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自由体位联合无会阴保护技术对初产妇自我效能感及分娩体验的影响

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中华临床医师杂志（电子版） 2022年第3期16卷 231-235页

作者：欧阳平沈凌庆阜阳市人民医院妇产科安徽阜阳236000

目的探讨自由体位联合无会阴保护技术对初产妇自我效能感及分娩体验的影响。方法选择2019年7月至2020年12月于阜阳市人民医院妇产科住院分娩的初产妇125例为研究对象,采用分层随机法分为试验组63例和对照组62例。试验组第二产程采用自... 详细信息

目的探讨自由体位联合无会阴保护技术对初产妇自我效能感及分娩体验的影响。方法选择2019年7月至2020年12月于阜阳市人民医院妇产科住院分娩的初产妇125例为研究对象,采用分层随机法分为试验组63例和对照组62例。试验组第二产程采用自由体位联合无会阴保护技术接生法,对照组第二产程采用仰卧位联合托肛保会阴接生法。比较2组分娩自我效能、会阴损伤情况、分娩结局、分娩体验等指标。结果干预后试验组初产妇的结果效能、期望效能及分娩自我效能总评分高于对照组[(127.43±15.22)分vs(116.28±13.34)分;(125.36±14.21)分vs(112.25±13.74)分;(252.79±31.32)分vs(228.53±32.14)分],差异有统计学意义(t=3.682、5.243、4.274,P均<0.05)。试验组会阴完整率、Ⅰ度裂伤率均高于对照组(22.22%vs 6.45%,52.38%vs 29.03%,χ^(2)=6.305、7.053,P均<0.05),Ⅱ度裂伤率及会阴侧切率均低于对照组(4.76%vs 17.74%,20.63%vs 46.77,χ^(2)=5.294、9.570,P均<0.05)。试验组自然分娩率显著高于对照组(84.1%vs 58.1%,χ^(2)=10.351,P<0.05),第二产程时间短于对照组[(46.14±7.23)min vs(58.26±8.31)min,t=8.703,P<0.05]。试验组自身能力、专业支持、安全感知、参与性、分娩体验总分高于对照组[(25.41±4.23)分vs(22.28±3.46)分;(20.32±2.51)分vs(18.76±2.16)分;(18.82±3.20)分vs(16.65±2.42)分;(17.18±2.34)分vs(15.62±3.21)分;(81.73±10.25)分vs(73.31±9.56)分],差异有统计学意义(t=4.524、3.722、4.271、3.108、4.748,P均<0.05)。结论自由体位联合无会阴保护技术有助于促进初产妇分娩自我效能的养成,减少会阴损伤程度,改善分娩结局,增强初产妇分娩体验感。

关键词：初产妇自由体位分娩无会阴保护分娩自我效能分娩体验

分娩球自由体位助产联合分娩镇痛仪对初产妇产痛及分娩结局的影响

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中国计划生育学杂志 2023年第3期31卷 561-565页

作者：欧阳平沈凌庆曹英英安徽省阜阳市人民医院 236000

目的:探讨分娩球的自由体位助产联合分娩镇痛仪对初产妇产痛及母婴结局的影响。方法:选取2021年1月-2022年9月在本院产科分娩的初产妇96例,随机分为两组,均提供一般助产护理,单一组配合分娩球+自由体位助产,联合组在单一组基础上联合分... 详细信息

目的:探讨分娩球的自由体位助产联合分娩镇痛仪对初产妇产痛及母婴结局的影响。方法:选取2021年1月-2022年9月在本院产科分娩的初产妇96例,随机分为两组,均提供一般助产护理,单一组配合分娩球+自由体位助产,联合组在单一组基础上联合分娩镇痛仪助产。采用疼痛数字(NRS)评分法评估两组产妇产痛程度,以分娩控制感(LAS)量表评估产妇分娩期间控制感;观察两组产程、分娩方式、分娩结局、产后出血量、软产道裂伤及新生儿1min Apgar评分;采用本院自拟满意度量表统计产妇满意率。结果:相比于单一组,联合组疼痛程度降低、分娩控制感提升(P0.05);联合组产后出血量(198.3±28.2ml)、会阴侧切率(2.5%)低于单一组(246.1±25.5ml、8.3%),新生儿1min Apgar评分(9.9±0.2分)及自然分娩率(95.8%)高于单一组(9.7±0.4分、83.3%),产妇总体满意率(97.8%)高于单一组(86.1%)(均P<0.05);两组软产道撕裂≥Ⅲ度几率无差异,联合组会阴完整几率(56.5%)高于单一组(27.9%)(P<0.05)。结论:分娩球的自由体位助产联合分娩镇痛仪能够作为辅助初产妇分娩的有效方式,可降低产痛并改善分娩结局。

关键词：初产妇产痛自由体位助产分娩镇痛仪分娩球分娩结局

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“一对一”全程助产对GDM产妇分娩质量的干预效果

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中国计划生育学杂志 2024年第5期32卷 1097-1100页

作者：曹英英欧阳平沈凌庆安徽省阜阳市人民医院 236000

目的:评估“一对一”全程助产护理干预对妊娠期糖尿病(GDM)产妇血糖控制和分娩质量效果的影响。方法:选取2020年6月-2022年11月本院收治的GDM产妇120例,根据不同的护理方法均分为观察组(60例)和对照组(60例)。对照组采用传统的常规助产... 详细信息

目的:评估“一对一”全程助产护理干预对妊娠期糖尿病(GDM)产妇血糖控制和分娩质量效果的影响。方法:选取2020年6月-2022年11月本院收治的GDM产妇120例,根据不同的护理方法均分为观察组(60例)和对照组(60例)。对照组采用传统的常规助产护理方式,观察组则在此基础上提供“一对一”全程助产护理干预。对比分析两组产妇血糖控制指标及分娩质量指标,产后问卷调查护理满意度。结果:两组首次检查糖化血红蛋白(HbA1c)、空腹血糖(FPG)和餐后2h血糖(2hPG)无差异(P>0.05),产后观察组HbA1c(5.91±1.03)%、FPG(5.57±0.91mmol/L)、2hPG(6.38±1.19mmol/L)均低于对照组(7.24%±1.45%、6.19±1.14mmol/L、8.17±1.60mmol/L),总产程时间(498.2±52.4min)、产后出血量(134.3±20.8ml)和视觉模拟评分(6.7±0.7分)均低于对照组(605.9±78.7min、169.1±36.0ml、8.2±1.4分),自然分娩率(88.3%)高于对照组(66.7%),新生儿并发症发生率(11.7%)低于对照组(31.7%),护理满意度(91.7%)高于对照组(76.7%)(均P<0.05)。结论:全程助产护理干预可有效控制GDM产妇血糖变化,减轻产妇机体疼痛感,提升分娩质量和护理满意度。

关键词：妊娠期糖尿病 “一对一”全程助产护理干预分娩质量满意度

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豆干黄浆水发酵条件优化及其作为酸浆豆腐凝固剂的应用研究

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中国粮油学报 2021年第9期36卷 157-163页

作者：陈斌杨玥熹李自成沈聆清李娟娟顾振宇浙江工商大学食品与生物工程学院杭州310018 国家级食品工程与质量安全实验教学中心杭州310018

在豆干成型产生的黄浆水中接种植物乳杆菌发酵,以活菌数和酸度为指标,采用单因素和正交实验,研究黄浆水发酵最佳工艺条件。采用高效液相色谱法研究黄浆水发酵前后有机酸含量的变化。通过持水率、色泽、质构特性、人员感官评价来综合评... 详细信息

在豆干成型产生的黄浆水中接种植物乳杆菌发酵,以活菌数和酸度为指标,采用单因素和正交实验,研究黄浆水发酵最佳工艺条件。采用高效液相色谱法研究黄浆水发酵前后有机酸含量的变化。通过持水率、色泽、质构特性、人员感官评价来综合评价酸浆豆腐的品质。研究表明,发酵最佳工艺条件为:葡萄糖添加量0.8%,初始pH 5.5、接种量8%、发酵时间48 h,发酵温度34℃。黄浆水经过植物乳杆菌发酵后,有机酸总含量增长了4倍,酒石酸、乳酸和琥珀酸含量增长幅度较大,但乙酸含量有所降低。与市售酸浆豆腐相比,试制酸浆豆腐凝胶强度和持水性较大,凝胶微观结构孔隙大,总体可接受性高。

关键词：黄浆水植物乳杆菌发酵酸浆豆腐

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Ru doping triggering reconstruction of cobalt phosphide for coupling glycerol electrooxidation with seawater electrolysis

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Journal of Energy Chemistry 2025年第1期100卷 317-326页

作者： Binglu Deng Jie shen Jinxing Lu Chuqiang Huang Zhuoyuan Chen Feng Peng Yunpeng Liu School of Materials Science and Hydrogen Energy Foshan University School of Chemistry and Chemical Engineering Guangzhou University Guangdong Key Laboratory for Hydrogen Energy Technologies

Seawater electrolysis is a promising approach for sustainable energy without relying on precious ***,the large-scale seawater electrolysis is hindered by low catalytic efficiency and severe anode corrosion caused by the harmful *** contrast to the oxygen evolution reaction （OER）and chlorin ion oxidation reaction （ClOR）,glycerol oxidation reaction （GOR） is more thermodynamically and kinetically favorable ***,a Ru doping cobalt phosphide （Ru-CoP2） is proposed as a robust bifunctional electrocatalyst for seawater electrolysis and GOR,for the concurrent productions of hydrogen and value-added *** in situ and ex situ characterization analyses demonstrated that Ru doping featured in the dynamic reconstruction process from Ru-CoP2to Ru-CoOOH,accounting for the superior GOR *** coupling GOR with hydrogen evolution was realized by employing Ru-CoP2as both anode and cathode,requiring only a low voltage of 1.43 V at 100 mA cm-2,which was 250 m V lower than that in alkaline *** work guides the design of bifunctional electrocatalysts for energy-efficient seawater electrolysis coupled with biomass resource upcycling.

关键词： Glycerol electrooxidation Hydrogen evolution Ru doping Cobalt phosphide Bifunctional electrocatalysts

Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons

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Neural Regeneration Research 2025年第6期20卷 1816-1824页

作者： Jiantao Cui Yueru shen Zheng Song Dinggang Fan Bing Hu Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Rab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles and their fusion with the cellular membrane. Rab5 has been reported to play an important role in the development of the zebrafish embryo;however, its role in axonal regeneration in the central nervous system remains unclear. In this study, we established a zebrafish Mauthner cell model of axonal injury using single-cell electroporation and two-photon axotomy techniques. We found that overexpression of Rab5 in single Mauthner cells promoted marked axonal regeneration and increased the number of intra-axonal transport vesicles. In contrast, treatment of zebrafish larvae with the Rab kinase inhibitor CID-1067700markedly inhibited axonal regeneration in Mauthner cells. We also found that Rab5 activated phosphatidylinositol 3-kinase(PI3K) during axonal repair of Mauthner cells and promoted the recovery of zebrafish locomotor function. Additionally, rapamycin, an inhibitor of the mechanistic target of rapamycin downstream of PI3K, markedly hindered axonal regeneration. These findings suggest that Rab5 promotes the axonal regeneration of injured zebrafish Mauthner cells by activating the PI3K signaling pathway.

关键词： axonal regeneration Mauthner cell nerve regeneration Rab5 zebrafish

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Tuning the interfacial reaction environment via pH-dependent and induced ions to understand C–N bonds coupling performance in NO3- integrated CO2 reduction to carbon and nitrogen compounds over dual Cu-based N-doped carbon catalyst

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Journal of Energy Chemistry 2025年第1期100卷 273-285页

作者： Tianhang Zhou Chen shen Zhenghao Wu Xingying Lan Yi Xiao College of Carbon Neutrality Future Technology State Key Laboratory of Heavy Oil Processing China University of Petroleum (Beijing) Institute of Materials Science TU Darmstadt Department of Chemistry Xi'an Jiaotong-Liverpool University Department of Mechanical and Mechatronics Engineering and Waterloo Institute of Nanotechnology University of Waterloo Waterloo

Dual atomic catalysts （DAC）,particularly copper （Cu2）-based nitrogen （N） doped graphene,show great potential to effectively convert CO2and nitrate （NO3-） into important industrial chemicals such as ethylene,glycol,acetamide,and urea through an efficient catalytical process that involves C–C and C–N ***,the origin of the coupling activity remained unclear,which substantially hinders the rational design of Cu-based catalysts for the N-integrated CO2reduction reaction （CO2RR）.To address this challenge,this work performed advanced density functional theory calculations incorporating explicit solvation based on a Cu2-based N-doped carbon (Cu2N6C10) catalyst for *** calculations are aimed to gain insight into the reaction mechanisms for the synthesis of ethylene,acetamide,and urea via coupling in the interfacial reaction *** to the sluggishness of CO2,the formation of a solvation electric layer by anions （F-,Cl-,Br-,and I-） and cations (Na+,Mg2+,K+,and Ca2+) leads to electron transfer towards the Cu *** process significantly accelerates the reduction of *** results reveal that*CO intermediates play a pivotal role in N-integrated ***,the Cu2-based N-doped carbon catalyst examined in this study has demonstrated the most potential for C–N coupling to *** findings reveal that through the process of a condensation reaction between*CO and NH2OH for urea synthesis,*NO3-is reduced to*NH3,and*CO2to*CCO at dual Cu atom *** dual-site reduction facilitates the synthesis of acetamide through a nucleophilic reaction between NH3and the ketene ***,we found that the I-and Mg2+ions,influenced by pH,were highly effective for acetamide and ammonia synthesis,except when F-and Ca2+were ***,the mechanisms of C–N bond formation were investigated via ab-initio molecular dynamics simulations,and we found that adjusting the micro-environment can change the dominant side reaction,shift

关键词： pH-dependent micro-environments C–N coupling Dual Cu-based nitrogen carbon catalysts Explicit solvation model Ion stabilizer AIMD

Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

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Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu Luo Min Song Lulu An Xiao Huang Qian Zhang Chenhao Zhang Tao shen Shuang Wang Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Electrolytic reduction

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai Xu Zhen Gu Hua Yan Dingding shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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