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“互联网+”背景下贵州非遗文创产业发展路径研究

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中国商论 2024年第4期 145-148页

作者：黄雪雯袁龙娟何林洁黔南民族师范学院贵州都匀558000

非物质文化遗产是人类历史长河和在人们日常生活中凝聚而成的文化精粹,非遗文化的艺术价值、工艺价值、文化价值以及商业价值等都将在文创设计时焕发新机,而形成产业将会激发出最大的发展潜能。目前,随着信息技术和互联网的飞速发展,贵... 详细信息

非物质文化遗产是人类历史长河和在人们日常生活中凝聚而成的文化精粹,非遗文化的艺术价值、工艺价值、文化价值以及商业价值等都将在文创设计时焕发新机,而形成产业将会激发出最大的发展潜能。目前,随着信息技术和互联网的飞速发展,贵州非遗的保护、传承以及发展迎来了新契机,而非遗文创产业是对其传承与保护的重要途径,也是推动经济增长的有效方式。本文在“互联网+”背景下分析贵州非遗基本现状及存在的问题,并为贵州非遗文创产业提出发展路径建议,以期促进贵州非遗产业的可持续发展,进而助力贵州经济发展。

关键词： “互联网+” 贵州非遗文创产业文化产业发展旅游资源

3D porous acellular cartilage matrix scaffold with surface mediated sustainable release of TGF-β3 for cartilage engineering

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Chinese Chemical Letters 2020年第7期31卷 1797-1800页

作者： Yixing Huang Xingfang Yu linjie he Xin Liao Shuo Wang Zhiyong Qian Liyan Shen Key Laboratory of Orthopedics of Zhejiang Province Department of OrthopedicsThe Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical UniversityWenzhou 325000China College of Pharmacy Zhejiang Pharmaceutical CollegeNingbo 315199China State Key Laboratory of Biotherapy and Cancer Center West China HospitalWest China Medical SchoolSichuan Universityand Collaborative Innovation Center for BiotherapyChengdu 610041China

Acellular tissue matrix scaffolds are much closer to tissue’s complex natural structure and biological characteristics,thus assess great advantages in cartilage *** used rabbit costal cartilage to prepare acellular microfilaments and further 3D porous acellular cartilage scaffold via ***(_L-lysine)/hyaluronic acid(PLL/HA)multilayer film was then built up onto the surface of the resulting porous ***,TGF-β3 was loaded into the PLL/HA multilayer film coated scaffold to obtain a 3D porous acellular cartilage scaffold with sustained releasing of TGF-β3 up to 60 *** success of this project will provide a new way for the treatment of articular cartilage ***,the anchoring and on-site sustained releasing of growth factors mediated by polyelectrolyte multilayered film can also provide a new method for improving the biocompatibility and the biofunctionality for other implanted biomaterials.

关键词： Acellular cartilage matrix scaffold TGF-β3 Polyelectrolyte multilayer film Sustainable release

基于CRISPR/Cas的分子诊断技术在病毒检测中的应用

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检验医学与临床 2024年第20期21卷 3100-3104页

作者：尹佳祺折小娟和林洁(综述) 季乐乐(审校) 空军军医大学学员六大队24中队陕西西安710032 空军军医大学基础医学院生理与病理生理学教研室陕西西安710032 空军军医大学国家级基础医学实验教学示范中心陕西西安710032

2019年,新型冠状病毒感染疫情的爆发对快速、特异、灵敏、简便且廉价的诊断技术提出了迫切需求,分子诊断技术成为备受关注的热点。但目前常用的聚合酶链反应分子诊断技术存在诸多局限性。近年来,新兴的规律间隔成簇短回文重复序列及其... 详细信息

2019年,新型冠状病毒感染疫情的爆发对快速、特异、灵敏、简便且廉价的诊断技术提出了迫切需求,分子诊断技术成为备受关注的热点。但目前常用的聚合酶链反应分子诊断技术存在诸多局限性。近年来,新兴的规律间隔成簇短回文重复序列及其相关蛋白(CRISPR/Cas)系统作为新型基因编辑工具为解决上述需求提供了可能。本研究综述了CRISPR/Cas系统的作用机制,并以不同Cas蛋白类型为线索,重点综述了多种CRISPR分子诊断技术及平台的原理及应用,同时关注其在病毒检测领域中的研究进展,并对CRISPR分子诊断技术的发展现状进行了总结。尽管CRISPR分子诊断技术目前处于起步阶段,存在污染、脱靶效应及序列依赖等局限性,该技术在分子诊断领域仍表现出革命性的发展潜力。

关键词： CRISPR 分子诊断 Ⅱ类Cas蛋白病毒检测小分子检测

Few-layered hexagonal boron nitride nanosheets stabilized Pt NPs for oxidation promoted adsorptive desulfurization of fuel oil

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Green Energy & Environment 2024年第3期9卷 495-506页

作者： Peiwen Wu Xin Song Linlin Chen Lianwen he Yingcheng Wu Duanjian Tao Jing he Chang Deng linjie Lu Yanhong Chao Mingqing Hua Wenshuai Zhu School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang212013China College of Chemical Engineering and Environment State Key Laboratory of Heavy Oil ProcessingChina University of Petroleum-BeijingBeijing102249China College of Chemistry and Chemical Engineering Jiangxi Normal UniversityNanchang330022China College of Science State Key Laboratory of Heavy Oil ProcessingChina University of Petroleum-BeijingBeijing102249China

A few-layered hexagonal boron nitride nanosheets stabilized platinum nanoparticles(Pt/h-BNNS)is engineered for oxidation-promoted adsorptive desulfurization(OPADS)of fuel *** was found that the few-layered structure and the defective sites of h-BNNS not only are beneficial to the stabilization of Pt NPs but also favor the adsorption of aromatic *** employing Pt/h-BNNS with a Pt loading amount of 1.19 wt%as the active adsorbent and air as an oxidant,a 98.0%sulfur removal over dibenzothiophene(DBT)is achieved along with a total conversion of the DBT to the corresponding sulfones(DBTO_(2)).Detailed experiments show that the excellent desulfurization activity originates from the few-layered structure of h-BNNS and the high catalytic activity of Pt *** addition,the OPADS system with Pt/h-BNNS as the active adsorbent shows remarkable stability in desulfurization performance with the existence of different interferents such as olefin,and aromatic ***,the Pt/h-BNNS can be recycled 12 times without a significant decrease in desulfurization ***,a process flow diagram is proposed for deep desulfurization of fuel oil and recovery of high value-added products,which would promote the industrial application of such OPADS strategy.

关键词： Desulfurization Adsorption Catalytic oxidation Active adsorbent Dibenzothiophene

Carbon emission quantification and reduction in pavement use phase:A review

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第1期11卷 69-91页

作者： linjie Zhu Jin Li Feipeng Xiao Key Laboratory of Road and Traffic Engineering of Ministry of Education Tongji UniversityShanghai 201804China

The carbon emissions arising from road pavement infrastructures have emerged as critical issue in recent *** life cycle of a pavement can be divided into five phases,namely raw materials and production,construction,use,maintenance and end of *** the use phase generates the highest carbon emissions throughout the pavement's life cycle,it is usually neglected in most pavement life cycle assessment(LCA)studies due to its complexity and ***,this review selected 126 relevant references,focuses on quantification methods,influential factors and reduction technologies of carbon emissions in pavement use *** the carbon accounting approached,the LCA approach,remains the most widely used for evaluating the environmental impact of ***,the primary influential factors on the use phase'carbon emission include pavement-vehicle interaction primarily affected by pavement roughness,pavement albedo and climate *** influential factors above indirectly cause changes in carbon emissions by influencing the pavement performance and subsequent vehicle ***,the review surveys carbon emission reduction technologies during pavement use phase,focusing mainly on reducing pavement rolling resistance and constructing cool *** pavements and permeable pavements are the most widely used cool pavement ***,the aspects involved in this paper hold significant promise for quantifying and reducing carbon emissions in the pavement use phase.

关键词： Pavement Carbon emission Life cycle assessment Use phase Emission reduction

Large-Scale Multi-Objective Optimization Algorithm Based on Weighted Overlapping Grouping of Decision Variables

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 363-383页

作者： Liang Chen Jingbo Zhang linjie Wu Xingjuan Cai Yubin Xu Shanxi Key Laboratory of Big Data Analysis and Parallel Computing Taiyuan University of Science and TechnologyTaiyuan030024China School of State Key Laboratory of Novel Software Technology Nanjing UniversityNanjing210008China

The large-scale multi-objective optimization algorithm(LSMOA),based on the grouping of decision variables,is an advanced method for handling high-dimensional decision ***,in practical problems,the interaction among decision variables is intricate,leading to large group sizes and suboptimal optimization effects;hence a large-scale multi-objective optimization algorithm based on weighted overlapping grouping of decision variables(MOEAWOD)is proposed in this ***,the decision variables are perturbed and categorized into convergence and diversity variables;subsequently,the convergence variables are subdivided into groups based on the interactions among different decision *** the size of a group surpasses the set threshold,that group undergoes a process of weighting and overlapping ***,the interaction strength is evaluated based on the interaction frequency and number of objectives among various decision *** decision variable with the highest interaction in the group is identified and disregarded,and the remaining variables are then reclassified into ***,the decision variable with the strongest interaction is added to each *** minimizes the interactivity between different groups and maximizes the interactivity of decision variables within groups,which contributed to the optimized direction of convergence and diversity exploration with different *** was subjected to testing on 18 benchmark large-scale optimization problems,and the experimental results demonstrate the effectiveness of our *** with the other algorithms,our method is still at an advantage.

关键词： Decision variable grouping large-scale multi-objective optimization algorithms weighted overlapping grouping direction-guided evolution

Establishment and application of liver cancer orthotopic PDX models in individualized anti-tumor treatment of angiogenesis targeted therapies

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Establishment and application of liver cancer orthotopic PDX...

Study on the Luminescence Properties of the Strain Compensated Quantum Well

2018年中国肿瘤标志物学术大会暨第十二届肿瘤标志物青年科学家论坛

作者： Ya Zhao Lele Ji Bingchao Qi linjie he Qichao Huang Jinliang Xing School of Life Science and Technology Xidian Univeristy Experimental Teaching Center of Basic Medicine Fourth Military Medical University

Objective: Patient-derived human tumor xenograft(PDX) models, in which the tumor fragments from patients are engrafted into immunodeficient mice. PDX could well maintain the multiple histological characteristics of tumor grafts. We successfully established a PDX mouse model of liver cancer in situ, and evaluated the validity of individualized anti-tumor treatment of angiogenesis targeted therapies in liver cancer. We also analyzed the effects of vascular targeting drugs on mitochondrial changes of liver cancer. Methods: PDX models was established by orthotopic transplantation of tumor tissues in NPG mice. he staining and immunohistochemical staining were used to compare the tissue morphological structure similarity between transplanted tumor tissue and tumor tissue of PDX model. Transmission electron microscopy was used to compare mitochondrial changes in patient tumor tissues and tumor tissues of PDX model, and mitochondrial changes before and after drug treatment of tumor tissue in PDX model Molecular investigations was exaimed to verify the genetic molecular characteristics of the PDX models. From the 3 rd generation, PDX tumors were permitted to grow to a volume of 150-200 mm3, then mice were randomized into 4 groups: 1)Bevacizumab;2) Sorafenib;3) Bevacizumab in combination with sorafenib;4) Negative control ***, changes of endothelial cells were investigated by Immunohistochemical expressions and immunofluorescence of CD31, and immunohistochemical expressions of ki67 for anti-tumor activity evaluation. Both the immunohistochemical expressions of CD31 and α-SMA were evaluated by vascular endothelial cells and pericytes. Results: The success rate was 28.7%( 4/14) in the establishment of liver cancer PDX mouse model,and the model well retained the characteristics of the primary *** relative tumor inhibition of combination therapy groups are more siginificant than the single therapy groups. Vascular normalization effect was found in both combination th

关键词： Angiogenesis targeted therapies Liver cancer Patient-derived xenografts Anti-tumor treatment Bevacizumab Sorafenib

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Journal of Computer and Communications 2013年第7期1卷 40-45页

作者： Tao Liu Jianjun Li Jiachun Li Jun Han Jun Deng linjie he Shengjie Lin Key Laboratory of Opto-Electronics Technology Beijing University of Technology Beijing China.

Compared with the conventional strained quantum well, the InGaAs/GaAsP strain compensated quantum well (SCQW) has better optical properties, as the well layer and the barrier layer lattice mismatch with each other which results in the introduction of stress. In this paper, we adopted the Kohn-Luttinger Hamiltonian, conducted some theoretical calculations using the transfer matrix method, and finally verified the following change trend of the InGaAs quantum well following the In-group through experiments: the growth of the low In-group can improve the epitaxial flatness of the active area;the growth of the high In-group can increase the wavelength as well as the strain. In this paper, we adopted the AlGaAs barrier material instead of the GaAsP, made an analysis on the level changes of the compensation quantum well, and successfully fostered the strain compensated quantum well structure using the metal-organic chemical vapor deposition (MOCVD) system which had better optical properties compared with the strained quantum wells.

关键词： InGaAs/AlGaAs InGaAs/GaAsP Strain Compensated Quantum Well MOCVD

Targeting the organelle for radiosensitization in cancer radiotherapy

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Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 52-71页

作者： Xiaoyan Sun linjie Wu Lina Du Wenhong Xu Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Afliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China

Radiotherapy is a well-established cytotoxic therapy for local solid cancers, utilizing high-energy ionizing radiation to destroy cancer cells. However, this method has several limitations, including low radiation energy deposition, severe damage to surrounding normal cells, and high tumor resistance to radiation. Among various radiotherapy methods, boron neutron capture therapy (BNCT) has emerged as a principal approach to improve the therapeutic ratio of malignancies and reduce lethality to surrounding normal tissue, but it remains deficient in terms of insufficient boron accumulation as well as short retention time, which limits the curative effect. Recently, a series of radiosensitizers that can selectively accumulate in specific organelles of cancer cells have been developed to precisely target radiotherapy, thereby reducing side effects of normal tissue damage, overcoming radioresistance, and improving radiosensitivity. In this review, we mainly focus on the field of nanomedicine-based cancer radiotherapy and discuss the organelle-targeted radiosensitizers, specifically including nucleus, mitochondria, endoplasmic reticulum and lysosomes. Furthermore, the organelle-targeted boron carriers used in BNCT are particularly presented. Through demonstrating recent developments in organelle-targeted radiosensitization, we hope to provide insight into the design of organelle-targeted radiosensitizers for clinical cancer treatment.

关键词： Cancer radiotherapy Organelle-target Radiosensitization Boron neutron capture therapy Nanomedicines