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Friction 2024年第2期12卷 291-304页

作者： Qingwen DAI Lei CHEN Jiabao PAN liping shi Dameng LIU Wei HUANG Xiaolei WANG College of Mechanical and Electrical Engineering Nanjing University of Aeronautics&AstronauticsNanjing 210016China State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China School of Mechanical Engineering Anhui Polytechnic UniversityWuhu 241000China School of Mechanical Engineering Anhui University of TechnologyMa’anshan 243032China

Robust superhydrophobic surfaces with excellent capacities of repelling water and anti-frosting are of importance for many mechanical components.In this work,wear-resistant superhydrophobic surfaces were fabricated by curing a mixture of polyurethane acrylate(PUA)coating and 1H,1H,2H,2H-Perfluorodecyltrichlorosilane(HFTCS)on titanium alloy(TC4)surfaces decorated with micropillars pattern,thus,composite functional surfaces with PUA coating in the valleys around the micropillars pattern of TC4 were achieved.Apparent contact angle on fabricated surfaces could reach 167°.Influences of the geometric parameters of micropillars pattern on the apparent contact angle were investigated,and the corresponding wear-resistant property was compared.Droplet impact and anti-frosting performances on the prepared surfaces were highlighted.An optimized design of surface texture with robust superhydrophobicity,controllable droplet impact,and anti-frosting performances was proposed.This design principle is of promising prospects for fabricating superhydrophobic surfaces in traditional mechanical systems.

关键词： surface texture robust superhydrophobic wear-resistant droplet impact anti-frosting

Surface plasmons interference nanogratings:wafer-scale laser direct structuring in seconds

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Light(Science & Applications) 2022年第7期11卷 1607-1614页

作者： liao Geng Wei Yan liping shi Min Qiu Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province School of EngineeringWestlake University18 Shilongshan RoadHangzhou 310024 Zhejiang ProvinceChina Institute of Advanced Technology Westlake Institute for Advanced Study18 Shilongshan RoadHangzhou 310024 Zhejiang ProvinceChina

It is always a great challenge to bridge the nano-and macro-worlds in nanoscience,for instance,manufacturing uniform nanogratings on a whole wafer in seconds instead of hours even days.Here,we demonstrate a single-step while extremely high-throughput femtosecond laser scanning technique to obtain wafer-scale,highly regular nanogratings on semiconductor-on-metal thin films.Our technique takes advantage of long-range surface plasmons-laser interference,which is regulated by a self-initiated seed.By controlling the scanning speed,two types of nanogratings are readily manufactured,which are produced by either oxidation or ablation.We achieve a record manufacturing speed(>1 cm^(2)s^(-1)),with tunable periodicity of∧<1μm.The fractional variation of their periodicity is evaluated to be as low as△∧/∧≈0.5%.Furthermore,by utilizing the semiconductor-on-metal film-endowed interference effects,an extremely high energy efficiency is achieved via suppressing light reflection during femtosecond laser nano-processing.As the fabricated nanogratings exhibit multi-functionality,we exemplify their practical applications in highly sensitive refractive index sensing,vivid structural colors,and durable superhydrophilicity.

关键词： utilizing wafer refractive

Regulation and control of wet friction of soft materials using surface texturing:A review

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Friction 2023年第3期11卷 333-353页

作者： Meng LI Wenbin shi Jun shi Tao WANG liping shi Xiaolei WANG Key Laboratory of Green Fabrication and Surface Technology of Advanced Metal Materials Anhui University of TechnologyMa'anshan 243002China Anhui Province Key Laboratory of Special and Heay Load Robot Anhui University of TechnologyMa'anshan 243032China School of Mechanical Engineering Anhui University of TechnologyMa'anshan 243032China College of Mechanical&Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Surface texturing is a smart strategy that is commonly used in nature or industry to improve the tribological properties of sliding surfaces.Herein,we focus on the recent research progress pertaining to the wet friction modification of soft elastomers via texturing.To consider the pertinent physical mechanisms,we present and discuss the fundamentals of wet sliding on soft surfaces(including dewetting and wetting transitions in compliant contacts).Subsequently,we consider the methods in which the characteristic textures regulate and control wet sliding behaviors on soft surfaces;these textures range from conventional patterns of dimples to bioinspired architectures and can either positively or adversely impact the interfacial friction force.Furthermore,we briefly address the perspectives,potential applications,and challenges of texture design for modifying the friction characteristics of soft materials.

关键词： soft material surface texture wet sliding friction

Comparative Studies on Wet Attaching Abilities of Different Salamander Species

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Journal of Bionic Engineering 2022年第1期19卷 92-102页

作者： Meng Li Qing Jiao liping shi Xiaolei Wang Key Laboratory of Green Fabrication and Surface Technology of Advanced Metal Materials Ministry of EducationAnhui University of TechnologyMa’anshan243002China Anhui Province Key Laboratory of Special and Heavy Load Robot Anhui University of TechnologyMa’anshan243032China School of Mechanical Engineering Anhui University of TechnologyMa’anshan243032China College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing210016China

Salamanders have evolved functions of attaching to a variety of surfaces under wet conditions,but racial diversity may cause a difference in attachment behaviors and epidermal characteristics.The sticking and climbing abilities of the Chinese Fire Belly Newt(CFBN),Chinese Warts Triton(CWT),Spotless Stout Newt(SSN),and Chinese Giant Salamander(CGS)on various surfaces were investigated and compared in terms of epidermal morphology,body size,and wettability.The results indicate that the spotless stout newt has an excellent ability for wet attachment,compared to other salamanders under a certain contact case,resulting from its lower mass/body surface area and more visible epidermal structures.Supplementation with moderate water is beneficial for salamander attachment,and the surface roughness in the flood case also promotes the wet attachment.The CFBN has the most hydrophilic epidermis among the samples,where the water droplet quickly spreads over,presenting a completely wetting case.This study offers a comprehensive understanding of the wet attachments and the epidermal characteristics of salamanders,which is meaningful for the application of bioinspired adhesives.

关键词： Wet attachment Salamander Epidermal structure Wettability

Drug delivery systems for colorectal cancer chemotherapy

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Chinese Chemical Letters 2024年第2期35卷 163-175页

作者： Wen Chen Kun shi Yan Yu Peipei Yang Zhongwu Bei Dong Mo liping Yuan Meng Pan Yu Chen Zhiyong Qian Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Colorectal cancer causes the third most common type of malignant tumors with high morbidity and mortality.Chemotherapy is currently one of the most effective and common treatments for colorectal cancer.However,the poor water solubility of some chemotherapeutics,untargeted drug delivery,and the undesirable systemic side effects of conventional treatment remain the major issues for colorectal cancer chemotherapy.Fortunately,drug delivery systems(DDS)based on biomaterials have been widely investigated and found to be capable of resolving those issues with good performance.Therefore,the main goal of this review is to summarize and discuss the progress and potential advantages of different DDS for colorectal cancer chemotherapy.We not only reviewed the nanocarriers used to improve the solubility of chemotherapeutics,including liposomes,micelles,and nanoparticles,but also discussed targeted DDS based on specific ligand-receptor recognition and tumor microenvironmental stimulus responses.Furthermore,locally administered systems based on hydrogels and microspheres,which have been shown to increase drug accumulation at the tumor site while decreasing systemic toxicity,were also emphasized.DDS provides a good option for improving the efficacy of chemotherapy in the treatment of colorectal cancer.

关键词： Colorectal cancer Chemotherapy Drug delivery systems Solubility Targeted Local administration

Hierarchically Structured Nb_(2)O_5 Microflowers with Enhanced Capacity and Fast-Charging Capability for Flexible Planar Sodium Ion Micro-Supercapacitors

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Nano-Micro Letters 2024年第4期16卷 97-109页

作者： Jiaxin Ma Jieqiong Qin Shuanghao Zheng Yinghua Fu liping Chi Yaguang Li Cong Dong Bin Li Feifei Xing Haodong shi Zhong‑Shuai Wu State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of Sciences457 Zhongshan RoadDalian 116023People’s Republic of China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001People’s Republic of China College of Science Henan Agricultural UniversityNo.63 Agricultural RoadZhengzhou 450002People’s Republic of China Dalian National Laboratory for Clean Energy Chinese Academy of Sciences457 Zhongshan RoadDalian 116023People’s Republic of China University of Chinese Academy of Sciences 19A Yuquan RoadShijingshan DistrictBeijing 100049People’s Republic of China Hebei Key Lab of Optic‑Electronic Information and Materials The College of Physics Science and TechnologyInstitute of Life Science and Green DevelopmentHebei UniversityBaoding 071002People’s Republic of China

Planar Na ion micro-supercapacitors(NIMSCs) that offer both high energy density and power density are deemed to a promising class of miniaturized power sources for wearable and portable microelectron-ics. Nevertheless, the development of NIMSCs are hugely impeded by the low capacity and sluggish Na ion kinetics in the negative electrode.Herein, we demonstrate a novel carbon-coated Nb_(2)O_5 microflower with a hierarchical structure composed of vertically intercrossed and porous nanosheets, boosting Na ion storage performance. The unique structural merits, including uniform carbon coating, ultrathin nanosheets and abun-dant pores, endow the Nb_(2)O_5 microflower with highly reversible Na ion storage capacity of 245 mAh g^(-1) at 0.25 C and excellent rate capability.Benefiting from high capacity and fast charging of Nb_(2)O_5 microflower, the planar NIMSCs consisted of Nb_(2)O_5 negative electrode and activated car-bon positive electrode deliver high areal energy density of 60.7 μWh cm^(-2),considerable voltage window of 3.5 V and extraordinary cyclability. Therefore, this work exploits a structural design strategy towards electrode materials for application in NIMSCs, holding great promise for flexible microelectronics.

关键词： Nb_(2)O_5 nanosheets Microflowers Sodium ion micro-supercapacitors Flexibility Energy storage

A soluble pH-responsive host-guest-based nanosystem for homogeneous exosomes capture with high-efficiency

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中国化学快报:英文版 2023年第8期34卷 296-301页

作者： Haiyan Wang Peng Liang Lei Zhang liping shi Yitong Ge Liyuan Zhang Xiaoqiang Qiao College of Pharmaceutical Sciences Key Laboratory of Public Health Safety of Hebei ProvinceKey Laboratory of Medicinal Chemistry and Molecular DiagnosisMinistry of EducationHebei UniversityBaoding 071002China College of Basic Medical Science Key Laboratory for Proteomics of Liaoning ProvinceDalian Medical UniversityDalian 116044China

Exosomes offer ideal biomarkers for liquid biopsies.However,high-efficient capture of exosomes has been proven to be extreme challenging.Here,we report a soluble pH-responsive host-guest-based nanosystem(pH-HGN)for homogeneous isolation of exosomes around physiological pH.The pH-HGN consists of two specifically functionalized modules.First,a pH-responsive module,poly-dimethylaminoethyl methacrylate,provides homogeneous capture circumstances and sharp pH-triggered self-assembly separation in aqueous solution to improve capture efficiency and reduce nonspecific adsorption.Second,a host-guest module,poly-acrylamide azobenzene andβ-cyclodextrin linked with exosomes-specific antibody,could act as the"cleavable bridge"to specific capture and subsequent rapid release of captured exosomes through host-guest interaction betweenβ-cyclodextrin and AAAB moieties.The pH-HGN offered high capture efficiencies for exosomes from two different cell lines,which were 90.2%±0.28%and 87.0%±4.6%for H1299 and MCF-7 cell-derived exosomes,respectively.The purity of isolated exosomes was(1.49±0.71)×10^(11)particles/μg,which was 4.1 times higher compared with the gold standard ultracentrifugation(UC)method.Furthermore,the isolated exosomes via the pH-HGN can preserve well integrity and biological activity.The developed pH-HGN was further successfully applied to differentiate lung cancer patients from healthy persons.These findings indicated that pH-HGN is a promising strategy in exosomes-based research and downstream applications.

关键词： Exosomes Homogeneous capture Soluble nanosystem pH-responsive polymer Host-guest interaction

Optical coherence tomography—in situ and high-speed 3D imaging for laser materials processing

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Light(Science & Applications) 2022年第10期11卷 2260-2261页

作者： Xiaodong Wang Xin Yuan liping shi School of Engineering Westlake UniversityHangzhou 310030 ZhejiangChina Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province Westlake University18 Shilongshan RoadHangzhou 310024 ZhejiangChina Institute of Advanced Technology Westlake Institute for Advanced Study18 Shilongshan RoadHangzhou 310024 Zhejiang ProvinceChina Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology1037 Luoyu roadWuhan 430079China

Exploiting Fourier-domain optical coherence tomography,a high-speed and real-time inspection of multi-photon 3D laser printing has been reported.We expect that this technique can be further extended to single shot com... 详细信息

关键词： laser high printing

Aptamers targeting SARS-CoV-2 nucleocapsid protein exhibit potential ant1ip1 an-coronavirus activity

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1186-1198页

作者： Minghui Yang Chunhui Li Guoguo Ye Chenguang Shen Huiping shi liping Zhong Yuxin Tian Mengyuan Zhao Pengfei Wu Abid Hussain Tian Zhang Haiyin Yang Jun Yang Yuhua Weng Xinyue Liu Zhimin Wang Lu Gan Qianyu Zhang Yingxia Liu Ge Yang Yuanyu Huang Yongxiang Zhao School of Life Science Advanced Research Institute of Multidisciplinary ScienceKey Laboratory of Molecular Medicine and BiotherapyBeijing Institute of TechnologyBeijing 100081China National Clinical Research Center for infectious disease Shenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China Guangdong Provincial Key Laboratory of Tropical Disease Research School of Public HealthSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Targeting Oncology National Center for International Research of Biotargeting TheranosticsGuangxi Key Laboratory of Biotargeting TheranosticsCollaborative Innovation Center for Targeting Tumor Diagnosis and TherapyGuangxi Medical UniversityNanning 530021China CAMS Key Laboratory of Antiviral Drug Research Beijing Key Laboratory of Antimicrobial AgentsInstitute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Emerging and recurrent infectious diseases caused by human coronaviruses(HCoVs)continue to pose a significant threat to global public health security.In light of this ongoing threat,the development of a broad-spectrum drug to combat HCoVs is an urgently priority.Herein,we report a series of anti-pan-coronavirus ssDNA aptamers screened using Systematic Evolution of Ligands by Exponential Enrichment(SELEX).These aptamers have nanomolar affinity with the nucleocapsid protein(NP)of Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and also show excellent binding efficiency to the N proteins of both SARS,MERS,HCoV-OC43 and-NL63 with affinity KD values of 1.31 to 135.36 nM.Such aptamer-based therapeutics exhibited potent antiviral activity against both the authentic SARS-CoV-2 prototype strain and the Omicron variant(BA.5)with EC50 values at 2.00 nM and 41.08 nM,respectively.The protein docking analysis also evidenced that these aptamers exhibit strong affinities for N proteins of pan-coronavirus and other HCoVs(−229E and-HKU1).In conclusion,we have identified six aptamers with a high pan-coronavirus antiviral activity,which could potentially serve as an effective strategy for preventing infections by unknown coronaviruses and addressing the ongoing global health threat.

关键词： acute threat conclusion

Phase II study of novel orally PI3Kα/δinhibitor TQ-B3525 in relapsed and/or refractory follicular lymphoma

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2193-2201页

作者： Huaqing Wang Jifeng Feng Yanyan Liu Zhengzi Qian Da Gao Xuehong Ran Hui Zhou Lihong Liu Binghua Wang Meiyun Fang Hebing Zhou Zhenqian Huang shi Tao Zhuowen Chen liping Su Hang Su Yu Yang Xiaobao Xie Huijing Wu Ping Sun Guoyu Hu Aibin Liang Zhiming Li Department of Oncology Tianjin Union Medical Center of Nankai UniversityTianjin 300121PR China The Institute of Translational Medicine Tianjin Union Medical Center of Nankai UniversityTianjin 300121PR China Department of Medical Oncology Jiangsu Cancer HospitalThe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009PR China Department of Medical Oncology Henan Cancer HospitalThe Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003PR China Department of Medical Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060PR China Department of Hematology The Affiliated Hospital of Inner Mongolia Medical College010050 HohhotPR China Department of Hematology Weifang People’s HospitalThe First Affiliated Hospital of Weifang Medical University261000 WeifangPR China Department of Lymphoma&Hematology Hunan Cancer HospitalThe Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University410013 ChangshaPR China Department of Hematology The Fourth Hospital of Hebei Medical University and Hebei Tumor Hospital050011 ShijiazhuangPR China Department of Lymphoma Weihai Central Hospital264400 WeihaiPR China Department of Hematology and Rheumatology The Affiliated Zhongshan Hospital of Dalian University116001 DalianPR China Department of Hematology Beijing Luhe Hospital101199 BeijingPR China Department of Hematology The First Affiliated Hospital of Guangzhou Medical University510120 GuangzhouPR China Department of Hematology The First Affiliated Hospital of Hainan Medical College570102 HaikouPR China Department of Hematology The First People’s Hospital of Foshan528000 FoshanPR China Department of Hematology Shanxi Cancer Hospital030013 TaiyuanPR China Department of Lymphoma Senior Department of HematologyThe Fifth Medical Center of Chinese PLA General Hospital100039 BeijingPR China Department of Lymphoma and Head and Neck Cancer Fujian Cancer Hospital350014 FuzhouPR China Department of Hematology The First People’s Hospit

This registration study assessed clinical outcomes of TQ-B3525,the dual phosphatidylinositol-3-kinase(PI3K)α/δinhibitor,in relapsed and/or refractory follicular lymphoma(R/R FL).This phase II study(ClinicalTrials.gov NCT04324879.Registered March 27,2020)comprised run-in stage and stage 2.R/R FL patients after≥2 lines therapies received oral 20 mg TQ-B3525 once daily in a 28-day cycle until intolerable toxicity or disease progression.Primary endpoint was independent review committee(IRC)-assessed objective response rate(ORR).Based on results(ORR,88.0%;duration of response[DOR],11.8 months;progression-free survival[PFS],12.0 months)in 25 patients at run-in stage,second stage study was initiated and included 82 patients for efficacy/safety analysis.Patients received prior-line(median,3)therapies,with 56.1%refractory to previous last therapies;73.2%experienced POD24 at baseline.At stage 2,ORR was 86.6%(71/82;95%CI,77.3-93.1%),with 28(34.2%)complete responses.Disease control rate was 95.1%due to 7(8.5%)stable diseases.Median time to response was 1.8 months.Among 71 responders,median DOR was not reached;18-month DOR rate was 51.6%.with median follow-up of 13.3 months,median PFS was 18.5(95%CI,10.2-not estimable)months.Median overall survival(OS)was not reached by cutoff date;24-month OS rate was estimated as 86.1%.Response rates and survival data were consistent across all subgroups.Grade 3 or higher treatment-related adverse events were observed in 63(76.8%)cases,with neutropenia(22.0%),hyperglycemia(19.5%),and diarrhea(13.4%)being common.TQ-B3525 showed favorable efficacy and safety for R/R FL patients after≥2 lines prior therapies.

关键词： lymphoma assessed initiated