3D porous acellular cartilage matrix scaffold with surface mediated sustainable release of TGF-β3 for cartilage engineering

作     者：Yixing Huang Xingfang Yu Linjie He Xin Liao Shuo Wang Zhiyong Qian Liyan Shen Yixing Huang;Xingfang Yu;Linjie He;Xin Liao;Shuo Wang;Zhiyong Qian;Liyan Shen

作者机构：Key Laboratory of Orthopedics of Zhejiang ProvinceDepartment of OrthopedicsThe Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical UniversityWenzhou 325000China College of PharmacyZhejiang Pharmaceutical CollegeNingbo 315199China State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalWest China Medical SchoolSichuan Universityand Collaborative Innovation Center for BiotherapyChengdu 610041China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2020年第31卷第7期

页      面：1797-1800页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：the National Natural Science Foundation of China(No.41506091) Zhejiang Provincial Public Welfare Project(No.2017C33035) Wenzhou Science&Technology Bureau(Nos.Y20170091,Y20190021) Health Commission of Zhejiang Province(No.2019KY465) Key Laboratory of Orthopaedics of Zhejiang Province(No.ZJGK1806Y) 

主　　题：Acellular cartilage matrix scaffold TGF-β3 Polyelectrolyte multilayer film Sustainable release 

摘      要：Acellular tissue matrix scaffolds are much closer to tissue’s complex natural structure and biological characteristics,thus assess great advantages in cartilage *** used rabbit costal cartilage to prepare acellular microfilaments and further 3D porous acellular cartilage scaffold via ***(_L-lysine)/hyaluronic acid(PLL/HA)multilayer film was then built up onto the surface of the resulting porous ***,TGF-β3 was loaded into the PLL/HA multilayer film coated scaffold to obtain a 3D porous acellular cartilage scaffold with sustained releasing of TGF-β3 up to 60 *** success of this project will provide a new way for the treatment of articular cartilage ***,the anchoring and on-site sustained releasing of growth factors mediated by polyelectrolyte multilayered film can also provide a new method for improving the biocompatibility and the biofunctionality for other implanted biomaterials.