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X射线纳米分辨立体成像及其在芯片表征中的应用

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光学学报 2024年第13期44卷 332-340页

作者：刘聪王飞翔陶芬杜国浩张玲汪俊邓彪上海大学微电子学院中国科学院上海高等研究院上海光源中心

在芯片制造技术持续发展的背景下，对纳米量级检测的需求也随之急剧增加。然而，传统的光学、电镜和X射线检测技术都存在一定的局限性。本文提出了一种快速、无损、纳米分辨的立体成像技术，该技术基于上海光源纳米三维成像线站（BL18B... 详细信息

在芯片制造技术持续发展的背景下，对纳米量级检测的需求也随之急剧增加。然而，传统的光学、电镜和X射线检测技术都存在一定的局限性。本文提出了一种快速、无损、纳米分辨的立体成像技术，该技术基于上海光源纳米三维成像线站（BL18B）的透射X射线显微镜（TXM），结合双目立体视觉原理构建了X射线纳米分辨立体成像系统，通过归一化互相关（NCC）匹配算法获得了标准样品分辨率靶的线条宽度、长度及深度等信息。仿真结果和分辨靶实验所得深度信息与实际深度之间的归一化标准差分别为1.441×10-2和8.11×10-4，验证了该方法获取样品深度信息的准确性。同时利用该方法实现了对芯片样品的精确检测，为芯片检测提供了一种新型纳米分辨无损解决方案。

关键词： X射线立体成像透射X射线显微镜纳米尺度分辨芯片检测

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Changes in the Non-targeted Metabolomic Profile of Three-year-old Toddlers with Elevated Exposure to Polycyclic Aromatic Hydrocarbons

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Biomedical and Environmental Sciences 2024年第5期37卷 479-493页

作者： LI Yang LIN Dan ZHANG Xiu Qin JU Guang Xiu SU Ya ZHANG Qian DUAN Hai Ping YU Wei Sen WANG Bing ling PANG Shu tao Department of Epidemiology and Health Statistics School of Public HealthQingdao UniversityQingdao 266021ShandongChina Department of Environmental Health Qingdao Municipal Center for Disease Control and PreventionQingdao Institute of Preventive MedicineQingdao 266033ShandongChina Physicochemical Laboratory Qingdao Municipal Center for Disease Control and PreventionQingdao Institute of Preventive MedicineQingdao 266033ShandongChina Section of Child Health Care Huangdao Maternity and Child Health Care Hospital of QingdaoQingdao 266499ShandongChina Qingdao Blood Center Qingdao 266071ShandongChina

Objective To investigate changes in the urinary metabolite profiles of children exposed to polycyclic aromatic hydrocarbons(PAHs)during critical brain development and explore their potential link with the intestinal *** Liquid chromatography-tandem mass spectrometry was used to determine ten hydroxyl metabolites of PAHs(OH-PAHs)in 36-month-old ***,37 children were categorized into low-and high-exposure groups based on the sum of the ten ***-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was used to identify non-targeted metabolites in the urine ***,fecal flora abundance was assessed by 16S rRNA gene sequencing using Illumina *** The concentrations of 21 metabolites were significantly higher in the high exposure group than in the low exposure group(variable importance for projection>1,P<0.05).Most of these metabolites were positively correlated with the hydroxyl metabolites of naphthalene,fluorine,and phenanthrene(r=0.336–0.531).The identified differential metabolites primarily belonged to pathways associated with inflammation or proinflammatory states,including amino acid,lipid,and nucleotide ***,these distinct metabolites were significantly associated with specific intestinal flora abundances(r=0.34–0.55),which were mainly involved in *** Higher PAH exposure in young children affected metabolic homeostasis,particularly that of certain gut microbiota-derived *** investigation is needed to explore the potential influence of PAHs on the gut microbiota and their possible association with neurodevelopmental outcomes.

关键词： Child Gut microbiota Non-targeted metabolomics Polycyclic aromatic hydrocarbons Urinary metabolite profile

Super P and MoO2/MoS2 co-doped gradient nanofiber membrane as multi-functional separator for lithium–sulfur batteries

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Rare Metals 2024年第9期43卷 4263-4273页

作者： Xin Liang Dong-Qing Zhao Qian-Qian Huang Sheng Liang Li-Li Wang Lei Hu ling-Li Liu Kun-Hong Hu Chong-Hai Deng Sheng Cheng Er-tao Zhu Hua-Xia Deng School of Energy Materials and Chemical Engineering LIB Technology Center of Anhui ProvinceHefei University Instrumental Analysis Centre Hefei University of Technology Hefei Youngy Energy Materials Co. Ltd. Department of Modern Mechanics University of Science and Technology of China

Lithium-sulfur battery is one of the most promising battery systems for industrialization due to its high theoretical specific capacity and high energy ***,the??shuttle effect??has restrained the advancement of lithium-sulfur *** this work,a gradient-structured nanofiber membrane with pure gelatin on one side and Super P-MoO2/MoS2-gelatin on the other side was created using a multi-step electrostatic spinning technique,which was applied for multi-functional separator for lithium-sulfur *** pure gelatin layer facing the anode side primarily homogenizes the lithium flux,whereas the Super P-MoO2/MoS2-gelatin layer facing the cathode side primarily adsorbs polysulfides by physical and chemical adsorption and enhancing polysulfide conversion *** findings demonstrate that even after 150 cycles at 0.2C,the lithium-sulfur battery can still sustain a discharge-specific capacity of 572.3 mAh·*** used with Li||Li symmetric batteries,it has a cycle life of more than 1200 *** commercialization of lithium-sulfur batteries is given a fresh idea by this straightforward preparation technique.

关键词： Li–S battery Membrane MoO2/MoS2 Nanofiber

Therapeutic Effectiveness of Leukocyte-and Platelet-rich Fibrin for Diabetic Foot Ulcers:A Retrospective Study

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Current Medical Science 2024年第3期44卷 568-577页

作者： Fen WANG Xiao-ling ZHANG Jing ZHANG Song GONG Jing tao Hui XIANG Xiao-qing FU Xu-na BIAN Xue-feng YU An-hui XU Cheng-la YI Shi-ying SHAO Department of Endocrinology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Branch of National Clinical Research Center for Metabolic Diseases Wuhan430030China Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Trauma Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Diabetic foot ulcer(DFU)is one of the most serious complications of ***-and platelet-rich fibrin(L-PRF)is a second-generation autologous platelet-rich *** study aims to investigate the clinical effects of L-PRF in patients with diabetes in real clinical *** Patients with DFU who received L-PRF treatment and standard of care(SOC)from 2018 to 2019 in Tongji Hospital were *** clinical information including patient characteristics,wound evaluation(area,severity,infection,blood supply),SOC of DFU,and images of ulcers was retrospectively extracted and analyzed.L-PRF treatment was performed every 7±2 days until the ulcer exhibited complete epithelialization or an overall percent volume reduction(PVR)greater than 80%.Therapeutic effectiveness,including overall PVR and the overall and weekly healing rates,was *** Totally,26 patients with DFU were enrolled,and they had an ulcer duration of 47.0(35.0,72.3)*** severity and infection of ulcers varied,as indicated by the Site,Ischemia,Neuropathy,Bacterial Infection,and Depth(SINBAD)scores of 2–6,Wagner grades of 1–4,and the Perfusion,Extent,Depth,Infection and Sensation(PEDIS)scores of 2–*** initial ulcer volume before L-PRF treatment was 4.94(1.50,13.83)cm3,and the final ulcer volume was 0.35(0.03,1.76)*** median number of L-PRF doses was 3(2,5).A total of 11 patients achieved complete epithelialization after the fifth week of treatment,and 19 patients achieved at least an 80%volume reduction after the seventh *** overall wound-healing rate was 1.47(0.63,3.29)cm3/week,and the healing rate was faster in the first 2 weeks than in the remaining *** treatment did not change the percentage of complete epithelialization or healing *** Adding L-PRF to SOC significantly improved wound healing in patients with DFU independent of the ankle brachial index,SINBAD score,or Wagner grade,indicating that this method is appropriate for D

关键词： diabetic foot ulcer autologous platelet-rich plasma leukocyte-and platelet-rich fibrin standard of care percentage volume reduction

Combination of AAV-delivered tumor suppressor PTEN with anti-PD-1 loaded depot gel for enhanced antitumor immunity

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Acta Pharmaceutica Sinica B 2024年第1期14卷 350-364页

作者： Yongshun Zhang Lan Yang Yangsen Ou Rui Hu Guangsheng Du Shuang Luo Fuhua Wu Hairui Wang Zhiqiang Xie Yu Zhang Chunting He Cheng Ma tao Gong ling Zhang Zhirong Zhang Xun Sun Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China Med-X Center for Materials College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Recent clinical studies have shown that mutation of phosphatase and tensin homolog deleted on chromosome 10(PTEN)gene in cancer cells may be associated with immunosuppressive tumor microenvironment(TME)and poor response to immune checkpoint blockade(ICB)***,efficiently restoring PTEN gene expression in cancer cells is critical to improving the responding rate to ICB ***,we screened an adeno-associated virus(AAV)capsid for efficient PTEN gene delivery into B16F10 tumor *** demonstrated that intratumorally injected AAV6-PTEN successfully restored the tumor cell PTEN gene expression and effectively inhibited tumor progression by inducing tumor cell immunogenic cell death(ICD)and increasing immune cell ***,we developed an anti-PD-1 loaded phospholipid-based phase separation gel(PPSG),which formed an in situ depot and sustainably release anti-PD-1 drugs within 42 days in *** order to effectively inhibit the recurrence of melanoma,we further applied a triple therapy based on AAV6-PTEN,PPSG^(@anti-PD-1)and CpG,and showed that this triple therapy strategy enhanced the synergistic antitumor immune effect and also induced robust immune memory,which completely rejected tumor *** anticipate that this triple therapy could be used as a new tumor combination therapy with stronger immune activation capacity and tumor inhibition efficacy.

关键词： Triple therapy Adeno-associated virus PTEN PPSG@anti-PD-1 CpG Immunogenic cell death Antitumor immune response Immune memory

An Improved Medical Image Fusion Algorithm for Anatomical and Functional Medical Images

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Chinese Journal of Biomedical Engineering(English Edition) 2009年第2期18卷 84-92页

作者： CHEN Mei-ling tao ling QIAN Zhi-yu College of Automation Engineering Nanjing University of Aeronautic ＆ Astronautic Nanjing 210016 China

In recent years,many medical image fusion methods had been exploited to derive useful information from multimodality medical image data,but,not an appropriate fusion algorithm for anatomical and functional medical *** this paper,the traditional method of wavelet fusion is improved and a new fusion algorithm of anatomical and functional medical images,in which high-frequency and low-frequency coefficients are studied *** choosing high-frequency coefficients,the global gradient of each sub-image is calculated to realize adaptive fusion,so that the fused image can reserve the functional information;while choosing the low coefficients is based on the analysis of the neighborbood region energy,so that the fused image can reserve the anatomical image's edge and texture *** results and the quality evaluation parameters show that the improved fusion algorithm can enhance the edge and texture feature and retain the function information and anatomical information effectively.

关键词：图像融合算法医学图像解剖信息功能融合图像纹理特征自适应融合图像数据

The Roadmap of 2D Materials and Devices Toward Chips

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Nano-Micro Letters 2024年第6期16卷 343-438页

作者： Anhan Liu Xiaowei Zhang Ziyu Liu Yuning Li Xueyang Peng Xin Li Yue Qin Chen Hu Yanqing Qiu Han Jiang Yang Wang Yifan Li Jun Tang Jun Liu Hao Guo tao Deng Songang Peng He Tian Tian‑ling Ren School of Integrated Circuits and Beijing National Research Center for Information Science and Technology(BNRist) Tsinghua UniversityBeijing 100049People’s Republic of China School of Microelectronics Fudan UniversityShanghai 200433People’s Republic of China State Key Laboratory of Dynamic Measurement Technology Shanxi Province Key Laboratory of Quantum Sensing and Precision MeasurementNorth University of ChinaTaiyuan 030051People’s Republic of China High‑Frequency High‑Voltage Device and Integrated Circuits R&D Center Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029People’s Republic of China School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044People’s Republic of China School of Integrated Circuits University of Chinese Academy of SciencesBeijing 100049People’s Republic of China IMECAS-HKUST-Joint Laboratory of Microelectronics Beijing 100029People’s Republic of China

Due to the constraints imposed by physical effects and performance degra certain limitations in sustaining the advancement of Moore’s ***-dimensional(2D)materials have emerged as highly promising candidates for the post-Moore era,offering significant potential in domains such as integrated circuits and next-generation ***,in this review,the progress of 2D semiconductors in process engineering and various electronic applications are summarized.A careful introduction of material synthesis,transistor engineering focused on device configuration,dielectric engineering,contact engineering,and material integration are given *** 2D transistors for certain electronic applications including digital and analog circuits,heterogeneous integration chips,and sensing circuits are ***,several promising applications(artificial intelligence chips and quantum chips)based on specific mechanism devices are ***,the challenges for 2D materials encountered in achieving circuit-level or system-level applications are analyzed,and potential development pathways or roadmaps are further speculated and outlooked.

关键词： Two-dimensional materials Roadmap Integrated circuits Post-Moore era

Wave field structure and power coupling features of blue-core helicon plasma driven by various antenna geometries and frequencies

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Chinese Physics B 2024年第3期33卷 480-487页

作者：王超刘佳苌磊卢凌峰张世杰周帆涛 State Key Laboratory of Power Transmission Equipment Technology School of Electrical EngineeringChongqing UniversityChongqing 400044China Shanghai Institute of Space Propulsion Shanghai 201112China Southwestern Institute of Physics Chengdu 610041China

This paper deals with wave propagation and power coupling in blue-core helicon plasma driven by various antennas and *** is found that compared to non-blue-core mode,for blue-core mode,the wave can propagate in the core region,and it decays sharply outside the *** power absorption is lower and steeper in radius for blue-core *** the effects of antenna geometry for blue-core mode,it shows that half helix antenna yields the strongest wave field and power absorption,while loop antenna yields the ***,near axis,for antennas with m=+1,the wave field increases with axial *** the core region,the wave number approaches to a saturation value at much lower frequency for non-blue-core mode compared to blue-core *** total loading resistance is much lower for blue-core *** findings are valuable to understanding the physics of blue-core helicon discharge and optimizing the experimental performance of blue-core helicon plasma sources for applications such as space propulsion and material treatment.

关键词： helicon plasma helicon wave helicon discharge radio frequency plasma source

BaTiO_(3)掺杂调控内建电场提升钙钛矿太阳能电池性能

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物理学报 2024年第3期73卷 334-345页

作者：金程程丁玲玲宋子馨陶海军南京航空航天大学材料科学与技术学院南京211106

碳基无空穴传输层钙钛矿太阳能电池(C-PSCs)因其替换了昂贵的贵金属电极,以及去掉了稳定性差的空穴传输材料而受到广泛关注.但是C-PSCs内部载流子分离和传输性能差阻碍了效率的提高,而内建电场的增强可以改善载流子传输性能从而提升电... 详细信息

碳基无空穴传输层钙钛矿太阳能电池(C-PSCs)因其替换了昂贵的贵金属电极,以及去掉了稳定性差的空穴传输材料而受到广泛关注.但是C-PSCs内部载流子分离和传输性能差阻碍了效率的提高,而内建电场的增强可以改善载流子传输性能从而提升电池光电性能.本文将铁电材料钕酸钡(BaTiO_(3))粉末作为添加剂引入钙钛矿前驱液中制备C-PSCs,改善钙钛矿薄膜形态,降低薄膜缺陷密度及提高C-PSCs载流子传输性能.结果表明,当BaTiO_(3)质量分数为1.0%时,钙钛矿薄膜均匀致密,电池的光电转换效率最高.对薄膜施加正向电压极化处理后,铁电材料BaTiO_(3)剩余极化电场增大了内建电场,为载流子输运和萃取提供充足的动力,从而抑制非辐射复合的发生;同时耗尽层宽度增大,反向饱和电流减小,电池性能显著提升,优化后最佳器件效率为9.02%.本文为钙钛矿吸收层掺杂实现内建电场调控提供了一种有效策略.

关键词：钙钛矿太阳能电池内建电场铁电材料载流子传输

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