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The effect of bladder function on the efficacy of transurethral prostatectomy in patients with benign prostatic hyperplasia:a retrospective,single-center study

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Asian Journal of Andrology 2024年第1期26卷 112-118页

作者： Jin Li Xian-yan-ling yi Ze-Yu Chen Bo Chen yin Huang Da-Zhou Liao Pu-Ze Wang De-Hong Cao Jian-Zhong Ai Liang-Ren Liu West China School of Medicine Sichuan UniversityChengdu 610041China Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China

We investigated the impact and predictive value of bladder function in patients with benign prostatic hyperplasia(BPH)on the efficacy of transurethral ***,imaging,and urodynamic data of patients who underwent transurethral prostatectomy at West China Hospital of Sichuan University(Chengdu,China)from July 2019 to December 2021 were ***-up data included the quality of life(QoL),International Prostate Symptom Score(IPSS),and IPSS storage and voiding(IPSS-s and IPSS-v).Moreover,urinary creatinine(Cr),nerve growth factor(NGF),brain-derived neurotrophic factor(BDNF),and prostaglandin estradiol(PGE2)were measured in 30 patients with BPH and 30 healthy *** indicators were determined by subgroup analyses and receiver operating characteristic(ROC)curve *** the 313 patients with BPH included,patients with severe micturition problems had more improvements but higher micturition grades postoperatively than those with moderate ***,good bladder sensation,compliance,and detrusor contractility(Dc)were predictors of low postoperative IPSS and *** urinary concentrations of BDNF/Cr,NGF/Cr,and PGE2/Cr in patients were significantly higher than those in healthy participants(all P<***1).After evaluation,only DC was significantly related to both urinary indicators and postoperative recovery of *** with good DC,as predicted by urinary indicators,had lower IPSS and IPSS-v than those with reduced DC at the 1st month postoperatively(both P<0.05).In summary,patients with impaired bladder function had poor *** combined levels of urinary BDNF/Cr,NGF/Cr,and PGE2/Cr in patients with BPH may be valid predictors of preoperative bladderfunction and postoperative recovery.

关键词： BPH function of bladder IPSS:urodynamics

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Morphogenesis of Pistillate Flowers of Cercidiphyllum japonicum(Cercidiphyllaceae)

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Journal of Integrative Plant Biology 2007年第9期49卷 1400-1408页

作者： Xiao-ling yan yi Ren Xian-Hua Tian Xiao-Hui Zhang College of Life Sciences Shaanxi Normal University Key Laboratory of Medicinal Plant Resource and Natural Pharmaceutical Chemistry of Ministry of Education Xi'an 710062 China

Floral morphogenesis and the development of Cercidiphyllumjaponicum Sieb. et Zucc. were observed by scanning electron microscopy （SEM）. The results showed that the pistillate inflorescences were congested spikes with the flowers arranged opposite. Great differences between the so-called ＂bract＂ and the vegetative leaf were observed both in morphogenesis and morphology. In morphogenesis, the ＂bract＂ primordium is crescent-shaped, truncated at the apex and not conduplicate, has no stipule primordium at the base but does have some inconspicuous teeth in the margin that are not glandular. The leaf primordium is triangular, cycloidal at the apex, conduplicate, has two stipule primordia at the base, has one gland-tooth at the apex occurring at first and some gland-teeth in the margin that occur later. In morphology, the ＂bract＂ is also different to the vegetative leaf in some characteristics that were also illustrated in the present paper. Based on the hypothesis that the bract is more similar to the vegetative leaf than the tepal, we considered that the so-called ＂bract＂ of *** might be the tepal of the pistillate flower in morphological nature. Therefore, each pistillate flower contains a tepal and a carpel. We did not find any trace of other floral organs in the morphogenesis of the pistillate flower. Therefore we considered that the unicarpellate status of extant Cercidiphyllum might be to highly reduce and advance characteristics that make the extant Cercidiphyllum isolated from both fossil Cercidiphyllum-like plants and its extant affinities.

关键词： Cercidiphyllumjaponicum leaf morphogenesis pistillate flower tepal.

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Simultaneous determination of 14β-lactam antibiotics in cosmetic products by liquid chromatography tandem mass spectrometry method

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Chinese Chemical Letters 2011年第3期22卷 334-337页

作者： Cai Sheng Wu Jin Lan Zhang yan ling Qiao yi Lin Wang Zhi Rong Chen Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China

In this study,a simple and rapid high-performance liquid chromatography-tandem mass spectrometry（HPLC-MS/MS） method was established and validated to determine the 14β-lactam antibiotics in cosmetic products,including 1（ceftazidime）,2（cefaclor）, 3（cefdinir）,4（ampicillin）,5（cefalexin）,6（ceftezole）,7（cefotaxim）,8（cefradine）,9（cefuroxime）,10（cephazoline）,11 （cefathiamidine）,12（cefoperazone）,13（cafalotin）,14（piperacillin）.

关键词： High-performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS) Cosmetic β-Lactam antibiotics

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Flexible and Stretchable Electrodes for In Vivo Electrophysiological and Electrochemical Monitoring

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Chinese Journal of Chemistry 2024年第13期42卷 1523-1545页

作者： Kai-Kai Sheng yi-Fei Lu Wen-Ting Fan yan-ling Liu College of Chemistry and Molecular Sciences Wuhan University WuhanHubei 430072China Core Facilty of Wuhan University WuhanHubei 430072China

In vivo monitoring of bioelectrical and biochemical signals with implanted electrodes has received great interest over the past ***,this faces huge challenges because of the severe mechanical mismatch between conventional rigid electrodes and soft biological *** recent years,the emergence of flexible and stretchable electrodes offers seamless and conformable biological-electronic interfaces and has demonstrated significant advantages for in vivo electrochemical and electrophysiological *** review first summarizes the strategies for electrode fabrication from the point of substrate and conductive ***,recent progress in electrode functionalization for improved performance is ***,the advances of flexible and stretchable electrodes in exploring bioelectrical and biochemical signals are ***,we present some challenges and perspectives ranging from electrode fabrication to application.

关键词： Flexible electrodes Conductive materials Stretchable structures Electrode functionalization In vivo monitoring Biochemical signals Bioelectrical signals

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New black-to-white hole solutions with improved geometry and energy conditions

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 30-43页

作者： Zhongwen Feng yi ling Xiaoning Wu Qingquan Jiang School of Physics and Astronomy China West Normal UniversityNanchong 637009China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Physics University of Chinese Academy of SciencesBeijing 100049China Institute of Mathematics Academy of Mathematics and System Science and Hua Loo-Keng Key Laboratory of MathematicsChinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100190China

We construct new black-to-white hole solutions which connect the geometry of spacetime at some gluing surface inside the *** continuity of the metric can be guaranteed up to the arbitrary order which is controlled by the power factor *** sort of black-to-white holes is characterized by the sub-Planckian scalar curvature,independent of the mass of black-to-white *** importantly,we show that the energy condition is only violated within a small region near the gluing *** geodesics of particles within the region from black hole to white hole is also *** turns out that the matter falling into the black hole may pass through the center without singularity and come out from the white *** scenario provides novel ideas for understanding the information loss paradox in traditional black hole physics.

关键词： regular black hole energy condition singularity quantum gravity

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Automated Identification of Ordered Phases for Simulation Studies of Block Copolymers

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Chinese Journal of Polymer Science 2024年第5期42卷 683-692,I0011页

作者： Yu-Chen Zhang Wei-ling Huang yi-Xin Liu State Key Laboratory of Molecule Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200433China

In unit cell simulations,identification of ordered phases in block copolymers(BCPs)is a tedious and time-consuming task,impeding the advancement of more streamlined and potentially automated research *** this study,we propose a scattering-based automated identification strategy(SAIS)for characterization and identification of ordered phases of BCPs based on their computed scattering *** approach leverages the scattering theory of perfect crystals to efficiently compute the scattering patterns of periodic morphologies in a unit *** the first stage of the SAIS,phases are identified by comparing reflection conditions at a sequence of Miller *** confirm or refine the identification results of the first stage,the second stage of the SAIS introduces a tailored residual between the test phase and each of the known candidate ***,our strategy incorporates a variance-like criterion to distinguish background species,enabling its extension to multi-species BCP *** has been demonstrated that our strategy achieves exceptional accuracy and robustness while requiring minimal computational ***,the approach allows for real-time expansion and improvement to the candidate phase library,facilitating the development of automated research workflows for designing specific ordered structures and discovering new ordered phases in BCPs.

关键词： Block copolymer Phase identification Scattering function

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Success of susceptibility-guided eradication of Helicobacter pylori in a region with high secondary clarithromycin and levofloxacin resistance rates

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World Journal of Gastroenterology 2024年第2期30卷 184-195页

作者： yan-Meng Wang Mo-Ye Chen Jing Chen Xin-He Zhang yan Feng Yu-Xi Han yi-ling Li Department of Gastroenterology The First Affiliated Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department The First Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina

BACKGROUND Resistance to clarithromycin(CLA)and levofloxacin(LFX)of Helicobacter pylori(***)is increasing in severity,and successful eradication is ***,the eradication success rate has greatly declined,leaving a large number of patients with previous treatment *** To investigate secondary resistance rates,explore risk factors for antibiotic resistance,and assess the efficacy of susceptibility-guided *** We recruited 154 subjects positive for Urea Breath Test who attended The First Affiliated Hospital of China Medical University between July 2022 and April *** underwent a string test after an overnight *** gastric juice was obtained and transferred to vials containing storage ***,DNA extraction and the specific DNA amplification were performed using quantitative polymerase chain reaction(qPCR).Demographic information was also analyzed as part of the *** on these results,the participants were administered susceptibility-guided *** was compared with that of the empiric treatment *** A total of 132 individuals tested positive for the *** ureA gene by qPCR *** resistance rate reached a high level of 82.6%(n=109),LFX resistance rate was 69.7%(n=92)and dual resistance was 62.1%(n=82).Gastric symptoms[odds ratio(OR)=2.782;95%confidence interval(95%CI):1.076-7.194;P=0.035]and rural residence(OR=5.152;95%CI:1.407-18.861;P=0.013)were independent risk factors for secondary resistance to CLA and LFX,respectively.A total of 102 and 100 individuals received susceptibility-guided therapies and empiric treatment,*** antibiotic susceptibility-guided treatment and empiric treatment groups achieved successful eradication rates of 75.5%(77/102)and 59.0%(59/411)by the intention-to-treat(ITT)analysis and 90.6%(77/85)and 70.2%(59/84)by the per-protocol(PP)analysis,*** eradication rates of these two treatment strategies were significantly

关键词： Helicobacter pylori Antibiotic resistance Clarithromycin Levofloxacin String-test Susceptibility-guided therapy Eradication rate

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Neoadjuvant chemotherapy for patients with locally advanced penile cancer:an updated evidence

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Asian Journal of Andrology 2022年第2期24卷 180-185页

作者： Xian-yan-ling yi De-Hong Cao Ping-Hong You Xing-Yu Xiong Xiao-Nan Zheng Ge Peng Da-Zhou Liao Hong Li Lu yang Jian-Zhong Ai Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China Department of Urology People’s Hospital of Deyang CityDeyang 618000China Department of Endocrinology and Metabolism West China Hospital of Sichuan UniversityChengdu 610041China

Neoadjuvant chemotherapy(NAC)has shown promising results in patients with locally advanced penile ***,no consensus exists on its applications for locally advanced penile ***,it is unclear which kind of chemotherapy regimen is the best ***,a systematic search of PubMed,Web of Science,and EMBASE was performed in March 2021 to assess the efficacy and safety of NAC for the treatment of patients with locally advanced penile *** Newcastle–Ottawa Scale was used to assess the risk of bias in each *** study synthesized 14 published *** study revealed that patients who achieved an objective response to NAC obtained a better survival outcome compared with those who did not achieve an objective *** addition,the objective response rates(ORRs)and pathological complete response(pCR)rates were 0.57 and 0.11,*** incidence of grade≥3 toxicity was *** analysis found that the ORR and pCR of the taxane–platinum(TP)regimen group performed better than those of the nontaxane–platinum(NTP)regimen group(0.57 vs 0.54 and 0.14 vs 0.07,respectively).Moreover,the TP regimen group had more frequent toxicity than the NTP regimen group(0.41 vs 0.26).However,further studies were warranted to confirm the findings.

关键词： chemotherapy regimen locally advanced penile cancer neoadjuvant chemotherapy response rate

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Design,fabrication,and characterization of hierarchical mechanical metamaterials

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Frontiers of Mechanical Engineering 2024年第1期19卷 73-83页

作者： Jian SONG Junfei yan Bengang yi Automotive Engineering Research Institute BYD Auto Industry Co.Ltd.Shenzhen 518000China College of Civil and Transportation Engineering Shenzhen UniversityShenzhen 518060China

Natural mechanical materials,such as bamboo and bone,often exhibit superior specific mechanical properties due to their hierarchical porous *** the principle of hierarchy as inspiration can facilitate the development of hierarchical mechanical metamaterials(HMMs)across multiple length scales via 3D *** this work,we propose self-similar HMMs that combine octet-truss(OCT)architecture as the first and second orders,with cubic architecture as the third or more *** HMMs were fabricated using stereolithography 3D printing,with the length sizes ranging from approximately 200µm to the centimeter *** compressive stress–strain behaviors of HMMs exhibit a zigzag characteristic,and the toughness and energy absorption can be significantly enhanced by the hierarchical *** compressive moduli are comparable to that of natural materials,and the strengths are superior to that of most polymer/metal foams,alumina hollow/carbon lattices,and other natural ***,the flexural stress–strain curves exhibit a nonlinear behavior,which can be attributed to the hierarchical architecture and local damage *** relatively high mechanical properties can be attributed to the synergistic effect of the stretch-dominated OCT architecture and the bending-dominated cube ***,an ultralight HMM-integrated unmanned aerial vehicle(HMM-UAV)was successfully designed and *** HMM-UAV is~85%lighter than its bulk counterpart,remarkably extending the flight duration time(~53%).This work not only provides an effective design strategy for HMMs but also further expands the application benchmark of HMMs.

关键词： 3D printing mechanical metamaterials hierarchical architecture mechanical behavior unmanned aerial vehicle(UAV)

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Global-local combined features to detect pain intensity from facial expression images with attention mechanism

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Journal of Electronic Science and Technology 2024年第3期22卷 80-93页

作者： Jiang Wu yi Shi Shun yan Hong-Mei yan yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou313001China MOE Key Laboratory for Neuroinformation School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu611731China College of Engineering University of California at Santa BarbaraSanta Barbara93106USA

The estimation of pain intensity is critical for medical diagnosis and treatment of *** the development of image monitoring technology and artificial intelligence,automatic pain assessment based on facial expression and behavioral analysis shows a potential value in clinical *** paper reports a framework of convolutional neural network with global and local attention mechanism(GLA-CNN)for the effective detection of pain intensity at four-level thresholds using facial expression ***-CNN includes two modules,namely global attention network(GANet)and local attention network(LANet).LANet is responsible for extracting representative local patch features of faces,while GANet extracts whole facial features to compensate for the ignored correlative features between *** the end,the global correlational and local subtle features are fused for the final estimation of pain *** under the UNBC-McMaster Shoulder Pain database demonstrate that GLA-CNN outperforms other state-of-the-art ***,a visualization analysis is conducted to present the feature map of GLA-CNN,intuitively showing that it can extract not only local pain features but also global correlative facial *** study demonstrates that pain assessment based on facial expression is a non-invasive and feasible method,and can be employed as an auxiliary pain assessment tool in clinical practice.

关键词： Attention Convolutional neural network Facial expression Pain intensity

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