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Casein kinase-2 inhibition promotes retinal ganglion cell survival after acute intraocular pressure elevation

Neural Regeneration Research 2024年第5期19卷 1112-1118页

作者： Meng Wang Shi-Qi Yao Yao Huang Jia-Jian Liang Yanxuan Xu Shaowan Chen Yuhang Wang Tsz Kin ng Wai Kit Chu Qi Cui ling-p.ng cen Joint Shantou International Eye center of Shantou University and The Chinese University of Hong Kong ShantouGuangdong ProvinceChina Shantou University Medical College ShantouGuangdong ProvinceChina Beijing Tongren Eye center Beijing Tongren HospitalCapital Medical UniversityBeijingChina Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong Special Administrative RegionChina

Intraocular pressure elevation can induce retinal ganglion cell death and is a clinically reversible risk factor for glaucoma,the leading cause of irreversible *** previously demonstrated that casein kinase-2 inhibition can promote retinal ganglion cell survival and axonal regeneration in rats after optic nerve *** investigate the underlying mechanism,in the current study we increased the intraocular pressure of adult rats to 75 mmHg for 2 hours and then administered a casein kinase-2 inhibitor(4,5,6,7-tetrabromo-2-azabenzimidazole or 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole)by intravitreal *** found that intravitreal injection of 4,5,6,7-tetrabromo-2-azabenzimidazole or 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole promoted retinal ganglion cell survival and reduced the number of infiltrating *** analysis showed that the mitogen activated protein kinase signaling pathway was involved in the response to intraocular pressure elevation but was not modulated by the casein kinase-2 ***,casein kinase-2 inhibition downregulated the expression of genes(Cck,Htrsa,Nef1,Htrlb,prph,Chat,Slc18a3,Slc5a7,Scn1b,Crybb2,Tsga10ip,and Vstm21)involved in intraocular pressure *** data indicate that inhibition of casein kinase-2 can enhance retinal ganglion cell survival in rats after acute intraocular pressure elevation via macrophage inactivation.

关键词： casein kinase-2 glaucoma intraocular pressure elevation macrophages retinal ganglion cells

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Association of Thyroid Nodules with Various Elements in Urine and Blood Serum: A Case-Control Study

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Biomedical and Environmental Sciences 2024年第3期37卷 320-324页

作者： LI Xiang Zhi WU Cai Lian cen Li Ting HUAng Ming Le HUAng Min Min QIU Mei Ting LU Xiao ling Guangxi Key Laboratory on precise prevention and Treatment for Thyroid Tumor The Second Affiliated Hospital of Guangxi University of Science and TechnologyGuangxi University of Science and TechnologyLiuzhou 545006GuangxiChina Department of public Health School of MedicineGuangxi University of Science and TechnologyLiuzhou 545005GuangxiChina Academic and Research Department The Second Affiliated Hospital of Guangxi University of Science and TechnologyGuangxi University of Science and TechnologyLiuzhou 545006GuangxiChina

Thyroid nodules are a common clinical problem caused by various factors,including environmental and nutritional factors and genetic *** environment can modulate and influence not only the risk of thyroid nodules but also the severity of disease in humans[1].The environment is awash with elements,and all mineral elements,including heavy metals and trace elements,are considered potentially toxic.A significantly higher incidence of thyroid cancer has been reported in populations exposed to low doses of metallic elements in volcanic areas over a long period[2].As research on thyroid disorders continues,it is becoming clear that abnormalities in trace elements in the body can affect the development of thyroid-related disorders.

关键词： Blood doses Serum

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Interferon-induced MXB protein restricts vimentin-dependent viral infection

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Acta pharmaceutica Sinica B 2024年第6期14卷 2520-2536页

作者： Dongrong Yi Ni An Quanjie Li Qian Liu Huihan Shao Rui Zhou Jing Wang Yongxin Zhang ling Ma Fei Guo Xiaoyu Li Zhenlong Liu Shan cen Institute of Medicinal Biotechnology Chinese Academy of Medical ScienceBeijing 100050China Institute of pathogen Biology Chinese Academy of Medical ScienceBeijing 100730China Lady Davis Institute for Medical Research Jewish General HospitalMontrealQuebec H3T 1E2Canada

Type I interferon(IFN)inhibits a wide spectrum of viruses through stimulating the expression of antiviral *** an IFN-induced protein,myxovirus resistance B(MXB)protein was reported to inhibit multiple highly pathogenic human *** remains to be determined whether MXB employs a common mechanism to restrict different ***,we find that IFN alters the subcellular localization of hundreds of host proteins,and this IFN effect is partially lost upon MXB *** results of our mechanistic study reveal that MXB recognizes vimentin(VIM)and recruits protein kinase B(AKT)to phosphorylate VIM at amino acid S38,which leads to reorganization of the VIM network and impairment of intracellular trafficking of virus protein complexes,hence causing a restriction of virus *** results highlight a new function of MXB in modulating VIM-mediated trafficking,which may lead towards a novel broad-spectrum antiviral strategy to control a large group of viruses that depend on VIM for successful replication.

关键词： MXB Vimentin Broad antiviral strategy Cytoskeleton network AKT

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perinatal outcomes of frozen-thawed embryo transfer following blastocyst-stage embryo transfer compared to those of cleavage-stage embryo transfer:analysis of 9408 singleton newborns using propensity score analysis

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Reproductive and Developmental Medicine 2024年第2期8卷 67-74页

作者： Hu-cen Zhong Qi Wan Yu-ling Hu Tian Li Li-Juan Huang Mao Wang Xin-Yue Hu Meng-Di Wang Zhao-Hui Zhong School of public Health Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of ChinaChongqing 400016China Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengdu 610041China Sichuan Jinxin Xinan Women and Children’s Hospital Chengdu 610041 SichuanChina Department of Reproductive Medicine the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China School of public Health Research Center for Medical and Social DevelopmentChongqing Medical UniversityChongqing 400016China

Objective:Regarding frozen-thawed embryo transfer(FET),there is limited consensus on whether extending embryo culture from the cleavage stage to the blastocyst stage affects perinatal *** study aimed to compare perinatal outcomes of singletons between blastocyst-stage embryo transfer(BT)and cleavage-stage embryo transfer(CT)in ***:A total of 9408 FET cycles that met the inclusion criteria were included in this retrospective cohort study between 2019 and ***-stage embryo transfers were performed in the BT group,and cleavage-stage embryo transfers were performed in the CT *** logistic regression analyses were performed,as well as propensity score matching(pSM)to adjust for ***:After pSM,a higher risk of pre-term birth(pTB;odds ratio[OR]:1.23,95%confidence interval[CI]:1.00-1.50,p=0.048)and being large for gestational age(LGA;OR:1.16,95%CI:1.00-1.35,p=0.050)was observed in the BT group compared to that in the CT *** stratified pSM,in the subgroup under 35 years of age,only an increased risk of LGA was observed in the BT group compared to the CT *** outcomes in the double-embryo transfer subgroup were similar to those in the unstratified ***,in the subgroup beyond 35 years of age and the single embryo transfer subgroup,perinatal outcomes were not statistically different between the BT and CT groups(p>0.05).Conclusions:In FET,prolonged embryo culture to the blastocyst stage increased the risk of pTB and LGA in single ***,stratified analysis based on age and the number of transferred embryos yielded different results,necessitating further mechanistic studies.

关键词： Frozen-thawed embryo transfer Blastocyst Cleavage stage perinatal outcomes pre-term birth Large for gestational age Small for gestational age

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功能化透明质酸在生物医药领域的研究进展

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石油化工 2024年第8期53卷 1080-1088页

作者：阿斯根奚桢浩岑莲赵玲华东理工大学化学工程联合国家重点实验室上海200237 华东理工大学化工学院上海市多相结构材料化学工程重点实验室上海200237

透明质酸(HA)是一种非硫酸化糖胺聚糖大分子,是细胞外基质的主要成分之一。由于独特的分子结构及生物活性,HA的应用领域广泛,并已有超过30年的应用历史。HA及其衍生物的分子特性,包括不同分子量范围对细胞、保湿和抗衰老的作用不同以及C... 详细信息

透明质酸(HA)是一种非硫酸化糖胺聚糖大分子,是细胞外基质的主要成分之一。由于独特的分子结构及生物活性,HA的应用领域广泛,并已有超过30年的应用历史。HA及其衍生物的分子特性,包括不同分子量范围对细胞、保湿和抗衰老的作用不同以及CD44靶向性,使其成为组织工程、伤口愈合、癌症治疗、眼科和化妆品等领域的热门原料之一。近年来,HA及其衍生物在生物医学领域中发挥着越来越重要的作用。重点介绍了近年来功能化HA应用在伤口愈合材料、软骨修复材料、药物载体、眼科材料、癌症治疗和化妆品方面的研究进展,HA多功能涂层、靶向纳米粒子和可注射水凝胶创新材料在前沿生物医用方向展现出巨大的应用前景。

关键词：透明质酸水凝胶支架组织工程学再生医学

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常见食源性病原菌的快速检测技术研究进展

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中国人兽共患病学报 2024年第2期40卷 123-133页

作者：俞佳岑叶平江玲丽高有领宁波卫生职业技术学院宁波315100 浙江万里学院生物与环境学院宁波315100

食源性病原菌广泛存在于自然环境中,可通过肉类、海产品、奶制品等多种媒介传播,引起食源性疾病的发生。目前检测食源性病原菌的方法主要以平板培养辅以生化鉴定和血清型鉴定为主,检测的周期较长,效率较低,因此建立快速、精准的食源性... 详细信息

食源性病原菌广泛存在于自然环境中,可通过肉类、海产品、奶制品等多种媒介传播,引起食源性疾病的发生。目前检测食源性病原菌的方法主要以平板培养辅以生化鉴定和血清型鉴定为主,检测的周期较长,效率较低,因此建立快速、精准的食源性病原菌检测方法对常见病原菌的现场检测及疾病的快速诊断尤为重要。本文对近年来常见食源性病原菌的快速检测方法进行了概述,主要包括免疫学检测手段、分子生物学检测方法和生物传感器检测技术,比较其优缺点,着重介绍了可以实现现场检测与实时检测的新兴技术:核酸-微流控检测技术,以期为常见食源性病原菌的预防与检测提供相关理论参考。

关键词：食源性病原菌食品安全快速检测核酸-微流控检测技术

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Artificial Bear Bile:A Novel Approach to Balancing Medical Requirements and Animal Welfare

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Engineering 2024年第7期38卷 100-112页

作者： Yong Li Yuhong Huang Nan Feng Hep.ng Zhang Jing Qu Shuanggang Ma Yunbao Liu Jiang Li Shaofeng Xu ling Wang Mi Zhang Jie Cai Weip.ng Wang Ru Feng Hang Yu Bo Yu Dailiang Liang Hep.ng Qin Suxiang Luo Yanfen Li Meifeng Li Ruihua Wang Chen Ma Yan Wang Xiaobo cen Xiaoxian Xu Boli Zhang Xiaoliang Wang Shishan Yu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300250China Zhongshan Belling Biotechnology Co. Ltd.Zhongshan 528437China Zhongshan Anshi Biopharmaceutical Co. Ltd.Zhongshan 528437China e WestChina-Frontier Pharma Tech Co.Ltd.Chengdu 610041China Tianjin University of Traditional Chinese Medicine Tianjin 301617China

Bear bile has been a valuable and effective medicinal material in traditional Chinese medicine(TCM)for over 13 ***,the current practice of obtaining it through bear farming is under scrutiny for its adverse impact on bear ***,we present a new approach for creating artificial bear bile(ABB)as a high-quality and sustainable alternative to natural bear *** study addresses the scientific challenges of creating bear bile alternatives through interdisciplinary collaborations across various fields,including resources,chemistry,biology,medicine,pharmacology,and TCM.A comprehensive efficacy assessment system that bridges the gap between TCM and modern medical terminology has been established,allowing for the systematic screening of therapeutic *** the utilization of chemical synthesis and enzyme engineering technologies,our research has achieved the environmentally friendly,large-scale production of bear bile therapeutic compounds,as well as the optimization and recomposition of ABB *** resulting ABB not only closely resembles natural bear bile in its composition but also offers advantages such as consistent product quality,availability of raw materials,and independence from threatened or wild *** preclinical efficacy evaluations have demonstrated the equivalence of the therapeutic effects from ABB and those from commercially available drained bear bile(DBB).Furthermore,preclinical toxicological assessment and phase I clinical trials show that the safety of ABB is on par with that of the currently used *** innovative strategy can serve as a new research paradigm for develop.ng alternatives for other endangered TCMs,thereby strengthening the integrity and sustainability of TCM.

关键词： Artificial bear bile Chemical profile Formula optimization pharmacodynamic consistency preclinical toxicological assessment

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Growth hormone-releasing hormone receptor signaling in experimental ocular inflammation and neuroprotection

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Neural Regeneration Research 2022年第12期17卷 2643-2648页

作者： ling-p.ng cen Tsz Kin ng Wai Kit Chu Chi pui p.ng Joint Shantou International Eye center of Shantou University and The Chinese University of Hong Kong ShantouGuangdong ProvinceChina Shantou University Medical College ShantouGuangdong ProvinceChina Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong Special Administrative RegionChina

Both inflammation and anti-inflammation are involved in the protection of retinal *** of the hypothalamic growth hormone-releasing hormone receptor(GHRHR)have been shown to possess potent anti-inflammatory properties in experimental disease models of various organs,some with systemic *** effects are also found in ocular inflammatory and neurologic injury *** experimental models of mice and rats,both growth hormone-releasing hormone receptor agonists and antagonists may alleviate death of ocular neural cells under certain experimental *** review explores the properties of growth hormone-releasing hormone receptor agonists and antagonists that lead to its protection against inflammatory responses induced by extrinsic agents or neurologic injures in ocular animal models.

关键词： neuroprotection ocular inflammation optic nerve injury retinal ganglion cells uveitis

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夜寒苏药膳对气虚体质人群疲劳状态的影响

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现代养生 2024年第15期24卷 1149-1152页

作者：黄继斌岑仪美陈玲周莹田娟何江黔南民族医学高等专科学校第二附属医院黔南州中医医院

目的探究夜寒苏药膳对气虚体质人群疲劳状态的影响及改善效果。方法选取2022年1月-2023年1月黔南州中医医院治未病中心收治的60例气虚患者作为研究对象。按照组间性别、年龄、病程均衡可比的原则，采用随机数字表法分为观察组与对照... 详细信息

目的探究夜寒苏药膳对气虚体质人群疲劳状态的影响及改善效果。方法选取2022年1月-2023年1月黔南州中医医院治未病中心收治的60例气虚患者作为研究对象。按照组间性别、年龄、病程均衡可比的原则，采用随机数字表法分为观察组与对照组，每组30例。观察组给予夜寒苏药膳治疗，对照组给予干山药治疗。比较两组患者的临床疗效、疲劳量表（FS-14评分）、生活健康量表（SF-36评分）以及生活满意度量表（SWLS评分）。结果治疗前，两组患者FS-14评分比较，差异无统计学意义（p>0.05）；治疗后，两组患者FS-14评分均降低，但观察组明显低于对照组，差异有统计学意义(ppp>0.05）；两组患者治疗后的SF-36评分在生理职能、生理机能、社会功能、躯体疼痛、精神健康、精力以及健康状况维度的评分均提高，但观察组均高于对照组，差异有统计学意义(pp>0.05）；治疗后，两组患者SWLS评分均升高，但观察组明显高于对照组，差异有统计学意义(p<0.05)。结论夜寒苏药膳可显著降低气虚体质人群的疲劳量表得分，改善疲劳状态，同时可以提高生活质量以及生活满意度。

关键词：夜寒苏气虚疲劳值黄姜花亚健康

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湖北省乡村振兴与新型城镇化耦合协调研究

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安徽农业科学 2024年第7期52卷 244-247,258页

作者：何涔锐孔令成湖北农村发展研究中心湖北荆州434023 长江大学经济与管理学院湖北荆州434023

乡村振兴与新型城镇化战略是共同解决城乡不平衡问题的关键,以湖北省地级市为研究对象,基于2010—2020年的数据,首先构建乡村振兴与新型城镇化指标体系,其次运用熵值法测算出两者得分,最后运用耦合协调度模型测算出两者之间的耦合度和... 详细信息

乡村振兴与新型城镇化战略是共同解决城乡不平衡问题的关键,以湖北省地级市为研究对象,基于2010—2020年的数据,首先构建乡村振兴与新型城镇化指标体系,其次运用熵值法测算出两者得分,最后运用耦合协调度模型测算出两者之间的耦合度和耦合协调度。结果表明:湖北省乡村振兴与新型城镇化发展水平呈波动增长趋势,且乡村振兴水平高于新型城镇化水平;各地市乡村振兴与新型城镇化之间的耦合协调度呈波动增长趋势。基于此,为了进一步提高湖北省乡村振兴和新型城镇化水平以及促进两者之间协调融合发展,提出了进一步延长农村产业链、完善城镇新型基础设施建设和发挥城镇溢出效应等对策建议。

关键词：乡村振兴新型城镇化耦合协调

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