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KCNMA1 promotes obesity-related hypertension:Integrated analysis based on genome-wide association studies

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Genes & Diseases 2023年第1期10卷 58-61页

作者： Yingchao Zhou Yuanyuan zhao lingfeng zha Mengchen Zhou Mengru Wang Xiang Cheng Zhengrong Huang Min Liu Tie Ke Xin Tu Heart Center Qingdao Women and Children's HospitalQingdao UniversityQingdaoShandong 266003China Key Laboratory of Molecular Biophysics of the Ministry of Education College of Life Science and TechnologyCenter for Human Genome ResearchHuazhong University of Science and TechnologyWuhanHubei 430074China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyKey Laboratory of Organ TransplantationMinistry of EducationNHC Key Laboratoryof Organ TransplantationKey Laboratory of Organ TransplantationChinese Academy of Medical SciencesWuhanHubei 430030China Department of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Cardiology The First Affiliated Hospital of Xiamen UniversityXiamenFujian 361003China Hypertension Department of Henan Provincial People's Hospital ZhengzhouHenan 450003China

Obesity is caused by an excessive accumulation of fat,which poses a risk to human *** China,the prevalence rates of overweight and obesity in adults were estimated to be 30.1%and 11.9%,respectively,ranking the first i... 详细信息

关键词： obesity hypertension prevalence

Analysis and solution of streak effect in high dynamic range CMOS image sensors

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Science China(Information Sciences) 2025年第1期68卷 402-403页

作者： Wanbin zha Jiangtao XU Jinghua AO Kaiming NIE Zhiyuan GAO School of Microelectronics Tianjin University Tianjin Key Laboratory of Imaging and Sensing Microelectronic Technology Tianjin University

The high dynamic range (HDR) CMOS image sensor has been widely used in many fields,such as autonomous driving and security guarding [1].The dual conversion gain (DCG)structure,which adjusts the conversion gain (CG) by changing the capacitors connected to the floating diffusion (FD)nodes in the pixel,is an effective and prevalent method for realizing HDR imaging [2].While the DCG structure can extend the dynamic range,in the practical HDR imaging process,the substantial number of photo-generated electrons in bright areas can cause significant voltage variations in the pixel *** variations affect the gray values in darker areas of the same image,leading to the streak effect [3].This study primarily investigates the streak effect caused by forward conduction current of the PN junction in DCG pixels,and proposes a circuit to suppress this effect.

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Insomnia and Coronary Artery Diseases:A Mendelian Randomisation Study

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Cardiology Discovery 2021年第3期1卷 154-162页

作者： Wenjuan zhang lingfeng zha Jiangtao Dong Qianwen Chen Jianfei Wu Tingting Tang Ni Xia Min zhang Jiao Jiao Tian Xie Chengqi Xu Xin Tu Shaofang Nie Department of Geriatrics The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Hubei Maternal and Child Health Hospital WuhanHubei 430070China Key Laboratory of Molecular Biophysics of Ministry of Education College of Life Science and TechnologyCenter for Human Genome ResearchCardio-X InstituteHuazhong University of Science and TechnologyWuhanHubei 430074China

Objective:Observational studies indicate that insomnia may increase the risk of developing and/or dying from cardiovascular diseases,especially coronary artery disease(CAD).Our purpose is to explore the underlying causal relationship between genetic variants susceptible to insomnia and the risk of CAD by Mendelian randomization ***:The study was conducted using publicly available statistical data on genetic variants identified from a genome-wide association meta-analysis of insomnia(n=113,006 individuals)and a genome-wide association meta-analysis of CAD(n=184,305 individuals),which consisted of both cases and *** genetic association between variants and CAD was assessed by the variants’association with insomnia,and estimations were integrated by an inverse-variance weighted ***:Among the Mendelian randomized analytical sample,8 variants were associated with insomnia complaints and *** there was no pleiotropic association with the latent *** addition,in the inverse-variance weighted meta-analysis(the estimations combined from the 8 variants),the odds ratio was 1.15(95%CI:1.05–1.25;P=0.002)for CAD,and in the weighted method analysis,the odds ratio was 1.14(95%CI:1.03–1.27;P=0.015)for ***:All of the data indicated that some valuable variants might involve in the development of CAD by leading the ***,insomnia might be a causal factor for CAD,and improving the quality of sleep might be a new way for populations with insomnia to prevent CAD.

关键词： Coronary artery diseases Genetic variants Insomnia Mendelian randomization

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单基因遗传性高血压的研究进展

中国医学前沿杂志（电子版） 2023年第12期15卷 70-78页

作者：郭爽查灵凤清华大学附属北京清华长庚医院血管外科清华大学临床医学院北京102218 华中科技大学同济医学院附属协和医院心血管内科生物靶向治疗研究湖北省重点实验室心血管疾病免疫诊疗湖北省工程研究中心湖北武汉430022

单基因遗传性高血压是一种符合孟德尔遗传规律、家族聚集性难治性高血压。单基因遗传性高血压的患病率相对较低,病因相对明确,由单基因突变所致。由于外显率不全,单基因遗传性高血压临床表型异质性显著,易造成误诊或漏诊,仅靠临床表现... 详细信息

单基因遗传性高血压是一种符合孟德尔遗传规律、家族聚集性难治性高血压。单基因遗传性高血压的患病率相对较低,病因相对明确,由单基因突变所致。由于外显率不全,单基因遗传性高血压临床表型异质性显著,易造成误诊或漏诊,仅靠临床表现并不能做出精准的诊断。基因检测是准确诊断单基因遗传性高血压的重要标准,结合基因筛查可识别患者家属致病突变的携带情况。单基因遗传性高血压分子遗传学研究有利于推动高血压发病机制的深入探索,早期明确诊断,选择合适的药物控制血压,改善疾病预后。随着基因检测技术的进步,目前已报道18种单基因遗传性高血压,本篇综述重点介绍临床上相对常见的几种单基因遗传性高血压的遗传研究现状。

关键词：基因遗传性高血压单基因遗传病

Microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei zha Guoli Zheng Thomas Skutella Karl Kiening Andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

冠脉支架内再狭窄的危险因素和致病机制及治疗进展

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生物医学转化 2024年第3期5卷 74-83页

作者：查灵凤王景林徐克华中科技大学同济医学院附属协和医院生物靶向治疗研究湖北省重点实验室心血管疾病免疫诊疗湖北省工程研究中心湖北武汉430022 武汉大学人民医院湖北武汉430060 南京市雨花医院江苏南京210012

冠心病(CAD)已成为全球范围内导致人口死亡的主要原因之一。经皮冠状动脉介入治疗(PCI)是CAD的主要治疗手段之一。冠脉支架内再狭窄(ISR)是指PCI后,血管再次发生狭窄的情况,约占PCI后的10%左右。冠脉ISR是一种极为复杂的疾病,尽管其确... 详细信息

冠心病(CAD)已成为全球范围内导致人口死亡的主要原因之一。经皮冠状动脉介入治疗(PCI)是CAD的主要治疗手段之一。冠脉支架内再狭窄(ISR)是指PCI后,血管再次发生狭窄的情况,约占PCI后的10%左右。冠脉ISR是一种极为复杂的疾病,尽管其确切发病机制尚不清楚,但目前普遍认为其涉及炎症、增殖和基质血管重塑等过程。多种危险因素已被确定与冠脉ISR相关,包括炎症、遗传因素、患者斑块异质性,以及PCI手术中支架植入操作不当。识别这些因素不仅有助于对患者危险程度进行分类,还加深了我们对冠脉ISR的理解,从而有助于制定个体化的治疗方案。在过去的40年中,越来越多的新材料和技术被应用于冠脉ISR的预防与治疗,包括药物洗脱支架、新型药物治疗、先进的血管内成像技术、可生物降解支架以及细胞治疗和基因治疗等。尽管取得了这些进展,冠脉ISR仍然是PCI并发症中的重要问题,因此,认识冠脉ISR的危险因素、理解其致病机制,并探索新的治疗策略至关重要。本文旨在综述冠脉ISR的危险因素、致病机制和治疗方面的最新进展,以供临床医生和未来研究人员参考。

关键词：冠脉支架内再狭窄经皮冠状动脉介入支架植入

血压与心血管疾病的关系:一项孟德尔随机化研究

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生物医学转化 2024年第1期5卷 92-100页

作者：孙巍巍李丹谢天查灵凤淮安市楚州中医院江苏淮安223200 华中科技大学同济医学院附属协和医院湖北武汉430022 华中科技大学同济医学院附属协和医院生物靶向治疗研究湖北省重点实验室心血管疾病免疫诊疗湖北省工程研究中心湖北武汉430022

血压在各种心血管疾病的发展和预后中起着至关重要的作用,但受限于传统流行病学的研究方法,并不能明确血压与心血管疾病之间的因果关系。孟德尔随机化(MR)研究是近年兴起的研究因果关系的方法。本项研究利用两样本MR方法探究血压(舒张压... 详细信息

血压在各种心血管疾病的发展和预后中起着至关重要的作用,但受限于传统流行病学的研究方法,并不能明确血压与心血管疾病之间的因果关系。孟德尔随机化(MR)研究是近年兴起的研究因果关系的方法。本项研究利用两样本MR方法探究血压(舒张压/收缩压)与常见心血管疾病之间的因果关系。结果显示,舒张压与脑动脉瘤(OR=2.00,95%CI:1.58~2.52,P=5.92×10^(-9)),主动脉瘤(OR=2.04,95%CI:1.69~2.46,P=9.02×10^(-14)),胸主动脉瘤(OR=2.21,95%CI:1.61~3.05,P=1.26×10^(-6)),房颤(OR=1.26,95%CI:1.16~1.37,P=4.74×10^(-8)),心肌梗死(OR=1.89,95%CI:1.68~2.13,P=1.06×10^(-25)),心衰(OR=1.34,95%CI:1.23~1.45,P=1.12×10^(-12))和缺血性中风(OR=1.60,95%CI:1.47~1.74,P=2.77×10^(-29))之间均存在显著的因果关系。收缩压与脑动脉瘤(OR=2.04,95%CI:1.62~2.57,P=1.76×10^(-9)),主动脉瘤(OR=1.29,95%CI:1.06~1.56,P=9.37×10^(-3)),房颤(OR=1.29,95%CI:1.18~1.42,P=3.55×10^(-8)),心肌梗死(OR=1.89,95%CI:1.68~2.13,P=8.09×10^(-26)),心衰(OR=1.37,95%CI:1.27~1.47,P=2.01×10^(-16))和缺血性中风(OR=1.49,95%CI:1.37~1.62,P=1.59×10^(-20))之间也存在显著的因果关联。遗传变异预测的收缩压和舒张压与心肌梗死、房颤、心衰和缺血性中风的风险升高显著相关,并大幅度增加动脉瘤的风险。及早发现和积极管理高血压,对心血管健康至关重要。降低血压是预防和控制心血管疾病的重要措施之一。通过调整生活方式和药物治疗,可以有效控制血压,减少心血管疾病的风险。

关键词：血压心血管疾病孟德尔随机化因果关系

The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

晋西黄土区不同植被恢复阶段土壤生态化学计量特征

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水土保持研究 2025年第1期32卷 30-38,47页

作者：高连炜张红丽查同刚北京林业大学水土保持学院北京100083 水利部水土保持监测中心北京100000

[目的]开展土壤生态化学计量特征随植被恢复进程的变化研究,探究植被恢复引起土壤养分变化规律及其作用机制,对认识植被恢复与土壤养分的关系,指导植被恢复实践具有重要意义。[方法]以晋西黄土区不同植被恢复阶段(撂荒地、草地、灌木林... 详细信息

[目的]开展土壤生态化学计量特征随植被恢复进程的变化研究,探究植被恢复引起土壤养分变化规律及其作用机制,对认识植被恢复与土壤养分的关系,指导植被恢复实践具有重要意义。[方法]以晋西黄土区不同植被恢复阶段(撂荒地、草地、灌木林、先锋阔叶林、针叶林)的5种林(草)地为研究对象,通过调查采样和室内分析,探究土壤生态化学计量特征随植被恢复的进程变化及其影响因素。[结果](1)随着植被的恢复,先锋阔叶林和针叶林阶段的SOC含量较上一阶段增加19.8%,土壤TN含量较上一阶段增加17.6%,而土壤TP含量较上一阶段减少12.4%;(2)随着植被恢复的发展,土壤C∶P和N∶P显著增加,C∶N的变化无明显规律,在先锋阔叶林和针叶林阶段的土壤C∶P较上一阶段增加26.6%;先锋阔叶林和针叶林阶段在0-40 cm土层的土壤N∶P较上一阶段增加40.2%,40-100 cm土层的土壤N∶P较上一阶段增加35.7%;土壤C∶N在不同植被恢复阶段间的变化未见明显规律,研究区土壤逐渐由C,N的限制转变为P的限制;(3)各植被恢复阶段土壤C∶P和N∶P主要与砂粒含量呈显著负相关,与孔隙度呈显著正相关,土壤C∶N与其他因子的相关性不明显。[结论]植被恢复有利于土壤C,N含量增加,改善土壤理化性质,在植被恢复过程应同时注重P元素的调控,以提高晋西黄土区植被生态恢复水平。

关键词：植被恢复土壤养分生态化学计量特征