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Elderly patients over 80 years undergoing colorectal cancer resection: Development and validation of a predictive nomogram for survival

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World Journal of Gastrointestinal Surgery 2023年第5期15卷 892-905页

作者： Aik Yong Chok Yun Zhao Hui lionel raphael chen Ivan En-Howe Tan Desmond Han Wen Chew Yue Zhao Marianne Kit Har Au Emile John Kwong Wei Tan Department of Colorectal Surgery Singapore General HospitalSingapore 169608Singapore Group Finance Analytics Singapore Health ServicesSingapore 168582Singapore Group Finance Singapore Health ServicesSingapore 168582Singapore Singhealth Community Hospitals Singapore 168582Singapore

BACKGROUND Surgery remains the primary treatment for localized colorectal cancer(CRC).Improving surgical decision-making for elderly CRC patients necessitates an accurate predictive *** To build a nomogram to predict the overall survival of elderly patients over 80 years undergoing CRC *** Two hundred and ninety-five elderly CRC patients over 80 years undergoing surgery at Singapore General Hospital between 2018 and 2021 were identified from the American College of Surgeons–National Surgical Quality Improvement Program(ACS-NSQIP)*** variables were selected using univariate Cox regression,and clinical feature selection was performed by the least absolute shrinkage and selection operator regression.A nomogram for 1-and 3-year overall survival was constructed based on 60%of the study cohort and tested on the remaining 40%.The performance of the nomogram was evaluated using the concordance index(C-index),area under the receiver operating characteristic curve(AUC),and calibration *** groups were stratified using the total risk points derived from the nomogram and the optimal cut-off *** curves were compared between the high-and low-risk *** Eight predictors:Age,Charlson comorbidity index,body mass index,serum albumin level,distant metastasis,emergency surgery,postoperative pneumonia,and postoperative myocardial infarction,were included in the *** AUC values for the 1-year survival were 0.843 and 0.826 for the training and validation cohorts,*** AUC values for the 3-year survival were 0.788 and 0.750 for the training and validation cohorts,respectively.C-index values of the training cohort(0.845)and validation cohort(0.793)suggested the excellent discriminative ability of the *** curves demonstrated a good consistency between the predictions and actual observations of overall survival in both training and validation cohorts.A significant difference in overall survival wa

关键词： Colorectal cancer Elderly Nomogram Overall survival Prognostic Risk stratification

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Outcomes after natural orifice extraction vs conventional specimen extraction surgery for colorectal cancer: A propensity scorematched analysis

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World Journal of Clinical Oncology 2022年第10期13卷 789-801页

作者： Isaac Seow-En lionel raphael chen Yi-Xin Li Yun Zhao Jing-Hui chen Hairil Rizal Abdullah Emile Kwong-Wei Tan Department of Colorectal Surgery Singapore General HospitalSingapore 169608Singapore Department of Surgery Duke-NUS Graduate Medical SchoolSingapore 169857Singapore Department of Anaesthesiology Singapore General HospitalSingapore 169608Singapore

BACKGROUND Natural orifice specimen extraction(NOSE)via the anus or vagina replaces conventional transabdominal specimen retrieval via the transabdominal route through a limited mid-line laparotomy or Pfannenstiel *** the number of laparoscopic ports further decreases operative abdominal wall *** techniques reduce the surgical wound size as well as the risk of incisionrelated *** To compare short-term outcomes following 3-port NOSE surgery with a matched cohort of conventional non-NOSE colorectal cancer *** Patients who underwent elective 3-port laparoscopic colorectal NOSE surgery between February to October 2021 were *** criteria for NOSE surgery was adapted from the 2019 International Consensus on Natural Orifice Specimen Extraction Surgery for colorectal *** with clinical T4 or N2 tumors on staging computed tomography were also *** propensity score-matched cohort was identified amongst patients who underwent conventional laparoscopic colorectal surgery from January 2019 to December *** was performed in the ratio of 1:4 based on age,gender,type of resection,and p-tumor node metastasis *** Over the eight-month study duration,14 consecutive cases(nine female,five male)of elective 3-port laparoscopic surgery with NOSE were performed for colorectal *** age and body mass index were 70(range 43-82)years and 24.1(range 20.0-31.7)kg/m2 *** patients underwent transanal NOSE and eight had transvaginal *** operative time,intraoperative blood loss and postoperative length of stay were 208(range 165-365)min,30(range 10-150)mL and 3(range 2-6)d ***(14%)suffered minor postoperative compilations not attributable to the NOSE *** follow-up duration was 12(range 8-15)*** instances of mortality,local or distant disease recurrence were recorded in this *** to the conventional surgery cohort of 56 patients,the 3

关键词： 3-port laparoscopy Colorectal surgery Natural orifice specimen extraction Transanal Transvaginal Minimally invasive surgery

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Nanofiber Materials for Lithium‑Ion Batteries

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Advanced Fiber Materials 2023年第4期5卷 1141-1197页

作者： Xinwang Cao Chang Ma Lei Luo Lei chen Hui cheng raphael Simha Orenstein Xiangwu Zhang National Engineering Laboratory for Advanced Yarn and Fabric Formation and Clean Production College of Textiles Science and EngineeringWuhan Textile UniversityWuhan 430200China Tianjin Municipal Key Lab of Advanced Fiber and Energy Storage Technology Tiangong UniversityTianjin 300387China Fiber and Polymer Science Program Department of Textile EngineeringChemistry and ScienceWilson College of TextilesNorth Carolina State UniversityRaleighNC 27695USA

The lithium-ion(Li-ion)battery has received considerable attention in the field of energy conversion and storage due to its high energy density and *** academic and commercial progress has been made in Li-ion battery *** area of advancement has been the addition of nanofiber materials to Li-ion batteries due to their unique and desirable structural features including large aspect ratios,high surface areas,controllable chemical compositions,and abundant composite *** the past few decades,considerable research efforts have been devoted to constructing advanced nanofiber materials possessing conductive networks to facilitate efficient electron transport and large specific surface areas to support catalytically active sites,both for the purpose of boosting electrochemical ***,we focus on recent advancements of nanofiber materials with carefully designed structures and enhanced electrochemical properties for use in Li-ion *** synthesis,structure,and properties of nanofiber cathodes,anodes,separators,and electrolytes,and their applications in Li-ion batteries are *** research challenges and prospects of nanofiber materials in Li-ion battery applications are delineated.

关键词： Nanofiber Lithium-ion battery Cathode Anode Separator Electrolyte

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Defect-density control of platinum-based nanoframes with high-index facets for enhanced electrochemical properties

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Nano Research 2019年第11期12卷 2881-2888页

作者： Shaohan Yang Shuna Li Lianghao Song Yipin Lv Zhongyao Duan Chunsheng Li raphael Francesco Praeg Daowei Gao Guozhu chen School of Chemistry and Chemical Engineering University of JinanJinan250022China Institute for Solar Fuels Helmholtz Zentrum Berlin für Materialien und Energie GmbHBerlin14109Germany Young Investigator Group Operando Characterization of Solar Fuel Materials Helmholtz-Zentrum Berlin für Materialien und Energie GmbHBerlin12489Germany

Structure-engineered platinum-based nanoframes(NFs)at the atomic level can effectively improve the catalytic performance for fuel cells and other heterogeneous catalytic *** report herein,a microwave-assisted wet-chemical method for the preparation of platinum-copper-cobalt NFs with tunable defect density and architecture,which exhibit enhanced activity and durability towards the electro-oxidation reactions of methanol(MOR)and formic acid(FAOR).By altering the reduction/capping agents and thus the nucleation/growth kinetics,trimetallic platinum-copper-cobalt hexapod NFs with different density high-index facets are ***,the rough hexapod nanoframes(rh-NFs)exhibit excellent specific activities towards MOR and FAOR,7.25 and 5.20 times higher than those of benchmark Pt/C,respectively,along with prolonged *** excellent activities of the rh-NFs are assigned to a synergistic effect,including high density of defects and high-index facets,suitable d-band center,and open-framework *** synergistic working mechanism opens up a new way for enhancing their electrocatalytic performances by increasing defect density and high-index facets in open-framework platinum-based NFs.

关键词： nanoframes defect-density high-index facets electrocatalyst

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Preface to the Special Issue on Antarctic Meteorology and Climate:Past,Present and Future

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Advances in Atmospheric Sciences 2020年第5期37卷 421-422页

作者： Jiping LIU David BROMWICH Dake chen Raul CORDERO Thomas JUNG Marilyn raphael John TURNER Qinghua YANG Department of Atmospheric and Environmental Sciences University at AlbanyState University of New YorkAlbanyNY 12222USA Polar Meteorology Group Byrd Polar and Climate Research CenterThe Ohio State UniversityColumbusOH 43210USA State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyHangzhou 310012China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China Departamento de Física University of SantiagoSantiago 3493Chile Alfred Wegener Institute Helmholtz Centre for Polar and Marine ResearchBremerhaven 27570Germany Institute of Environmental Physics University of BremenBremen 28359Germany Department of Geography University of California-Los AngelesLos AngelesCA 90095USA British Antarctic Survey Natural Environment Research CouncilCambridgeCB30ETUK School of Atmospheric Sciences Sun Yat-sen UniversityZhuhai 519082China

The Antarctic,including the continent of Antarctica and the Southern Ocean,is a critically important part of the Earth *** in Antarctic meteorology and climate has always been a challenging *** and predicting weather patterns in the Antarctic are important for understanding their role in local-to-global processes and facilitating field studies and logistical operations in the Antarctic(e.g.,Walsh et al.,2018).Studies of climate change in the Antarctic are comparatively neglected compared to those of the ***,significant climate changes have occurred in the Antarctic in the past several decades,i.e.,a strong warming over the Antarctic Peninsula even with a recent minor cooling,a deepening of the Amundsen Sea low,a rapid warming of the upper ocean north of the circumpolar current,an increase of Antarctic sea ice since the late 1970s followed by a recent rapid decrease,and an accelerated ice loss from the Antarctic ice shelf/sheet since the late 1970s(e.g.,Turner et al.,2005;raphael et al.,2016;Sallée,2018;Parkinson,2019;Rignot et al.,2019).Investigating recent climate change in the Antarctic and the underlying mechanisms are important for predicting future climate change and providing information to policymakers.

关键词： Antarctic warming meteorology

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SARS-CoV-2 Does Not Replicate in Aedes Mosquito Cells nor Present in Field-Caught Mosquitoes from Wuhan

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Virologica Sinica 2020年第3期35卷 355-358页

作者： Han Xia Evans Atoni Lu Zhao Nanjie Ren Doudou Huang Rongjuan Pei Zhen chen Jin Xiong raphael Nyaruaba Shuqi Xiao Bo Zhang Zhiming Yuan Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China

Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARSCoV-2), the etiologic agent of COVID-19, is an enveloped,positive-sense single-stranded RNA virus that first discovered in December 2019 from a seafood m... 详细信息

关键词： Wuhan agent envelope

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Collagen membrane functionalized with magnesium oxide via room-temperature atomic layer deposition promotes osteopromotive and antimicrobial properties

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Bioactive Materials 2023年第12期30卷 46-61页

作者： Soumya Saha raphael Cavalcante Costa Mirela Caroline Silva Joao Matheus Fonseca-Santos Lin chen Abhijit H.Phakatkar Harshdeep Bhatia Leonardo P.Faverani Valentim A.R.Barao Tolou Shokuhfar Cortino Sukotjo Christos Takoudis Department of Biomedical Engineering University of Illinois ChicagoChicagoUSA Department of Prosthodontics and Periodontology Piracicaba Dental SchoolUniversity of Campinas(UNICAMP)PiracicabaSao PauloBrazil Department of Diagnosis and Surgery Division of Oral and Maxillofacial Surgery and ImplantologySao Paulo State University(UNESP)School of DentistryAraçatubaSao PauloBrazil Department of Periodontics Center for Wound Healing and Tissue RegenerationCollege of DentistryUniversity of Illinois ChicagoChicagoUSA Department of Chemical Engineering University of Illinois ChicagoChicagoUSA Department of Restorative Dentistry University of Illinois Chicago College of DentistryChicagoUSA

Artificial bone grafting materials such as collagen are gaining interest due to the ease of production and ***,collagen must be supplemented with additional coating materials for improved ***,we report room-temperature atomic layer deposition(ALD)of MgO,a novel method to coat collagen membranes with *** techniques such as X-ray photoelectron spectroscopy,Raman spectroscopy,and electron beam dispersion mapping confirm the chemical nature of the *** electron and atomic force microscopies show the surface topography and morphology of the collagen fibers were not altered during the ALD of *** release of magnesium ions promotes bone growth,and we show the deposited MgO film leaches trace amounts of Mg when incubated in phosphate-buffered saline at 37◦*** coated collagen membrane had a superhydrophilic surface immediately after the deposition of *** film was not toxic to human cells and demonstrated antibacterial properties against bacterial ***,in vivo studies performed on calvaria rats showed MgO-coated membranes(200 and 500 ALD)elicit a higher inflammatory response,leading to an increase in angiogenesis and a greater bone formation,mainly for Col-MgO500,compared to uncoated *** on the characterization of the MgO film and in vitro and in vivo data,the MgO-coated collagen membranes are excellent candidates for guided bone regeneration.

关键词： coating magnesium atomic

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透水再生骨料混凝土研究进展

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硅酸盐通报 2020年第1期39卷 150-156页

作者：陈尚权高越青梁超锋 raphael Desire 邵晓蓉绍兴文理学院建筑工程系绍兴312000 同济大学建筑工程系上海200092

透水再生骨料混凝土(PRAC)是近年来新兴的一种环境友好型混凝土,利用建筑废弃物破碎所得再生骨料置换天然骨料,改善传统混凝土在城市路面建设中的弊端,实现废物资源再利用和建筑材料的可持续发展。总结了水灰比、孔隙率、再生骨料粒径... 详细信息

透水再生骨料混凝土(PRAC)是近年来新兴的一种环境友好型混凝土,利用建筑废弃物破碎所得再生骨料置换天然骨料,改善传统混凝土在城市路面建设中的弊端,实现废物资源再利用和建筑材料的可持续发展。总结了水灰比、孔隙率、再生骨料粒径和取代率、成型工艺等因素对透水再生骨料混凝土力学性能、透水性以及耐久性的影响,并提出了有待进一步研究的问题。已有研究成果表明再生骨料可以用于制备透水混凝土,应用于停车场、人行道及植生护坡等工程。

关键词：透水混凝土再生骨料力学性能透水性耐久性

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考古遗址博物馆空间结构的感知影响探析

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山西建筑 2024年第15期50卷 6-10页

作者：陈梓欣曾克明朱迪广州美术学院建筑艺术设计学院广东广州510006 澳门城市大学创新设计学院中国澳门999078

以空间句法为方法论对考古遗址博物馆的遗址空间进行可达性与可见性的空间感知探索,以彼得·卒姆托的柯伦巴艺术博物馆、拉斐尔·莫内欧的梅里达国立古罗马艺术博物馆、莫伯治的南越王墓博物院等三座遗址博物馆为主要研究对象,探究其遗... 详细信息

以空间句法为方法论对考古遗址博物馆的遗址空间进行可达性与可见性的空间感知探索,以彼得·卒姆托的柯伦巴艺术博物馆、拉斐尔·莫内欧的梅里达国立古罗马艺术博物馆、莫伯治的南越王墓博物院等三座遗址博物馆为主要研究对象,探究其遗址空间的结构对空间感知的影响。结合建筑师对遗址空间的更新理念与空间句法分析成果,证明遗址空间的可达性与可见性对博物馆建筑具有一定连接意义,验证遗址空间对考古遗址博物馆的吸引程度与重要意义。

关键词：考古遗址博物馆遗址空间可见性可达性空间感知

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七日谈:大师和工作室的故事

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世界建筑 2015年第4期 30-39,136页

作者：刘晨清华大学建筑学院

人类的建筑活动可以一直追溯到文明诞牛之初2400年前,柏拉图曾明确指出,建筑师是"工匠的指挥者"。而职业建筑师工作室的出现,却是18世纪中叶之后的事情。直到19世纪,建筑才成为一种专门职业。几千年中,"建筑师"、"大师"一再被重新定义... 详细信息

人类的建筑活动可以一直追溯到文明诞牛之初2400年前,柏拉图曾明确指出,建筑师是"工匠的指挥者"。而职业建筑师工作室的出现,却是18世纪中叶之后的事情。直到19世纪,建筑才成为一种专门职业。几千年中,"建筑师"、"大师"一再被重新定义。在现代建筑教育出现之前,建筑师都是从其它行业"跨界"从事建筑,其工作室大都为一件具体的作品而存在。本文以"七日谈"的形式,试举现代建筑师工作室之先例七种。从古埃及大祭司印何阗到文艺复兴绘画巨匠拉斐尔,七位大师的故事或要引发当今建筑师对自身实践的思考。

关键词：大师工匠工匠的领袖工作室手工业行会

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