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Building Simulation 2022年第6期15卷 1051-1066页

作者： lipeng lv Yuhang Wu Changsheng Cao Lingjie Zeng Jun Gao Wuhao Xie Jing Zhang Institute of HVAC Engineering School of Mechanical EngineeringTongji UniversityShanghai200092China College of Environmental Science and Engineering Tongji UniversityShanghai200092China

The effects of different human walking patterns on contaminant dispersion in residential kitchens were investigated through computational fluid dynamics simulation with the dynamic mesh method.A tracer gas experiment was performed to verify the feasibility and accuracy of the simulation *** characteristics induced by human walking were minutely described,and the transient capture efficiency of the range hood was adopted to assess the impact of human walking *** walking parallel to a counter,human walking parallel to a counter manned by another human,and human walking toward a counter were *** showed that the mutual effect of the wake and thermal plume caused contaminant dispersion and decreased the performance of the range hood as the human subject walked beside the *** a standing person operated ahead the counter,the wake would affect the thermal plume in a certain *** decrement of capture efficiency approached 0.5 in the most unfavorable ***,the coaction of the positive/negative pressure zone and impinging air jet drew the thermal plume to the human *** fluctuation of capture efficiency in this condition was moderate relative to that for the human walking pattern beside the *** research could provide a comprehensive overview of different human walking patterns and their impact on residential kitchens and thereby facilitate the maintenance of kitchen air quality.

关键词： human walking overset mesh method dynamic simulation flow characteristics residential kitchen

Pressure and flowrate distribution in central exhaust shaft with multiple randomly operating range hoods

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Building Simulation 2022年第1期15卷 149-165页

作者： Lingjie Zeng Leqi Tong Jun Gao Bowen Du Chengquan Zhang lipeng lv Changsheng Cao Xihui Ding College of Environmental Science and Engineering Tongji UniversityShanghai 200092China School of Mechanical Engineering Tongji UniversityShanghai 200092China Department of civil and mineral engineering University of TorontoTorontoCanada

Central flues are now commonly adopted in high-rise residential buildings in China for cooking oil fumes(COF)*** hoods of all floors are connected to the central shaft,where oil fumes were gathered and exhausted through the outlet at the building *** households may cook and use their range hood at random periods,there is great uncertainty of the amount of COF being *** addition,users can often adjust the exhaust rate of the range hood according to their *** a result,thousands of possible operating conditions consisting of distinct combinations of on/off conditions and fan speed occur randomly in the central COF exhaust system,causing the exhaust performance to vary considerably from condition to *** work developed a mathematical model for characterizing the operation of the central COF exhaust system in a high-rise residential building as well as its iterative solving ***-scale tests coupled with CFD simulation referring to a real 30-floor building were conducted to validate the proposed *** results show that the model agreed well with the CFD and experimental data under various system operating ***,the Monte-Carlo method was introduced to simulate the random operating characteristics of the system,and a hundred thousand cases corresponding to distinct system operating conditions were sampled and statistically analyzed.

关键词： central exhaust shaft building ventilation range hood high-rise residential building randomly operating Monte-Carlo simulation

Influence of materials’hygric properties on the hygrothermal performance of internal thermal insulation composite systems

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Energy and Built Environment 2023年第3期4卷 315-327页

作者： Lingjie Zeng Yuqing Chen Changsheng Cao lipeng lv Jun Gao Jingguang Li Chongyang Zhang School of Mechanical Engineering Tongji UniversityShanghai 200092China Shanghai Research Institute of Building Sciences(Group)Co.Ltd. ShanghaiChina

Internal thermal insulation composite system(ITICS)can be an important measure for the energy-saving retrofitting of ***,ITICS may cause harmful effects on the hygrothermal performance of building *** work investigated the influence of the materials’hygric properties on the hygrothermal perfor-mance of a typical ITICS in different climate conditions in *** base wall materials,the traditional concrete and a new type aerated concrete,were tested and compared for their hygric properties *** influence of the hygroscopicity of exterior plasters,the permeability of insulation materials and the climate conditions were then analyzed with WUFI *** hygrothermal performance was evaluated with consideration of the total water content(TWC)of the walls and the moisture flux strength,the relative humidity(RH)and the mould growth risk at the interface between the base wall and the insulation layer(B-I interface).The numerical analysis implies that the TWC of internal insulated walls depends mainly on the hygroscopicity of exterior plaster and the wind-driven rain *** upper limits for the water absorption coefficient of exterior plasters used in Bei-jing,Shanghai and Fuzhou are 1e-9,1e-10,1e-10 m^(2)/s *** such limits are guaranteed,a vapour tight system created by using insulation materials with a large vapour resistance factor or adding a vapour barrier can improve the hygrothermal performance of ITICS,especially for concrete walls in cold climate.

关键词： Internal thermal insulation composite systems Hygrothermal performance assessment Hygirc properties of building materials Different climate conditions

Localization and characterization of intermittent pollutant source in buildings with ventilation systems:Development and validation of an inverse model

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Building Simulation 2021年第3期14卷 841-855页

作者： Lingjie Zeng Jun Gao lipeng lv Bowen Du Yalei Zhang Ruiyan Zhang Wei Ye Xu Zhang College of Environmental Science and Engineering Tongji UniversityShanghai200092China School of Mechanical Engineering Tongji UniversityShanghai 200092China Department of Civil and Mineral Engineering University of TorontoTorontoCanada

Terrorist attacks through building ventilation systems are becoming an increasing *** case pollutants are intentionally released in a building with mechanical ventilation systems,it is critical to localize the source and characterize its releasing *** inverse modeling studies have adopted the adjoint probability method to identify the source location and used the Tikhonov regularization method to determine the source releasing profile,but the selection of the prediction model and determination of the regularization parameter remain *** limitations can affect the identification accuracy and prolong the computational time *** address the difficulties in solving the inverse problems,this work proposed a Markov-chain-oriented inverse approach to identify the temporal release rate and location of a pollutant source in buildings with ventilation systems and validated it in an experimental *** the modified Markov chain,the source term was discrete by each time step,and the pollutant distribution was directly calculated with no *** forward Markov chain was reversed to characterize the intermittently releasing profile by introducing the Tikhonov regularization method,while the regularized parameter was determined by an automatic iterative discrepancy *** source location was further estimated by adopting the Bayes *** chamber experiments,the effectiveness of the proposed inverse model was validated,and the impact of the sensor performance,quantity and placement,as well as pollutant releasing curves on the identification accuracy of the source intensity was explicitly *** showed that the inverse model can identify the intermittent releasing rate efficiently and promptly,and the identification error for pollutant releasing curves with complex waveforms is about 20%.

关键词： intermittent source inverse identification Markov chain regularization parameter ventilation system

A novel method for identifying SARS-CoV-2 infection mutants via an epitope-specific CD8^(+)T cell test

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Biosafety and Health 2024年第3期6卷 143-152页

作者： Congling Qiu Bo Peng Chanchan Xiao Pengfei Chen lipeng Mao Xiaolu Shi Zhen Zhang Ziquan lv Qiuying lv Xiaomin Zhang Jiaxin Li Yanhao Huang Qinghua Hu Guobing Chen Xuan Zou Xiaofeng Liang Department of Public Health and Preventive Medicine School of MedicineJinan UniversityKangtai Biological Vaccine Industry Research Institute/Disease Prevention and Control Institute of Jinan UniversityGuangzhou 510632China Shenzhen Center for Disease Control and Prevention Shenzhen 518020China Department of Microbiology and Immunology Institute of Geriatric ImmunologySchool of MedicineJinan UniversityGuangzhou 510632China Key Laboratory of Viral Pathogenesis&Infection Prevention and Control(Jinan University) Ministry of EducationGuangzhou 510632China The Sixth Affiliated Hospital Jinan UniversityGuangzhou 510632China Department of Systems Biomedical Sciences School of MedicineJinan UniversityGuangzhou 510632China Microbiology Laboratory Shenzhen Center for Disease Control and PreventionShenzhen 518020China Department of Communicable Diseases Control and Prevention Shenzhen Center for Disease Control and PreventionShenzhen 518020China Central Laboratory Shenzhen Center for Disease Control and PreventionShenzhen 518020China

Since the outbreak of the coronavirus disease 2019(COVID-19)epidemic in 2019,the public health system has faced enormous *** the individuals who test positive for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a key step for interrupting chains of transmission of SARS-CoV-2 and reducing COVID-19-associated *** the increasing of asymptomatic infections,it is difficult to track asymptomatic infections through epidemiological surveys and virus whole-genome ***,due to the cross-reactivity of neutralizing antibodies produced by multiple virus subtypes,neutralizing antibody detection cannot be used to determine whether an individual has a history of infection with a specific subtype of *** recruited 4 human leukocyte antigen A2(HLA-A2)infections,15 individuals who received three doses of inactivated vaccines,and 30 breakthrough infections after vaccination and discussed a case-tracking approach to detect epitope-specific CD8^(+)T cells in the peripheral blood of close contacts,including accurate HLA typing based on ribonucleic acid(RNA)-sequencing and flow cytometry data and the comparison and characterization of SARS-CoV-2 HLA-A2 and HLA-A24 epitope-specific CD8^(+)T *** individuals who received three doses of inactivated vaccine,we observed that the CD8^(+)T cell specificity for ancestral epitopes was significantly higher than for mutated epitopes,and the fold change of CD8^(+)T cells corresponding to mutated epitopes relative to ancestral epitopes was less than *** enzyme-linked immunospot(ELISpot)results further validate this *** study forms a“method for understanding the infection history of SARS-CoV-2 subtypes based on the proportion of epitope-specific CD8^(+)T cells in the peripheral blood of subjects”,covering up to 46%of the population,including HLA-A2+and HLA-A24+donors,providing a novel method for SARS-CoV-2 infected case tracing.

关键词： Asymptomatic coronavirus disease 2019 (COVID-19) Epitopes Specific CD8^(+)T cell ELISpot

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抽水蓄能项目前期管理工作探析

建筑经济 2024年第S1期45卷 160-162页

作者：赵东阳吕宗强郭李鹏中国三峡建工(集团)有限公司四川成都610041

本文介绍抽水蓄能项目前期工作的目标任务和管理程序,从建设单位立场,从选点规划、预可行性研究、可行性研究三个阶段梳理部分常见问题,结合已有管理经验给出具体应对措施,分享建议和思考,力图为类似项目提供借鉴。

关键词：抽水蓄能前期工作选点规划

Photo-triggered nucleus targeting for cancer drug delivery

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Nano Research 2021年第8期14卷 2630-2636页

作者： Yafei Li Wen lv Lang Wang Yarning Zhang lipeng Yang Tianyi Wang Linyong Zhu Yufeng Wang Weiping Wang Department of Pharmacology and Pharmacy Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Dr.Li Dak-Sum Research Centre The University of Hong KongHong KongChina Department of Chemistry The University of Hong Kong Hong Kong China School of Chemistry and Molecular Engineering East China University of Science and Technology Shanghai 200030China

Here,we report a strategy to deliver drug nanoparticles into cells with nucleus-targeting ability under a spatiotemporal *** nanoparticles were constructed through self-assembly of photoresponsive prodrugs and free *** incorporating a nucleus localization sequence in the system,drug nanoparticles could be delivered into nuclei upon visible light *** drug nanoparticles showed high drug loading capacity and specific nucleus-targeting ability,which efficiently killed cancer *** self-assembly strategy could be applied to other hydrophobic drugs and targeting ligands for photo-controlled organelle-targeted drug delivery.

关键词： phototargeting dePEGylation nucleus targeting coumarin photoresponsive prodrugs

兰坪金顶跑马坪铅锌矿床的三维地质结构与控矿构造

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岩石学报 2022年第11期38卷 3531-3541页

作者：薛力鹏薛传东刘靖坤王维王宇吕思猛昆明理工大学地球科学系昆明650093 云南省有色地质局地质地球物理化学勘查院昆明650216

滇西北金顶超大型铅锌矿田位于青藏高原东南缘兰坪中-新生代盆地中部,是三江成矿带中南段最典型的密西西比河谷型(MVT)矿床之一,其构造控矿和盆地流体成矿特征明显受控于印度-欧亚大陆碰撞有关的区域挤压构造。近年来,矿床浅部地质条件... 详细信息

滇西北金顶超大型铅锌矿田位于青藏高原东南缘兰坪中-新生代盆地中部,是三江成矿带中南段最典型的密西西比河谷型(MVT)矿床之一,其构造控矿和盆地流体成矿特征明显受控于印度-欧亚大陆碰撞有关的区域挤压构造。近年来,矿床浅部地质条件与资源状况已被充分揭露,但其深部地质结构、构造控矿差异性仍不清楚,这也制约了成矿预测和找矿新发现。本文以矿田东北部的跑马坪大型隐伏矿床为研究对象,利用三维地质建模及空间分析方法,识别矿化空间变化及其与断层、不整合面和地层岩性的配置关系,分析构造控矿规律及可能的流体运聚趋势。结果表明,跑马坪铅锌矿床的成矿作用与近E-W向挤压构造对中新统金顶砂泥岩(Mio-j)与上三叠统三合洞组(T_(3)s)不整合面的差异性破坏关系密切,近NS和NE向逆断层与NW向走滑-掀斜断层组合是最重要的控矿构造。其中,近NE向逆断层与不整合面是成矿流体运聚的主要通道,而近于平行的NW向走滑-掀斜断层上盘的T_(3)s高孔渗性角砾状灰岩、含灰岩角砾砂岩及裂隙带因为富含H_(2)S等还原性流体而成为与Mio-j富含金属氧化性盆地卤水混合和金属沉淀就位的最有利空间。由此,逆断层和走滑-掀斜断层组合、特定地层岩性与不整合面联合控制了流体汇聚与混合成矿作用,断层沟通了同位叠加的上三叠统油气藏储层和渐新统-中新统盆地卤水(带),这是铅锌成矿的关键。该成矿模型在金顶矿田及邻区与类似地区均具有普遍指导意义。最后,本文预测沿跑马坪矿区深部及其南北侧延伸区域还存在多条NE向隐伏控矿断层,其成矿潜力大,是下一步找矿勘查的有利靶区。

关键词：三维地质模型空间分析构造控矿金顶跑马坪铅锌矿床青藏高原东南缘

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Redox-responsive biocompatible nanocarriers based on novel heparosan polysaccharides for intracellular anticancer drug delivery

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Asian Journal of Pharmaceutical Sciences 2020年第1期15卷 83-94页

作者： lipeng Qiu Lu Ge Miaomiao Long Jing Mao Kamel SAhmed Xiaotian Shan Huijie Zhang Li Qin Guozhong lv Jinghua Chen School of Pharmaceutical Sciences Jiangnan UniversityWuxi 214122China Wuxi Higher Health Vocational Technology School Wuxi 214028China Wuxi Third Renmin Hospital Wuxi 214041China

Heparosan is a natural precursor of heparin biosynthesis in mammals. It is stable in blood circulation but can be degraded in lysosomes, showing good biocompatibility and long circulation features. So heparosan can be designed as anticancer drug carriers to increase tumor selectivity and improve the therapeutic effect. A novel redox-sensitive heparosancystamine-vitamin E succinate(KSV) micelle system was constructed for intracellular delivery of doxorubicin(DOX). Simultaneously, the redox-insensitive heparosan-adipic acid dihydrazide-vitamin E succinate copolymer(KV) was synthesized as control. DOX-loaded micelles(DOX/KSV) with an average particle size of 90–120 nm had good serum stability and redox-triggered depolymerization. In vitro drug release test showed that DOX/KSV micelles presented obvious redox-triggered release behavior compared with DOX/KV. Cytotoxicity and cell uptake were investigated using MGC80-3 tumor cells and COS7 fibroblast-like cells. The cell survival rate of blank micelles was more than 90%, and the cytotoxicity of DOX/KSV in MGC80-3 cells was higher than in COS7 cells, indicating that the carrier has better biocompatibility and less toxicity side effect. The cytotoxicity of DOX/KSV against MGC80-3 cells was significantly greater than that of free DOX and DOX/KV. Furthermore, compared with DOX/KV in MGC80-3 cells, DOX/KSV micelles uptook more anticancer drugs and then released DOX faster into the cell nucleus. The micelles were endocytosed by multiple pathways, but clathrin-mediated endocytosis was the main pathway. Therefore, heparosan polysaccharide could be a potential option as anticancer carrier for enhancing efficacy and mitigating toxicity.

关键词： Heparosan Vitamin E succinate Redox-sensitive micelles Drug delivery

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罗茨高效真空泵应用探讨

电站辅机 2022年第1期43卷 33-38页

作者：徐海荣吕峰金利鹏浙江浙能温州发电有限公司浙江温州325602

电厂中凝汽器真空系统节能改进潜力较大,其中罗茨高效真空泵节能应用广泛。介绍了罗茨真空泵系统特点、节能原理,并对其在电厂的应用过程中实际节能效果进行了评估,对其它类似的真空系统推广具有参考意义。

关键词：电厂节能罗茨真空泵