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Changes in the nutritional status of nine vitamins in patients with esophageal cancer during chemotherapy

World Journal of Gastroenterology 2021年第19期27卷 2366-2375页

作者： Lan-Qing Liang ling-ling meng Bo-Ning Cai Ze-Ping Cui Na Ma Le-Hui Du Wei Yu Bao-Lin Qu Sheng-Qiang Feng Fang Liu Department of Radiotherapy Chinese PLA General HospitalBeijing 100853China Department of Health Service The Guard Bureau of Joint Staff Department of Chinese PLABeijing 100017China

BACKGROUND Many studies have investigated the relationships between vitamins and esophageal cancer(EC).Most of these studies focused on the roles of vitamins in the prevention and treatment of EC,and few studies have examined the changes in vitamin nutritional status and their influencing factors before and after chemotherapy for *** may have a considerable effect on EC patients’vitamin levels and hematological *** To research the nutritional status of multiple vitamins in EC patients during chemotherapy and to assess its clinical *** EC patients admitted to our center from July 2017 to September 2020 were enrolled in this *** concentrations of nine vitamins(A,D,E,B9,B12,B1,C,B2 and B6),hemoglobin,total protein,albumin,blood calcium,blood phosphorus concentrations and body mass index(BMI)were measured in all EC *** changes in nine vitamins,hematological indicators and BMI were compared before and after two cycles of *** possible influential factors were *** In total,203 EC patients receiving chemotherapy were enrolled in this *** degrees of vitamin A,D,C and B2 deficiency and weight loss were found in these patients,and the proportions of vitamin B2 and vitamin C deficiencies increased significantly after chemotherapy(both P<0.05).Serum concentrations of vitamins A,C,B2 and B6 and BMI before and after chemotherapy were statistically significant(all P<0.05).Multivariate analysis showed that vitamin A levels significantly differed between male and female EC patients,whereas vitamin D concentration significantly differed in EC patients in different stages(all P<0.05).Correlations were observed between the changes in serum concentrations of vitamin A and C before and after two cycles chemotherapy and the change in BMI(P<0.05).Hemoglobin,total protein,serum albumin and blood calcium concentrations significantly decreased in EC patients after chemotherapy(all P<0.05),while the blo

关键词： Esophageal cancer Chemotherapy Vitamins Nutritional status Body mass index

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Block copolymer of am and dmaam by atrp

Block copolymer of am and dmaam by atrp

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2005年全国高分子学术论文报告会

作者： Xiao-Ju Lu, Shu-ling Gong, ling-Zhi meng, ling-ling Wang, Cheng Li, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072

＜正＞In this paper cyclic four-N-atom compound（TAT）was synthesized and used as ligand of atom transfer radical *** of AM by ATRP was carried out in room temperature using methyl-2-chrolopropionate（MCP）as initiato... 详细信息

关键词： polydentate cyclic ligand aqueous medium ATRP

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Building Distributed Web GIS: A Mobile Agent Based Approach

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Wuhan University Journal of Natural Sciences 2001年第Z1期6卷 474-481页

作者： jhguan@*** Guan Ji hong 1 , Zhou Shui geng 2 , Bian Fu ling 3, meng ling kui 3 1. School of Computer, Wuhan University, Wuhan 430072, China 2. State Key Laboratory of Software Engineering, Wuhan University, Wuhan 430072, Chin School of Computer Wuhan University Wuhan China State Key Laboratory of Software Engineering Wuhan University Wuhan China College of Remote Sensing and Information Engineering Wuhan University Wuhan China

The diversity of GISs and the wide spread availability of WWW have led to an increasing amount of research on integrating a variety of heterogeneous and autonomous GISs in a cooperative environment to construct a new generation of GIS characterizing in open architecture, distributed computation, interoperability, and extensibility. Our on going research project MADGIS (Mobile Agent based Distributed Geographic Information System) is reported, in which we propose the architecture of MADGIS to meet the requirements of integrating distributed GIS applications under Internet environment. We first describe the architecture of MADGIS, and detailed discussions focusing on the structure of client site, server site and mobile agent in MADGIS. Then we explore key techniques for MADGIS implementation.

关键词： distributed GIS mobile agent architecture mobility interoperability

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Self-assemble of amphiphilic block poly（acrylamide）

Self-assemble of amphiphilic block poly（acrylamide）

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2005年全国高分子学术论文报告会

作者： Xiao-Ju Lu, Shu-ling Gong, ling-Zhi meng, ling-ling Wang, Cheng Li, Zhao-Qiang Wu, Li-Fen Zhang College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072

＜正＞It is well-known that the relative block length of the corona and core forming blocks of the copolymer can influence the morphology of the resulting aggregates in *** paper will focus on the effect of hydrophili... 详细信息

关键词： amphiphilic block copolymer self-organization vesicles

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Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2823-2837页

作者： Qiuquan Cai Lianghui meng Meina Quan ling Wang Jing Ren Chenguang Zheng Jiajia Yang Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Innovation Center for Neurological Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin UniversityTianjinChina Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive *** presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s *** use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent *** a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive *** article provides a summary of the application of ultrasound technology for treating Alzheimer’s disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound *** is placed on the benefits of introducing these treatment methods and their potential *** found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-βplaque *** believe that ultrasound is an effective therapy for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnetic resonance imaging-guided focused ultrasound microbubbles scanning ultrasound ultrasound ultrasound stimulation

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Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

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Neural Regeneration Research 2025年第1期20卷 67-81页

作者： Yubo Wang Tingli Yuan Tianjie Lyu ling Zhang meng Wang Zhiying He Yongjun Wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering Research Center of Stem Cells Translational Medicine ShanghaiChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell

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The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying Chen Yinyi Xiong Qin Zhou ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

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Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping Yu Emily Choi Michael QJiang ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

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基于SWMM模型的城市排水区域降雨及地表产流特征

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应用生态学报 2016年第11期27卷 3659-3666页

作者：熊丽君黄飞徐祖信李怀正龚玲玲董梦珂同济大学长江水环境教育部重点实验室上海200092 上海市环境科学研究院上海200233 上海世博城市最佳实践区商务有限公司上海200011

以上海市中心城区典型排水区域为研究对象,基于SWMM模型连续模拟2009—2011年降雨径流,分析区域235场降雨及地表径流特征.结果表明:该区域发生频率较高的降雨具有雨量小、强度低的特点,雨量为0~10 mm、平均降雨强度为0~5 mm·h^(-1)、... 详细信息

以上海市中心城区典型排水区域为研究对象,基于SWMM模型连续模拟2009—2011年降雨径流,分析区域235场降雨及地表径流特征.结果表明:该区域发生频率较高的降雨具有雨量小、强度低的特点,雨量为0~10 mm、平均降雨强度为0~5 mm·h^(-1)、降雨峰值为0~10 mm·h^(-1)的降雨发生频率最大,分别占所有研究降雨场次的66.4%、88.8%和79.6%,这对于该区域应用低影响开发措施削减小雨量或低强度降雨下的径流和面源污染具有重要意义;径流量总体随着降雨量增大而增大,区域降雨产流临界值不仅与降雨量有关,还与平均降雨强度和降雨历时有关,2 mm以下的降雨基本不产流;2~4 mm的降雨如降雨强度在1.6mm·h^(-1)以下,产流量不到1 mm,当降雨量在4 mm以上、平均降雨强度大于1.6 mm·h^(-1)时,区域基本产流.基于SWMM径流模拟结果,建立适合该区域的径流量与降雨因子的回归方程,其调整R2均大于0.97,能较好反映该区域径流量与降雨因子的关系.研究结果可为该区域更好地规划低影响开发措施和削减排水系统溢流污染提供计算基础,并为类似区域的径流研究提供参考.

关键词： SWMM 降雨径流回归分析低影响开发

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清胆化石汤配合保胆取石术治疗胆结石临床观察

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现代中药研究与实践 2017年第5期31卷 65-67页

作者：张淑玲孟令军铜川市妇幼保健院陕西铜川727007

目的探讨、评估清胆化石汤配合保胆取石术治疗胆囊结石的临床疗效。方法选取2014年7月到2016年1月医院收取的87例初患的胆囊结石患者,对其进行微创保胆取石术,术后五天随机分为两组,实验组(n_1=43)服用清胆化石汤,对照组(n_2=44)服用牛... 详细信息

目的探讨、评估清胆化石汤配合保胆取石术治疗胆囊结石的临床疗效。方法选取2014年7月到2016年1月医院收取的87例初患的胆囊结石患者,对其进行微创保胆取石术,术后五天随机分为两组,实验组(n_1=43)服用清胆化石汤,对照组(n_2=44)服用牛磺熊去氧胆酸,观察术后并发症,胆囊恢复情况以及复发率。结果术后半年与一年,实验组与对照组的腹胀,右上腹不适与胆绞痛的发生率均显著比术前低(P0.05),但实验组胆囊排空指数比对照组高,同时胆囊壁厚比对照组低(P<0.05)。结论胆化石汤在预防胆囊结石复发方面和牛磺熊去氧胆酸疗效相当。在恢复、增强胆囊功能方面,清胆化石汤效果甚至优于牛磺熊去氧胆酸。

关键词：胆囊结石清胆化石汤保胆取石术牛磺熊去氧胆酸

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