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Roles of Adinandra nitida(Theaceae) and camellianin A in HCl/ethanol-induced acute gastric ulcer in mice

Food Science and Human Wellness 2022年第4期11卷 1053-1063页

作者： Erdong Yuan Yingyi Lian Qiuhua Li Zhaoxiang Lai lingli sun Xingfei Lai Ruohong Chen Shuai Wen Junquan Zhu Wenji Zhang Shili sun School of Food Science and Engineering South China University of TechnologyGuangzhou 510641China Tea Research Institute Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory of Tea Resources Innovation&UtilizationGuangzhou 510640China Guangdong Society of Plant Protection Guangdong 510640China

Gastric ulcer is a global health concern nowadays. Adinandra nitida, known as Shibi tea, is a flavonoidrich plant found in South China. A. nitida possesses many healthy properties, such as antioxidation and reducing blood pressure. However, its effects on gastric ulcer have not been investigated. This study aimed to investigate the effects of the Shibi tea water extract(STE) and its main flavonoid camellianin A(CA) in hydrochloric acid(HCl) and ethanol(Et OH)-induced acute gastric ulcer in mice. Administration of CA and STE for continuous two days after stimulation by HCl/Et OH significantly attenuated the deterioration of gastric mucosal damage by lowering the gross gastric mucosal index, histopathological injury index, the oxidative stress, the expression of the inflammatory cytokines TNF-α and IL-6, and the expression of inflammatory mediators i NOS and COX-2. Western blotting and immunohistochemistry analysis showed that CA and STE regulated the inflammatory signaling pathway protein levels of IκB-α and NF-κB. Taken together, our study verified that CA and STE have antioxidative and anti-inflammatory effects in gastric ulcer mice. We propose that A. nitida should be developed as natural functional food for acute gastric ulcer patients base on the gastroprotective effects of STE and its main flavonoid CA.

关键词： Adinandra nitida(Theaceae) Camellianin A Gastric ulcer Oxidative stress Anti-inflammation

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Genotypes Diversity of Acute Gastroenteritis Outbreaks Caused by Human Sapovirus-Beijing Municipality,China,2015-2021

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China CDC weekly 2023年第28期5卷 625-631页

作者： Yang Jiao Taoli Han Xiao Qi Yan Gao Jianhong Zhao Yue Zhang Beibei Li Zheng Zhang Jialiang Du lingli sun Beijing Chaoyang District Center for Disease Control and Prevention BeijingChina National Institutes for Food and Drug Control BeijingChina

Introduction:Human sapovirus(HuSaV)is an enteric virus responsible for sporadic cases and outbreaks of acute gastroenteritis(AGE)globally.A seven-year active surveillance study was conducted to investigate the molecular epidemiology of HuSaVs associated with AGE outbreaks in Chaoyang District of Beijing Municipality,China from January 2015 to December ***:Fecal and anal swab samples were obtained from patients experiencing AGE *** were identified through reverse transcription polymerase chain reaction(RT-PCR),and partial viral protein 1(VP1)sequences(approximately 434 base pairs)were utilized for genotyping,single nucleotide polymorphism(SNP)analysis,and phylogenetic ***:HuSaVs were identified in 71 AGE outbreaks,demonstrating a detection rate of 10.5%,second only to *** primary demographic affected by HuSaV were children under the age of 5 in kindergarten *** rates tended to peak during two distinct periods:May to June and September to *** genotyping,seven distinct genotypes ***.3 was the most prevalent,accounting for 54.9%of cases,followed by GI.1(12.7%),GI.2(9.9%),GII.5(7.0%),GI.5(2.8%),GI.6(1.4%),GII.1(1.4%),and untyped cases(9.9%).A phylogenetic analysis of GII.3 identified three distinct groups,with 15 notable SNPs ***:This study offers a comprehensive analysis of the persistent prevalence of HuSaV outbreaks in Chaoyang District,Beijing Municipality,*** time,the diversity of HuSaV subtypes has shifted,and it is now recognized as the second leading viral agent responsible for AGE *** highlights the importance of ongoing surveillance in the future.

关键词： epidemiology Human enteritis

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Tea and Citrus maxima complex induces apoptosis of human liver cancer cells via PI3K/AKT/mTOR pathway in vitro

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Chinese Herbal Medicines 2022年第3期14卷 449-458页

作者： Shuai Wen Ran An Dongli Li Junxi Cao Zhigang Li Wenji Zhang Ruohong Chen Qiuhua Li Xingfei Lai lingli sun Shili sun Tea Research Institute Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory of Tea Resources Innovation&UtilizationGuangzhou510640China School of Biotechnology and Health Sciences Wuyi UniversityJiangmen 529020China International Healthcare Innovation Institute(Jiangmen) Jiangmen 529040China

Objective:In this study,black tea and Citrus maxima(BT-CM),yellow tea and ***(YT-CM),green tea and ***(GT-CM)as subjects,the active ingredient content and antioxidant activity of three tea and ***(T-CM)were *** effects of three T-CMs on apoptosis of liver cells in vitro and its mechanism were further ***:National standard method and HPLC were used for active ingredient ***,cell fow cytometry and Western blot were used to analyze the effects of three T-CMs on cell proliferation,apoptosis,and its underlying molecular ***:The content of tea polyphenols,free amino acids,ratio of polyphenols and amino acids,ester catechins,non-ester catechins and caffeine in YT-CM and GT-CM was significantly higher than that of *** in vitro antioxidant capacity of YT-CM and GT-CM was also significantly stronger than that of *** T-CMs had the effects of inhibiting proliferation,arresting cell cycle and inducing apoptosis in HepG2 and Bel7402 cells,especially YT-CM and *** blot analysis showed three T-CMs activated PI3K/AKT/mTOR signaling pathway and regulated the expression levels of apoptosis-related proteins Bax,Bcl-2 and Caspase-3/***-CM and GT-CM had better ability to change the signal pathway than ***:In short,T-CMs,which combined different degrees of fermentation tea with ***,were rich in nutrients and biologically active substances.T-CMs,especially YT-CM and GT-CM,are healthy drinks that help to prevent and treat liver cancer.

关键词： apoptosis Citrus maxima cv.Tomentosa liver cancer signaling pathway tea

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Smoking influences outcome in patients who had thrombolysed ischaemic stroke:the ENCHANTED study

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Stroke & Vascular Neurology 2021年第3期6卷 395-401,I0033,I0034页

作者： lingli sun Lili Song Jie Yang Richard I Lindley Thompson Robinson Pablo M Lavados Candice Delcourt Hisatomi Arima Bruce Ovbiagele John Chalmers Craig S Anderson Xia Wang The George Institute for Global Health Peking University Health Science CentreBeijingChina The George Institute for Global Health University of New South WalesSydneyNSWAustralia Department of Neurology The First Affiliated Hospital of Chengdu Medical CollegeChengduChina Faculty of Medicine University of SydneySydneyNSWAustralia Department of Cardiovascular Sciences and NIHR Biomedical Research Unit for Cardiovascular Sciences University of LeicesterLeicesterUK Clínica Alemana de Santiago Universidad del DesarrolloSantiago de ChileRegion Metropolitana de SChile Department of Preventive Medicine and Public Health Faculty of MedicineFukuoka UniversityFukuokaJapan San Francisco VA Healthcare System University of CaliforniaSan FranciscoCaliforniaUSA

Background and purpose As studies vary in defining the prognostic significance of smoking in acute ischaemic stroke(AIS),we aimed to determine the relation of smoking and key outcomes in patient participants who had thrombolysed AIS of the international quasi-factorial randomised Enhanced Control of Hypertension and Thrombolysis Stroke Study(ENCHANTED).Methods Post-hoc analyses of ENCHANTED,an international quasi-factorial randomised evaluation of intravenous alteplase-dose comparison and levels of blood pressure control in patients who had thrombolysed *** logistic regression models with inverse probability of treatment weighting(IPTW)propensity scores were used to determine associations of self-reported smoking status and clinical outcomes,according to 90-day modified Rankin Scale(mRS)scores and symptomatic intracerebral haemorrhage(sICH).Results Of 4540 patients who had an AIS,there were 1008(22.2%)current smokers who were younger and predominantly male,with more comorbidities of hypertension,coronary artery disease,atrial fibrillation and diabetes mellitus,and greater baseline neurological impairment,compared with *** univariate analysis,current smokers had a higher likelihood of a favourable shift in mRS scores(OR 0.88,95%CI 0.77 to 0.99;p=0.038)but this association reversed in a fully adjusted model with IPTW(adjusted OR 1.15,95%CI 1.04 to 1.28;p=0.009).A similar trend was also apparent for dichotomised poor outcome(mRS scores 2–6:OR 1.18,95%CI 1.05 to 1.33;p=0.007),but not with the risk of sICH across standard *** Smoking predicts poor functional recovery in patients who had thrombolysed *** registration number NCT01422616.

关键词： patients smoke acute

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On Estimators of Coefficients of Linear Model Based on EMB Multiple Imputation

On Estimators of Coefficients of Linear Model Based on EMB M...

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第十届海峡两岸统计与概率研讨会

作者： Yang Guijun sun lingli Meng jie China Center of Economic and Statistics Research Tianjin University of Finance and Economics

This paper simulates coefficients estimators of linear model based on the EMB multiple imputation, analyzes their statistical properties and compares with the ones base on PMM multiple imputation and DA multiple imputation, separately. The simulation shows that the absolute values of the bias and mean squared error of the coefficients estimators increase as the multiplicity of imputation increases, the estimated variance significantly increases also. The multiplicity of imputation is suggested as around 15 under completely random non-response mechanism or under random non-response mechanism such that the estimators are good statistically. Under non-response at not random mechanism depended on explained variable, it’s appropriate for the greater number of imputation. To be careful to use the EMB multiple imputation under non-response at non random mechanism depended on other variable, as the difference between mean squared error and estimated variance of the coefficients estimators is very large.

关键词： EMB Imputation Non-response Mechanism Non-response Rate Imputation Multiplicity

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Response of tilt and strain meters in Hubei province to the 2011 Mw9. 0 Japan earthquake

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Geodesy and Geodynamics 2011年第4期2卷 46-52页

作者： sun lingli Li Ming Wei Guichun Luo Junqiu Zhang Weihua Institute of Seismology China Earthquake Administration Wuhan 430071 China

Tih and strain meters of the deformation-observation network in Hubei Province all responded to the Mw9.0 Japan earthquake on March 11,2011. By analyzing the co-seismic responses,we found that firstly there was essentially a linear correlation between response time and epicentral distance. Secondly, there was some correlation between maximum response amplitude and earthquake magnitude as well as between the duration and earthquake magnitude. Thirdly, the response amplitudes and decay rates were different for different types of instruments. Due to less data-sampling frequency, the deformation instruments, could not display the first motion of P and S waves, but responded mainly to far-field surface waves. Before the earthquake, the NS earthtide component recorded by the cave stainmeter at Yichang was distorted for nearly eight hours. While digital deformation observation did not show complete information about the earthquake source, it still reflected some key features of seismic-wave propagation.

关键词： Mw9.0 Japan earthquake co-seismic effect crustal deformation observation at fixed sites

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A Continuous Wavelet-based Approach to Identifying Modal Parameters for the AR Model of Helicopters

A Continuous Wavelet-based Approach to Identifying Modal Par...

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第三届国际机械工程与力学会议

作者： Xufei HE Zhongmin DENG lingli sun Lingjun LIN Astronautics School Beijing University of Aeronautics and Astronautics Wuhan Bureau of General Armament Department

The dynamic characteristics of helicopters have been a great consideration in the engineering field. This work presents a wavelet-based approach to determining modal parameters of a helicopter. Continuous wavelet transforms are applied to the dynamic responses of its fuselage. An auto regression （AR） model in the wavelet domain is established from the discrete equations of motion. Modal parameters such as modal frequency, damping ratio and mode shape are then computed from the coefficient matrices of AR models by solving an eigenvalue problem. The effects of wavelet transform scale coefficient and noise on the accuracy to estimate the modal parameters are further investigated. Results comparison are carried out with Least Squares Compiles Exponential estimation method and finite element analysis, to verify that the applied wavelet approach is with high resolution and insensitive to noise, suitable for modal parameters identification of helicopters.

关键词： continuous wavelet dynamic characteristic parameter estimation auto regression

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贵州乡村旅游与农村经济复合发展模式探索

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贵州农业科学 2013年第6期41卷 216-220页

作者：孙伶俐武昌理工学院商学院湖北武汉430223

为贵州乡村旅游和农村经济发展提供参考依据,针对乡村旅游与农村经济复合发展存在的问题,在分析乡村旅游及农村经济发展现状的基础上,提出了特色果园、特色农业生态园、特色养殖等特色农村经济与乡村旅游的复合发展模式,并提出了相应的... 详细信息

为贵州乡村旅游和农村经济发展提供参考依据,针对乡村旅游与农村经济复合发展存在的问题,在分析乡村旅游及农村经济发展现状的基础上,提出了特色果园、特色农业生态园、特色养殖等特色农村经济与乡村旅游的复合发展模式,并提出了相应的对策。

关键词：乡村旅游农村经济复合发展模式贵州

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Impact of COVID-2019 on stroke services in China: survey from the Chinese Stroke Association

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Stroke & Vascular Neurology 2020年第4期5卷 323-330页

作者： Xia Wang Menglu Ouyang Cheryl Carcel Chen Chen lingli sun Jie Yang Yao Zhang Guofang Chen Shoujiang You Yongjun Cao Lu Ma Xin Hu Yi Sui Craig Anderson Lili Song Yongjun Wang David Wang The George Institute for Global Health Faculty of MedicineUniversity of New South WalesSydneyNew South WalesAustralia Department of Neurology Shanghai East HospitalShanghaiShanghaiChina Stroke Division The George Institute China at Peking University Health Science CentreBeijingPR ChinaShanghaiChina Department of Neurology The First Affiliated Hospital of Chengdu Medical CollegeChengduChina Department of Neurology Shenyang Brain HospitalShenyang Medical CollegeShenyangChina Department of Neurology Xuzhou Central HospitalXuzhouJiangsuChina Department of Neurology The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina Department of Neurosurgery West China Hospital of MedicineChengduSichuanChina Department of Neurology Royal Prince Alfred HospitalSydneyNSWAustralia Department of Neurology China National Clinical Research Center for Neurological DiseaseBeijingChina Department of Neurology Tiantan Clinical Trial and Research Center for StrokeBeijingChina Neurovascular Division Department of NeurologyBarrow Neurological InstituteSt.Joseph's Hospital and Medical CenterPhoenixArizonaUSA

Background The COVID-19 pandemic and physical distancing guidelines have compelled stroke practices worldwide to reshape their delivery of care *** aimed to illustrate how the stroke services were interrupted during the pandemic in *** A 61-item questionnaire designed on Wenjuanxing Form was completed by doctors or nurses who were involved in treating patients with stroke from 1 February to 31 March *** A total of 415 respondents completed the online survey after informed consent was *** the respondents,37.8%,35.2%and 27.0%were from mild,moderate and severe epidemic areas,***,the proportion of severe impact(reduction>50%)on the admission of transient ischaemic stroke,acute ischaemic stroke(AIS)and intracerebral haemorrhage(ICH)was 45.0%,32.0%and 27.5%,*** numbers were 36.9%,27.9%and 22.3%;36.5%,22.1%and 22.6%;and 66.4%,47.5%and 41.1%in mild,moderate and severe epidemic areas,respectively(all p50%),as reported by 54.4%of the respondents,while thrombectomy was 39.3%.These were 44.4%,26.3%;44.2%,39.4%;and 78.2%,56.5%,in mild,moderate and severe epidemic areas,respectively(all p<0.0001).For patients with acute ICH,39.8%reported the impact was severe or moderate for those eligible for surgery who had *** numbers were 27.4%,39.0%and 58.1%in mild,moderate and severe epidemic areas,*** staff resources,about 20%(overall)to 55%(severe epidemic)of the respondents reported moderate or severe impact on the on-duty doctors and *** We found a significant reduction of admission for all types of patients with stroke during the *** were less likely to receive appropriate care,for example,thrombolysis/thrombectomy,after being admitted to the *** service in severe COVID-19 epidemic areas,for example,Wuhan,was much more severely impacted compared with other regions in China

关键词： nurse admitted services

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旅行社在旅游供应链中的地位演化及其策略分析

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物流技术 2013年第6期32卷 203-205页

作者：孙伶俐武昌理工学院湖北武汉430000

对旅行社在旅游供应链中地位作用的演化进行了分析,指出在信息技术网络化背景下旅行社与旅游供应商、旅游消费者相比其地位和作用正在逐步受到削弱和边缘化,接着分析了旅行社地位作用弱化给旅游供应链运作所产生的影响,最后得出旅行社... 详细信息

对旅行社在旅游供应链中地位作用的演化进行了分析,指出在信息技术网络化背景下旅行社与旅游供应商、旅游消费者相比其地位和作用正在逐步受到削弱和边缘化,接着分析了旅行社地位作用弱化给旅游供应链运作所产生的影响,最后得出旅行社在旅游供应链中的核心地位应该得到重新确认和塑造的结论,并从旅游消费者、旅游供应商以及旅行社自身素质提升等方面提出了实现这一目标的相关建议和策略。

关键词：旅行社旅游供应链地位演化

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