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Dyslipidemia and cardiovascular disease risk factors in patients with type 1 diabetes:A single-center experience

World Journal of Diabetes 2021年第1期12卷 56-68页

作者： Sari Krepel Volsky Shlomit Shalitin Elena Fridman Michal Yackobovitch-Gavan liora lazar Rachel Bello Tal Oron Ariel Tenenbaum Liat de Vries Yael Lebenthal National Center for Childhood Diabetes The Jesse Z and Sara Lea Shafer Institute for Endocrinology and DiabetesSchneider Children's Medical Center of IsraelPetach-Tikva 4920235Israel Sackler School of Medicine Tel Aviv UniversityTel Aviv 6997801Israel

BACKGROUND Type 1 diabetes(T1D)contributes to altered lipid profiles and increases the risk of cardiovascular disease(CVD).Youth with T1D may have additional CVD risk factors within the first decade of *** To examine risk factors for dyslipidemia in young subjects with *** Longitudinal and cross-sectional retrospective study of 170 young subjects with T1D(86 males;baseline mean age 12.2±5.6 years and hemoglobin A1c 8.4%±1.4%)were followed in a single tertiary diabetes center for a median duration of 15 *** for outcomes of lipid profiles at last visit(total cholesterol[TC],triglycerides[TGs],low-density lipoprotein-cholesterol[LDL-c],and highdensity lipoprotein-cholesterol[HDL-c])were analyzed by stepwise linear regression *** At baseline,79.5%of the patients had at least one additional CVD risk factor(borderline dyslipidemia/dyslipidemia[37.5%],pre-hypertension/hypertension[27.6%],and overweight/obesity[16.5%])and 41.6%had multiple(≥2)CVD risk factors.A positive family history of at least one CVD risk factor in a first-degree relative was reported in 54.1%of the *** of elevated TC:family history of CVD(β[SE]=23.1[8.3],P=0.006);of elevated LDL-c:baseline diastolic blood pressure(DBP)(β[SE]=11.4[4.7],P=0.003)and family history of CVD(β[SE]=20.7[6.8],P=0.017);of elevated TGs:baseline DBP(β[SE]=23.8[9.1],P=0.010)and family history of CVD(β[SE]=31.0[13.1],P=0.020);and of low HDL-c levels:baseline DBP(β[SE]=4.8[2.1],P=0.022]).CONCLUSION Our findings suggest that elevated lipid profiles are associated with DBP and a positive family history of *** is of utmost importance to prevent and control modifiable risk factors such as these,as early as childhood,given that inadequate glycemic control and elevation in blood pressure intensify the risk of dyslipidemia.

关键词： Type 1 diabetes Children and adolescents Cardiovascular disease risk factors Dyslipidemia Hypertension Family history of cardiovascular disease risk factors

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Lean Healthy Children with Short Stature Have Distinct Eating Patterns

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Journal of Food Science and Engineering 2016年第6期6卷 299-307页

作者： Shir Hadani Yael Lebenthal liora lazar Raanan Shamir Moshe Phillip Michal Yackobovitch-Gavan The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes National Center for Childhood Diabetes Schneider Children's Medical Center of Israel Petah Tikva 49202 Israel Sackler Faculty of Medicine Tel Aviv University Tel Aviv 699 78 Israel Institute for Gastroenterology Nutrition and Liver Diseases Schneider Children's Medical Center of Israel Petah Tikva 49202 Israel

Nutrition plays an essential role in normal linear growth in children. Knowledge of the eating styles and dietary consumption of healthy short children from developed countries is scarce. The aim of this study was to investigate the dietary patterns in idiopathic short stature （ISS） and relatively low weight children compared to children with normal stature and weight. This research is a case-control study of 86 pre-pubertal healthy children, mean age 5.9 ± 1.5 years. The study group comprised 43 ISS children; 43 age-matched children with normal stature and weight served as controls. Outcome measures included： dietary patterns and physical activity. The absolute daily average energy, protein and carbohydrate intake was significantly lower in the ISS children （P 〈 0.05）; after correcting for body surface area, no significant differences were found between groups. Intake of micronutrients calcium, iron, zinc, vitamin A and vitamin C, expressed as percentage from Recommended Dietary Allowance, was significantly lower in the ISS children （P 〈 0.05）, who had lower food responsiveness, higher satiety responsiveness, lesser enjoyment of food and were slower eaters （P 〈 0.001）. Physical activity was sedentary in both the ISS cases and controls. Our findings in healthy, pre-pubertal, relatively lean ISS children point to a distinct eating pattern with no alteration in physical activity. Understanding the differences in dietary intake and eating behaviors may be beneficial in the development of targeted nutritional intervention for lean ISS children.

关键词： Dietary patterns eating behaviors lean children short stature.

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Interactive mobile equipment safety task-training in surface mining

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International Journal of Mining Science and Technology 2021年第4期31卷 743-751页

作者： lazar Zujovic Vladislav Kecojevic Dragan Bogunovic Department of Mining Engineering West Virginia UniversityMorgantown 26501USA North American Coal Corporation Farmington 87401USA

Improving the quality of equipment training for the Heavy Equipment Operators(HEO)is a critical task in improving safety and eliminating equipment-related injuries in *** of major responsibilities for the HEOs is proper machine *** miner safety training includes the use of hardcopy documents and video ***,modern mobile and computer technology offers tremendous potential to improve the training *** this study,we apply a 360-degree camera,opensource platform WordPress^(TM),and the software Unity3D in order to create materials and tools for the HEOs safety training to help trainees better understand the pre-shift safety machine *** computer-based safety task training developed in this research is tested and implemented at a surface mine in the southern United States.

关键词： Heavy equipment operators Safety task training 360-degree image/video Virtual reality

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A resilience-based approach in managing the closure and abandonment of large mine tailing ponds

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International Journal of Mining Science and Technology 2020年第5期30卷 737-746页

作者： Dragan Komljenovic lazar Stojanovic Vladimir Malbasic Aleksandar Lukic Hydro-Québec Research Institute(IREQ) VarennesQC J3X 1S1Canada Faculty of Mining University of Banja Luka79101 PrijedorBosnia and Herzegovina ArcelorMittal Prijedor d.o.o.Prijedor 79101 PrijedorBosnia and Herzegovina

Mining tailing ponds are large infrastructure objects whose life cycle spans over several *** are indispensable for certain types of mines where technological process produces and rejects *** also have potential to generate risks for human life,property and *** that reason,it is essential to adequately manage them throughout all the stages of their life *** phase of their closure and abandonment is less studied and *** paper proposes a holistic resilience-based approach for analyzing this phase of their life *** proposed methodology is validated through a case study at an actual surface iron ore mine in Bosnia and Herzegovina.

关键词： Mine tailing ponds Closure Abandonment Resilience Risks Uncertainties Complexity

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Decision Support for Integrated Management of Local-Level Adaptation to Climate Changes: The Case of Serbia

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International Journal of Disaster Risk Science 2021年第4期12卷 479-494页

作者： Petar Vranić Srđan Glišović lazar Velimirović Mathematical Institute of the Serbian Academy of Sciences and Arts 11001BelgradeSerbia Faculty of Occupational Safety in Niš University of Niš18000NišSerbia

Projected climate changes will additionally increase the already significant risk of natural hazard-related disasters in Serbia and the west Balkan region as a *** is about to introduce the strategy for climate change adaptation and ***,a national decision-support system for implementation of the climate change law and strategy is yet to be *** study contributes to the implementation of adaptation policies at subnational levels by development of a decision-support model for local-level management of the climate change adaptation *** study explores the potential for synergetic application of multicriteria decision making analysis and probabilistic reasoning methods by focusing on Bayesian networks,analytical hierarchy processes,and geographic information systems for selection of priority adaptation *** study was based on the formation of causal chains,which enable linking management decisions and socioeconomic or biophysical consequences into articulated sequences of conditional relationships.A model was tested in the forestry sector,and it clearly pointed out development of an early warning system and planning of water intake basins as priority adaptation *** the results are shown as a probability distribution for each alternative solutions,the model can assist decision makers with prompt evaluation of various scenarios.

关键词： Bayesian networks Climate change adaptation Multicriteria decision-making Serbia Wildfire risk

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Channeling of fast ions through the bent carbon nanotubes： The extended two-fluid hydrodynamic model

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Chinese Physics B 2016年第4期25卷 274-283页

作者： lazar Karbunar Dusko Borka Ivan Radovic Zoran L Miskovic School of Electrical Engineering University of Belgrade Bulevar Kralja Aleksandra 73 11120 Belgrade Serbia Vinca Institute of Nuclear Sciences University of Belgrade P. O. Box 522 11001 Belgrade Serbia Department of Applied Mathematics and Waterloo Institute for Nanotechnology University of Waterloo Waterloo Ontario Canada N2L 3G1

We investigate the interactions of charged particles with straight and bent single-walled carbon nanotubes （SWNTs） under channeling conditions in the presence of dynamic polarization of the valence electrons in carbon, This polarization is described by a cylindrical, two-fluid hydrodynamic model with the parameters taken from the recent modelling of several independent experiments on electron energy loss spectroscopy of carbon nano-structures. We use the hydrodynamic model to calculate the image potential for protons moving through four types of SWNTs at a speed of 3 atomic units. The image potential is then combined with the Doyle-Turner atomic potential to obtain the total potential in the bent carbon nanotubes. Using that potential, we also compute the spatial and angular distributions of protons channeled through the bent carbon nanotubes, and compare the results with the distributions obtained without taking into account the image potential.

关键词： nanotubes channeling dynamic polarization

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Fekete-Gauss Spectral Elements for Incompressible Navier-Stokes Flows:The Two-Dimensional Case

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Communications in Computational Physics 2013年第5期13卷 1309-1329页

作者： Laura lazar Richard Pasquetti Francesca Rapetti Lab.J.A.Dieudonne UMR 7351 CNRS UNSUniversite de Nice-Sophia Antipolis06108 Nice Cedex 02France

Spectral element methods on simplicial meshes,say TSEM,show both the advantages of spectral and finite element methods,i.e.,spectral accuracy and geometrical *** present a TSEM solver of the two-dimensional(2D)incompressible Navier-Stokes equations,with possible extension to the 3D *** uses a projection method in time and piecewise polynomial basis functions of arbitrary degree in *** so-called Fekete-Gauss TSEM is employed,i.e.,Fekete(***)points of the triangle are used as interpolation(***)*** the sake of consistency,isoparametric elements are used to approximate curved *** resolution algorithm is based on an efficient Schur complement method,so that one only solves for the element boundary ***,the algebraic system is never assembled,therefore the number of degrees of freedom is not *** accuracy study is carried out and results are provided for classical benchmarks:the driven cavity flow,the flow between eccentric cylinders and the flow past a cylinder.

关键词： Spectral elements simplicial meshes Fekete-Gauss approximation Navier-Stokes equations projection methods domain decomposition

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Predictors of rebleeding and in-hospital mortality in patients with nonvariceal upper digestive bleeding

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World Journal of Clinical Cases 2019年第18期7卷 2687-2703页

作者： Daniela Cornelia lazar Sorin Ursoniu Adrian Goldis Department of Internal Medicine I University Medical ClinicUniversity of Medicine and Pharmacy "Victor Babes"Timisoara 300041Timis CountyRomania Department of Public Health and Health Management University of Medicine and Pharmacy "Victor Babes"Timisoara 300041Timis CountyRomania Department of Gastroenterology and Hepatology University of Medicine and Pharmacy "Victor Babes"Timisoara 300041Timis CountyRomania

BACKGROUND Nonvariceal upper digestive bleeding (NVUDB) represents a severe emergency condition and is associated with significant morbidity and mortality. Despite a decrease in the incidence due to the widespread use of potent therapy with proton pump inhibitors as well as the implementation of modern endoscopic techniques, the mortality rate associated with NVUDB is still high. AIM To identify the clinical, biological, and endoscopic parameters associated with a poor outcome in patients with NVUDB to allow the stratification of risk, which will lead to the implementation of the most accurate management. METHODS We performed a retrospective study including patients who were admitted to the Gastroenterology Department of Clinical Emergency County Hospital Timisoara, Romania, with a diagnosis of NVUDB between 1 January 2008 and 31 December 2016. All the data were collected from the patient’s records, including demographic data, medication history, hemodynamic status, paraclinical tests, and endoscopic features as well as the methods of hemostasis, rate of rebleeding, need for surgery and death;we also assessed the Rockall score of the patients, length of hospitalization and associated comorbidities. All these parameters were evaluated as potential risk factors associated with rebleeding and death in patients with *** We included a batch of 1581 patients with NVUDB, including 523 (33%) females and 1058 (67%) males with a median age of 66 years. The main cause of NVUDB was peptic ulcer (73% of patients). More than one-third of the patients needed endoscopic treatment. Rebleeding rate was 7.72%;surgery due to failure of endoscopic hemostasis was needed in 3.22% of cases;the in-hospital mortality rate was 8.09%, and the bleeding-episode-related mortality rate was 2.97%. Although our predictive models for rebleeding and death had a low sensitivity, the specificity was very high, suggesting a better discriminative capacity for identifying patients with better out

关键词： Nonvariceal upper digestive bleeding Risk factors Rebleeding Death Outcome

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A novel LC–MS/MS assay for methylprednisolone in human plasma and its pharmacokinetic application

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Asian Journal of Pharmaceutical Sciences 2016年第3期11卷 459-468页

作者： Sridhar Siddiraju Mercy lazar Lal Prasanth Tadiboyina Sirisha Department of Pharmaceutical Chemistry Malla Reddy College of Pharmacy Osmania University Department of Pharmacy Shri Jagdishprasad Jhabarmal Tibrewala University Department of Pharmaceutical Chemistry JSS College of Pharmacy JSS University

Methylprednisolone is a synthetic glucocorticoid. In our report, the authors proposed a sensitive and selective liquid chromatography/tandem mass spectrometry(LC–MS/MS) assay for the determination of methylprednisolone applying budesonide as internal standard. Liquid–liquid extraction(LLE) having tert–butyl methyl ether(TBME) have been employed to extract methylprednisolone from the plasma samples. Immediately after reconstitution, the samples were chromatographed on a C18 column using an isocratic mobile phase composed of 10 m M ammonium formate buffer and acetonitrile(35:65, v/v). A flow rate of 1.00 ml/min was used to elute the analyte form the column. Analysis was carried out with an API–4000 LC–MS/MS instrument operated in multiple reaction-monitoring(MRM) mode. The linearity has been proven within the concentration range of 10.1–804 ng/ml in plasma samples. The precision(%CV) and accuracy results in five validation batches across five concentration levels were well within the acceptance limits. The drug was stable under different conditions. The particular assay has been proficiently put on pharmacokinetic study in healthy male subjects.

关键词： Human plasma LC-MS/MS Method validation Methylprednisolone Pharmacokinetics

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Artificial intelligence as a noninvasive tool for pancreatic cancer prediction and diagnosis

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World Journal of Gastroenterology 2023年第12期29卷 1811-1823页

作者： Alexandra Corina Faur Daniela Cornelia lazar Laura Andreea Ghenciu Department of Anatomy and Embriology “Victor Babeș”University of Medicine and Pharmacy TimișoaraTimișoara 300041TimișRomania Department V of Internal Medicine I Discipline of Internal Medicine IVUniversity of Medicine and Pharmacy“Victor Babes”TimișoaraTimișoara 300041TimișRomania DepartmentⅢ Discipline of Pathophysiology“Victor Babeș”University of Medicine and PharmacyTimișoara 300041TimișRomania

Pancreatic cancer(PC)has a low incidence rate but a high mortality,with patients often in the advanced stage of the disease at the time of the first *** detected,early neoplastic lesions are ideal for surgery,offering the best *** lesions of the pancreas include pancreatic intraepithelial neoplasia and mucinous cystic neoplasms,with intraductal papillary mucinous neoplasms being the most commonly *** study focused on predicting PC by identifying early signs using noninvasive techniques and artificial intelligence(AI).A systematic English literature search was conducted on the PubMed electronic database and other *** obtained a total of 97 studies on the subject of pancreatic *** final number of articles included in our study was 44,34 of which focused on the use of AI algorithms in the early diagnosis and prediction of pancreatic *** algorithms can facilitate diagnosis by analyzing massive amounts of data in a short period of *** can be made through AI algorithms by expanding image and electronic medical records databases,which can later be used as part of a screening program for the general ***-based screening models should involve a combination of biomarkers and medical and imaging data from different *** requires large numbers of resources,collaboration between medical practitioners,and investment in medical infrastructures.

关键词： Pancreatic cancer Early pancreatic lesions Pancreatic neoplasia Artificial intelligence Deep learning Machine learning Radiomics Diagnosis Pancreas

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