Interferon-induced MXB protein restricts vimentin-dependent viral infection
作者机构：Institute of Medicinal BiotechnologyChinese Academy of Medical ScienceBeijing 100050China Institute of Pathogen BiologyChinese Academy of Medical ScienceBeijing 100730China Lady Davis Institute for Medical ResearchJewish General HospitalMontrealQuebec H3T 1E2Canada
出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)
年 卷 期：2024年第14卷第6期
页 面：2520-2536页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学]
基 金：appreciate the National Microbial Resource Center(No.NMRC-2020-3) the CAMS Collection Center of Pathogenic Microorganisms(CAMS-CCPM-A)for providing valuable reagents supported by Beijing Natural Science Foundation 7242097(to Dongrong Yi) National Natural Science Foundation of China 81902075(to Dongrong Yi) CAMS Innovation Fund for Medical Sciences 2021-I2M-1-038(to Shan Cen) 2021-I2M-1-030(to Quanjie Li) 2021-I2M-1-043(to Xiaoyu Li)
主 题：MXB Vimentin Broad antiviral strategy Cytoskeleton network AKT
摘 要：Type I interferon(IFN)inhibits a wide spectrum of viruses through stimulating the expression of antiviral *** an IFN-induced protein,myxovirus resistance B(MXB)protein was reported to inhibit multiple highly pathogenic human *** remains to be determined whether MXB employs a common mechanism to restrict different ***,we find that IFN alters the subcellular localization of hundreds of host proteins,and this IFN effect is partially lost upon MXB *** results of our mechanistic study reveal that MXB recognizes vimentin(VIM)and recruits protein kinase B(AKT)to phosphorylate VIM at amino acid S38,which leads to reorganization of the VIM network and impairment of intracellular trafficking of virus protein complexes,hence causing a restriction of virus *** results highlight a new function of MXB in modulating VIM-mediated trafficking,which may lead towards a novel broad-spectrum antiviral strategy to control a large group of viruses that depend on VIM for successful replication.
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