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A scintillator detector for beam tuning of low-energy single electron accelerator

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Radiation Detection Technology and Methods 2017年第1期1卷 29-39页

作者： yu-lan Li yun-ting Gu yu-guang Xie Jun-hui yue Jun-guang Lv Shun-li Niu Shi-lun Pei Feng Shi ling-da yu Hang Zhao Wen-qi Yan Pin Lv Zhi-yuan Peng Geng-lan Li Guangxi University Nanning 530004GuangxiChina Institute of High Energy Physics Beijing 100049China State Key Laboratory of Particle Detection and Electronics Beijing 100049China University of Chinese Academy of Sciences Beijing 100049China

Purpose Nine scintillator detectors were developed for beam tuning of low-energy single electron accelerator instead of the picoammeter and Faraday cup,both of which will be insensitive to the weak-current beam lower than *** The detectors are based on plastic scintillator and photomultiplier tube(PMT)and the beam is 100 Hz pulsed electrons in the energy range of 0.1 to *** beam flux was tuned from about 107 to quasi-single electron for each bunch according to the measurement results of these detectors installed along the beam pipe and after *** order to determine the number of electrons in a bunch,the gains of each PMT were finely calibrated,and the energy response of each detector was calibrated with 207Bi radioactive ***,the deposited energy in the plastic scintillator,the electron detection efficiency and light collection efficiency,as a function of electron incident energy,were also simulated in detail by *** Nine detectors worked well at a gain of 0.6×10^(6) after installation in the beam pipe,and the number of electrons in a bunch could be measured at each detector *** single electron peak was seen when the beam reached the final *** The commissioning result shows that the beam was tuned to quasi-single electron level successfully and the scintillator detector is an effective method to measure the weak-current beam lower than picoampere.

关键词： Beam tuning Single electron beam PMT Plastic scintillator Slit

A high sensitivity tune measurement system for BEPCII

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Radiation Detection Technology and Methods 2022年第1期6卷 88-96页

作者： Jun He Yan-feng Sui Yan-hua Lu Yao-yao Du Lin Wang Hui-zhou Ma Yong Li Ying Zhao ling-da yu Tao-guang Xu Jun-hui yue Jian-she Cao Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

Background The tune is one of the most important parameters of the storage ring which play a crucial role in the brightness *** synchrotron radiation will suppress the oscillation and make the detection unusual difficulty without any kicker *** A new high sensitivity tune measurement system is developed to show the real-time tune during the *** Peak diode detectors are used to convert short beam pulses from a button BPM into slowly varying *** DC components,constituting a large background related to beam offsets,are suppressed by series capacitors,while the small signals related to beam oscillations are passed to the subsequent stages for amplification and *** A direct diode detection technique based on the diode peak hold circuit could increase the sensitivity by hundreds time which gets a clearly tune peak even with synchrotron radiation and bunch-by-bunch feedback damping.

关键词： Collider High sensitivity Direct diode detection Real-time tune Red Pitaya

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping yu Emily Choi Michael QJiang ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

An Effective Group Oriented Access Control Model

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An Effective Group Oriented Access Control Model

一种基于后项不定长关联规则的Web个性化推荐方法

第二十四届中国数据库学术会议

作者： SHEN Zhou SONG Jie WANG da-ling yu Ge SHEN De-Rong WAMG Nan QI Wen (School of Information Science and Engineering,Northeastern University,Shenyang 110004)

In large modern enterprise information secure systems,the management of users and access rights is a complex and important *** Role-Based Access Control(RBAC) models have been applied widely as a generalized approach to access *** the authorization of users in large systems,the authorization for users only based on role can not meet the access control *** this paper,a group oriented access control model is proposed,which is based on RBAC model and further improve *** the model,the user is governed by group and permission is organized by the *** model can meet users’ requirements of security and implement the access control for users well in control policy and effectivity.

关键词： RBAC User model Web security

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计算机科学 2003年第12期30卷 69-72,88页

作者：丁增喜王菊英王大玲鲍玉斌于戈东北大学信息科学与工程学院沈阳110004

1引言随着Internet的发展,电子商务、远程教育等各种基于网络的服务也得到迅猛发展.实现网上信息个性化已经成为一种热点.

关键词： Internet Web 个性化推荐方法后项不定长关联规则

Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures

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Neural Regeneration Research 2025年第1期20卷 265-276页

作者： Yao yuan lingqi yu Xudong Zhuang Dongjing Wen Jin He Jingmei Hong Jiayu Xie Shengan ling Xiaoyue Du Wenfeng Chen Xinrui Wang Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouFujian ProvinceChina NHC Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate(Fujian Maternity and Child Health Hospital) FuzhouFujian ProvinceChina Medical Research Center Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology and Institute of Neurology of The First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina

Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory *** develop in vivo models to study the role of Na^(+)/K^(+)-ATPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human ATP1A1 gene mutations that cause *** located within the helical linker region of human ATP1A1(I592T,A597T,P600T,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRISPR/Cas9-mediated genome editing,generating the Atpα^(TTTF)*** addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571T),Atpα^(A576T),Atpα^(P579T),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive *** these alleles,we found two that could be maintained as homozygotes(Atpα^(I571T)and Atpα^(P579T)).Three alleles(Atpα^(A576T),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut *** found that the Atpαallele carrying these CMT2-associated mutations showed differential phenotypes in *** heterozygous for Atpα^(TTTF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal *** Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump.

关键词： ATP1A1 Atpα bang-sensitive paralysis Charcot-Marie-Tooth disease type 2 CRISPR/Cas9 homology-directed repair Na^(+)/K^(+)-ATPase point mutation seizures sodium pump

Literature study on traditional Chinese medicine syndromes after renal transplantation

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World Journal of Transplantation 2025年第1期15卷 150-155页

作者： yun-Peng Guo ling-Xue Bao yu-Yang Wang Quan Wen Gai Hang Bo Chen Tongliao Clinical Medical College Inner Mongolia Medical UniversityTongliao 028000Inner Mongolia Autonomous RegionChina Department of Urology Tongliao People's HospitalTongliao 028000Inner Mongolia Autonomous RegionChina

BACKGROUND Kidney transplantation is the most effective means to treat patients with renal failure,but its postoperative problems such as rejection reactions,immunosuppressant poisoning,chronic transplant kidney nephropathy,*** have not been effectively *** study searched for literature on traditional Chinese medicine(TCM)syndromes after kidney transplantation in China,conducted statistical analysis of the results,and sought to identify the underlying *** To understand the TCM syndromes after renal transplantation and associated rules and provide a theoretical basis for further clinical *** The literature pertaining to TCM syndromes in renal transplantation,published in the China National Knowledge Infrastructure,Wanfang database,and WIP database from 1970 to 2021,was meticulously searched and comprehensively and statistically *** Following the established inclusion and exclusion criteria,13 studies were selected for ***-renal transplantation,no significant discrepancy was noted among the groups based on the location of TCM ***,when categorized according to TCM pathogenic factors,the groups with spleen and kidney yang deficiency,as well as liver and kidney yin deficiency,exhibited a statistically significant difference in the *** Currently,the research on TCM syndromes pertaining to renal transplantation is in its nascent *** is imperative to conduct a multicentric,large-scale survey of TCM syndromes subsequent to renal transplantation in the ensuing years.

关键词： Kidney transplantation Syndrome Literature analysis Traditional Chinese medicine Systematic review

Experimental Studies on Extraction of Modified Suction Caisson (MSC) in Sand by Reverse Pumping Water

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China Ocean Engineering 2021年第2期35卷 272-280页

作者： HUANG ling-xia ZHANG yu-kun LI da-yong College of Civil Engineering Fuzhou UniversityFuzhou 350108China Key Laboratory of Civil Engineering Disaster Prevention and Mitigation Shandong University of Science and TechnologyQingdao 266590China

A suction caisson can be extracted by applying reverse pumping water,which cannot be regarded as the reverse process of installation because of the dramatically different soil−structure interaction *** tests were first carried out in this study to investigate the extraction behavior of the modified suction caisson(MSC)and the regular suction caisson(RSC)in sand by reverse pumping *** effects of the installation ways(suction-assisted or jacking installation)and the reverse pumping rate on the variations of the over-pressure resulting form reverse pumping water were *** was found that neither the RSC nor the MSC can be fully extracted from *** the maximum extraction displacement is obtained,the hydraulic gradient of the sand in the suction caisson reaches the critical value,leading to seepage *** addition,the maximum extraction displacement decreases with the increasing reverse pumping *** the same reverse pumping rate,the final extraction displacements for the RSC and MSC installed by suction are lower than those for the RSC and MSC installed by *** final extraction displacement of MSC is almost equal to that of the RSC with the same internal compartment *** on the force equilibrium,a method of estimating the maximum extraction displacement is *** has been proved that the proposed method can rationally predict the maximum extraction displacement and the corresponding over-pressure.

关键词： modified suction caisson(MSC) model test extraction critical hydraulic gradient maximum extraction displacement

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu ling-Jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors