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Conversion therapy in advanced perihilar cholangiocarcinoma based on patient-derived organoids:A case report

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4274-4280页

作者： Yong-Gang He ling-yu zhang Jing Li Zheng Wang Chong-yu Zhao Lu Zheng Xiao-Bing Huang Department of Hepatobiliary The Second Affiliated Hospital of Army Medical UniversityChongqing 400037China School of Clinical Oncology Fujian Medical UniversityFujian Cancer HospitalFuzhou 350014Fujian ProvinceChina Fujian Key Laboratory of Translational Cancer Medicine Fuzhou 350014Fujian ProvinceChina

BACKGROUND Patient-derived organoids(PDOs)have been demonstrated to predict the response to drugs in multiple cancer ***,it remains unclear about its application in *** SUMMARY A 59-year-old woman was admitted to the hospital due to upper abdominal pain for over 8 *** to relevant examinations,she was diagnosed as perihilar cholangiocarcinoma(pCCA)with intrahepatic metastasis and perihilar lymphatic *** multidisciplinary team discussion,percutaneous transhepatic cholangiodrainage was performed to relieve biliary obstruction,and puncture biopsy was conducted to confirm the pathological *** chemoembolization with nab-paclitaxel was used in combination with toripalimab and lenvatinib,but the levels of tumor markers including alpha fetal protein,carcinoembryonic antigen,carbohydrate antigen 15-3 and cancer antigen 125 were still *** PDO for drug screening showed sensitive to gemcitabine and ***,the chemotherapy regimen was adjusted to gemcitabine and cisplatin in combination with toripalimab and *** 4 cycles of treatment,the tumor was assessed resectable,and radical surgical resection was performed *** year after surgery,the patient was still alive,and no recurrence or *** PDOs for drug sensitivity contribute to screening effective chemotherapy drugs for advanced pCCA,promoting conversion therapy and improving the prognosis.

关键词： Patient-derived organoids Perihilar cholangiocarcinoma Conversion therapy Drug screening Intrahepatic metastasis Case report

Evaluation of retinal and choroidal thickness changes in overweight and obese adults without ocular symptoms by swept-source optical coherence tomography

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 707-712页

作者： Qing-Jian Li Sheng-Mei Zhou ling-yu zhang An-Ni Lin Yang zhang Jing Jiang Xin Che Yi-Wen Qian Yan Liu Zhi-Liang Wang Department of Ophthalmology Huashan HospitalFudan UniversityShanghai 200040China Eye Institute of Xiamen University Xiamen University School of MedicineXiamen 361005Fujian ProvinceChina Department of Gastroenterology Huashan HospitalFudan UniversityShanghai 200040China

AIM:To evaluate the relationship of overweight and obesity with retinal and choroidal thickness in adults without ocular symptoms by swept-source optical coherence tomography(SS-OCT).METHODS:According to the body mass index(BMI)results,the adults enrolled in the cross-sectional study were divided into the normal group(18.50≤BMI<25.00 kg/m^(2)),the overweight group(25.00≤BMI<30.00 kg/m^(2)),and the obesity group(BMI≥30.00 kg/m^(2)).The one-way ANOVA and the Chi-square test were used for ***’s correlation analysis was used to evaluate the relationships between the measured ***:This research covered the left eyes of 3 groups of 434 age-and sex-matched subjects each:normal,overweight,and *** mean BMI was 22.20±1.67,26.82±1.38,and 32.21±2.35 kg/m^(2) in normal,overweight and obesity groups,*** choroid was significantly thinner in both the overweight and obesity groups compared to the normal group(P<0.05 for all),while the retinal thickness of the three groups did not differ ***’s correlation analysis showed that BMI was significantly negatively correlated with choroidal thickness,but no significant correlation was observed between BMI and retinal ***:Choroidal thickness is decreased in people with overweight or *** on changes in choroidal thickness contributes to the understanding of the mechanisms of certain ocular disorders in overweight and obese adults.

关键词： overweight obesity body mass index choroidal thickness retinal thickness swept-source optical coherence tomography

Pilot plant study on ozonation and biological activated carbon process for drinking water treatment

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Journal of Environmental Sciences 2006年第2期18卷 232-235页

作者： KONG ling-yu zhang Xiao-jian WANG Zhan-sheng Department of Environmental Science and Engineering Tsinghua University Beijing 100084 China

A study on advanced drinking water treatment was conducted in a pilot scale plant taking water from conventional treatment process. Ozonation-biological activated carbon process （O3-BAC） and granular activated carbon process （GAC） were evaluated based on the following parameters： CODMn, UV254, total organic carbon （TOC）, assimilable organic carbon （AOC） and biodegradable dissolved organic carbon （BDOC）. In this test, the average removal rates of CODMn, UV254 and TOC in O3-BAC were 18.2%, 9.0% and 10.2% higher on （AOC） than in GAC, respectively. Ozonation increased 19.3-57.6 μg Acetate-C/L in AOC-P17, 45.6-130.6 μg Acetate-C/L in AOC-NOX and 0.1-0.5 mg/L in BDOC with ozone doses of 2 8 mg/L. The optimum ozone dose for maximum AOC formation was 3 mgO3/L. BAC filtration was effective process to improve biostability.

关键词： ozonation biological activated carbon CODMn UV254 TOC AOC BDOC biostability

A novel bioinspired mechanism to elucidate the movement flexibility of the honeybee abdomen driven by muscles

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Insect Science 2022年第4期29卷 1181-1194页

作者： yu-ling zhang Shao-Ze Yan You-Jian Liang Division of Intelligent and Biomechanical Systems State Key Laboratory of TribologyDepartment of Mechanical EngineeringTsinghua UniversityBeijingChina DFH Satellite Co. Ltd.BeijingChina

The abdomen of a honeybee is a blueprint for bioinspired mechanical design because of its movement flexibility and ***,the abdominal muscles closely related to the movement flexibility mechanism have not been fully identified,limiting the potential biological advantage of their use in bionic mechanism *** this study,we reveal the muscle distribution of the complete muscular driving unit in a honeybee abdomen using stereoscopy and scanning electron microscopy,and the muscle distribution was effectively verified using X-ray tomography.A novel equivalent unit mechanism(EUM)was then proposed and the kinematic analysis indicated that the extension ratio,bending angle,and swing angle of the EUM reached 9.36%,1.22°,and 4.43°,*** deformation ability of the EUM was consistent with the movement of the abdomen,confirming the movement *** work may provide a new perspective for distributed bionic mechanism design.

关键词： bionics equivalent unit mechanism honeybee abdomen movement flexibility muscle

Glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide dual receptor agonist DA-CH5 is superior to exendin-4 in protecting neurons in the 6-hydroxydopamine rat Parkinson model

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Neural Regeneration Research 2021年第8期16卷 1660-1670页

作者： ling-yu zhang Qian-Qian Jin Christian Hölscher Lin Li Gerontology Institute Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Forensic Pathology Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Second HospitalShanxi Medical UniversityTaiyuanShanxi ProvinceChina Research and Experimental Center Henan University of Chinese MedicineZhengzhouHenan ProvinceChina

Patients with Parkinson's disease(PD) have impaired insulin signaling in the brain. Incretin hormones, including glucagon-like peptide-1(GLP-1) and glucose-dependent insulinotropic polypeptide(GIP), can re-sensitize insulin signaling. In a recent phase II clinical trial, the first GLP-1 mimic, exendin-4, has shown reliable curative effect in patients with PD. DA-CH5 is a novel GLP-1/GIP receptor unimolecular coagonist with a novel peptide sequence added to cross the blood-brain barrier. Here we showed that both exendin-4 and DA-CH5 protected against 6-hydroxydopamine(6-OHDA) cytotoxicity, inhibited apoptosis, improved mitogenesis and induced autophagy flux in SH-SY5Y cells via activation of the insulin receptor substrate-1(IRS-1)/alpha serine/threonine-protein kinase(Akt)/c AMP response element-binding protein(CREB) pathway. We also found that DA-CH5(10 nmol/kg) daily intraperitoneal administration for 30 days post-lesion alleviated motor dysfunction in rats and prevented stereotactic unilateral administration of 6-OHDA induced dopaminergic neurons loss in the substantia nigra pars compacta. However, DA-CH5 showed curative effects in reducing the levels of α-synuclein and the levels of pro-inflammatory cytokines(tumor necrosis factor-α, interleukin-1β). It was also more effective than exendin-4 in inhibiting apoptotic process and protecting mitochondrial functions. In addition, insulin resistance was largely alleviated and the expression of autophagy-related proteins was upregulated in PD model rats after DA-CH5 treatment. These results in this study indicate DA-CH5 plays a therapeutic role in the 6-OHDAunilaterally lesioned PD rat model and is superior to GLP-1 analogue exendin-4. The study was approved by the Animal Ethics Committee of Shanxi Medical University of China.

关键词： neurodegenerative disease Parkinson's disease insulin resistance inflammation GLP-1/GIP receptor unimolecular co-agonist

A positive feedback circuit for ROP-mediated polar growth

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Molecular Plant 2021年第3期14卷 395-410页

作者： En Li yu-ling zhang Xuelian Shi Han Li Xuefeng yuan Sha Li Yan zhang State Key Laboratory of Crop Biology College of Life SciencesShandong Agricultural UniversityTai'an 271018China Shandong Province Key Laboratory of Agricultural Microbiology College of Plant ProtectionShandong Agricultural UniversityTai'an 271018China

Tip growth is a special type of polarized growth in which a single and unique polarization site is established and *** of Plants(ROP)proteins,which represent the only class of Rho GTPases in plants,regulate tip *** dynamic and asymmetric distribution of ROPs is critical for the establishment and maintenance of tip growth,and requires at least one positive feedback loop,which is still ***,we report a positive feedback circuit essential for tip growth of root hairs,in which ROPs,ROP activators and effectors,and AGC1.5 subfamily kinases are interconnected by sequential oligomerization and ***1.5 subfamily kinases interact with and phosphorylate two guanine nucleotide exchange factors(GEFs)of ROPs,RopGEF4 and *** also interact with two ROP effectors,ICR2/RIP3 and MIDD1/RIP4,which bridge active ROPs with *** loss of the AGC1.5 subfamily kinases or ICR2 and MIDD1 compromised root hair growth due to reduced ROP *** found that asymmetric targeting of RopGEF4 and RopGEF10 is controlled by AGC1.5-dependent ***,we discovered that the ROP effectors recruit AGC1.5 to active ROP domains at the plasma membrane during root hair growth and are critical for AGC1.5-dependent phosphorylation of *** the large number of AGC kinases in plants,this positive feedback circuit may be a universal theme for plant cell polar growth.

关键词： Rho GTPases AGC kinase membrane recruitment phosphorylation asymmetric growth

High-order harmonic generation of ZnO crystals in chirped and static electric fields

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Chinese Physics B 2024年第1期33卷 335-343页

作者：张玲玉何永林谢卓璇高芳艳徐清芸葛鑫磊罗香怡郭静 Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China School of Physics and Electromechanical Engineering Hexi UniversityZhangye 734000China Institute of Theoretical Physics Hexi UniversityZhangye 734000China College of Physical Science and Technology Bohai UniversityJinzhou 121013China College of Physics and Electronic Information Baicheng Normal UniversityBaicheng 137000China

High harmonic generation in ZnO crystals under chirped single-color field and static electric field are investigated by solving the semiconductor Bloch equation(SBE). It is found that when the chirp pulse is introduced, the interference structure becomes obvious while the harmonic cutoff is not extended. Furthermore, the harmonic efficiency is improved when the static electric field is included. These phenomena are demonstrated by the classical recollision model in real space affected by the waveform of laser field and inversion symmetry. Specifically, the electron motion in k-space shows that the change of waveform and the destruction of the symmetry of the laser field lead to the incomplete X-structure of the crystal-momentum-resolved(k-resolved) inter-band harmonic spectrum. Furthermore, a pre-acceleration process in the solid four-step model is confirmed.

关键词： high-order harmonic generation the semiconductor Bloch equation k-resolved inter-band harmonic spectrum four-step semiclassical model

A Rice Panicle Mutant Created by Transformation with an Antisense cDNA Library

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Journal of Integrative Plant Biology 2006年第11期48卷 1300-1305页

作者： yuan-ling Chen Qun-yu zhang yu-yu Jian yue-Sheng Yang Kai-Dong Liu Yao-Guang Liu Key Laboratory of Plant Functional Genomics and Biotechnology of Guangdong College of Life Sciences South China Agricultural University Guangzhou 510642 China

A rice （Oryza sativa L.） mutant displaying defects in panicle development was identified among transformants in a transgenic mutagenlzed experiment using an antlsense cDNA library prepared from young rice panicles. In the mutant, the average splkelet number was reduced to 59.8 compared with 104.3 in wild-type plants. In addition, the seed-setting rate of the mutant was low （39.3%） owing to abnormal female development. Genetic analysis of T1 and T2 progeny showed that the traits segregated In a 3 （mutant）： 1 （wild type） ratio and the mutation was cosegregated with the transgene. Southern blot and thermal asymmetric interlaced polymerase chain reaction analyses showed that the mutant had a single T-DNA insertion on chromosome 5, where no gene was tagged. Sequencing analysis found that the transgenic antisense cDNA was derived from a gene encoding an F-box protein in chromosome 7 with unidentified function. This and another four homologous genes encoding putative F-box proteins form a gene cluster. These results indicate that the phenotyplc mutations were most likely due to the silencing effect of the expressed transgenic antisense construct on the member（s） of the F-box gene cluster.

关键词： antisense gene silencing F-box protein panicle development rice.

Automated Identification of Ordered Phases for Simulation Studies of Block Copolymers

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Chinese Journal of Polymer Science 2024年第5期42卷 683-692,I0011页

作者： yu-Chen zhang Wei-ling Huang Yi-Xin Liu State Key Laboratory of Molecule Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200433China

In unit cell simulations,identification of ordered phases in block copolymers(BCPs)is a tedious and time-consuming task,impeding the advancement of more streamlined and potentially automated research *** this study,we propose a scattering-based automated identification strategy(SAIS)for characterization and identification of ordered phases of BCPs based on their computed scattering *** approach leverages the scattering theory of perfect crystals to efficiently compute the scattering patterns of periodic morphologies in a unit *** the first stage of the SAIS,phases are identified by comparing reflection conditions at a sequence of Miller *** confirm or refine the identification results of the first stage,the second stage of the SAIS introduces a tailored residual between the test phase and each of the known candidate ***,our strategy incorporates a variance-like criterion to distinguish background species,enabling its extension to multi-species BCP *** has been demonstrated that our strategy achieves exceptional accuracy and robustness while requiring minimal computational ***,the approach allows for real-time expansion and improvement to the candidate phase library,facilitating the development of automated research workflows for designing specific ordered structures and discovering new ordered phases in BCPs.

关键词： Block copolymer Phase identification Scattering function