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超声造影评估颈动脉斑块新生血管分级与小而密低密度脂蛋白水平的相关性分析

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中国超声医学杂志 2024年第6期40卷 625-628页

作者：况李君陶玲玲陈曦樊金芳杨雁雯周伟上海交通大学医学院附属瑞金医院卢湾分院超声科上海交通大学医学院附属瑞金医院超声科

目的探讨颈动脉斑块超声造影(CEUS)新生血管(IPN)分级与小而密低密度脂蛋白(sdLDL-C)水平的相关性。方法采用常规超声筛查129例颈动脉粥样硬化斑块患者，共129个斑块，然后对患者进行CEUS检查。CEUS将斑块分为4组：0级、1级、2级、3... 详细信息

目的探讨颈动脉斑块超声造影(CEUS)新生血管(IPN)分级与小而密低密度脂蛋白(sdLDL-C)水平的相关性。方法采用常规超声筛查129例颈动脉粥样硬化斑块患者，共129个斑块，然后对患者进行CEUS检查。CEUS将斑块分为4组：0级、1级、2级、3级，于超声造影后第2天测定sdLDL-C等血液指标。采用单因素及Logistic回归分析，分析与斑块IPN分级相关指标。结果 4组中sdLDL-C平均值分别为0.49、0.86、1.02和1.12 mmol/L,差异有统计学意义(P<0.05)。Spearman相关性分析显示，斑块IPN分级与sdLDL-C水平呈线性相关(r=0.363,P<0.001)。多因素Logistic回归分析提示sdLDL-C为斑块IPN分级的独立危险因素(P<0.05)。结论 sdLDL-C水平与斑块IPN分级呈正向相关，sdLDL-C水平可能会促进斑块易损性，为临床治疗提供理论依据。

关键词：超声造影颈动脉斑块新生血管小而密低密度脂蛋白

超声联合BRAF V600E基因突变构建列线图预测甲状腺微小乳头状癌颈部淋巴结转移

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中国超声医学杂志 2024年第4期40卷 374-377页

作者：赵颖燕李伟伟陶玲玲樊金芳陈曦詹维伟周伟上海交通大学医学院附属瑞金医院卢湾分院超声科上海交通大学医学院附属瑞金医院超声科

目的对甲状腺微小乳头状癌(PTMC)超声图像进行分析，探讨超声特征联合BRAFV600E基因突变构建列线图模型对颈部淋巴结转移进行预测并评估其效能。方法回顾性分析首次行手术的132例PTMC患者的临床资料、超声特征以及BRAFV600E基因突变... 详细信息

目的对甲状腺微小乳头状癌(PTMC)超声图像进行分析，探讨超声特征联合BRAFV600E基因突变构建列线图模型对颈部淋巴结转移进行预测并评估其效能。方法回顾性分析首次行手术的132例PTMC患者的临床资料、超声特征以及BRAFV600E基因突变检测结果，根据术后病理结果分为颈部淋巴结转移组与非转移组，进行单因素和多因素Logistic回归分析并建立列线图模型，使用受试者工作特征(ROC)曲线评估其诊断效能。结果 132例入组患者包括颈部淋巴结转移组39例和93例，两组患者在年龄，肿瘤大小、微钙化，BRAFV600E基因突变方面差异有统计学意义(P<0.05)。年龄≤45岁、病灶≥5 mm、BRAFV600E基因突变阳性是PTMC颈部淋巴结转移的危险因素。列线图模型ROC曲线下面积为0.73,准确度为78.8%,灵敏度为59.0%,特异度为87.1%。结论超声特征结合BRAFV600E基因突变可对PTMC颈部淋巴结转移进行预测，对临床诊疗提供一定帮助。

关键词：超声甲状腺微小乳头状癌颈部淋巴结列线图

不同大小峡部甲状腺乳头状癌临床及超声特征的对比分析

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中国超声医学杂志 2024年第5期40卷 485-488页

作者：樊金芳陶玲玲詹维伟李伟伟况李君杨雁雯周伟上海交通大学医学院附属瑞金医院卢湾分院超声科上海交通大学医学院附属瑞金医院超声科

目的探讨不同大小峡部甲状腺乳头状癌(PTC)的临床及超声特征差异。方法回顾性分析203例峡部PTC的临床及超声特征，按照结节最大径分为>5 mm和≤5 mm组，进行组间对比分析。结果多因素分析发现边界、纵横比、微钙化、回声均匀性、包... 详细信息

目的探讨不同大小峡部甲状腺乳头状癌(PTC)的临床及超声特征差异。方法回顾性分析203例峡部PTC的临床及超声特征，按照结节最大径分为>5 mm和≤5 mm组，进行组间对比分析。结果多因素分析发现边界、纵横比、微钙化、回声均匀性、包膜侵犯、淋巴结转移在两组间差异有统计学意义，与≤5 mm组相比，>5 mm组结节更多表现为纵横比<1、微钙化、边界清、回声不均、包膜侵犯、高淋巴结转移率(P<0.05)。结论不同大小的峡部PTC超声特征存在一定差异，临床应更仔细甄别。

关键词：甲状腺乳头状癌峡部超声特征淋巴结转移

Wetting-drying effect on the strength and microstructure of cementphosphogypsum stabilized soils

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 1049-1058页

作者： lingling Zeng Xia Bian Jiaxing Weng tao Zhang College of Civil Engineering Zhejiang University of TechnologyHanzhou310014China Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai UniversityNanjing210098China State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhou221116China Jiangsu Water Source Company Ltd.of the Eastern Route of the South-to-North Water Diversion Project Nanjing210000China Power China Zhongnan Engineering Corporation Limited Changsha410027China

Phosphogypsum has often been used as an effective and environmentally friendly binder for partial replacement of cement,improving the engineering properties of slurries with high water ***,the influence of phosphogypsum on the physicomechnical properties of stabilized soil subjected to wettingedrying cycles is not well understood to *** this study,the effect of phosphogypsum on the durability of stabilized soil was studied by conducting a series of laboratory experiments,illustrating the changes in mass loss,pH value and unconfined compressive strength(qu)with wettingdrying *** test results showed that the presence of phosphogypsum significantly restrained the mass loss in the early stage(lower than the 4th cycle),which in turn led to a higher qu of stabilized soil than that without *** the 4th cycle,a sudden increase in mass loss was observed for stabilized soil with phosphogypsum,resulting in a significant drop in qu to a value lower than those without phosphogypsum at the 6th *** addition,the qu of stabilized soils correlated well with the measured soil pH irrespective of phosphogypsum content for all wettingedrying *** to the microstructure observation via scanning electron microscope(SEM)and X-ray diffraction(XRD)tests,the mechanisms relating the sudden loss of qu for the stabilized soils with phosphogypsum after the 4th wetting-drying cycle are summarized as follows:(i)the disappearance of ettringite weakening the cementation bonding effect,(ii)the generation of a larger extent of microcrack,and(iii)a lower pH value,in comparison with the stabilized soil without phosphogypsum.

关键词： Wetting-drying Phosphogypsum Microstructure Durability

小乳腺癌的临床病理及超声特征与腋下淋巴结转移的相关性分析

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医学影像学杂志 2024年第1期34卷 46-49,61页

作者：杨雁雯周伟李伟伟陶玲玲樊金芳况李君上海交通大学医学院附属瑞金医院卢湾分院超声科上海200020 上海交通大学医学院附属瑞金医院超声科上海200025

目的探讨小乳腺癌的临床病理及常规超声特征与腋下淋巴结转移的关系。方法选取95例小乳腺癌患者的临床病理特征及常规超声特征资料,将腋下淋巴结分为转移组(31例)及未转移组(64例),先对小乳腺癌的临床病理及常规超声检查特征进行单因素... 详细信息

目的探讨小乳腺癌的临床病理及常规超声特征与腋下淋巴结转移的关系。方法选取95例小乳腺癌患者的临床病理特征及常规超声特征资料,将腋下淋巴结分为转移组(31例)及未转移组(64例),先对小乳腺癌的临床病理及常规超声检查特征进行单因素分析,然后对单因素分析具有统计学差异的参数进行多因素分析。结果腋下淋巴结转移31例,无转移64例,多因素回归分析结果显示临床病理特征中病理分级、雌激素受体(ER)、孕激素(PR),常规超声检查中小乳腺癌肿块呈垂直位、内部有微钙化、血流分级为Ⅱ-Ⅲ级是腋下淋巴结转移的独立影响因素。结论小乳腺癌的部分临床病理及超声特征与发生腋下淋巴结转移具有相关性,对于预测小乳腺癌患者腋下淋巴结转移具有一定的价值。

关键词：小乳腺癌淋巴结转移超声检查

Insulator-to-conductor transition driven by the Rashba–Zeeman effect

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npj Computational Materials 2020年第1期6卷 247-253页

作者： lingling tao Evgeny Y.Tsymbal Department of Physics and Astronomy&Nebraska Center for Materials and Nanoscience University of NebraskaLincolnNE 68588USA

The Rashba effect has recently attracted great attention owing to emerging physical properties associated with *** interplay between the Rashba effect and the Zeeman effect,being produced by the exchange field,is expected to broaden the range of these properties and even result in novel *** we predict an insulator-to-conductor transition driven by the Rashba–Zeeman *** first illustrate this effect using a general Hamiltonian model and show that the insulator-to-conductor transition can be triggered under certain Rashba and exchange-field strengths.

关键词： effect Zeeman conductor

Perspectives of spin-valley locking devices

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Chinese Physics B 2023年第10期32卷 15-21页

作者：陶玲玲 School of Physics Harbin Institute of TechnologyHarbin 150001China

Valleytronics is an emerging field of research which utilizes the valley degree of freedom to encode ***,it is technically nontrivial to produce a stable valley polarization and to achieve efficient control and manipulation of ***–valley locking refers to the coupling between spin and valley degrees of freedom in the materials with large spin–orbit coupling(SOC)and enables the manipulation of valleys indirectly through controlling ***,we review the recent advances in spin–valley locking physics and outline possible device *** particular,we focus on the spin–valley locking induced by SOC and external electric field in certain two-dimensional materials with inversion symmetry and demonstrate the intriguing switchable valley–spin polarization,which can be utilized to design the promising electronic devices,namely,valley-spin valves and logic gates.

关键词： spin–valley locking spintronics valleytronics spin–orbit coupling

Reversal of the magnetoelectric effect at a ferromagnetic metal/ferroelectric interface induced by metal oxidation

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npj Computational Materials 2021年第1期7卷 1890-1896页

作者： Zhaojin Chen Qiong Yang lingling tao Evgeny Y.Tsymbal School of Materials Science and Engineering Xiangtan UniversityXiangtanHunan 411105China Department of Physics and Astronomy University of NebraskaLincolnNE 68588USA

Multiferroic materials composed of ferromagnetic and ferroelectric components are interesting for technological applications due to sizable magnetoelectric coupling allowing the control of magnetic properties by electric *** to being compatible with the silicon-based technology,HfO2-based ferroelectrics could serve as a promising component in the composite ***,a strong charge-mediated magnetoelectric coupling has been predicted for a Ni/HfO_(2) multiferroic ***,using density functional theory calculations,we systematically study the effects of the interfacial oxygen stoichiometry relevant to experiments on the magnetoelectric effect at the Ni/HfO_(2) *** demonstrate that the magnetoelectric effect is very sensitive to the interface stoichiometry and is reversed if an oxidized Ni monolayer is formed at the *** reversal of the magnetoelectric effect is driven by a strong Ni−O bonding producing exchange-split polarization-sensitive antibonding states at the Fermi *** argue that the predicted reversal of the magnetoelectric effect is typical for other 3d ferromagnetic metals,such as Co and Fe,where the metal-oxide antibonding states have an opposite spin polarization compared to that in the pristine ferromagnetic *** results provide an important insight into the mechanism of the interfacial magnetoelectric coupling,which is essential for the physics and application of multiferroic heterostructures.

关键词： ferromagnetic ferroelectric bonding

Stem cells and neurodegenerative diseases

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Science China(Life Sciences) 2008年第4期51卷 287-294页

作者： HOU lingling & HONG tao Institute of Biological Science and Technology, Beijing Jiaotong University, Beijing 100044, China Institute of Biological Science and Technology Beijing Jiaotong University Beijing China

Neurodegenerative diseases are characterized by the neurodegenerative changes or apoptosis of neurons involved in networks, which are important to specific physiological functions. With the de-velopment of old-aging society, the incidence of neurodegenerative diseases is on the increase. How-ever, it is difficult to diagnose for most of neurodegenerative diseases. At present, there are too few effective therapies. Advances in stem cell biology have raised the hope and possibility for the therapy of neurodegenerative diseases. Recently, stem cells have been widely attempted to treat neurodegen-erative diseases of animal model. Here we review the progress and prospects of various stem cells, including embryonic stem cells, mesenchymal stem cell and neural stem cells and so on, for the treatments of neurodegenerative diseases, such as Parkinson’s disease, Alzheimer’s disease, Hunt-ington’s disease and Amyotrophic lateral sclerosis/Lou Gehrig’s disease.

关键词： stem cells neurodegenerative diseases therapy