability for the NO_(3)^(−)to NH_(3) conversion in neutral electrolyte because of big surface area,fast mass transport,superhydrophilic surface,and optimized electronic structure.B/Fe-Co_(2) P HNCs can achieve the high NH3 yield rate(22.67 mg h^(−1) mg_(cat)^(−1))as well as Faradaic efficiency(97.54%)for NO_(3)^(−)RR,greatly outperforming most of non-precious metal based NO_(3)^(−)RR electrocatalysts.

关键词： Nitrate electroreduction reaction Ammonia synthesis Transition metal phosphides Hollow nanocubes

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玉米秸秆与金针菇菌糠不同混合比例对发酵全混合日粮营养品质和霉菌毒素含量的影响

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畜牧与饲料科学 2024年第2期45卷 20-28,34页

作者：李小冬于二汝洪莉平尚以顺裴成江罗近平陈才俊贵州省农业科学院/贵州省草业研究所贵州贵阳550006 贵阳康养职业大学贵州贵阳550081 贵州大学动物科学学院贵州贵阳550025

[目的]研究以玉米秸秆和金针菇菌糠作为粗饲料加工调制肉牛发酵全混合日粮(fermented total mixed ration,FTMR)时二者的最佳配比,为菌糠等副产物高值化利用提供技术支撑。[方法]设置7个不同比例的粗饲料混合处理组,玉米秸秆与金针菇菌... 详细信息

[目的]研究以玉米秸秆和金针菇菌糠作为粗饲料加工调制肉牛发酵全混合日粮(fermented total mixed ration,FTMR)时二者的最佳配比,为菌糠等副产物高值化利用提供技术支撑。[方法]设置7个不同比例的粗饲料混合处理组,玉米秸秆与金针菇菌糠的比例分别为8∶2(T1组)、7∶3(T2组)、6∶4(T3组)、5∶5(T4组)、4∶6(T5组)、3∶7(T6组)、2∶8(T7组),再以精粗比为4∶6(鲜重)添加肉牛精料补充料,混合均匀后加工制成全混合日粮(total mixed ration,TMR);将不同处理组的TMR样品装入青贮袋,压实密封后抽真空,遮光保存于室内,自然发酵60 d制成FTMR;分别测定并比较TMR和FTMR的营养组分含量和霉菌毒素含量,同时,测定FTMR的发酵参数,确定最优配比。[结果]①随着玉米秸秆与金针菇菌糠配比降低,TMR的DM含量呈逐渐降低趋势,CP含量呈逐渐增加趋势,NDF和ADF含量总体呈逐渐增加趋势,EE含量呈波动性变化。②随着玉米秸秆与金针菇菌糠配比降低,FTMR的DM含量呈逐渐下降趋势,与发酵前相比,T4组的DM损失率最低;T3组和T4组FTMR的CP含量显著(P0.05),与发酵前相比,T1组~T4组FTMR的EE含量下降,T5组~T7组增加;T1组~T5组FTMR的NDF含量显著(P0.05);T6组和T7组FTMR样品检测到微量的BA,其余各组均未检出;T3组FTMR的AN/TN比值最低,除T6组和T7组AN/TN比值超过10%外,其余各组均小于10%。各组TMR样品以及各组FTMR样品中AFB1、ZEN、OTA含量组间差异均不显著(P>0.05),参考《饲料卫生标准》(GB 13078—2017),发酵前后样品中霉菌毒素均未超过阈值。④主效应分析结果表明,发酵处理显著(P0.05)影响;发酵处理、玉米秸秆和金针菇菌糠混合比例处理、发酵和混合比例组合效应对发酵前后样品的OTA含量无显著(P>0.05)影响。[结论]综合营养组分和霉菌毒素含量以及发酵品质分析,采用玉米秸秆混合金针菇菌糠调制FTMR的方式能高效保存利用秸秆和菌糠等副产物,二者以6∶4(T3组)或5∶5(T4组)配比时效果较好。

关键词：玉米秸秆金针菇菌糠发酵全混合日粮营养组分发酵品质霉菌毒素

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Study on a semi-resolved CFD-DEM method for rod-like particles in a gas-solid fluidized bed

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Particuology 2024年第4期87卷 20-36页

作者： liping He Zhengxian Liu Yongzhi Zhao Department of Mechanics School of Mechanical EngineeringTianjin UniversityTianjin300350China Insttute of Process quipment College of Energy EngineeringZhejiang UniversityHangzhou30027China

Based on a semi-resolved CFD-DEM coupling method,this study proposed a method that uses the minimum distance between the fluid grid and the particle boundary as a reference value to determine the degree of influence of the target fluid grid on the particle's drag force.A fluidized bed of rod-like particles was chosen as a typical case to investigate the effect of different fluid grid scales on various fluidized bed characteristic *** calculation performance of the semi-resolved and unre-solved CFD-DEM coupling algorithm on key fluidized bed characteristic parameters such as average pressure drop,particle frequency distribution with bed height,and particle orientation distribution were *** was found that the semi-resolved CFD-DEM coupling algorithm gradually obtained results with higher consistency with decreasing fluid grid scale for key parameters such as particle frequency distribution with bed height,particle orientation distribution,and time-history mixing index,exhibiting a phenomenon similar to grid independence in fluid *** comparing with experimental results,it was verified that the semi-resolved CFD-DEM coupling algorithm can be applied to simulate multi-granular gas-solid systems with fluid grid scales equivalent to particle *** algorithm solves the limitation of fluid grid scale in the unresolved CFD-DEM coupling framework and improves the grid adaptability of the CFD-DEM coupling simulation algorithm.

关键词： CFD-DEM Semi-resolved method Fluid-solid flow Non-spherical particle Fluidized bed

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